Dust-to-gas ratio resurgence in circumstellar disks due to the formation of giant planets: the case of HD 163296

The amount of dust present in circumstellar disks is expected to steadily decrease with age due to the growth from micron-sized particles to planetesimals and planets. Mature circumstellar disks, however, can be observed to contain significant amounts of dust and possess high dust-to-gas ratios. Using HD 163296 as our case study, we explore how the formation of giant planets in disks can create the conditions for collisionally rejuvenating the dust population, halting or reversing the expected trend. We combine N-body simulations with statistical methods and impact scaling laws to estimate the dynamical and collisional excitation of the planetesimals due to the formation of HD 163296's giant planets. We show that this process creates a violent collisional environment across the disk that can inject collisionally produced second-generation dust into it, significantly contributing to the observed dust-to-gas ratio. The spatial distribution of the dust production can explain the observed local enrichments in HD 163296's inner regions. The results obtained for HD 163296 can be extended to any disk with embedded forming giant planets and may indicate a common evolutionary stage in the life of such circumstellar disks. Furthermore, the dynamical excitation of the planetesimals could result in the release of transient, non-equilibrium gas species like H2O, CO2, NH3 and CO in the disk due to ice sublimation during impacts and, due to the excited planetesimals being supersonic with respect to the gas, could produce bow shocks in the latter that could heat it and cause a broadening of its emission lines.Comment: 18 pages, 9 figures, 2 tables. Accepted for publication on The Astrophysical Journa

A new perspective on the irregular satellites of Saturn - II Dynamical and physical origin

The origin of the irregular satellites of the giant planets has been long debated since their discovery. Their dynamical features argue against an in-situ formation suggesting they are captured bodies, yet there is no global consensus on the physical process at the basis of their capture. In this paper we explore the collisional capture scenario, where the actual satellites originated from impacts occurred within Saturn's influence sphere. By modeling the inverse capture problem, we estimated the families of orbits of the possible parent bodies and the specific impulse needed for their capture. The orbits of these putative parent bodies are compared to those of the minor bodies of the outer Solar System to outline their possible region of formation. Finally, we tested the collisional capture hypothesis on Phoebe by taking advantage of the data supplied by Cassini on its major crater, Jason. Our results presented a realistic range of solutions matching the observational and dynamical data.Comment: 26 Pages, 21 Figure

Optical mapping of neuronal activity during seizures in zebrafish

Mapping neuronal activity during the onset and propagation of epileptic seizures can provide a better understanding of the mechanisms underlying this pathology and improve our approaches to the development of new drugs. Recently, zebrafish has become an important model for studying epilepsy both in basic research and in drug discovery. Here, we employed a transgenic line with pan-neuronal expression of the genetically-encoded calcium indicator GCaMP6s to measure neuronal activity in zebrafish larvae during seizures induced by pentylenetretrazole (PTZ). With this approach, we mapped neuronal activity in different areas of the larval brain, demonstrating the high sensitivity of this method to different levels of alteration, as induced by increasing PTZ concentrations, and the rescuing effect of an anti-epileptic drug. We also present simultaneous measurements of brain and locomotor activity, as well as a high-throughput assay, demonstrating that GCaMP measurements can complement behavioural assays for the detection of subclinical epileptic seizures, thus enabling future investigations on human hypomorphic mutations and more effective drug screening methods. Notably, the methodology described here can be easily applied to the study of many human neuropathologies modelled in zebrafish, allowing a simple and yet detailed investigation of brain activity alterations associated with the pathological phenotype

Acute haemolysis in childhood falciparum malaria

Acute haemolysis associated with clinical episodes of high-level Plasmodium falciparum parasitaemia was studied in 20 children from an holoendemic area (coastal Tanzania). The change in blood haemoglobin (Hb) concentration ranged from -46 to +5 g/L during the 72-h observation period and was linearly related to maximum parasitaemia. Balance studies between loss of blood Hb, increase in plasma Hb and appearance of Hb in the urine indicated that extravascular clearance of red cells was the predominant mode of erythrocyte clearance. Most subjects, however, showed minor signs of intravascular haemolysis. The plasma Hb was ≪1% of blood Hb and haemoglobinuria was detected in 14/20 children but the excretion of Hb in urine was \u3c0.5% of total Hb loss. Haemoglobinuria was, however, a marker of severe haemolysis, since the maximum blood Hb loss in children without haemoglobinuria was 10 g/L. Erythrocyte-bound opsonins known to induce erythrophagocytosis, i.e., complement C3c fragments and autologous IgG, were increased in all patients. In the patients with major haemolysis, the changes correlated to the haemolysis over time. Hence, a similar mechanism for predominantly extravascular erythrocyte clearance may be operative in acute malarial anaemia, normal erythrocyte senescence and other forms of acute haemolysis

Neoadjuvant chemoradiation and pancreaticoduodenectomy for initially locally advanced head pancreatic adenocarcinoma

International audienceThe most accepted treatment for locally advanced pancreatic adenocarcinoma (LAPA) is chemoradiotherapy (CRT). We sought to determine the benefit of pancreaticoduodenectomy (PD) in patients with LAPA initially treated by neoadjuvant CRT

Probing the origin of the dark material on Iapetus

Among the icy satellites of Saturn, Iapetus shows a striking dichotomy between its leading and trailing hemispheres, the former being significantly darker than the latter. Thanks to the VIMS imaging spectrometer on-board Cassini, it is now possible to investigate the spectral features of the satellites in Saturn system within a wider spectral range and with an enhanced accuracy than with previously available data. In this work, we present an application of the G-mode method to the high resolution, visible and near infrared data of Phoebe, Iapetus and Hyperion collected by Cassini/VIMS, to search for compositional correlations. We also present the results of a dynamical study on the efficiency of Iapetus in capturing dust grains travelling inward in Saturn system to evaluate the viability of Poynting-Robertson drag as the physical mechanism transferring the dark material to the satellite. The results of spectroscopic classification are used jointly with the ones of the dynamical study to describe a plausible physical scenario for the origin of Iapetus' dichotomy. Our work shows that mass transfer from the outer Saturnian system is an efficient mechanism, particularly for the range of sizes hypothesised for the particles composing the newly discovered outer ring around Saturn. Both spectral and dynamical data indicate Phoebe as the main source of the dark material. However, we suggest a multi-source scenario where now extinct prograde satellites and the disruptive impacts that generated the putative collisional families played a significant role in supplying the original amount of dark material.Comment: 20 pages, 4 tables, 11 figures, major revision (manuscript extended and completed, figures added and corrected, new results added), minor revision and finalization of author list, moderate revision (update of the manuscript following reviewer's feedback and discovery of the new Saturnian outer ring

Two-year observations of the Jupiter polar regions by JIRAM on board Juno

We observed the evolution of Jupiter's polar cyclonic structures over two years between February 2017 and February 2019, using polar observations by the Jovian InfraRed Auroral Mapper, JIRAM, on the Juno mission. Images and spectra were collected by the instrument in the 5‐μm wavelength range. The images were used to monitor the development of the cyclonic and anticyclonic structures at latitudes higher than 80° both in the northern and the southern hemispheres. Spectroscopic measurements were then used to monitor the abundances of the minor atmospheric constituents water vapor, ammonia, phosphine and germane in the polar regions, where the atmospheric optical depth is less than 1. Finally, we performed a comparative analysis with oceanic cyclones on Earth in an attempt to explain the spectral characteristics of the cyclonic structures we observe in Jupiter's polar atmosphere

A new perspective on the irregular satellites of Saturn - I Dynamical and collisional history

The dynamical features of the irregular satellites of the giant planets argue against an in-situ formation and are strongly suggestive of a capture origin. Since the last detailed investigations of their dynamics, the total number of satellites have doubled, increasing from 50 to 109, and almost tripled in the case of Saturn system. We have performed a new dynamical exploration of Saturn system to test whether the larger sample of bodies could improve our understanding of which dynamical features are primordial and which are the outcome of the secular evolution of the system. We have performed detailed N--Body simulations using the best orbital data available and analysed the frequencies of motion to search for resonances and other possible perturbing effects. We took advantage of the Hierarchical Jacobian Symplectic algorithm to include in the dynamical model of the system also the gravitational effects of the two outermost massive satellites, Titan and Iapetus. Our results suggest that Saturn's irregular satellites have been significantly altered and shaped by the gravitational perturbations of Jupiter, Titan, Iapetus and the Sun and by the collisional sweeping effect of Phoebe. In particular, the effects on the dynamical evolution of the system of the two massive satellites appear to be non-negligible. Jupiter perturbs the satellites through its direct gravitational pull and, indirectly, via the effects of the Great Inequality, i.e. its almost resonance with Saturn. Finally, by using the Hierarchical Clustering Method we found hints to the existence of collisional families and compared them with the available observational data.Comment: 26 Pages, 27 Figures, 4 Table