40-Gb/s TDM-PON downstream with low-cost EML transmitter and 3-level detection APD receiver

We report a cost-effective 40-Gb/s TDM-PON downstream utilizing an integrated DFB-EAM in OLT and an APD-based 3-level detection receiver in ONU, achieving a high power budget of 23.4 dB in real time operation

Pénicilline détruite par la pénicillinase ou par la soude et croissance du Poulet

Ferrando F., Brenot-Antier D., Philippe J., Fortier R., Basquin R., Bressou Ch. Pénicilline détruite par la pénicillinase ou par la soude et croissance du Poulet. In: Bulletin de l'Académie Vétérinaire de France tome 106 n°6, 1953. pp. 345-348

Excitation and relaxation in atom-cluster collisions

Electronic and vibrational degrees of freedom in atom-cluster collisions are treated simultaneously and self-consistently by combining time-dependent density functional theory with classical molecular dynamics. The gradual change of the excitation mechanisms (electronic and vibrational) as well as the related relaxation phenomena (phase transitions and fragmentation) are studied in a common framework as a function of the impact energy (eV...MeV). Cluster "transparency" characterized by practically undisturbed atom-cluster penetration is predicted to be an important reaction mechanism within a particular window of impact energies.Comment: RevTeX (4 pages, 4 figures included with epsf

Early warning system of natural hazards and decrease of climat impact from aviation; ALARM funded project

Aviation safety can be jeopardised by multiple hazards arising from natural phenomena, e.g., severe weather, aerosols/gases from natural hazard, and space weather. Furthermore, there are the anthropogenic emissions and climate impact of aviation that could be reduced. To mitigate such risk and/or to decrease climate impact, tactical decision-making processes could be enhanced through the development of multihazard monitoring and Early Warning System (EWS). With this objective in mind, ALARM consortium has implemented alert products (i.e., observations, detection and data access in near realtime) and tailored product (notifications, flight level — FL contamination, risk area, and visualization of emission/risk level) related to Natural Airborne Hazard (NAH, i.e., volcanic, dust and smoke clouds) and environmental hotspots. New selective detection, nowcasting and forecasts of such risks for aviation have been implemented as part of ALARM prototype EWS. This system has two functionalities. One is to provide alerts on a global coverage using remote sensing from satellites and models (focus on NAH, space weather activity and environmental hotspots). A second focuses on detecting severe weather and exceptional SO2 conditions around a selection of few airports, on providing nowcasts and forecasts of risk conditions

PerR Confers Phagocytic Killing Resistance and Allows Pharyngeal Colonization by Group A Streptococcus

The peroxide response transcriptional regulator, PerR, is thought to contribute to virulence of group A Streptococcus (GAS); however, the specific mechanism through which it enhances adaptation for survival in the human host remains unknown. Here, we identify a critical role of PerR-regulated gene expression in GAS phagocytosis resistance and in virulence during pharyngeal infection. Deletion of perR in M-type 3 strain 003Sm was associated with reduced resistance to phagocytic killing in human blood and by murine macrophages in vitro. The increased phagocytic killing of the perR mutant was abrogated in the presence of the general oxidative burst inhibitor diphenyleneiodonium chloride (DPI), a result that suggests PerR-dependent gene expression counteracts the phagocyte oxidative burst. Moreover, an isogenic perR mutant was severely attenuated in a baboon model of GAS pharyngitis. In competitive infection experiments, the perR mutant was cleared from two animals at 24 h and from four of five animals by day 14, in sharp contrast to wild-type bacteria that persisted in the same five animals for 28 to 42 d. GAS genomic microarrays were used to compare wild-type and perR mutant transcriptomes in order to characterize the PerR regulon of GAS. These studies identified 42 PerR-dependent loci, the majority of which had not been previously recognized. Surprisingly, a large proportion of these loci are involved in sugar utilization and transport, in addition to oxidative stress adaptive responses and virulence. This finding suggests a novel role for PerR in mediating sugar uptake and utilization that, together with phagocytic killing resistance, may contribute to GAS fitness in the infected host. We conclude that PerR controls expression of a diverse regulon that enhances GAS resistance to phagocytic killing and allows adaptation for survival in the pharynx

Global Monitoring of Volcanic SO2 Degassing Using Sentinel-5 Precursor Tropomi

We present here the TROPOMI SO 2 product, which is publicly available since April 2018. We describe the capabilities and limitations of the product for the monitoring of volcanic SO 2 degassing. With several examples, we illustrate the benefit of a small satellite pixel of 3.5 x 5.5 km 2 . Owing to its improved detection limit, the data can be used to generate time series of SO 2 mass over number of volcanoes, with a large range of SO 2 emissions. We use Nyiragongo as a show case and correlate the SO 2 mass data with lava lake level estimates and local measurements of the seismicity. This paper also presents on-going developments to further improve the performance of the product for weak SO 2 loadings using a new algorithm, COBRA

FYVE-Dependent Endosomal Targeting of an Arrestin-Related Protein in Amoeba

International audienceBACKGROUND: Visual and β-arrestins are scaffolding proteins involved in the regulation of receptor-dependent intracellular signaling and their trafficking. The arrestin superfamilly includes several arrestin domain-containing proteins and the structurally related protein Vps26. In Dictyostelium discoideum, the arrestin-domain containing proteins form a family of six members, namely AdcA to -F. In contrast to canonical arrestins, Dictyostelium Adc proteins show a more complex architecture, as they possess, in addition to the arrestin core, other domains, such as C2, FYVE, LIM, MIT and SAM, which potentially mediate selective interactions with either lipids or proteins. METHODOLOGY AND PRINCIPAL FINDINGS: A detailed analysis of AdcA has been performed. AdcA extends on both sides of the arrestin core, in particular by a FYVE domain which mediates selective interactions with PI(3)P, as disclosed by intrinsic fluorescence measurements and lipid overlay assays. Localization studies showed an enrichment of tagged- and endogenous AdcA on the rim of early macropinosomes and phagosomes. This vesicular distribution relies on a functional FYVE domain. Our data also show that the arrestin core binds the ADP-ribosylation factor ArfA, the unique amoebal Arf member, in its GDP-bound conformation. SIGNIFICANCE: This work describes one of the 6 arrestin domain-containing proteins of Dictyostelium, a novel and atypical member of the arrestin clan. It provides the basis for a better understanding of arrestin-related protein involvement in trafficking processes and for further studies on the expanding roles of arrestins in eukaryotes