System impacts of solar dynamic and growth power systems on space station

Concepts for the 1990's space station envision an initial operational capability with electrical power output requirements of approximately 75 kW and growth power requirements in the range of 300 kW over a period of a few years. Photovoltaic and solar dynamic power generation techniques are contenders for supplying this power to the space station. A study was performed to identify growth power subsystem impacts on other space station subsystems. Subsystem interactions that might suggest early design changes for the space station were emphasized. Quantitative analyses of the effects of power subsystem mass and projected area on space station controllability and reboost requirements were conducted for a range of growth station configurations. Impacts on space station structural dynamics as a function of power subsystem growth were also considered

Gambaran Kadar Gula Darah Dan Asam Urat Pada Siswa Obes Di SMP Negeri 1 Manado

: Obesity is defined as abnormal or excessive fat accumulation which is risky to health. Complications of obesity are diverse, including increased blood sugar and uric acid levels. Obesity has a high prevalence and tends to increase. This study aimed to obtain the profile of blood sugar and uric acid levels among obese students. This was a descriptive study with a cross sectional design. Population of this study was obese students of Junior High School (SMP 1) Manado. Total samples were 13 obese students consisted of 52.8% females and 47.2% males. There were 15.4% subjects with high blood sugar levels and 53.8% subjects with high blood uric acid levels. Conclusion: In this study, the minority of obese students had high blood sugar levelslevel of blood sugar but the majority had high blood uric acid levels

The effectiveness of iPad in enhancing instruction in mathematics teaching and learning for secondary schools in Saudi Arabia

Tablet devices, such as the iPad, have emerged among the most essential educational tools due to features that facilitate the learning and teaching process without the limitations of time or location. Tablet devices and their range of applications (apps) can potentially improve both the teaching and learning processes and the communication between teachers and students. However, there are concerns about the benefits of using tablet devices and their different apps in the learning process, including the extent to which students actually use them for educational purposes. Therefore, this study sought to evaluate the effectiveness of iPad usage, including various applications, in terms of improving students' mathematics achievement and motivation based on accomplishing the goals of mathematics lessons in a 10th grade secondary school in Saudi Arabia (SA). To achieve this, iPad devices were deliberately introduced to support teachers and students in the teaching and learning of mathematics. The study also sought to evaluate the impact that iPad usage and the various applications would have on mathematics teachers’ perspectives regarding the teaching of mathematics concepts in the same secondary school in SA. While there are now many opportunities for technology to be used in the education sector, there is still a need for a better understanding of how and to what extent iPad devices and the various dedicated education apps can be integrated in teaching and learning in secondary schools in SA, particularly with regard to mathematics education. This is an important matter, as it has several wider implications for curriculum design, classroom practice, teacher and student education, and the development of greater understanding of learning and cognition in technology-enhanced learning settings. To generate insights into the effectiveness of introducing iPad devices and various apps related to teaching and learning mathematics in Saudi secondary schools, the study used a logical model design for program evaluation based on a mixed-method approach. A quasi-experimental design was applied as the primary quantitative approach, while the secondary qualitative approach was carried out simultaneously. The quasi-experimental period stretched over two months. In the first month, class A was the treatment group and pupils in that group used iPads and relevant apps to learn mathematics, while class B was the control group, with the pupils using traditional methods based on using books, paper, and pencils. The treatment was switched between the two classes in the second month. Data were collected from a pre-test and two post-tests (quantitative data), semi-structured interviews, and a focus group interview (qualitative data). The participants in this quasi-experimental study included 50 students from two classes in the 10th grade (25 participants in each class), as well as four teachers who took part in the interviews. The focus groups comprised eight groups of six students, four groups from each class. The quantitative data were analysed using a multi-statistical method in IBM SPSS and the qualitative data were analysed using thematic analysis. The study uncovered a wide range of evidence indicating encouraging results for the integration of the iPad and relevant applications in the process of teaching and learning mathematics in educational systems, particularly in Saudi Arabian secondary schools. The findings of the quantitative data showed that the iPad devices and the applications used significantly improved students’ achievement in the period during which they were encouraged to use these devices to learn mathematics, with better results than when they used the traditional methods (books, paper, and pencils). However, this improvement might not occur if the students or teacher are not trained to use the device and the various educational apps employed in this quasi-experimental study. The findings of the students' focus group interviews revealed largely positive views towards the use of the iPad device and its apps, such as education platform apps and various communication apps. This device and its apps promoted students’ performance in mathematics by providing immediate feedback, improving their mathematical skills, helping them to prepare for tests, and assisting them to search for information, thus equipping them with a better understanding of the content. The majority of students also found the use of these devices to be a source of motivation and they encouraged them to learn mathematics and achieve the goals of the lesson plans to a greater degree than when working with conventional methods. Moreover, the students were dependent on this device and its apps for their learning and viewed is as a useful and supportive educational tool for facilitating their communication and enhancing their collaboration, as well as organising their time and studies. However, while most of the students believed that the iPad and its apps encourage them to study mathematics, some students reported that they were not inclined to use this device to learn mathematics. They stated that their preference was to handwrite notes or complete mathematics activities using paper and pencil because they found it difficult to write certain symbols on the device. They also reported encountering several obstacles, such as interrupted or slow internet connection, low battery level, difficulty recharging the battery, some apps hanging during use, and the iPad screen breaking easily. The findings of the teacher interviews showed that, in general, the perception was that both teachers and students benefitted from the use of the iPad, and the apps were deemed useful tools for facilitating and improving the in-class teaching and learning processes. They believed that this device assisted them in achieving the lesson objectives faster than previous teaching methods. It also helped them to immediately ascertain their students' academic level, improve their students' performance, motivate their students to learn mathematics, and provide instant feedback for their students. The findings also demonstrate that iPads facilitated collaboration and communication among students, as well as developing their creativity, critical thinking, and self-reliance skills. However, the results also illustrated that there are several elements that make both teachers and students in SA public schools unwilling or unable to use the device and its apps. For instance, the infrastructure of schools may not be equipped to integrate the technology, especially so in the case of iPads. In addition, teachers were afraid to integrate iPad use in the classroom because they lacked the knowledge to use this device and its apps for educational purposes. They also faced continuing obstacles and limitations in using the iPad and its apps in the classroom environment. These obstacles were mainly associated with technical issues, such as lack of connection to the internet or battery problems. Other issues included students forgetting to bring their iPad device or using non-instructional apps in the classroom. The study, therefore, proposes some solutions to these obstacles, which could be beneficial for schools to consider before deciding whether to integrate iPad devices and their various apps in the classroom. Therefore, this study helps provide insights and evidence regarding iPad usage with various educational apps in the classroom. The implications of these findings are considered in relation to students’ development, teachers’ development, and the educational technology and school development curricula in SA secondary schools. Some suggestions regarding future research based on this are also offered

miR-34a Promotes Vascular Smooth Muscle Cell Calcification by Downregulating SIRT1 (Sirtuin 1) and Axl (AXL Receptor Tyrosine Kinase).

Objective- Vascular calcification (VC) is age dependent and a risk factor for cardiovascular and all-cause mortality. VC involves the senescence-induced transdifferentiation of vascular smooth muscle cells (SMCs) toward an osteochondrogenic lineage resulting in arterial wall mineralization. miR-34a increases with age in aortas and induces vascular SMC senescence through the modulation of its target SIRT1 (sirtuin 1). In this study, we aimed to investigate whether miR-34a regulates VC. Approach and Results- We found that miR-34a and Runx2 (Runt-related transcription factor 2) expression correlates in young and old mice. Mir34a <sup>+/+</sup> and Mir34a <sup>-/-</sup> mice were treated with vitamin D, and calcium quantification revealed that Mir34a deficiency reduces soft tissue and aorta medial calcification and the upregulation of the VC Sox9 (SRY [sex-determining region Y]-box 9) and Runx2 and the senescence p16 and p21 markers. In this model, miR-34a upregulation was transient and preceded aorta mineralization. Mir34a <sup>-/-</sup> SMCs were less prone to undergo senescence and under osteogenic conditions deposited less calcium compared with Mir34a <sup>+/+</sup> cells. Furthermore, unlike in Mir34a <sup>+/+</sup> SMC, the known VC inhibitors SIRT1 and Axl (AXL receptor tyrosine kinase) were only partially downregulated in calcifying Mir34a <sup>-/-</sup> SMC. Strikingly, constitutive miR-34a overexpression to senescence-like levels in human aortic SMCs increased calcium deposition and enhanced Axl and SIRT1 decrease during calcification. Notably, we also showed that miR-34a directly decreased Axl expression in human aortic SMC, and restoration of its levels partially rescued miR-34a-dependent growth arrest. Conclusions- miR-34a promotes VC via vascular SMC mineralization by inhibiting cell proliferation and inducing senescence through direct Axl and SIRT1 downregulation, respectively. This miRNA could be a good therapeutic target for the treatment of VC

An Empirical Study of User Navigation during Document Triage

Περιέχει το πλήρες κείμενοDocument triage is the moment in the information seeking process when the user first decides the relevance of a document to their information need[17]. This paper reports a study of user behaviour during document triage. The study reveals two main findings: first, that there is a small set of common navigational patterns; second, that certain document features strongly influence users’ navigation

Seismic interferometry applied to local fracture seismicity recorded at Planchón-Peteroa Volcanic Complex, Argentina-Chile

Although the Planchon-Peteroa Volcanic Complex (PPVC) has undergone many hazardous eruptions, only a small number of geological, geochemical, and geophysical studies have been performed to describe this active volcanic system. In order to characterize the subsurface structures present at the PPVC, we applied seismic interferometry to fracture seismicity originating in this volcanic complex and along active geologic faults located nearby. We utilized seismic data recorded by two arrays of stations deployed in Argentina and Chile. Nine of these stations (three in Chile and six in Argentina) recorded data simultaneously and were used for this application. Only seismic events with energy arriving (sub) vertically to the stations were chosen for processing. According to the magnitude and the location of the selected seismic events, relocated seismic sources were used for the Chilean stations while, for the Argentine stations, only seismic sources located near that array were used. We obtained seismic evidence of the location of the subsurface reflectors underneath each station using zero-offset reflection responses retrieved from seismic interferometry by autocorrelation of (time windows extracted from) the selected seismic events. Then, applying a comparative analysis between the seismic results and the available geological information, we imaged the shallow subsurface of the area enclosed by the Chilean stations, and also by the Argentine stations. The results are consistent with the available geological information, provide accurate depth values for several subsurface discontinuities, indicate areas of higher heterogeneity, and support the emplacement of a magma body at ∼4 km depth from the surface. This work shows the first application of a novel variation of seismic interferometry based on autocorrelations to local-earthquake data recorded in a volcanic area.Facultad de Ciencias Astronómicas y Geofísica

HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model

Age-related macular degeneration (AMD) is the leading cause of irreversible vision loss. The protein HtrA1 is enriched in retinal pigment epithelial (RPE) cells isolated from AMD patients and in drusen deposits. However, it is poorly understood how increased levels of HtrA1 affect the physiological function of the RPE at the intracellular level. Here, we developed hfRPE (human fetal retinal pigment epithelial) cell culture model where cells fully differentiated into a polarized functional monolayer. In this model, we fine-tuned the cellular levels of HtrA1 by targeted overexpression. Our data show that HtrA1 enzymatic activity leads to intracellular degradation of tubulin with a corresponding reduction in the number of microtubules, and consequently to an altered mechanical cell phenotype. HtrA1 overexpression further leads to impaired apical processes and decreased phagocytosis, an essential function for photoreceptor survival. These cellular alterations correlate with the AMD phenotype and thus highlight HtrA1 as an intracellular target for therapeutic interventions towards AMD treatment

Self-Organizing Networks in Complex Infrastructure Projects

While significant importance is given to establishing formal organizational and contractual hierarchies, existing project management techniques neglect the management of self-organizing networks in large-infrastructure projects. We offer a case-specific illustration of self-organization using network theory as an investigative lens. The findings have shown that these networks exhibit a high degree of sparseness, short path lengths, and clustering in dense “functional” communities around highly connected actors, thus demonstrating the small-world topology observed in diverse real-world self-organized networks. The study underlines the need for these non-contractual functions and roles to be identified and sponsored, allowing the self-organizing network the space and capacity to evolve

Zeb1 modulates hematopoietic stem cell fates required for suppressing acute myeloid leukemia

Zeb1, a zinc finger E-box binding homeobox epithelial-mesenchymal (EMT) transcription factor, confers properties of ‘stemness’, such as self-renewal, in cancer. Yet little is known about the function of Zeb1 in adult stem cells. Here, we used the hematopoietic system, as a well-established paradigm of stem cell biology, to evaluate Zeb1 mediated regulation of adult stem cells. We employed a conditional genetic approach using the Mx1-Cre system to specifically knockout (KO) Zeb1 in adult hematopoietic stem cells (HSCs) and their downstream progeny. Acute genetic deletion of Zeb1 led to rapid onset thymic atrophy and apoptosis driven loss of thymocytes and T cells. A profound cell-autonomous self-renewal defect and multi-lineage differentiation block was observed in Zeb1 KO HSCs. Loss of Zeb1 in HSCs activated transcriptional programs of deregulated HSC maintenance and multi-lineage differentiation genes, and of cell polarity, consisting of cytoskeleton, lipid metabolism/lipid membrane and cell adhesion related genes. Notably, Epithelial cell adhesion molecule (EpCAM) expression was prodigiously upregulated in Zeb1 KO HSCs, which correlated with enhanced cell survival, diminished mitochondrial metabolism, ribosome biogenesis, and differentiation capacity and an activated transcriptomic signature associated with acute myeloid leukemia (AML) signaling. ZEB1 expression was downregulated in AML patients and Zeb1 KO in the malignant counterparts of HSCs - leukemic stem cells (LSCs) - accelerated MLL-AF9 and Meis1a/Hoxa9-driven AML progression, implicating Zeb1 as a tumor suppressor in AML LSCs. Thus, Zeb1 acts as a transcriptional regulator in hematopoiesis, critically co-ordinating HSC self-renewal, apoptotic and multi-lineage differentiation fates required to suppress leukemic potential in AML

Mapping atopic dermatitis and anti–IL-22 response signatures to type 2–low severe neutrophilic asthma

Background: Transcriptomic changes in patients who respond clinically to biological therapies may identify responses in other tissues or diseases. Objective: We sought to determine whether a disease signature identified in atopic dermatitis (AD) is seen in adults with severe asthma and whether a transcriptomic signature for patients with AD who respond clinically to anti–IL-22 (fezakinumab [FZ]) is enriched in severe asthma. Methods: An AD disease signature was obtained from analysis of differentially expressed genes between AD lesional and nonlesional skin biopsies. Differentially expressed genes from lesional skin from therapeutic superresponders before and after 12 weeks of FZ treatment defined the FZ-response signature. Gene set variation analysis was used to produce enrichment scores of AD and FZ-response signatures in the Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes asthma cohort. Results: The AD disease signature (112 upregulated genes) encompassing inflammatory, T-cell, TH2, and TH17/TH22 pathways was enriched in the blood and sputum of patients with asthma with increasing severity. Patients with asthma with sputum neutrophilia and mixed granulocyte phenotypes were the most enriched (P < .05). The FZ-response signature (296 downregulated genes) was enriched in asthmatic blood (P < .05) and particularly in neutrophilic and mixed granulocytic sputum (P < .05). These data were confirmed in sputum of the Airway Disease Endotyping for Personalized Therapeutics cohort. IL-22 mRNA across tissues did not correlate with FZ-response enrichment scores, but this response signature correlated with TH22/IL-22 pathways. Conclusions: The FZ-response signature in AD identifies severe neutrophilic asthmatic patients as potential responders to FZ therapy. This approach will help identify patients for future asthma clinical trials of drugs used successfully in other chronic diseases