First-time versus repeat visitors’ behavior patterns: a GPS analysis

Past research conducted on visitors' behavior has highlighted the differences between first-time and repeat visitors in urban and natural settings. To determine whether these differences also exist in a monumental city, we have studied visitor behavior in the historic city of Girona (Spain). Data from 1288 GPS tracking were recorded. Of these, 928 were first-time visitors, and the remaining 360 corresponded to repeat visitors. Findings show that there is very little difference in how first-time and repeat visitors act, compared to visitor behavior in other types of tourist destinations. Nevertheless, the results do demonstrate differences between low frequency visitors (between 1 and 4 visits) and high frequency visitors (more than 4 visits). These results suggest that sightseeing creates very homogeneous behavior pattern between first-time and repeat visitors, and highlight the need to differentiate repeat visitors according to the number of visits done in the monumental city

The Emotional Competence Assessment Questionnaire (ECAQ) for Children Aged from 3 to 5 Years : Validity and Reliability Evidence

In order to assess emotional competence in children, it is necessary to have psychometrically sound measures. To the best of our knowledge, there is no available tool to assess emotional competence in children from 3 to 5 years old that assesses the five emotional competences of the Bisquerra model and can be easily and quickly answered in the school environment. The objective of this study is to develop a measure, the Emotional Competence Assessment Questionnaire (ECAQ), and to provide evidence of its psychometric quality. Qualitative evidence was obtained from a systematic review, from two expert committees and from five discussion groups. On the other hand, quantitative validity and reliability evidence was obtained from a sample of 1088 students and other smaller subsamples. The results suggest that the ECAQ is a short and easy-to-use tool, easily understood by administrators. The quantitative results confirm a general factor of emotional competence adjusted for three specific factors. This factor has excellent internal consistency and test-retest reliability. The ECAQ has therefore been shown to be a promising tool for assessing emotional competence in children between 3 and 5 years of age

Impact of Diabetes on Work Cessation: Data from the GAZEL cohort study

International audienceOBJECTIVE: To measure the impact of diabetes on work cessation, i.e., on the risks of work disability, early retirement, and death while in the labor force. RESEARCH DESIGN AND METHODS: We used data from the GAZEL prospective cohort of 20,625 employees of the French national gas and electricity company "EDF-GDF." We identified 506 employees with diabetes and randomly selected 2,530 nondiabetic employed control subjects matched for major sociodemographic and occupational characteristics. Using a multistate Cox model, we estimated hazard ratios (HRs) comparing the risks of transition from employment to disability, retirement, and death over time between participants with versus without diabetes. RESULTS: Employment rate decreased more rapidly in participants with diabetes (51.9 and 10.1% at 55 and 60 years, respectively) compared with nondiabetic participants (66.5 and 13.4%, respectively). Participants with diabetes had significantly increased risks of transition from employment to disability (HR 1.7 [95% CI 1.0-2.9]), retirement (HR 1.6 [1.5-1.8]), and death (HR 7.3 [3.6-14.6]) compared with participants without diabetes. Between 35 and 60 years, each participant with diabetes lost an estimated mean time of 1.1 year in the workforce (95% CI 0.99-1.14) compared with a nondiabetic participant. CONCLUSIONS: Our results provide evidence for a profound negative impact of diabetes on workforce participation in France. Social and economic consequences are major for patients, employers, and society-a burden that is likely to increase as diabetes becomes more and more common in the working-aged population

A new reversal mode in exchange coupled antiferromagnetic/ferromagnetic disks: distorted viscous vortex

Magnetic vortices have generated intense interest in recent years due to their unique reversal mecha-nisms, fascinating topological properties, and exciting potential applications. In addition, the exchangecoupling of magnetic vortices to antiferromagnets has also been shown to lead to a range of novelphenomena and functionalities. Here we report a new magnetization reversal mode of magnetic vorticesin exchange coupled Ir20Mn80/Fe20Ni80microdots: distorted viscous vortex reversal. In contrast to thepreviously known or proposed reversal modes, the vortex is distorted close to the interface and viscouslydragged due to the uncompensated spins of a thin antiferromagnet, which leads to unexpected asymme-tries in the annihilation and nucleationfields. These results provide a deeper understanding of the physicsof exchange coupled vortices and may also have important implications for applications involvingexchange coupled nanostructure

Localized self-heating in large arrays of 1D nanostructures

One dimensional (1D) nanostructures offer a promising path towards highly efficient heating and temperature control in integrated microsystems. The so called self-heating effect can be used to modulate the response of solid state gas sensor devices. In this work, efficient self-heating was found to occur at random networks of nanostructured systems with similar power requirements to highly ordered systems (e.g. individual nanowires, where their thermal efficiency was attributed to the small dimensions of the objects). Infrared thermography and Raman spectroscopy were used to map the temperature profiles of films based on random arrangements of carbon nanofibers during self-heating. Both the techniques demonstrate consistently that heating concentrates in small regions, the here-called 'hot-spots'. On correlating dynamic temperature mapping with electrical measurements, we also observed that these minute hot-spots rule the resistance values observed macroscopically. A physical model of a random network of 1D resistors helped us to explain this observation. The model shows that, for a given random arrangement of 1D nanowires, current spreading through the network ends up defining a set of spots that dominate both the electrical resistance and power dissipation. Such highly localized heating explains the high power savings observed in larger nanostructured systems. This understanding opens a path to design highly efficient self-heating systems, based on random or pseudo-random distributions of 1D nanostructures

Alcohol consumption, masculinity, and alcohol-related violence and anti-social behaviour in sportspeople

Alcohol Research UK; Australian Research Council in collaboration with VicHealth; Alcohol and Drug Foundation; Australian National Preventative Health Agenc

Phospholipase C-ε Regulates Epidermal Morphogenesis in Caenorhabditis elegans

Migration of cells within epithelial sheets is an important feature of embryogenesis and other biological processes. Previous work has demonstrated a role for inositol 1,4,5-trisphosphate (IP3)-mediated calcium signalling in the rearrangement of epidermal cells (also known as hypodermal cells) during embryonic morphogenesis in Caenorhabditis elegans. However the mechanism by which IP3 production is stimulated is unknown. IP3 is produced by the action of phospholipase C (PLC). We therefore surveyed the PLC family of C. elegans using RNAi and mutant strains, and found that depletion of PLC-1/PLC-ε produced substantial embryonic lethality. We used the epithelial cell marker ajm-1::gfp to follow the behaviour of epidermal cells and found that 96% of the arrested embryos have morphogenetic defects. These defects include defective ventral enclosure and aberrant dorsal intercalation. Using time-lapse confocal microscopy we show that the migration of the ventral epidermal cells, especially of the leading cells, is slower and often fails in plc-1(tm753) embryos. As a consequence plc-1 loss of function results in ruptured embryos with a Gex phenotype (gut on exterior) and lumpy larvae. Thus PLC-1 is involved in the regulation of morphogenesis. Genetic studies using gain- and loss-of-function alleles of itr-1, the gene encoding the IP3 receptor in C. elegans, demonstrate that PLC-1 acts through ITR-1. Using RNAi and double mutants to deplete the other PLCs in a plc-1 background, we show that PLC-3/PLC-γ and EGL-8/PLC-β can compensate for reduced PLC-1 activity. Our work places PLC-ε into a pathway controlling epidermal cell migration, thus establishing a novel role for PLC-ε

Type 2 diabetes, socioeconomic status and life expectancy in Scotland (2012-2014):a population-based observational study

Aims/hypothesis: The aim of this study was to assess the role of socioeconomic status (SES) in the associations between type 2 diabetes and life expectancy in a complete national population. Methods: An observational population-based cohort study was performed using the Scottish Care Information – Diabetes database. Age-specific life expectancy (stratified by SES) was calculated for all individuals with type 2 diabetes in the age range 40–89 during the period 2012–2014, and for the remaining population of Scotland aged 40–89 without type 2 diabetes. Differences in life expectancy between the two groups were calculated. Results: Results were based on 272,597 individuals with type 2 diabetes and 2.75 million people without type 2 diabetes (total for 2013, the middle calendar year of the study period). With the exception of deprived men aged 80–89, life expectancy in people with type 2 diabetes was significantly reduced (relative to the type 2 diabetes-free population) at all ages and levels of SES. Differences in life expectancy ranged from −5.5 years (95% CI −6.2, −4.8) for women aged 40–44 in the second most-deprived quintile of SES, to 0.1 years (95% CI −0.2, 0.4) for men aged 85–89 in the most-deprived quintile of SES. Observed life-expectancy deficits in those with type 2 diabetes were generally greater in women than in men. Conclusions/interpretation: Type 2 diabetes is associated with reduced life expectancy at almost all ages and levels of SES. Elimination of life-expectancy deficits in individuals with type 2 diabetes will require prevention and management strategies targeted at all social strata (not just deprived groups)