Periodically driven stochastic un- and refolding transitions of biopolymers

Mechanical single molecule experiments probe the energy profile of biomolecules. We show that in the case of a profile with two minima (like folded/unfolded) periodic driving leads to a stochastic resonance-like phenomenon. We demonstrate that the analysis of such data can be used to extract four basic parameters of such a transition and discuss the statistical requirements of the data acquisition. As advantages of the proposed scheme, a polymeric linker is explicitly included and thermal fluctuations within each well need not to be resolved.Comment: 7 pages, 5 figures, submitted to EP

Phase Transition in Two Species Zero-Range Process

We study a zero-range process with two species of interacting particles. We show that the steady state assumes a simple factorised form, provided the dynamics satisfy certain conditions, which we derive. The steady state exhibits a new mechanism of condensation transition wherein one species induces the condensation of the other. We study this mechanism for a specific choice of dynamics.Comment: 8 pages, 3 figure

Biological and physical oceanographic observations pertaining to the trawl fishery in a region of persistent coastal upwelling

An upwelling episode in the Point Sal region of the central California coast is examined by using data obtained by a data buoy. The episodes was interrupted by the abrupt abatement of the strong wind which promotes coastal upwelling. The mean hourly upwelling index is calculated to be higher than the 20 year mean monthly value. During 3 days of light wind commercial bottom trawl operations were possible. Shipboard estimates of chlorophyll content in surface waters during trawling show the high concentrations that are indicative of a rich biomass of phytoplankton, a result of the upwelling episode. Satellite imagery shows the extent of the upwelling water to be of the order of 100 km offshore; the result of many upwelling episodes. Shipboard echo sounder data show the presence of various delmersal species and of zooplakton; the latter graze on the phytoplankton in the upper euphotic layers. The fish catch data are recorded according to species for 2 days of trawling, and the catch per trawl hour is recorded

`t Hooft Anomaly Matching for QCD

I present a set of theories which display non-trivial `t Hooft anomaly matching for QCD with $F$ flavors. The matching theories are non-Abelian gauge theories with "dual" quarks and baryons, rather than the purely confining theories of baryons that `t Hooft originally searched for. The matching gauge groups are required to have an $F\pm 6$ dimensional representation. Such a correspondence is reminiscent of Seiberg's duality for supersymmetric (SUSY) QCD, and these theories are candidates for non-SUSY duality. However anomaly matching by itself is not sufficiently restrictive, and duality for QCD cannot be established at present. At the very least, the existence of multiple anomaly matching solutions should provide a note of caution regarding conjectured non-SUSY dualities.Comment: 8 pages, LaTeX, version to be published in PR

Analysis of global routine immunisation coverage shows disruption and stagnation during the first two-years of the COVID-19 pandemic with tentative recovery in 2022

Whilst it is now widely recognised that routine immunisation (RI) was disrupted by the COVID-19 pandemic in 2020, and further so in 2021, the extent of continued interruptions in 2022 and/or rebounds to previous trends remains unclear. We modelled country-specific RI trends using validated estimates of national coverage from the World Health Organisation and United Nation Children's Fund for 182 countries (accounting for > 97% of children globally), to project expected diphtheria, tetanus, and pertussis-containing vaccine first-dose (DTP1), third-dose (DTP3) and measles-containing vaccine first-dose (MCV1) coverage for 2020-2022 based on pre-pandemic trends (from 2000 to 2019). We provide further evidence of peak pandemic immunisation disruption in 2021, followed by tentative recovery in 2022. We report a 3.4% (95 %CI: [2.5%; 4.4%]) decline in global DTP3 coverage in 2021 compared to 2000-2019 trends, from an expected 89.8% to reported 86.4%. This coverage gap reduced to a 2.7% (95 %CI: [1.8%; 3.6%]) decline in 2022, with reported coverage rising to 87.2%. Similar results were seen for DTP1 and MCV1. Whilst partial rebounds are encouraging, global coverage decline translates to a 17-year setback in RI to 2005 levels, and the majority of countries retain coverage at or lower than pre-pandemic levels. The Americas, Africa, and Asia were the most impacted regions; and low- and middle-income countries the most affected income groups. The number of annual Zero Dose (ZD) children - indicating those receiving no immunisations - increased from 12.1 million (M) globally in 2019 to a peak of 16.7 M in 2021, then reduced to 13.1 M in 2022. Overall, we estimate an excess of 8.8 M ZD children cumulatively in 2020-2022 compared to pre-pandemic levels. This work can be used as an objective baseline to inform future interventions to prioritise and target interventions, and facilitate catch-up of growing populations of under- and un-immunised children

Criterion for phase separation in one-dimensional driven systems

A general criterion for the existence of phase separation in driven one-dimensional systems is proposed. It is suggested that phase separation is related to the size dependence of the steady-state currents of domains in the system. A quantitative criterion for the existence of phase separation is conjectured using a correspondence made between driven diffusive models and zero-range processes. Several driven diffusive models are discussed in light of the conjecture

The Beck Initiative : training school-based mental health staff in cognitive therapy

A growing literature supports cognitive therapy (CT) as an efficacious treatment for youth struggling with emotional or behavioral problems. Recently, work in this area has extended the dissemination of CT to school-based settings. The current study has two aims: 1) to examine the development of therapists’ knowledge and skills in CT, an evidence-based approach to promoting student well-being, and 2) to examine patterns of narrative feedback provided to therapists participating in the program. As expected, school therapists trained in CT demonstrated significant gains in their knowledge of CT theory and in their demonstration of CT skills, with the majority of therapists surpassing the accepted threshold of competency in CT. In addition, an examination of feedback content suggested that narrative feedback provided to therapists most frequently consisted of positive feedback and instructions for future sessions. Suggestions for future research regarding dissemination of CT are discussed in light of increasing broad access to evidence based practices.peer-reviewe

Static cylindrical symmetry and conformal flatness

We present the whole set of equations with regularity and matching conditions required for the description of physically meaningful static cylindrically symmmetric distributions of matter, smoothly matched to Levi-Civita vacuum spacetime. It is shown that the conformally flat solution with equal principal stresses represents an incompressible fluid. It is also proved that any conformally flat cylindrically symmetric static source cannot be matched through Darmois conditions to the Levi-Civita spacetime. Further evidence is given that when the Newtonian mass per unit length reaches 1/2 the spacetime has plane symmetry.Comment: 13 pages, Late

Formation of a three-dimensional plasma boundary after decay of the plasma response to resonant magnetic perturbation fields

First time experimental evidence is presented for a direct link between the decay of a n = 3 plasma response and the formation of a three-dimensional (3D) plasma boundary. We inspect a lower single-null L-mode plasma which first reacts at sufficiently high rotation with an ideal resonant screening response to an external toroidal mode number n = 3 resonant magnetic perturbation field. Decay of this response due to reduced bulk plasma rotation changes the plasma state considerably. Signatures such as density pump out and a spin up of the edge rotation-which are usually connected to formation of a stochastic boundary-are detected. Coincident, striation of the divertor single ionized carbon emission and a 3D emission structure in double ionized carbon at the separatrix is seen. The striated C II pattern follows in this stage the perturbed magnetic footprint modelled without a plasma response (vacuum approach). This provides for the first time substantial experimental evidence, that a 3D plasma boundary with direct impact on the divertor particle flux pattern is formed as soon as the internal plasma response decays. The resulting divertor structure follows the vacuum modelled magnetic field topology. However, the inward extension of the perturbed boundary layer can still not directly be determined from these measurements