Optimal rotations of deformable bodies and orbits in magnetic fields

Deformations can induce rotation with zero angular momentum where dissipation is a natural ``cost function''. This gives rise to an optimization problem of finding the most effective rotation with zero angular momentum. For certain plastic and viscous media in two dimensions the optimal path is the orbit of a charged particle on a surface of constant negative curvature with magnetic field whose total flux is half a quantum unit.Comment: 4 pages revtex, 4 figures + animation in multiframe GIF forma

Moments of unconditional logarithmically concave vectors

We derive two-sided bounds for moments of linear combinations of coordinates od unconditional log-concave vectors. We also investigate how well moments of such combinations may be approximated by moments of Gaussian random variables.Comment: 14 page

On the spacing distribution of the Riemann zeros: corrections to the asymptotic result

It has been conjectured that the statistical properties of zeros of the Riemann zeta function near z = 1/2 + \ui E tend, as $E \to \infty$, to the distribution of eigenvalues of large random matrices from the Unitary Ensemble. At finite $E$ numerical results show that the nearest-neighbour spacing distribution presents deviations with respect to the conjectured asymptotic form. We give here arguments indicating that to leading order these deviations are the same as those of unitary random matrices of finite dimension $N_{\rm eff}=\log(E/2\pi)/\sqrt{12 \Lambda}$, where $\Lambda=1.57314 ...$ is a well defined constant.Comment: 9 pages, 3 figure

Pharmacological therapies in post stroke recovery: Recommendations for future clinical trials

Stroke is a leading cause of serious long-term disability in adults and is the second leading cause of death worldwide. Early reperfusion and neuroprotection techniques have been the focus of much effort with the aim of very acute treatment of the stroke. Targeting different mechanisms, pharmacological therapies have the potential to reduce disability in a large fraction of patients who survive the acute stroke. The brain's capacity to reorganize after stroke through plasticity mechanisms can be modulated by pharmacological agents. A number of therapeutic interventions are under study, including small molecules, growth factors, and monoclonal antibodies. Recently it has been shown that the SSRI fluoxetine improved motor deficit in patients with ischaemic stroke and hemiplegia which appeared to be independent of the presence of depression. In this context, it is of major importance to support innovative research in order to promote the emergence of new pharmacological treatments targeting neurological recovery after stroke, as opposed to acute de-occlusion and neuroprotection. This paper is the work of a group of 14 scientists with aim of (1) addressing key areas of the basic and clinical aspects of human brain plasticity after stroke and potential pharmacological targets for recovery, (2) asking questions about the most appropriate characteristics of clinical trials testing drugs in post stroke recovery and (3) proposing recommendations for future clinical trials. © 2013 Springer-Verlag Berlin Heidelberg

Falsification Of The Atmospheric CO2 Greenhouse Effects Within The Frame Of Physics

The atmospheric greenhouse effect, an idea that many authors trace back to the traditional works of Fourier (1824), Tyndall (1861), and Arrhenius (1896), and which is still supported in global climatology, essentially describes a fictitious mechanism, in which a planetary atmosphere acts as a heat pump driven by an environment that is radiatively interacting with but radiatively equilibrated to the atmospheric system. According to the second law of thermodynamics such a planetary machine can never exist. Nevertheless, in almost all texts of global climatology and in a widespread secondary literature it is taken for granted that such mechanism is real and stands on a firm scientific foundation. In this paper the popular conjecture is analyzed and the underlying physical principles are clarified. By showing that (a) there are no common physical laws between the warming phenomenon in glass houses and the fictitious atmospheric greenhouse effects, (b) there are no calculations to determine an average surface temperature of a planet, (c) the frequently mentioned difference of 33 degrees Celsius is a meaningless number calculated wrongly, (d) the formulas of cavity radiation are used inappropriately, (e) the assumption of a radiative balance is unphysical, (f) thermal conductivity and friction must not be set to zero, the atmospheric greenhouse conjecture is falsified.Comment: 115 pages, 32 figures, 13 tables (some typos corrected

Endothelin receptor B antagonists decrease glioma cell viability independently of their cognate receptor

Background: Endothelin receptor antagonists inhibit the progression of many cancers, but research into their influence on glioma has been limited. Methods: We treated glioma cell lines, LN-229 and SW1088, and melanoma cell lines, A375 and WM35, with two endothelin receptor type B (ETRB)-specific antagonists, A-192621 and BQ788, and quantified viable cells by the capacity of their intracellular esterases to convert non-fluorescent calcein AM into green-fluorescent calcein. We assessed cell proliferation by labeling cells with carboxyfluorescein diacetate succinimidyl ester and quantifying the fluorescence by FACS analysis. We also examined the cell cycle status using BrdU/propidium iodide double staining and FACS analysis. We evaluated changes in gene expression by microarray analysis following treatment with A-192621 in glioma cells. We examined the role of ETRB by reducing its expression level using small interfering RNA (siRNA). Results: We report that two ETRB-specific antagonists, A-192621 and BQ788, reduce the number of viable cells in two glioma cell lines in a dose- and time-dependent manner. We describe similar results for two melanoma cell lines. The more potent of the two antagonists, A-192621, decreases the mean number of cell divisions at least in part by inducing a G2/M arrest and apoptosis. Microarray analysis of the effects of A-192621 treatment reveals up-regulation of several DNA damage-inducible genes. These results were confirmed by real-time RT-PCR. Importantly, reducing expression of ETRB with siRNAs does not abrogate the effects of either A-192621 or BQ788 in glioma or melanoma cells. Furthermore, BQ123, an endothelin receptor type A (ETRA)-specific antagonist, has no effect on cell viability in any of these cell lines, indicating that the ETRB-independent effects on cell viability exhibited by A-192621 and BQ788 are not a result of ETRA inhibition. Conclusion: While ETRB antagonists reduce the viability of glioma cells in vitro, it appears unlikely that this effect is mediated by ETRB inhibition or cross-reaction with ETRA. Instead, we present evidence that A-192621 affects glioma and melanoma viability by activating stress/DNA damage response pathways, which leads to cell cycle arrest and apoptosis. This is the first evidence linking ETRB antagonist treatment to enhanced expression of DNA damage-inducible genes

Classification of primary and incisional abdominal wall hernias

A classification for primary and incisional abdominal wall hernias is needed to allow comparison of publications and future studies on these hernias. It is important to know whether the populations described in different studies are comparable.Comparative StudyConsensus Development ConferenceJournal ArticleReviewSCOPUS: ar.jinfo:eu-repo/semantics/publishe

Generation and Utilization of Volatile Fatty Acids and Alcohols in Hydrothermally Altered Sediments in the Guaymas Basin, Gulf of California

Volatile fatty acids (VFAs) and alcohols are key intermediates of anaerobic carbon metabolism, yet their biogeochemical cycling remains poorly constrained in hydrothermal systems. We investigated the abundance, stable carbon isotopic composition, and metabolic cycling of VFAs and alcohols to elucidate their generation and utilization pathways in hydrothermally influenced sediments (4 °C to 90 °C) from the Guaymas Basin. Acetate (up to 229 μM) and methanol (up to 37 μM) were abundant in porewaters. The δ13C values of acetate varied between −35.6‰ and −18.1‰. Carbon isotopic signatures, thermodynamic predictions, and experimental incubations suggested biological sources such as fermentation and acetogenesis for acetate. Acetate and methanol were predominantly consumed by nonmethanogenic processes (e.g., sulfate reduction), as reflected in high oxidation rates versus low methanogenesis rates, and further evidenced through inhibition experiments with molybdate. These results reveal an important role for VFAs and alcohols as energy sources for diverse chemoheterotrophs in organic-rich hydrothermally influenced sediments

Grassroots Creative Hubs: Urban Regeneration, Recovered Industrial Factories and Cultural Production in Buenos Aires and Rio de Janeiro

This chapter examines the nature, functioning and politics of grassroots creative hubs as contained in refurbished industrial factories. The renewal and transformation of factories into arts and cultural venues has been a key feature of post-industrial urbanism in the last three decades. Examples abound across the world, from railway and power stations to post office buildings and chocolate factories, these recovered infrastructures have been re-signified as cultural facilities – performing or multi-arts centres, galleries, cultural centres, creative economy laboratories, incubators and museums. These initiatives, be that they are led by local governments or community groups, are part of broader urban strategies for revitalising historical centres, revalorising cultural heritage and creating work opportunities as well as resources for tourism and business investment. But can a factory building be considered a creative hub? Does the materiality of these urban artefacts provide a solution to the oftentransient nature of ephemeral cultural urbanism? Refurbishing old industrial factories and warehouses for cultural use and creative production has been the subject of much investigation since the 1980s-1990s, mainly through the study of culture-led urban regeneration and gentrification (Zukin, 1989; Montgomery, 1995; Evans and Shaw, 2004; Mommaas, 2004; Pratt, 2009), and more recently, creative industry clusters and districts (Evans, 2009; Zukin and Braslow, 2011; O’Connor and Gu, 2012). These studies have pointed out the problems that arise from the organisation, management and long-term sustainability of converted industrial sites, as well as from the policy uses and abuses that often pave the way to real-estate development and social displacement. Drawing on insights from urban sociology and critical geography, the chapter conducts a case-study analysis of two cultural and creative economy factories in Latin America: Fábrica Bhering in Rio de Janeiro, Brazil, and IMPA, la Fábrica Cultural in Buenos Aires, Argentina. The chapter is comprised of three sections: the first discusses whether recovered industrial factories can be thought of as creative hubs in relation to ephemeral cultural urbanism; the second examines the two case-studies in the context of Brazil and Argentina; and the third offers concluding remarks. Overall the chapter contributes a Latin American perspective on culture-led urban regeneration to the study of creative hubs. Particularly, grassroots creative initiatives of urban renewal are presented as an alternative to the exclusionary gentrification processes to which creative hubs and other territorial forms of creativity are often related to, in times largely shaped by neoliberal operations driven by real-estate interests and alliances between political and economic urban elites

Geometric Approach to Pontryagin's Maximum Principle

Since the second half of the 20th century, Pontryagin's Maximum Principle has been widely discussed and used as a method to solve optimal control problems in medicine, robotics, finance, engineering, astronomy. Here, we focus on the proof and on the understanding of this Principle, using as much geometric ideas and geometric tools as possible. This approach provides a better and clearer understanding of the Principle and, in particular, of the role of the abnormal extremals. These extremals are interesting because they do not depend on the cost function, but only on the control system. Moreover, they were discarded as solutions until the nineties, when examples of strict abnormal optimal curves were found. In order to give a detailed exposition of the proof, the paper is mostly self\textendash{}contained, which forces us to consider different areas in mathematics such as algebra, analysis, geometry.Comment: Final version. Minors changes have been made. 56 page