17 research outputs found
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abbas M.
- Abdul Rasheed A.
- Abdul A.
- Abdul-Kadir R.
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- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 31/01/2024
- Field of study
Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Pregnancy and neonatal outcomes of COVID-19: The PAN-COVID study
- Author
- Ahmed Amna
- Ajay Bini
- Aladangady Narendra
- Aldika Akbar M.I
- Amin Allison
- Anderson Michelle
- Andrasova Martina
- Anim-Somuah Millicent
- Armstrong Maggie
- Arya Rita
- Asghar Anila
- Atkinson Vicki
- Bale Nichola
- Balling Trevor
- Banerjee J.
- Barker Katie
- Barra Fabio
- Bishop Linda
- Black Mairead
- Blunden Susara
- Bourke Miriam
- Bourne T.
- Brain Jessie
- Bray Maryanne
- Bressington Catherine
- Camarasa Laura
- Cantliffe Jane
- Chapman Lianne
- Chester Mark
- Chiu Yee POON Liona
- Churchill David
- Cloherty Karen
- Collins Emma
- Coxon Sarah
- Crawford Isobel
- Cresswell Janet
- Dall'Asta Andrea
- Darmawan Ernawati
- Davies Ru
- Davies Ruth
- Divakar Hema
- Dixon Caroline
- Ekladios Sarah
- Elbahnasawy Mohamed
- Elliott Kerry
- Emmet Louise
- Essien Sandra
- Everden Caroline
- Fayadh Anam
- Flood Chris
- Frankland Lisa
- Gada Ruta
- Garner Zoe
- Gbinigie Helen
- Gerede Angeliki
- Germán Caro Waldo
- Giri Vibha
- Glenn-Sansum Coralie
- Glyn-Jones Liz
- Goddard Julie
- Gorti Mahalakshmi
- Gowans Sharon
- Greer Sandra
- Grigsby Stephanie
- Grindey Julie
- Grozeva D.
- Halawa Sherry
- Hammond Bev
- Harrington Andrea
- Harrington Siân C
- Harris Laura
- Hassan Wassim
- Heal Carrie
- Higgins Shelly
- Hinshaw Kim
- Hughes Robin
- Huson Coralie
- Iliodromiti Stamatina
- Jaleel Shazia
- Javaid Muglu
- Jennings Jacqui
- Jokhi Roobin
- Jones Sharon
- Kermack Alexandra J
- Khare Manjiri
- Khunda Aethele
- Kidwai Salman
- Kirby N.
- Knight Caroline
- Kousar Rukhsana
- Lee Fidelma
- Lees C.
- Liebling Rachel
- Mackay Ami
- Mahdi Amy
- Malarselvi Mani
- Mansfield Roshni
- Margarit Lavinia
- Martin Hayley L.
- Mason Nicky
- McCooty Shanteela
- McKeown Gillian
- Mead Joanna
- Meadows Emma
- Mills Emma
- Millward Helen
- Milton R.
- MK Jarvie Eleanor
- Mossop Jude
- Mullins E.
- Murtha Victoria
- Mutema E.
- Möller-Christensen Christine
- Nallapeta Soum
- Narayanan Sankara
- Nejad Avideah
- Newport Rachel
- Nicoll Antony
- O'Brien Clare
- Owen Hilary
- Panagiotis Christofidis Plastiras
- Parra-Cordero Mauro
- Peers Beth
- Perkins Donna
- Perry A.
- Playle R.
- Prefumo Federico
- Radford Jane
- Rajeswary Ms.Jyothi
- Rallis Dimitrios
- Rand Abby
- Ratcliffe Sam
- RATHER BA
- Raven Jamie-Louise
- Revell Kirsty
- Robinson Kate
- Robinson Sophie
- Roland Berger MD
- Romero Elena
- Rozto?il Ale?
- Sameena Kausar Ms
- Satodia Prakash
- Shah Ahmar
- Shah Neil
- Sherris Leanne
- Sinha Barkha
- Sobhy Bakry Mohamed
- Southam Donna
- Stables Sarah
- Sukrutha Veerareddy
- Swaminathan Louise
- Syson Jennifer
- Tanton Emma
- Tipper Jacqueline
- Tiziana Frusca SSA
- Townson J.
- Vasu Vimal
- Verma Amit
- Viner Alexandra
- Vrapi Enxhi
- Watkins Karen
- Wee Ling
- Windsor Laurie
- Wixted Donna
- Woodward Zoe
- Wu Pensée
- Wyatt Cheryl
- XIE Mingxing
- Zill-e-Huma Rabia
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/09/2022
- Field of study
Objective
To assess perinatal outcomes for pregnancies affected by suspected or confirmed SARS-CoV-2 infection.
Methods
Prospective, web-based registry. Pregnant women were invited to participate if they had suspected or confirmed SARS-CoV-2 infection between 1st January 2020 and 31st March 2021 to assess the impact of infection on maternal and perinatal outcomes including miscarriage, stillbirth, fetal growth restriction, pre-term birth and transmission to the infant.
Results
Between April 2020 and March 2021, the study recruited 8239 participants who had suspected or confirmed SARs-CoV-2 infection episodes in pregnancy between January 2020 and March 2021.
Maternal death affected 14/8197 (0.2%) participants, 176/8187 (2.2%) of participants required ventilatory support. Pre-eclampsia affected 389/8189 (4.8%) participants, eclampsia was reported in 40/ 8024 (0.5%) of all participants.
Stillbirth affected 35/8187 (0.4 %) participants. In participants delivering within 2 weeks of delivery 21/2686 (0.8 %) were affected by stillbirth compared with 8/4596 (0.2 %) delivering ≥ 2 weeks after infection (95 % CI 0.3–1.0). SGA affected 744/7696 (9.3 %) of livebirths, FGR affected 360/8175 (4.4 %) of all pregnancies.
Pre-term birth occurred in 922/8066 (11.5%), the majority of these were indicated pre-term births, 220/7987 (2.8%) participants experienced spontaneous pre-term births. Early neonatal deaths affected 11/8050 livebirths. Of all neonates, 80/7993 (1.0%) tested positive for SARS-CoV-2.
Conclusions
Infection was associated with indicated pre-term birth, most commonly for fetal compromise. The overall proportions of women affected by SGA and FGR were not higher than expected, however there was the proportion affected by stillbirth in participants delivering within 2 weeks of infection was significantly higher than those delivering ≥ 2 weeks after infection. We suggest that clinicians’ threshold for delivery should be low if there are concerns with fetal movements or fetal heart rate monitoring in the time around infection
Evaluation of appendicitis risk prediction models in adults with suspected appendicitis
- Author
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- Zhang Ay
- Zhou S
- Zorrilla L
- Zuin M
- Zurleni Tz
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2019
- Field of study
Background
Appendicitis is the most common general surgical emergency worldwide, but its diagnosis remains challenging. The aim of this study was to determine whether existing risk prediction models can reliably identify patients presenting to hospital in the UK with acute right iliac fossa (RIF) pain who are at low risk of appendicitis.
Methods
A systematic search was completed to identify all existing appendicitis risk prediction models. Models were validated using UK data from an international prospective cohort study that captured consecutive patients aged 16–45 years presenting to hospital with acute RIF in March to June 2017. The main outcome was best achievable model specificity (proportion of patients who did not have appendicitis correctly classified as low risk) whilst maintaining a failure rate below 5 per cent (proportion of patients identified as low risk who actually had appendicitis).
Results
Some 5345 patients across 154 UK hospitals were identified, of which two‐thirds (3613 of 5345, 67·6 per cent) were women. Women were more than twice as likely to undergo surgery with removal of a histologically normal appendix (272 of 964, 28·2 per cent) than men (120 of 993, 12·1 per cent) (relative risk 2·33, 95 per cent c.i. 1·92 to 2·84; P < 0·001). Of 15 validated risk prediction models, the Adult Appendicitis Score performed best (cut‐off score 8 or less, specificity 63·1 per cent, failure rate 3·7 per cent). The Appendicitis Inflammatory Response Score performed best for men (cut‐off score 2 or less, specificity 24·7 per cent, failure rate 2·4 per cent).
Conclusion
Women in the UK had a disproportionate risk of admission without surgical intervention and had high rates of normal appendicectomy. Risk prediction models to support shared decision‐making by identifying adults in the UK at low risk of appendicitis were identified
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
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- Abbas M.
- Abdul Rasheed A.
- Abdul A.
- Abdul-Kadir R.
- Abdusamad K.
- Abernethy K.
- Aboelela H.
- Abouzaid M.
- Abraham M.
- Abraham T.
- Abrams J.
- Abu H.
- Abu-Arafeh A.
- Acton C.
- Adam F.
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- Adams C.
- Adams D.
- Adams L.
- Addo A.
- Adedeji O.
- Adegoke K.
- Adewunmi E.
- Adeyemo T.
- Agbeko R.
- Aggarwal S.
- Ahmad S.
- Ahmed A.
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- Ainsworth M.
- Ajmi A.
- Akili S.
- Al Aaraj A.
- Al Balushi A.
- Al-Asadi A.
- Al-Khalil M.
- Al-Ramadhani B.
- Al-Saadi Z.
- Al-Shahi Salman R.
- Al-Sheklly B.
- Albert P.
- Alegria A.
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- Central Coordinating Office (for the RECOVERY Collaborative Group)
- Century H.
- Chadwick J.
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- Chakraborty A.
- Chamberlain S.
- Chambers E.
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- Chawla V.
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- Chiswick C.
- Chivima B.
- Chmiel C.
- Chrisopoulou A.
- Christian P.
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- Church E.
- Cianci N.
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- Clark E.
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- Clifford S.
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- Coker O.
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- Collini Paul
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- Data Monitoring Committee of the RECOVERY Collaborative Group
- Daunt A.
- Dave V.
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- Fairbairn I.
- Fairclough A.
- Falconer E.
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- Fancois V.
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- Farzana S.
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- Health records (for the RECOVERY Collaborative Group)
- Hector G.
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- Local Clinical Centre staff (for the RECOVERY Collaborative Group)
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- Publication venue
- Nature Publishing Group
- Publication date
- Field of study
Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
European Network of Trainees in Obstetrics and Gynaecology: experiences from the 2016 exchange programme in Turin, Italy.
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
INTRODUCTION: The European Network of Trainees in Obstetrics and Gynaecology (ENTOG) is an organization representing trainees from 30 European member countries. Together with the European Board and College of Obstetrics and Gynaecology (EBCOG), it seeks to achieve the highest possible standards of training and consequently to improve the quality of medical care in the field of gynaecology and obstetrics. Every year, the ENTOG council meets and holds a scientific meeting in a different European country. To coincide with this, the host country arranges an exchange, to which each member country can send two trainees. This exchange allows trainees to gain insight into both daily clinical work and the structure of the health care system. METHODS: This article reports the experiences of participants in the May 2016 ENTOG exchange to Turin, Italy. The aim is to outline differences in training between Germany and Italy as well as some striking differences with other European countries. PERSPECTIVE: The participants' personal benefit from this unique experience was not only to get familiar with the Italian trainee programme and health care system, but also to exchange experiences among representatives from other European countries and build up a young gynaecological network within Europe
A scoping review of community paramedicine: evidence and implications for interprofessional practice
- Author
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Anisotropic radiation modelling of macroseismic intensities for estimation of the attenuation structure of the upper crust in Greece
- Author
- A. Dahle
- A. Frankel
- A. G. Galanopoulos
- A. G. Galanopoulos
- A. G. Galanopoulos
- B. C. Papazachos
- B. C. Papazachos
- B. C. Papazachos
- B. C. Papazachos
- B. C. Papazachos
- B. F. Howell
- C. A. Cornell
- D. Jongsma
- D. P. McKenzie
- D. Prochazkova
- G. F. Panza
- H. J. Al-Shukri
- I. N. Gupta
- J. Drakopoulos
- J. F. Everden
- J. G. Anderson
- J. K. Drakopoulos
- J. Makris
- K. Aki
- K. Levenberg
- M. L. Sbar
- N. D. Delibasis
- N. N. Ambraseys
- N. R. Tilford
- N. Theodulidis
- P. E. Comninakis
- P. Suhadolc
- P. W. Marquadt
- S. A. Kovachev
- S. K. Singh
- T. Hashida
- T. Hashida
- T. Taymaz
- T. Utsu
- U. Chandra
- U. Chandra
- W. M. Ewing
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1992
- Field of study
P1141: IBRUTINIB AND RITUXIMAB AS FIRST LINE THERAPY FOR MANTLE CELL LYMPHOMA: A MULTICENTRE, REAL-WORLD UK STUDY
- Author
- A. Beech
- A. Everden
- A. Gibb
- A. Hodson
- A. Lord
- A. Tivey
- B. Jackson
- C. Bedford
- C. Hildyard
- C. Rees
- D. Lewis
- D. Tucker
- D. Wrench
- E. Davies
- E. Nga
- F. Miall
- H. Marr
- I. Qureshi
- J. Bailey
- J. Goddard
- J. Norman
- J. Wilson
- J. Wright
- K. Linton
- L. Lowry
- M. Flont
- M. Koppana
- M. Prahladan
- M. Wilson
- N. Crosbie
- N. Thomas
- R. Guerrero Camacho
- R. Shotton
- S. Jones
- S. Moule
- S. Paneesha
- S. Smith
- T. A. Eyre
- T. Nicholson
- T. Sutton
- W. Swe
- Publication venue
- Wiley
- Publication date
- 01/06/2022
- Field of study
Dexamethasone treatment of pregnant F0 mice leads to parent of origin-specific changes in placental function of the F2 generation
- Author
- A. J. Everden
- A. L. Fowden
- A. N. Sferruzzi-Perri
- Ain
- Audette
- Baisden
- Barlow
- Benediktsson
- Brownfoot
- Coan
- Const�ncia
- Cottrell
- Cramer
- Crudo
- Cuffe
- de Vries
- Dodic
- Drake
- Drake
- Drozdowski
- Drude
- Fowden
- Franko
- H. M. Phillips
- Hahn
- Hauser
- Hewitt
- Igosheva
- Iqbal
- Isganaitis
- Khan
- Lager
- Lindsay
- Lindsay
- Liu
- Long
- Long
- Long
- Meijer
- Moisiadis
- Montano
- Morrison
- Nyirenda
- O. R. Vaughan
- O?Connell
- O?Connell
- O?Sullivan
- Radford
- Radford
- Ross
- Shoener
- Smith
- Sugden
- Vaughan
- Vaughan
- Watkins
- Woods
- Xu
- Publication venue
- 'CSIRO Publishing'
- Publication date
- 01/01/2015
- Field of study
The Metronomic Society and the Natural Environment
- Author
- A Brookes
- A Burns
- B Nettleton
- B Nettleton
- B Nettleton
- D Frick
- E Dissanyake
- E G Mishler
- E O Wilson
- F H George
- FW Matson
- H Freeman
- J A Russell
- J F Wohlwill
- J Gribbin
- J L Nasar
- J Quay
- Joseph Grange
- L Mumford
- L Rodwin
- L Trilling
- L Watson
- M Castells
- M S Gazzaniga
- M Shoard
- M Young
- N Everden
- P Tompkins
- R Dawkins
- R Restak
- R S Ulrich
- R S Ulrich
- S Kaplan
- S Osherson
- T Hore
- Z Rubin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study