804 research outputs found

    Electromechanical stream-structure instabilities

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    Electromechanical stream-structure instabilitie

    Continuum electromechanics group electromechanical co-streaming and counter- streaming instabilities

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    Instability dynamics of two highly conducting finite length streams in relative motion coupled by transverse electric or longitudinal magnetic fiel

    Pilot actions in European cities - Stuttgart

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    The field of urban climatology has a long tradition in Stuttgart. It exists as discipline in Stuttgart since 1938. Stuttgart was the first city to establish its own Department of Climatology to research ways of improving the flow of fresh air into the city and to reduce thermal stress in most populated city districts. The specialist department of Urban Climatology, within the Environmental Protection Office, deals with tasks relating to environmental meteorology within the scope of air pollution control and also relating to urban and global climate protection. So in Stuttgart the urban heat island phenomenon (UHI) is studied for several decades, leading to a high level understanding of the UHI and the problems which it causes. The UHI causes an increase in air temperatures and thermal stress, that are identified as most negative impacts on human health and urban living. In the view of global climate change and the predicted temperature rise for the Stuttgart region of 1.5–2 K in this century, the negative impacts of UHI on human health and urban living will become more problematic in the future. According to the results of climate models the frequency of very hot days is expected to jump by nearly 30 % at the end of the century. The rising temperatures due to the global climate change in combination with the temperature shift as a result of the UHI will intensify the heat stress in urban areas, that leads to a significant increasing risk to human health, in particular to the very young and elderly. Not least due its importance for the human health and the quality of urban life in Stuttgart, the UHI is focussed by urban planners and is noticed by the future development of the city. Within the pilot action study in Stuttgart several measure for reducing the UHI and the impacts on urban living and human health are analysed by the use of micro-scale and macro-scale simulations. With the help of these analysis realisable measure are selected. The most useful measures are implemented into a developmoutline plan for the redevelopment of the city district Stuttgart-West by the municipal urban planners

    Plasma Magnetohydrodynamics and Energy Conversion

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    Contains reports on four research projects.National Science Foundation (Grant G-24073)United States Air Force, Aeronautical Systems Division, Aeronautical Accessories Laboratory, Wright-Patterson Air Force Base (Contract AF33(616)-7624

    Intensification of chemotherapy for the treatment of solid tumours: feasibility of a 3-fold increase in dose intensity with peripheral blood progenitor cells and granulocyte colony-stimulating factor.

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    Dose intensity may be an important determinant of the outcome in cancer chemotherapy, but is often limited by cumulative haematological toxicity. The availability of haematopoietic growth factors such as granulocyte colony-stimulating factor (G-CSF) and of peripheral blood progenitor cell (PBPC) transplantation has allowed the development of a new treatment strategy in which several courses of high-dose combination chemotherapy are administered for the treatment of solid tumours. PBPCs were mobilised before chemotherapy using 12 or 30 micrograms kg-1 day-1 G-CSF (Filgrastim) for 10 days, and were collected by 2-5 leucaphereses. The yields of mononuclear cells, colony-forming units and CD34-positive cells were similar at the two dose levels of Filgrastim, and the numbers of PBPCs were sufficient for rescue following multiple cycles of chemotherapy. High-dose chemotherapy (cyclophosphamide 2.5 g m-2 for 2 days, etoposide 300 mg m-2 for 3 days and cisplatin 50 mg m-2 for 3 days) was administered sequentially for a median of three cycles (range 1-4) to ten patients. Following the 30 evaluable cycles, the median duration of leucopenia < or = 0.5 x 10(9) l-1 and < or = 1.0 x 10(9) l-1 was 7 and 8 days respectively. The median time of thrombopenia < or = 20 x 10(9) l-1 was 6 days. There was no cumulative haematological toxicity. The duration of leucopenia, but not of thrombopenia, was inversely related to the number of reinfused CFU-GM (granulocyte-macrophage colony-forming units). In the majority of patients, neurotoxicity and ototoxicity became dose limiting after three cycles of therapy. However, the average dose intensity delivered was about three times higher than in a standard regimen. The complete response rate in patients with small-cell lung cancers was 66% (95% CI 30-92%) and the median progression-free survival and overall survival were 13 months and 17 months respectively. These results are encouraging and should be compared, in a randomised fashion, with standard dose chemotherapy
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