Aqu\ued hay gato encerrado

Attivit\ue0 didattica di fraseologia spagnola in soporto digitale (casa editrice SM, Madrid) http://www.sm-ele.com/ArchivosColegios/NuevoELEAdmin/Archivos/MasClaroQueElAgua/PROYECTO%20GATO.pd

"Historia de las palabras"

En el art\uedculo se describe una propuesta did\ue1ctica para el aprendizaje de l\ue9xico en ELE basada en una perspectiva etnoling\ufc\uedstica y antropol\uf3gic

Jorge Guill\ue9n, Vanni Scheiwiller. Un epistolario Prefazione di Cesare Segre

Epistolario completo tra il poeta spagnolo Jorge Guill\ue9n e il suo editore milanese Vanni Scheiwiller; trascrizione di tutte le lettere tra i due custodite nell'Archivio Apice (Universit\ue0 degli Studi di Milano) e nella Biblioteca Nacional (Madrid), con prefazione di Cesare Segre ("Brandelli di Passato")

Magnon straintronics in the 2D van der Waals ferromagnet CrSBr from first-principles

The recent isolation of two-dimensional (2D) magnets offers tantalizing opportunities for spintronics and magnonics at the limit of miniaturization. One of the key advantages of atomically-thin materials is their outstanding deformation capacity, which provides an exciting avenue to control their properties by strain engineering. Herein, we investigate the magnetic properties, magnon dispersion and spin dynamics of the air-stable 2D magnetic semiconductor CrSBr ($T_C$ = 146 K) under mechanical strain using first-principles calculations. Our results provide a deep microscopic analysis of the competing interactions that stabilize the long-range ferromagnetic order in the monolayer. We showcase that the magnon dynamics of CrSBr can be modified selectively along the two main crystallographic directions as a function of applied strain, probing the potential of this quasi-1D electronic system for magnon straintronics applications. Moreover, we predict a strain-driven enhancement of $T_C$ considering environmental screening by ~30%, allowing the propagation of spin waves at higher temperatures

Deficiency of Parkinson's disease-related gene Fbxo7 is associated with impaired mitochondrial metabolism by PARP activation

The Parkinson's disease (PD)-related protein F-box only protein 7 (Fbxo7) is the substrate-recognition component of the Skp1-Cullin-F-box protein E3 ubiquitin ligase complex. We have recently shown that PD-associated mutations in Fbxo7 disrupt mitochondrial autophagy (mitophagy), suggesting a role for Fbxo7 in modulating mitochondrial homeostasis. Here we report that Fbxo7 deficiency is associated with reduced cellular NAD(+) levels, which results in increased mitochondrial NADH redox index and impaired activity of complex I in the electron transport chain. Under these conditions of compromised respiration, mitochondrial membrane potential and ATP contents are reduced, and cytosolic reactive oxygen species (ROS) production is increased. ROS activates poly (ADP-ribose) polymerase (PARP) activity in Fbxo7-deficient cells. PARP inhibitor restores cellular NAD(+) content and redox index and ATP pool, suggesting that PARP overactivation is cause of decreased complex I-driven respiration. These findings bring new insight into the mechanism of Fbxo7 deficiency, emphasising the importance of mitochondrial dysfunction in PD

Caracterización geoquímica de la esméctica en varias formaciones arcillosas de los flyschs del Campo de Gibraltar (Cádiz, España)

The «Jimena clays», «basal series of Aljibe» and «blocky clays» formations are compared from the mineralogical and geochemical analysis. The mineralogy of clays is very similar in all the sequences analyzed and consists of quartz, smectite, illite and kaolinite. Smaller amounts of feldspar, gypsum and chlorite are locally presento In the 2-20 μm and < 2 μm size-fractions smectite is the most abundant mineral. The mineralogical similarity is also manifested on the chemical composition of these materials. Smectite compositions correspond to montmorillonite suggesting, along the trace element content that these smectites are weathearing products of acidic magmatic and sedimentary rocks. The homogeneity of the analyzed sequences indicates an homology in these formations and a great uniformity in the supplies during the Cretaceous-Eocene times.Se comparan desde un punto de vista mineralógico y geoquímico las formaciones definidas como «arcillas de Jimena», «sucesión basal del Aljibe» y «arcillas con bloques». Su mineralogía resulta muy similar: cuarzo, esmectita, ilita y caolinita, junto con pequeñas proporciones de feldespato, yeso y clorita. En las fracciones 2-20 µm y < 2 μm la esmectita es el mineral más abundante. La semejanza mineralógica se pone también de manifiesto en la composición química de estos materiales. La composición de las esmectitas corresponde a montmorillonita y sugiere un origen detrítico para las mismas. El contenido en diversos elementos traza indica que estos materiales son el producto de la meteorización de rocas magmáticas ácidas junto con rocas sedimentarias antiguas. La homogeneidad de las secuencias analizadas indica, asimismo, una homología de todas las formaciones y una gran uniformidad en los aportes durante el intervalo Cretácico-Eoceno, época a la que se atribuye su depósito

Familial Alzheimer's Disease Lymphocytes Respond Differently Than Sporadic Cells to Oxidative Stress: Upregulated p53-p21 Signaling Linked with Presenilin 1 Mutants

Familial (FAD) and sporadic (SAD) Alzheimer's disease do not share all pathomechanisms, but knowledge on their molecular differences is limited. We previously reported that cell cycle control distinguishes lymphocytes from SAD and FAD patients. Significant differences were found in p21 levels of SAD compared to FAD lymphocytes. Since p21 can also regulate apoptosis, the aim of this study was to compare the response of FAD and SAD lymphocytes to oxidative stress like 2-deoxy-D-ribose (2dRib) treatment and to investigate the role of p21 levels in this response. We report that FAD cells bearing seven different PS1 mutations are more resistant to 2dRib-induced cell death than control or SAD cells: FAD cells showed a lower apoptosis rate and a lower depolarization of the mitochondrial membrane. Despite that basal p21 cellular content was lower in FAD than in SAD cells, in response to 2dRib, p21 mRNA and protein levels significantly increased in FAD cells. Moreover, we found a higher cytosolic accumulation of p21 in FAD cells. The transcriptional activation of p21 was shown to be dependent on p53, as it can be blocked by PFT-α, and correlated with the increased phosphorylation of p53 at Serine 15. Our results suggest that in FAD lymphocytes, the p53-mediated increase in p21 transcription, together with a shift in the nucleocytoplasmic localization of p21, confers a survival advantage against 2dRib-induced apoptosis. This compensatory mechanism is absent in SAD cells. Thus, therapeutic and diagnostic designs should take into account possible differential apoptotic responses in SAD versus FAD cells