Erudition et culture savante de l’Antiquité à l’époque moderne

4e de couverture : L\u27 ÉRUDITION renvoie à la collecte, à la lecture et à l’exploitation des sources. Pendant quinze siècles, du IIIe au XVIIIe siècle, dans l’Europe de culture gréco-latine et au Proche-Orient, les érudits ont abondamment puisé dans les écrits des Anciens, mais loin d’être de simples compilateurs, ils s’appropriaient les écrits qu’ils citaient, s’efforçaient de les rendre accessibles à leurs lecteurs et les mettaient au service d’un projet pédagogique ou intellectuel cohérent. Les écrits des érudits renseignent sur leur manière de travailler et sur les objectifs qu’ils poursuivaient. L’érudition fut-elle neutre ? Avait-elle pour seule mission de diffuser des savoirs et d’accroître la connaissance dans différentes disciplines ? Quels que fussent ses objectifs, elle reposait sur des pratiques que l’on retrouve pendant quinze siècles : l’apprentissage de langues étrangères, l’emprunt de manuscrits, le recours constant à la correspondance. Les aspects matériels de l’érudition sont un aspect important de la vie intellectuelle. Le travail effectué dans les scriptoria, la mise au point d’index et de tables des matières, la publication de lieux communs aidèrent les savants dans leurs recherches. Au xviii e  siècle, la figure de l’honnête homme, qui supplanta celle de l’érudit, posa des problèmes spécifiques aux éditeurs qui durent mettre en œuvre de nouvelles stratégies pour minimiser les risques que leur posaient les livres érudits. À côté des savants et des humanistes reconnus, des hommes et des femmes participaient à la vie intellectuelle de leur époque, sans rédiger d’œuvres majeures. Membres de réseaux de correspondants, vulgarisateurs éclairés, lecteurs attentifs, ils contribuaient à la diffusion de la culture savante en enseignant, en encourageant la vie de l’esprit et en faisant connaître par leurs écrits les idées nouvelles

MapX: an In-Situ Mapping X-Ray Fluorescence Instrument for Detection of Biosignatures and Habitable Planetary Environments

The search for evidence of life or its processes on other worlds takes on two major themes: the detection of biosignatures indicating extinct or extant life, or the determination that an environment either has or once had the potential to harbor living organisms. In situ elemental imaging is useful in either case, since features on the mm to m scale reveal geological processes which may indicate past or present habitability. Further, biomineralization can leave traces in the morphology and element distribution of surfaces. The Mapping X-ray Fluorescence Spectrometer (MapX) is an in-situ instrument designed to identify these features on planetary surfaces [1]. Progress on instrument development, data analysis methods, and element quantification are presented

Powder Handling Device for Analytical Instruments

Method and system for causing a powder sample in a sample holder to undergo at least one of three motions (vibration, rotation and translation) at a selected motion frequency in order to present several views of an individual grain of the sample. One or more measurements of diffraction, fluorescence, spectroscopic interaction, transmission, absorption and/or reflection can be made on the sample, using light in a selected wavelength region

Mapping alpha-Particle X-Ray Fluorescence Spectrometer (Map-X)

Many planetary surface processes (like physical and chemical weathering, water activity, diagenesis, low-temperature or impact metamorphism, and biogenic activity) leave traces of their actions as features in the size range 10s to 100s of micron. The Mapping alpha-particle X-ray Spectrometer ("Map-X") is intended to provide chemical imaging at 2 orders of magnitude higher spatial resolution than previously flown instruments, yielding elemental chemistry at or below the scale length where many relict physical, chemical, and biological features can be imaged and interpreted in ancient rocks

Geometry of phase separation

We study the domain geometry during spinodal decomposition of a 50:50 binary mixture in two dimensions. Extending arguments developed to treat non-conserved coarsening, we obtain approximate analytic results for the distribution of domain areas and perimeters during the dynamics. The main approximation is to regard the interfaces separating domains as moving independently. While this is true in the non-conserved case, it is not in the conserved one. Our results can therefore be considered as a first-order approximation for the distributions. In contrast to the celebrated Lifshitz-Slyozov-Wagner distribution of structures of the minority phase in the limit of very small concentration, the distribution of domain areas in the 50:50 case does not have a cut-off. Large structures (areas or perimeters) retain the morphology of a percolative or critical initial condition, for quenches from high temperatures or the critical point respectively. The corresponding distributions are described by a $c A^{-\tau}$ tail, where $c$ and $\tau$ are exactly known. With increasing time, small structures tend to have a spherical shape with a smooth surface before evaporating by diffusion. In this regime the number density of domains with area $A$ scales as $A^{1/2}$, as in the Lifshitz-Slyozov-Wagner theory. The threshold between the small and large regimes is determined by the characteristic area, ${\rm A} \sim [\lambda(T) t]^{2/3}$. Finally, we study the relation between perimeters and areas and the distribution of boundary lengths, finding results that are consistent with the ones summarized above. We test our predictions with Monte Carlo simulations of the 2d Ising Model.Comment: 10 pages, 8 figure

Antibiotic stewardship implementation and patient-level antibiotic use at hospitals with and without on-site Infectious Disease specialists.

Many US hospitals lack Infectious Disease (ID) specialists, which may hinder antibiotic stewardship efforts. We sought to compare patient-level antibiotic exposure at Veterans Health Administration (VHA) hospitals with and without an on-site ID specialist, defined as an ID physician and/or ID pharmacist. This retrospective VHA cohort included all acute-care patient-admissions during 2016. A mandatory survey was used to identify hospitals' antibiotic stewardship processes and their access to an on-site ID specialist. Antibiotic use was quantified as days of therapy (DOT) per days-present and categorized based on National Healthcare Safety Network definitions. A negative binomial regression model with risk adjustment was used to determine the association between presence of an on-site ID specialist and antibiotic use at the level of patient-admissions. Eighteen of 122 (14.8%) hospitals lacked an on-site ID specialist; there were 525,451 (95.8%) admissions at ID hospitals and 23,007 (4.2%) at non-ID sites. In the adjusted analysis, presence of an ID specialist was associated with lower total inpatient antibacterial use [OR 0.92, (95% CI, 0.85-0.99)]. Presence of an ID specialist was also associated with lower use of broad-spectrum antibacterials [OR 0.61 (95% CI, 0.54-0.70)] and higher narrow-spectrum beta-lactam use [OR 1.43 (95% CI, 1.22-1.67)]. Total antibacterial exposure (inpatient plus post-discharge) was lower among patients at ID versus non-ID sites [OR 0.92 (95% CI, 0.86-0.99)]. Patients at hospitals with an ID specialist received antibiotics in a way more consistent with stewardship principles. The presence of an ID specialist may be important to effective antibiotic stewardship

Antibiotic Stewardship Implementation and Antibiotic Use at Hospitals With and Without On-site Infectious Disease Specialists.

BackgroundMany US hospitals lack infectious disease (ID) specialists, which may hinder antibiotic stewardship efforts. We sought to compare patient-level antibiotic exposure at Veterans Health Administration (VHA) hospitals with and without an on-site ID specialist, defined as an ID physician and/or ID pharmacist.MethodsThis retrospective VHA cohort included all acute-care patient admissions during 2016. A mandatory survey was used to identify hospitals' antibiotic stewardship processes and their access to an on-site ID specialist. Antibiotic use was quantified as days of therapy per days present and categorized based on National Healthcare Safety Network definitions. A negative binomial regression model with risk adjustment was used to determine the association between presence of an on-site ID specialist and antibiotic use at the level of patient admissions.ResultsEighteen of 122 (14.8%) hospitals lacked an on-site ID specialist; there were 525 451 (95.8%) admissions at ID hospitals and 23 007 (4.2%) at non-ID sites. In the adjusted analysis, presence of an ID specialist was associated with lower total inpatient antibacterial use (odds ratio, 0.92; 95% confidence interval, .85-.99). Presence of an ID specialist was also associated with lower use of broad-spectrum antibacterials (0.61; .54-.70) and higher narrow-spectrum β-lactam use (1.43; 1.22-1.67). Total antibacterial exposure (inpatient plus postdischarge) was lower among patients at ID versus non-ID sites (0.92; .86-.99).ConclusionsPatients at hospitals with an ID specialist received antibiotics in a way more consistent with stewardship principles. The presence of an ID specialist may be important to effective antibiotic stewardship

Distribuição do carbono nas frações do solo sob área de floresta.

As transformações dos sistemas naturais nas regiões tropicais, geralmente cobertas por florestas com grande biomassa representam uma importante causa do aumento da concentração de CO2 atmosférico. Estimou-se a estocagem e a suscetibilidade potencial do carbono no solo do ecossistema sob floresta, até 2 m de profundidade, a partir da determinação da qualidade e a da quantidade do carbono orgânico nas diversas frações do solo em área de floresta primária na Amazônia Central. Fracionou-se a matéria orgânica do solo (MOS) por densidade e granulometria, obtendo-se: FLF (fração leve livre), FLIA (fração leve intra-agregada), F-areia (fração areia), F-argila (fração argila) e F-silte (fração silte). As amostras de solo para o fracionamento e análises físicas foram coletadas em posições topográficas distintas (platô, vertente e baixio), em parcelas de 20 m x 40 m, nas camadas entre 0-5, 5-10, 10-20, 20-40, 40-60, 60-80, 80-100, 100-160 e 160-200 cm de profundidade. Na superfície, o carbono está estocado na fração leve livre (FLF) e em profundidade na fração pesada (F-argila). A distribuição do carbono nas frações do solo foram de 112,6 Mg ha-1 (FLF), 2,5 Mg ha-1 (FLIA), 40,5 Mg ha-1 (F-silte), 56,2 Mg ha-1 (F-argila) e 28,3 Mg ha-1 (F-areia). O carbono orgânico do solo (COS) estocado no platô (Latossolo), vertente (Argissolo) e baixio (Espodossolo) foi de 86,1 Mg ha-1, 72,6 Mg ha-1 e 81,4 Mg ha-1, respectivamente, potencializando uma capacidade de emissão para a atmosfera de 240,1 Mg ha-1

Full Field X-Ray Fluorescence Imaging Using Micro Pore Optics for Planetary Surface Exploration

Many planetary surface processes leave evidence as small features in the sub-millimetre scale. Current planetary X-ray fluorescence spectrometers lack the spatial resolution to analyse such small features as they only provide global analyses of areas greater than 100 mm(exp 2). A micro-XRF spectrometer will be deployed on the NASA Mars 2020 rover to analyse spots as small as 120m. When using its line-scanning capacity combined to perpendicular scanning by the rover arm, elemental maps can be generated. We present a new instrument that provides full-field XRF imaging, alleviating the need for precise positioning and scanning mechanisms. The Mapping X-ray Fluorescence Spectrometer - "Map-X" - will allow elemental imaging with approximately 100m spatial resolution and simultaneously provide elemental chemistry at the scale where many relict physical, chemical and biological features can be imaged in ancient rocks. The arm-mounted Map-X instrument is placed directly on the surface of an object and held in a fixed position during measurements. A 25x25 mm(exp 2) surface area is uniformly illuminated with X-rays or alpha-particles and gamma-rays. A novel Micro Pore Optic focusses a fraction of the emitted X-ray fluorescence onto a CCD operated at a few frames per second. On board processing allows measuring the energy and coordinates of each X-ray photon collected. Large sets of frames are reduced into 2d histograms used to compute higher level data products such as elemental maps and XRF spectra from selected regions of interest. XRF spectra are processed on the ground to further determine quantitative elemental compositions. The instrument development will be presented with an emphasis on the characterization and modelling of the X-ray focussing Micro Pore Optic. An outlook on possible alternative XRF imaging applications will be discussed