Efüzyonlu otitis mediada polisakkarid streptococcus pneumoniae ve haemophilus influenzae aşilari ile ventilasyon tüpü etkinli?inin karşilaştirilmasi

Objective: Otitis media with effusion (OME) is a common childhood infection. Streptococcus pneumoniae and Haemophilus influenzae are very common bacterial pathogens in the etiology of OME. The purpose of the study is providing immunization against these pathogens and to see how it affects the course and recurrence of OME according to insert ventilation tube. Material and Methods: Ventilation tube was performed to 45 patients with OME between the ages of 2 to 13.H. influenzae type b conjugate vaccine and Pneumococcal polysaccharide vaccine containing 23 serotypes were applied together with an interval of 1 week to 35 patients between the ages of 2 to 13 who did not accept the application of ventilation tube. Patients with systemic diseases, immunodeficiency, allergy history, craniofacial malformations (for example, cleft palate, retrognathia, choanal atresia), previously application of the tube or history of ear surgery were excluded from the study. All patients were evaluated with pneumotoscopy and tympanometry at first week and at 1, 3, 6, 9, 12th months after the therapy and the findings were recorded. Results: The best results of vaccination group (VG) were obtained at the end of 12th month. Complete remission was observed in 24 (68.6%) patients and partial remission was observed in one patient at the end of 12th month. Also complete remission in 28 (62.2%) patients and partial remission in 3 (6.7%) patients was observed at the tube group (TG). Statistical analysis showed no significant difference between AT and TG in terms of healing rates (p?0.05). Conclusion: Vaccination of the patients with OME against S. pneumoniae and H. influenzae reduces the progression and recurrence of OME, but it's not more effective than ventilation tube. © 2014 by Türki ye Klinikleri

The effect of 2100 MHz radiofrequency radiation of a 3G mobile phone on the parotid gland of rats

11th International Congress of Otorhinolaryngology and Head and Neck Surgery -- APR 17-19, 2014 -- Ankara, TURKEYDevrim, Erdinc/0000-0001-7326-5104; Tomruk, Arin/0000-0002-7600-0811; Devrim, Erdinc/0000-0001-7326-5104; Devrim, Erdinc/0000-0001-7326-5104; UNSAL, VELID/0000-0003-1415-0563; Ozgur-Buyukatalay, Elcin/0000-0001-6428-918XWOS: 000346756300007PubMed: 25456509Purpose: We aimed to evaluate the effect of 2100 MHz radiofrequency radiation on the parotid gland of rats in short and relatively long terms. Material and methods: Thirty Wistar albino rats were divided into four groups. Groups A and B served as the control groups (for 10 days and 40 days, respectively), and each group included six rats. Groups C and D were composed of nine rats each, and they were the exposure groups. The rats were exposed to 2100 MHz radiofrequency radiation emitted by a generator, simulating a third generation mobile phone for 6 hours/day, 5 days/week, for 10 or 40 days. Following exposure, the rats were sacrificed and parotid glands were removed. Histopathological and biochemical examinations were performed. Results: Although there were no histopathological changes in the control groups except for two animals in group A and three animals in group B, the exposure groups C (10 days) and D (40 days) showed numerous histopathological changes regarding salivary gland damage including acinar epithelial cells, interstitial space, ductal system, vascular system, nucleus, amount of cytoplasm and variations in cell size. The histopathological changes were more prominent in group D compared to group C. There was statistically significant different parameter regarding variation in cell size between the groups B and D (p = 0.036). Conclusion: The parotid gland of rats showed numerous histopathological changes after exposure to 2100 MHz radiofrequency radiation, both in the short and relatively long terms. Increased exposure duration led to an increase in the histopathological changes. (C) 2015 Elsevier Inc. All rights reserved

Clinical importance of preoperative fine needle aspiration biopsy and computed tomography in parotid gland masses

Objectives. To determine the diagnostic value of fine needle aspiration biopsy (FNAB) and computedtomography (CT) in parotid masses in the basis of postoperative histopathological results. Methods. The recordsof 68 patients diagnosed with a parotid mass and undergone parotis surgery between November 2004 andFebruary 2011 were evaluated retrospectively. Preoperative FNAB and the CT findings were compared withpostoperative histopathological findings. Results. The study included 36 (58%) female and 26 (42%) malepatients. The mean age of the patients was 43.9 years. No statistically significant difference was detected withregards to the performances of both FNAB and the CT (p0.797). When it was evaluated in a detail, theperformance of parotid CT(81.82%) to diagnose a mass in parotid gland was relatively better than FNAB(72.73%). The performance of FNAB (94.12%) to detect healthy ones was also greater than parotid CT (90.2%).Conclusion. We emphasize that preoperative FNAB and parotid CT should be performed to the patients witha parotid mass. The use of these two tests together can minimize the risk rate have been proved

Nazal Septum Perforasyon Tamirinde Fasya Ve Yağ Dokusu Kullanımı: Deneysel Tavşan Modeli

Purpose: The objective of this study is to present a new method in septum perforation repair. Methods: In this study, 12 New Zealand White mature rabbits were used. The rabbits are divided into two groups equally. In all rabbits, a standard perforation was operated on nasal septum by using a 4mm-diamater punch(12.983 mm2). In the experiment group, the perforations were closed by fascia and fat tissue. Any procedure was not implemented in the control group. Rabbits were sacrified 4 weeks later. Cartilaginous septums were removed for digital evaluation. Samples were photographed and perforation areas were calculated by using photograph analyze program. Mean decrease in perforation size between the groups were compared. Results: At the end of the study period the mean perforation area in study group was 1.35±0.51 mm2 and in control group was 4.81±0.49 mm2 (P<0,0009). The mean rate of decrease in perforation size was 89.58 % and 62.95 % in experiment and control group, respectively (P<0.0009). Furthermore, a total closing was determined in a sample in experiment group. Conclusion: The method explained here is applicable and effective choice in septal perforation repair.Amaç: Bu çalışmanın amacı septum perforasyon tamirinde yeni bir metod ortaya koymaktır.. Gereç ve Yöntemler: Bu çalışmada 12 beyaz, erişkin Yeni Zelanda tavşanı kullanıldı.Tavşanlar eşit olarak iki gruba ayrıldı.Tüm tavşanlarda 4mm çaplı punch aleti(12.983 mm2) kullanılarak standart perforasyon oluşturuldu. Deney grubunda perforasyon fasya ve yağ dokusuyla kapatıldı. Kontrol grubuna herhangibir prosedür uygulanmadı. Dört hafta sonra tavşanlar sakrifiye edildi. Dijital değerlendirme için kartilaj septum çıkarıldı.Örnekler fotoğraflandı ve perforasyon alanları fotğraf analiz programı kullanılarak hesaplandı. Perforasyon alanındaki ortalama küçülme yönünden gruplar karşılaştırıldı. Bulgular: Çalışma periyodunun sonunda ortalama perforasyon alanı çalışma grubunda 1.35±0.51 mm2 iken kontrol grubunda 4.81±0.49 mm2 idi(P<0,0009). Perforasyon alanındaki ortalama küçülme oranı sırasıyla çalışma ve control grubunda 89.58 % and 62.95 % olarak bulundu(P<0.0009). Ayrıca çalışma grubunda bir örnekte total kapanma saptandı. Sonuç: Burada tanımlanan metod septum perforasyon onarımında uygulanabilir ve efektif bir seçenektir

The effect of tacrolimus on facial nerve injury: Histopathological findings in a rabbit model

36th Turkish National Meeting of the Otorhinolaryngology - Head and Neck Surgery -- NOV 05-09, 2014 -- Antalya, TURKEYBayram, Cem/0000-0001-8717-4668; Sargon, Mustafa Fevzi/0000-0001-6360-6008WOS: 000384277600001PubMed: 27465503Hypothesis: Tacrolimus helps healing of facial nerve injury. Background: Positive effects of tacrolimus on axon regeneration and healing of injured peripheral nerves (eg. sciatic nerve) have been reported in the literature. Tacrolimus may be an additional treatment method that could improve the nerve healing after surgical treatment of cut injury of facial nerve. Methods: 20 New Zealand rabbits were randomly separated into control and study groups of 10. In control group, no medical treatment was given after facial nerve anastomosis, and the animals were followed up for 2 months. In the study group rabbits were given 1 mg/kg/day tacrolimus subcutaneously for 2 months after the facial nerve anastomosis. The histopathologic findings of axon regeneration like axon myelination were analyzed in both groups under electron and light microscopy. The data obtained in the groups were compared. Results: Greater axon diameters, thicker myelin sheaths, and higher total number of myelinated axons were found in the tacrolimus group, suggesting better regeneration in this group when compared to the control group. There was less vacuolar degeneration in the study group. All these findings suggest that tacrolimus positively affects healing after facial nerve anastomosis. Conclusion: The results of this study indicate that tacrolimus has favorable effects on the healing process of the facial nerve after end-to-end anastomosis. Tacrolimus maybe a promising agent in the future for nerve regeneration following traumatic facial paralysis surgery. (C) 2016 Elsevier Inc. All rights reserved

Sneezing And Runny Nose: Should Allergy Testing Be Routinely Performed?

The need for routine determination of rhinitis subtypes by allergy testing and the relevance between symptoms and allergy were evaluated. A retrospective study at a tertiary hospital, ENT clinic. One hundred and twenty-seven adult patients with sneezing and runny nose for at least 6 months for the last two consecutive years were included. The age range was 16-60. Allergy testing was only positive in 43.4% of the patients. Excluding mixed rhinitis, persistent sneezing and runny nose were mostly related to anatomical deformities, mainly septal deviation followed by vasomotor rhinitis. Persistent sneezing and runny nose may be caused by different etiologies other than allergy. Determination of rhinitis subtypes is important for accurate treatment of patients with these symptoms. Taking appropriate medical history and performing a good physical exam with objective allergy testing are highly recommended.Wo