Differences in Total Score of Positive and Negative Syndrome Scale between Bataknese and Javanese Men with Schizophrenia Receiving Risperidone Treatment

BACKGROUND: Schizophrenia is a psychopathological syndrome clinic involving cognition, emotion, perception and other aspects from the individual which interferences. This interference is normally started before age 25, and it can affect all social classes. AIM: To find out the difference in total positive and negative syndrome scale (PANSS) scores in schizophrenia between Bataknese and Javanese who have received treatment with risperidone. METHODS: This study is a prospective study. This study used numeric comparative analytic two unpaired groups to observe the differences of PANSS score of the man with schizophrenia between Bataknese and Javanese who had received risperidone treatment. RESULTS: Our study found that the average score of PANSS for Bataknese was 49.76 ± 12.65 and Javanese was 42.43 ± 9.05. CONCLUSION: There was a difference score of PANSS for the man with schizophrenia between Bataknese and Javanese who had received risperidone treatment for 6 weeks (p = 0.037)

Temporal changes in the epidemiology, management, and outcome from acute respiratory distress syndrome in European intensive care units: a comparison of two large cohorts

Background: Mortality rates for patients with ARDS remain high. We assessed temporal changes in the epidemiology and management of ARDS patients requiring invasive mechanical ventilation in European ICUs. We also investigated the association between ventilatory settings and outcome in these patients. Methods: This was a post hoc analysis of two cohorts of adult ICU patients admitted between May 1–15, 2002 (SOAP study, n = 3147), and May 8–18, 2012 (ICON audit, n = 4601 admitted to ICUs in the same 24 countries as the SOAP study). ARDS was defined retrospectively using the Berlin definitions. Values of tidal volume, PEEP, plateau pressure, and FiO2 corresponding to the most abnormal value of arterial PO2 were recorded prospectively every 24 h. In both studies, patients were followed for outcome until death, hospital discharge or for 60 days. Results: The frequency of ARDS requiring mechanical ventilation during the ICU stay was similar in SOAP and ICON (327[10.4%] vs. 494[10.7%], p = 0.793). The diagnosis of ARDS was established at a median of 3 (IQ: 1–7) days after admission in SOAP and 2 (1–6) days in ICON. Within 24 h of diagnosis, ARDS was mild in 244 (29.7%), moderate in 388 (47.3%), and severe in 189 (23.0%) patients. In patients with ARDS, tidal volumes were lower in the later (ICON) than in the earlier (SOAP) cohort. Plateau and driving pressures were also lower in ICON than in SOAP. ICU (134[41.1%] vs 179[36.9%]) and hospital (151[46.2%] vs 212[44.4%]) mortality rates in patients with ARDS were similar in SOAP and ICON. High plateau pressure (> 29 cmH2O) and driving pressure (> 14 cmH2O) on the first day of mechanical ventilation but not tidal volume (> 8 ml/kg predicted body weight [PBW]) were independently associated with a higher risk of in-hospital death. Conclusion: The frequency of and outcome from ARDS remained relatively stable between 2002 and 2012. Plateau pressure > 29 cmH2O and driving pressure > 14 cmH2O on the first day of mechanical ventilation but not tidal volume > 8 ml/kg PBW were independently associated with a higher risk of death. These data highlight the continued burden of ARDS and provide hypothesis-generating data for the design of future studies

The clinical relevance of oliguria in the critically ill patient : Analysis of a large observational database

Funding Information: Marc Leone reports receiving consulting fees from Amomed and Aguettant; lecture fees from MSD, Pfizer, Octapharma, 3 M, Aspen, Orion; travel support from LFB; and grant support from PHRC IR and his institution. JLV is the Editor-in-Chief of Critical Care. The other authors declare that they have no relevant financial interests. Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Urine output is widely used as one of the criteria for the diagnosis and staging of acute renal failure, but few studies have specifically assessed the role of oliguria as a marker of acute renal failure or outcomes in general intensive care unit (ICU) patients. Using a large multinational database, we therefore evaluated the occurrence of oliguria (defined as a urine output 16 years) patients in the ICON audit who had a urine output measurement on the day of admission were included. To investigate the association between oliguria and mortality, we used a multilevel analysis. Results: Of the 8292 patients included, 2050 (24.7%) were oliguric during the first 24 h of admission. Patients with oliguria on admission who had at least one additional 24-h urine output recorded during their ICU stay (n = 1349) were divided into three groups: transient - oliguria resolved within 48 h after the admission day (n = 390 [28.9%]), prolonged - oliguria resolved > 48 h after the admission day (n = 141 [10.5%]), and permanent - oliguria persisting for the whole ICU stay or again present at the end of the ICU stay (n = 818 [60.6%]). ICU and hospital mortality rates were higher in patients with oliguria than in those without, except for patients with transient oliguria who had significantly lower mortality rates than non-oliguric patients. In multilevel analysis, the need for RRT was associated with a significantly higher risk of death (OR = 1.51 [95% CI 1.19-1.91], p = 0.001), but the presence of oliguria on admission was not (OR = 1.14 [95% CI 0.97-1.34], p = 0.103). Conclusions: Oliguria is common in ICU patients and may have a relatively benign nature if only transient. The duration of oliguria and need for RRT are associated with worse outcome.publishersversionPeer reviewe

Penerapan Fuzzy Logic Tsukamoto pada Pembangunan Kandang Ayam Pintar

Dari hasil wawancara dengan pakar unggas didapatkan bahwa kondisi suhu dan kelembaban udara dapat mempengaruhi produktifitas dan kesehatan ayam karena suhu dan kelembaban yang tidak stabil. Pada penelitian ini dibangun “kandang ayam” pintar menggunakan metode Tsukamoto untuk menghitung durasi waktu dalam pengaturan suhu dan kelembaban. Kandang ayam pintar menggunakan sensor suhu, kelembaban udara, Real Time Clock untuk mengatur pemberian pakan secara otomatis, limit switch untuk memperingati peternak untuk mengisi stok pakan ayam dan sensor gas ammonia yang disimulasikan menggunakan potensio untuk mendeteksi gas ammonia yang terdapat dalam kandang ayam. Berdasarkan pengujian, dengan adanya metode fuzzy logic tsukamoto yang dibantu sistem sebagai acuan untuk dapat menentukan titik-titik krusial, dan membuat kondisi kandang ayam menjadi stabil dengan durasi waktu yang panjang, agar pada saat cuaca diluar kandang berubah drastis, cuaca di dalam kandang tidak berubah drastis seperti kondisi cuaca diluar kandang. Keluaran aplikasi yang dibuat memiliki akurasi 100%

Correlation between Leprosy Children with Nutritional Status, Personal Hygiene, BCG Vaccination History and Occupancy Density in Gresik Regency

Even though Indonesia has achieved elimination status, leprosy is still an important health problem in Indonesia because of its debilitating nature. East Java is one of the provinces with the highest leprosy burden in Indonesia, with a high percentage of children cases. Many factors are thought to affect leprosy transmission. Among them are nutritional status, personal hygiene, BCG vaccination history, and occupancy density. The purpose of this study was to determine the relationship between nutritional status, personal hygiene, BCG vaccination history, and occupancy density with the incidence of leprosy in children in the Gresik Regency. This is an analytic observational research with a case-control approach. This research was conducted in December 2019. The number of samples were 60 respondents, consisting of 30 cases and 30 controls. The results of multivariate analysis showed that there was a relationship between nutritional status (p = 0.041; OR = 9,628), history of BCG vaccination (p = 0.032; OR = 22,164) and occupancy density (p = 0.003; OR = 14,810) with leprosy in children. Nutritional status, personal hygiene, BCG vaccination history, and occupancy density are significantly associated with the incidence of leprosy in children, with occupancy density as the most significant factor and history of BCG vaccination as the strongest risk predictor associated with the development of leprosy in the pediatric population

Conformational dynamics in substrate-binding domains influences transport in the ABC importer GlnPQ

The conformational dynamics in ABC transporters is largely elusive. The ABC importer GlnPQ from Lactococcus lactis has different covalently linked substrate-binding domains (SBDs), thus making it an excellent model system to elucidate the dynamics and role of the SBDs in transport. We demonstrate by single-molecule spectroscopy that the two SBDs intrinsically transit from open to closed ligand-free conformation, and the proteins capture their amino acid ligands via an induced-fit mechanism. High-affinity ligands elicit transitions without changing the closed-state lifetime, whereas low-affinity ligands dramatically shorten it. We show that SBDs in the closed state compete for docking onto the translocator, but remarkably the effect is strongest without ligand. We find that the rate-determining steps depend on the SBD and the amino acid transported. We conclude that the lifetime of the closed conformation controls both SBD docking to the translocator and substrate release