8,159 research outputs found
Comparison of first pass bolus AIFs extracted from sequential 18F-FDG PET and DSC-MRI of mice.
Accurate kinetic modelling of in vivo physiological function using positron emission tomography (PET) requires determination of the tracer time-activity curve in plasma, known as the arterial input function (AIF). The AIF is usually determined by invasive blood sampling methods, which are prohibitive in murine studies due to low total blood volumes. Extracting AIFs from PET images is also challenging due to large partial volume effects (PVE). We hypothesise that in combined PET with magnetic resonance imaging (PET/MR), a co-injected bolus of MR contrast agent and PET ligand can be tracked using fast MR acquisitions. This protocol would allow extraction of a MR AIF from MR contrast agent concentration-time curves, at higher spatial and temporal resolution than an image-derived PET AIF. A conversion factor could then be applied to the MR AIF for use in PET kinetic analysis. This work has compared AIFs obtained from sequential DSC-MRI and PET with separate injections of gadolinium contrast agent and 18F-FDG respectively to ascertain the technique's validity. An automated voxel selection algorithm was employed to improve MR AIF reproducibility. We found that MR and PET AIFs displayed similar character in the first pass, confirmed by gamma variate fits (p<0.02). MR AIFs displayed reduced PVE compared to PET AIFs, indicating their potential use in PET/MR studies.This work was funded by an MRC studentship and travel to PSMR 2013 was funded by the EU COST action for PET/MR.This is the author accepted manuscript. The final version is available from Elsevier via http://dx.doi.org/10.1016/j.nima.2013.08.07
Molecular Gas in Infrared Ultraluminous QSO Hosts
We report CO detections in 17 out of 19 infrared ultraluminous QSO (IR QSO)
hosts observed with the IRAM 30m telescope. The cold molecular gas reservoir in
these objects is in a range of 0.2--2.1 (adopting a
CO-to- conversion factor ). We find that the molecular gas properties of IR QSOs,
such as the molecular gas mass, star formation efficiency () and the CO (1-0) line widths, are indistinguishable
from those of local ultraluminous infrared galaxies (ULIRGs). A comparison of
low- and high-redshift CO detected QSOs reveals a tight correlation between
L and for all QSOs. This suggests that,
similar to ULIRGs, the far-infrared emissions of all QSOs are mainly from dust
heated by star formation rather than by active galactic nuclei (AGNs),
confirming similar findings from mid-infrared spectroscopic observations by
{\it Spitzer}. A correlation between the AGN-associated bolometric luminosities
and the CO line luminosities suggests that star formation and AGNs draw from
the same reservoir of gas and there is a link between star formation on
kpc scale and the central black hole accretion process on much smaller scales.Comment: 30 pages, 9 figures, accepted for publication in The Astrophysical
Journa
Biochemical alterations in the follicular fluid of bovine peri-ovulatory follicles and their association with final oocyte maturation
Follicular fluid (FF), a product of vascular transudate and granulosa and thecal cell secretions, is the milieu that has evolved to support oocyte growth and maturation which plays a central role in oocyte quality determination. Therefore, a suboptimal FF composition may be reflected in compromised oocyte progression through maturation, fertilization, or embryo development. To date, the composition of bovine FF remains understudied. To address this, we comprehensively characterized the metabolomic constituency of bovine FF in the period during which the oocyte undergoes meiotic maturation. More specifically, FF from pre (−24 h) and peri (−2 h)-ovulatory follicles was profiled by high-throughput untargeted ultra-HPLC tandem mass spectroscopy. A total of 634 metabolites were identified, comprising lipids (37.1%), amino acids (30.0%), xenobiotics (11.5%), nucleotides (6.8%), carbohydrates (4.4%), cofactors and vitamins (4.4%), peptides (3.6%), and energy substrates (2.1%). The concentrations of 67 metabolites were significantly affected by the stage of follicle development, 33.3% (n = 21) were reduced (P ≤ 0.05) by a mean of 9.0-fold, whereas 46 were elevated (P ≤ 0.05) by a mean of 1.7-fold in peri- vs pre-ovulatory FF. The most pronounced individual metabolite concentration decreases were observed in hypoxanthine (98.9- fold), xanthine (65.7-fold), 17β-oestradiol (12.4-fold), and inosine (4.6-fold). In contrast, the greatest increases were in retinal (4.9-fold), 1-methyl-5-imidazoleacetate (2.7-fold), and isovalerylcarnitine (2.7-fold). This global metabolomic analysis of bovine FF temporal dynamics provides new information for understanding the environment supporting oocyte maturation and facilitating ovulation that has the potential for improving oocyte quality both in vivo and in vitro
Identifying Overlapping and Hierarchical Thematic Structures in Networks of Scholarly Papers: A Comparison of Three Approaches
We implemented three recently proposed approaches to the identification of
overlapping and hierarchical substructures in graphs and applied the
corresponding algorithms to a network of 492 information-science papers coupled
via their cited sources. The thematic substructures obtained and overlaps
produced by the three hierarchical cluster algorithms were compared to a
content-based categorisation, which we based on the interpretation of titles
and keywords. We defined sets of papers dealing with three topics located on
different levels of aggregation: h-index, webometrics, and bibliometrics. We
identified these topics with branches in the dendrograms produced by the three
cluster algorithms and compared the overlapping topics they detected with one
another and with the three pre-defined paper sets. We discuss the advantages
and drawbacks of applying the three approaches to paper networks in research
fields.Comment: 18 pages, 9 figure
Current Fluctuations of the One Dimensional Symmetric Simple Exclusion Process with Step Initial Condition
For the symmetric simple exclusion process on an infinite line, we calculate
exactly the fluctuations of the integrated current during time
through the origin when, in the initial condition, the sites are occupied with
density on the negative axis and with density on the positive
axis. All the cumulants of grow like . In the range where , the decay of the distribution of is
non-Gaussian. Our results are obtained using the Bethe ansatz and several
identities recently derived by Tracy and Widom for exclusion processes on the
infinite line.Comment: 2 figure
The reductive activation of CO2 across a Ti═Ti double bond: synthetic, structural, and mechanistic studies
[Image: see text] The reactivity of the bis(pentalene)dititanium double-sandwich compound Ti(2)Pn(†)(2) (1) (Pn(†) = 1,4-{Si(i)Pr(3)}(2)C(8)H(4)) with CO(2) is investigated in detail using spectroscopic, X-ray crystallographic, and computational studies. When the CO(2) reaction is performed at −78 °C, the 1:1 adduct 4 is formed, and low-temperature spectroscopic measurements are consistent with a CO(2) molecule bound symmetrically to the two Ti centers in a μ:η(2),η(2) binding mode, a structure also indicated by theory. Upon warming to room temperature the coordinated CO(2) is quantitatively reduced over a period of minutes to give the bis(oxo)-bridged dimer 2 and the dicarbonyl complex 3. In situ NMR studies indicated that this decomposition proceeds in a stepwise process via monooxo (5) and monocarbonyl (7) double-sandwich complexes, which have been independently synthesized and structurally characterized. 5 is thermally unstable with respect to a μ-O dimer in which the Ti–Ti bond has been cleaved and one pentalene ligand binds in an η(8) fashion to each of the formally Ti(III) centers. The molecular structure of 7 shows a “side-on” bound carbonyl ligand. Bonding of the double-sandwich species Ti(2)Pn(2) (Pn = C(8)H(6)) to other fragments has been investigated by density functional theory calculations and fragment analysis, providing insight into the CO(2) reaction pathway consistent with the experimentally observed intermediates. A key step in the proposed mechanism is disproportionation of a mono(oxo) di-Ti(III) species to yield di-Ti(II) and di-Ti(IV) products. 1 forms a structurally characterized, thermally stable CS(2) adduct 8 that shows symmetrical binding to the Ti(2) unit and supports the formulation of 4. The reaction of 1 with COS forms a thermally unstable complex 9 that undergoes scission to give mono(μ-S) mono(CO) species 10. Ph(3)PS is an effective sulfur transfer agent for 1, enabling the synthesis of mono(μ-S) complex 11 with a double-sandwich structure and bis(μ-S) dimer 12 in which the Ti–Ti bond has been cleaved
Delayed differentiation of vaginal and uterine microbiomes in dairy cows developing postpartum endometritis
Bacterial overgrowth in the uterus is a normal event after parturition. In contrast to the healthy cow, animals unable to control the infection within 21 days after calving develop postpartum endometritis. Studies on the Microbial Ecology of the bovine reproductive tract have focused on either vaginal or uterine microbiomes. This is the first study that compares both microbiomes in the same animals. Terminal Restriction Fragment Length Polymorphism of the 16S rRNA gene showed that despite large differences associated to individuals, a shared community exist in vagina and uterus during the postpartum period. The largest changes associated with development of endometritis were observed at 7 days postpartum, a time when vaginal and uterine microbiomes were most similar. 16S rRNA pyrosequencing of the vaginal microbiome at 7 days postpartum showed at least three different microbiome types that were associated with later development of postpartum endometritis. All three microbiome types featured reduced bacterial diversity. Taken together, the above findings support a scenario where disruption of the compartmentalization of the reproductive tract during parturition results in the dispersal and mixing of the vaginal and uterine microbiomes, which subsequently are subject to differentiation. This differentiation was observed early postpartum in the healthy cow. In contrast, loss of bacterial diversity and dominance of the microbiome by few bacterial taxa were related to a delayed succession at 7DPP in cows that at 21 DPP or later were diagnosed with endometritis.Department of Agriculture, Food and the MarineScience Foundation Irelan
Spectropolarimetry of R Coronae Borealis in 1998--2003: Discovery of Transient Polarization at Maximum Brightness
We present an extended optical spectropolarimetry of R CrB from 1998 January
to 2003 September. The polarization was almost constant in the phase of maximum
brightness, being consistent with past observations. We detected, however,
temporal changes of polarization ( %) in 2001 March and August, which
were the first detection of large polarization variability in R CrB near
maximum brightness. The amplitude and the position angle of the `transient
polarization' were almost constant with wavelength in both two events. There
was a difference by about 20 degrees in the position angle between the two
events. Each event could be explained by light scattering due to short-lived
dust puff occasionally ejected off the line of sight. The flatness of the
polarization against the wavelength suggests that the scatterer is a mixture of
dust grains having various sizes. The rapid growth and fading of the transient
polarization favors the phenomenological model of dust formation near the
stellar photosphere (e.g., within two stellar radii) proposed for the time
evolution of brightness and chromospheric emission lines during deeply
declining periods, although the fading timescale can hardly be explained by a
simple dispersal of expanding dust puff with a velocity of km s
. Higher expansion velocity or some mechanism to destroy the dust grains
should be needed.Comment: 22 pages, 10 figures, accepted for publication in A
Gravitating discs around black holes
Fluid discs and tori around black holes are discussed within different
approaches and with the emphasis on the role of disc gravity. First reviewed
are the prospects of investigating the gravitational field of a black
hole--disc system by analytical solutions of stationary, axially symmetric
Einstein's equations. Then, more detailed considerations are focused to middle
and outer parts of extended disc-like configurations where relativistic effects
are small and the Newtonian description is adequate.
Within general relativity, only a static case has been analysed in detail.
Results are often very inspiring, however, simplifying assumptions must be
imposed: ad hoc profiles of the disc density are commonly assumed and the
effects of frame-dragging and completely lacking. Astrophysical discs (e.g.
accretion discs in active galactic nuclei) typically extend far beyond the
relativistic domain and are fairly diluted. However, self-gravity is still
essential for their structure and evolution, as well as for their radiation
emission and the impact on the environment around. For example, a nuclear star
cluster in a galactic centre may bear various imprints of mutual star--disc
interactions, which can be recognised in observational properties, such as the
relation between the central mass and stellar velocity dispersion.Comment: Accepted for publication in CQG; high-resolution figures will be
available from http://www.iop.org/EJ/journal/CQ
Solitary waves in the Nonlinear Dirac Equation
In the present work, we consider the existence, stability, and dynamics of
solitary waves in the nonlinear Dirac equation. We start by introducing the
Soler model of self-interacting spinors, and discuss its localized waveforms in
one, two, and three spatial dimensions and the equations they satisfy. We
present the associated explicit solutions in one dimension and numerically
obtain their analogues in higher dimensions. The stability is subsequently
discussed from a theoretical perspective and then complemented with numerical
computations. Finally, the dynamics of the solutions is explored and compared
to its non-relativistic analogue, which is the nonlinear Schr{\"o}dinger
equation. A few special topics are also explored, including the discrete
variant of the nonlinear Dirac equation and its solitary wave properties, as
well as the PT-symmetric variant of the model
- …