Making the People. An Interview with Paulina Ochoa Espejo, Haverford College

Paulina Ochoa Espejo is an Associate Professor of political science at Haverford College. She is the author of On Borders: Territories, Legitimacy and the Rights of Place (OUP, 2020), The Time of Popular Sovereignty: Process and the Democratic State (PSUP, 2011) and co–editor of the Oxford Handbook of Populism (2017)

Reconfiguración socioespacial y autoorganización en las Villas 1, 11, 14 y Barrio 31 ex Villa 31 en la Ciudad Autónoma de Buenos Aires

El proceso de evolución del espacio urbano en la Ciudad Autónoma de Buenos Aires fue escenario de reconfiguraciones que intentaron dar respuesta a las permanentes reestructuraciones que, en ocasiones surgen como respuesta a la aplicación de políticas neoliberales que afectan al tejido social y por consiguiente las relaciones espaciales tal como plantea Sousa Santos. Esto lleva a sectores populares a buscar una manera de habitar el espacio de la ciudad para poder situarse cerca de los centros laborales y abaratar los costos de transporte. El caso de la Ciudad Autónoma de Buenos Aires, en general, y de las urbanizaciones en Villa 1, 11, 14 y el Barrio 31, nos permiten considerar la importancia que adquieren los procesos de urbanización en los barrios populares y cómo a través de ellos se modifica la ciudad y las vidas de las personas. Ahora bien, estos procesos nos van a permitir pensar las ciudades como sistemas, que nacen crecen y se extienden. Es a partir de estos conceptos iniciales de la teoría del caos que nos permitimos abordar el desorden en la ciudad de buenos Aires, entendiendo por desorden los asentamientos irregulares y algunas fenómenos y comportamientos que son diversos.Instituto de Investigaciones en Humanidades y Ciencias Sociale

Contourite characterization and its discrimination from other deep‐water deposits in the Gulf of Cadiz contourite depositional system

This project was funded through the Joint Industry Project supported by BP, ENI, ExxonMobil, TOTAL, Wintershall Dea and TGS, within the framework of "The Drifters" Research Group at Royal Holloway University of London (RHUL), in conjunction with the projects CTM 2012-39599-C03, CGL2015-66835-P, CTM2016-75129C3-1-R, CGL2016-80445-R (AEI/FEDER, UE) and B-RNM-072-UGR18. This research used data and samples collected by IODP Expedition 339 aboard the Joides Resolution. Data was acquired at the XRF Core Scanner Lab at MARUM -Center for Marine Environmental Sciences, University of Bremen, Germany. Our thanks to Dr Javier Dorador (RHUL, UK) for the high-resolution core imaging treatment, to Dr David Roque (ICMAN-CSIC, Spain) for his help in the hydrographic panels from Fig. 2, and to Dr Angel Puga-Bernabeu (University of Granada, Spain) for revision that helped to improve the original version of the manuscript before submission. This study significantly benefited from discussions with all who attended the IODP Exp. 339 MOW meeting in Heidelberg (Germany) in January 2019. We would like to thank Associate Editor Dr Adam McArthur and the three reviewers, Dr Rachel Brackenridge, Dr Giancarlo Davoli and Dr Adriano Viana, for their positive and constructive comments that helped us improve the manuscript.Despite numerous efforts to properly differentiate between contourites and other deep‐water deposits in cores and outcrops, reliable diagnostic criteria are still lacking. The co‐occurrence of downslope and along‐slope sedimentary processes makes it particularly difficult to differentiate these relatively homogeneous deposits. The main aim of this paper is to identify differences in deep‐water sediments based on Principal Component Analysis of grain size and geochemistry, sedimentary facies, and reinforced by microfacies and ichnofacies. The sediments studied were obtained from two International Ocean Drilling Program Expedition 339 sites in mounded and sheeted drifts in the Gulf of Cadiz. The statistical approach led to the discernment of hemipelagites, silty contourites, sandy contourites, bottom current reworked sands, fine‐grained turbidites and debrites over a range of depositional and physiographic elements. These elements are linked to contourite drifts, the drift‐channel transition, the contourite channel and distal upper slope. When bottom currents or gravity‐driven flows are not the dominant depositional process, marine productivity and continental input settling forms the main depositional mechanism in deep‐water environments. This is reflected by a high variability of the first principal component in hemipelagic deposits. The stacked principal component variability of these deposits evidences that the contourite drift and the adjacent contourite channel were influenced by the interrelation of hemipelagic, gravitational and bottom current induced depositional processes. This interrelation questions the paradigm that a drift is made up solely of muddy sediments. The interrelation of sedimentary processes is a consequence of the precession‐driven changes in the intensity of the Mediterranean Outflow Water related to Mediterranean climate variability, which are punctuated by millennial‐scale variability. Associated vertical and lateral shifts of the Mediterranean Outflow Water, and therefore of its interface with the East North Atlantic Central Water, controlled sediment input and favoured turbulent sediment transport in the middle slope. During the interglacial precession maxima/insolation minima, a more vigorous upper core of the Mediterranean Outflow Water and the enhanced impact of the East North Atlantic Central Water – Mediterranean Outflow Water interface allowed for the development of the sandier contourite deposits.BP within the "The Drifters" Research Group at Royal Holloway University of London (RHUL)ENI within the "The Drifters" Research Group at Royal Holloway University of London (RHUL)ExxonMobil within the "The Drifters" Research Group at Royal Holloway University of London (RHUL)TOTAL within the "The Drifters" Research Group at Royal Holloway University of London (RHUL)Wintershall Dea within the "The Drifters" Research Group at Royal Holloway University of London (RHUL)TGS within the "The Drifters" Research Group at Royal Holloway University of London (RHUL)AEI/FEDER, UE CTM 2012-39599-C03 CGL2015-66835-P CTM2016-75129C3-1-R CGL2016-80445-RB-RNM-072-UGR1

Estudio de viabilidad financiera para la adquisición de una bodega de almacenamiento de la empresa Química Integrada S.A. en el municipio de Mosquera.

Trabajo de Síntesis AplicadaLa compañía Química Integrada S.A, actualmente fabricantes de productos químicos para el tratamiento de aguas tanto potables como residuales, donde tiene un enfoque de diseño, producción y comercialización. ahora bien, para que el objetivo de crecimiento de la compañía a razón de sus activos, se realiza un estudio de viabilidad financiera para la adquisición de una bodega de almacenamiento.CAPÍTULO 1 INTRODUCCIÓN E INFORMACIÓN GENERAL CAPÍTULO 2 PRESENTACIÓN DE RESULTADOS CAPÍTULO 3 CONCLUSIONES Y RECOMENDACIONES ANEXOSEspecializaciónEspecialista en Análisis y Administración Financier

Narrowing the Genetic Causes of Language Dysfunction in the 1q21.1 Microduplication Syndrome

The chromosome 1q21.1 duplication syndrome (OMIM# 612475) is characterized by head anomalies, mild facial dysmorphisms, and cognitive problems, including autistic features, mental retardation, developmental delay, and learning disabilities. Speech and language development are sometimes impaired, but no detailed characterization of language problems in this condition has been provided to date. We report in detail on the cognitive and language phenotype of a child who presents with a duplication in 1q21.1 (arr[hg19] 1q21.1q21.2(145,764,455-147,824,207) × 3), and who exhibits cognitive delay and behavioral disturbances. Language is significantly perturbed, being the expressive domain the most impaired area (with significant dysphemic features in absence of pure motor speech deficits), although language comprehension and use (pragmatics) are also affected. Among the genes found duplicated in the child, CDH1L is upregulated in the blood of the proband. ROBO1, a candidate for dyslexia, is also highly upregulated, whereas, TLE3, a target of FOXP2, is significantly downregulated. These changes might explain language, and particularly speech dysfunction in the proband

Impact of a lecture abour empirical bases of hypnosis on beliefs and attitudes toward hypnosis among Cuban health professionals.

The aim of this study is to examine whether a lecture on hypnosis can modify attitudes and misconceptions about hypnosis. The sample consisted of 97 health professionals from institutions of Havana City. Group 1 consisted of 46 participants who received a lecture on hypnosis. Group 2 consisted of 51 participants who received a lecture about Urology. The Valencia Scale of Attitudes and Beliefs toward HypnosisTherapist was applied before and after the lecture. Results indicated that there were significant differences between the groups in which Group 1 showed more positive attitudes toward hypnosis. However, both groups showed similar misconceptions about hypnosis and memory, which changed significantly in Group 1 after receiving the lecture about hypnosis, but not in Group 2. Therefore, the lecture about hypnosis had a significant impact in correcting participants" misconceptions about memory and hypnosis

Análisis de la aplicación de la Metodología del Valor Ganado en un proyecto de la localidad de Pataz, año 2022

La investigación busco dar respuesta a la pregunta ¿Que aporte brinda el análisis de la aplicación de la Metodología del Valor Ganado en un proyecto de la localidad de Pataz, año 2022?, planteándose como objetivo el Determinar que mejora se extrae del análisis de la aplicación de la Metodología del Valor Ganado en un proyecto de la localidad de Pataz, año 2022; teniendo como escenario el proyecto denominado “CREACIÓN DEL CENTRO DE COMERCIALIZACIÓN EN LA CIUDAD DE PATAZ DEL DISTRITO DE PATAZ – PROVINCIA DE LA LIBERTAD, I ETAPA”; donde se aplicó un estudio de tipo Básico–Descriptivo, con diseño Descriptivo-Evaluativo–Transversal, usando la técnica del análisis documental mediante la ficha de recolección de datos y el registro digital; obteniendo como resultado que la EVM posee deficiencias al evaluar la dimensión tiempo en los proyectos, a raíz que este método no concibe que se den resultados fuera del plazo contractual; del mismo modo el aporte brindado se basa en la aplicación complementaria de la metodología Earned Schelude, la cual permite calcular la situación del proyecto, con respecto al tiempo, de manera más precisa, al no estar limitada por el plazo contractualThe research sought to answer the question: What contribution does the analysis of the application of the Earned Value Methodology provide in a project in the town of Pataz, year 2022? considering the objective of determining what improvement is extracted from the analysis of the application. of the Earned Value Methodology in a project in the town of Pataz, year 2022; having as scenario the project called "CREATION OF THE COMMERCIALIZATION CENTER IN THE CITY OF PATAZ OF THE DISTRICT OF PATAZ - PROVINCE OF LA LIBERTAD, I STAGE"; where a Basic-Descriptive study was applied, with a Descriptive-Evaluative-Cross-sectional design, using the documentary analysis technique through the data collection sheet and the digital record; obtaining as a result that the EVM has deficiencies when evaluating the time dimension in the projects, due to the fact that this method does not conceive that results are given outside the contractual term; In the same way, the contribution provided is based on the complementary application of the Earned Schelude methodology, which allows calculating the situation of the project, with respect to time, more precisely, as it is not limited by the contractual term..Tesi

Pliocene anisotropy of magnetic susceptibility (AMS) and diatom stratigraphy from the Wilkes Land margin

第3回極域科学シンポジウム　横断セッション「海・陸・氷床から探る後期新生代の南極寒冷圏環境変動」11月26日（月）、27日（火） ２階ラウン

Enumeration and Characterization of Circulating Tumor Cells in Patients with Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization

Circulating tumor cells (CTCs), and particularly circulating cancer stem cells (cCSC), are prognostic biomarkers for different malignancies and may be detected using liquid biopsies. The ex vivo culture of cCSCs would provide valuable information regarding biological aggressiveness and would allow monitoring the adaptive changes acquired by the tumor in real time. In this prospective pilot study, we analyzed the presence of EpCAM+ CTCs using the IsoFlux system in the peripheral blood of 37 patients with hepatocellular carcinoma undergoing transarterial chemoembolization (TACE). The average patient age was 63.5 ± 7.9 years and 91.9% of the patients were men. All patients had detectable CTCs at baseline and 20 patients (54.1%) showed CTC aggregates or clusters in their peripheral blood. The increased total tumor diameter (OR: 2.5 (95% CI: 1.3–4.8), p = 0.006) and the absence of clusters of CTCs at baseline (OR: 0.2 (95% CI: 0.0–1.0), p = 0.049) were independent predictors of a diminished response to TACE. Culture of cCSC was successful in five out of thirty-three patients, mostly using negative enrichment of CD45− cells, ultra-low adherence, high glucose, and a short period of hypoxia followed by normoxia. In conclusion, the identification of clusters of CTCs before TACE and the implementation of standardized approaches for cCSC culture could aid to predict outcomes and to define the optimal adjuvant therapeutic strategy for a true personalized medicine in hepatocellular carcinoma

Circulating Tumor Cells in Hepatocellular Carcinoma: A Comprehensive Review and Critical Appraisal

Hepatocellular carcinoma (HCC) is the fifth most common neoplasm and a major cause of cancer-related death worldwide. There is no ideal biomarker allowing early diagnosis of HCC and tumor surveillance in patients receiving therapy. Liquid biopsy, and particularly circulating tumor cells (CTCs), have emerged as a useful tool for diagnosis and monitoring therapeutic responses in different tumors. In the present manuscript, we evaluate the current evidence supporting the quantitative and qualitative assessment of CTCs as potential biomarkers of HCC, as well as technical aspects related to isolation, identification, and classification of CTCs. Although the dynamic assessment of CTCs in patients with HCC may aid the decision-making process, there are still many uncertainties and technical caveats to be solved before this methodology has a true impact on clinical practice guidelines. More studies are needed to identify the optimal combination of surface markers, to increase the efficiency of ex-vivo expansion of CTCs, or even to target CTCs as a potential therapeutic strategy to prevent HCC recurrence after surgery or to hamper tumor progression and extrahepatic spreading