1,118 research outputs found
Surface Polymer Network Model and Effective Membrane Curvature Elasticity
A microscopic model of a surface polymer network - membrane system is
introduced, with contact polymer surface interactions that can be either
repulsive or attractive and sliplinks of functionality four randomly
distributed over the supporting membrane surface anchoring the polymers to it.
For the supporting surface perturbed from a planar configuration and a small
relative number of surface sliplinks, we investigate an expansion of the free
energy in terms of the local curvatures of the surface and the surface density
of sliplinks, obtained through the application of the Balian - Bloch -
Duplantier multiple surface scattering method. As a result, the dependence of
the curvature elastic modulus, the Gaussian modulus as well as of the
spontaneous curvature of the "dressed" membrane, ~{\sl i.e.} polymer network
plus membrane matrix, is obtained on the mean polymer bulk end to end
separation and the surface density of sliplinks.Comment: 15 pages with one included compressed uuencoded figure
Effect of supplementation with B vitamins and antioxidants on levels of asymmetric dimethylarginine (ADMA) and C-reactive protein (CRP): a double-blind, randomised, factorial design, placebo-controlled trial.
The common ‘thermolabile' variant of methylene tetrahydrofolate reductase is a major determinant of mild hyperhomocysteinaemia
Mild hyperhomocysteinaemia is a major risk factor for vascular disease and neural tube defects (NTDs), conferring an approximately three-fold relative risk for each condition. It has several possible causes: heterozygosity for rare loss of function mutations in the genes for 5,10-methylene tetrahydrofolate reductase (MTHFR) or cystathionine-β-synthase (CBS); dietary insufficiency of vitamin co-factors B6, B12 or folates; or homozygosity for a common ‘thermolabile' mutation in the MTHFR gene which has also been associated with vascular disease and NTDs. We quantified the contribution of the thermolabile mutation to the hyperhomocysteinaemic phenotype in a working male population (625 individuals). Serum folate and vitamin B12 concentrations were also measured and their relationship with homocysteine status and MTHFR genotype assessed. The homozygous thermolabile genotype occurred in 48.4, 35.5, and 23.4% of the top 5,10, and 20% of individuals (respectively) ranked by plasma homocysteine levels, compared with a frequency of 11.5% in the study population as a whole, establishing that the mutation is a major determinant of homocysteine levels at the upper end of the range. Serum folate concentrations also varied with genotype, being lowest in thermolabile homozygotes. The MTHFR thermolabile genotype should be considered when population studies are designed to determine the effective homocysteine-lowering dose of dietary folate supplements, and when prophylactic doses of folate are recommended for individual
EXPLORING THE ROLE OF OSPREYS IN EDUCATION
Recent research in childhood education has demonstrated that experiences in nature are important in shaping early environmental consciousness (Hinds and Sparks 2008, Hussar and Horvath 2011, Cheng and Monroe 2012) and ultimately the expression of pro-environmental attitudes and behaviors during adulthood (Wells and Lekies 2006, Chawla and Cushing 2007, Collado et al. 2013). Increasingly, those experiences happen via written and electronic media (e.g., textbooks, computer screens) or in very anthropogenic environments (e.g., in parks and zoos) and less through direct contact with nature, a concept Louv (2005) referred to as ‘‘nature deficit disorder.’’ Even in schools where environmental education is prioritized, the extent of access to outdoor classroom activities or experiential learning opportunities can limit the degree to which children can observe, explore, and directly experience the natural world (Hudson 2001, Louv 2005, Ernst 2009). Interestingly, the same information technologies that might serve to limit contact with nature also have the potential to enhance and encourage interest and concern for the natural world (Blewitt 2011, Pearson et al. 2011). We believe this is an important paradox that warrants much further exploration and evaluation within educational and scientific communities
Anisotropic distribution functions for spherical galaxies
A method is presented for finding anisotropic distribution functions for
stellar systems with known, spherically symmetric, densities, which depends
only on the two classical integrals of the energy and the magnitude of the
angular momentum. It requires the density to be expressed as a sum of products
of functions of the potential and of the radial coordinate. The solution
corresponding to this type of density is in turn a sum of products of functions
of the energy and of the magnitude of the angular momentum. The products of the
density and its radial and transverse velocity dispersions can be also
expressed as a sum of products of functions of the potential and of the radial
coordinate. Several examples are given, including some of new anisotropic
distribution functions. This device can be extended further to the related
problem of finding two-integral distribution functions for axisymmetric
galaxies.Comment: 5 figure
Large-scale pharmacogenomic study of sulfonylureas and the QT, JT and QRS intervals: CHARGE Pharmacogenomics Working Group
Sulfonylureas, a commonly used class of medication used to treat type 2 diabetes, have been associated with an increased risk of cardiovascular disease. Their effects on QT interval duration and related electrocardiographic phenotypes are potential mechanisms for this adverse effect. In 11 ethnically diverse cohorts that included 71 857 European, African-American and Hispanic/Latino ancestry individuals with repeated measures of medication use and electrocardiogram (ECG) measurements, we conducted a pharmacogenomic genome-wide association study of sulfonylurea use and three ECG phenotypes: QT, JT and QRS intervals. In ancestry-specific meta-analyses, eight novel pharmacogenomic loci met the threshold for genome-wide significance (P<5 × 10−8), and a pharmacokinetic variant in CYP2C9 (rs1057910) that has been associated with sulfonylurea-related treatment effects and other adverse drug reactions in previous studies was replicated. Additional research is needed to replicate the novel findings and to understand their biological basis
New results from the NA57 experiment
We report results from the experiment NA57 at CERN SPS on hyperon production
at midrapidity in Pb-Pb collisions at 158 GeV/ and 40 GeV/.
, and yields are compared with those from the STAR
experiment at the higher energy of the BNL RHIC. , , \
and preliminary transverse mass spectra are presented and interpreted
within the framework of a hydro-dynamical blast wave model.Comment: 8 pages, 3 figures, contribution to the proceedings of The XXXVIIIth
Rencontres de Moriond "QCD and High Energy Hadronic Interactions
Expansion dynamics of Pb-Pb collisions at 40 A GeV/c viewed by negatively charged hadrons
In this paper we present results on transverse mass spectra and Hanbury-Brown
and Twiss correlation functions of negatively charged hadrons, which are
expected to be mostly negative pions, measured in Pb-Pb collisions at 40 A
GeV/c beam momentum. Based on these data, the collision dynamics and the
space-time extent of the system at the thermal freeze-out are studied over a
centrality range corresponding to the most central 53% of the Pb--Pb inelastic
cross section. Comparisons with freeze-out conditions of strange particles and
HBT results from other experiments are discussed.Comment: 29 pages, 18 figure
Results on hyperon production from the NA57 experiment
Recent results on hyperon production in Pb--Pb collisions from the NA57
experiment are reported. Strangeness enhancement and the transverse mass
spectra properties at 158 GeV per nucleon are described.Comment: submitted to Acta Phys. Hung. A (Heavy Ion Physics
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