39 research outputs found

    Propuesta de un programa de Mentoring para una agencia de una empresa financiera de la regi贸n La Libertad

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    La presente investigaci贸n tuvo como prop贸sito contribuir en potenciar conocimientos y habilidades de los colaboradores de una agencia de una empresa financiera de la regi贸n La Libertad, por lo que el objetivo general fue proponer un programa de mentoring. Dicha investigaci贸n tuvo un enfoque cualitativo de nivel descriptivo y dise帽o no experimental, por lo cual se recolect贸 informaci贸n a trav茅s de entrevistas para realizar un an谩lisis del material narrativo aplicado a la poblaci贸n y muestra que estuvo conformada por 14 personas entre gerente, jefes de 谩rea y colaboradores. Los resultados obtenidos permitieron conocer la situaci贸n actual del proceso de formaci贸n del talento humano, identificar tipo de mentoring, los temas, medios a utilizar, y las estrategias de evaluaci贸n, que sirvieron para la elaboraci贸n de la propuesta. Concluyendo que regularme el proceso de formaci贸n de los colaboradores se da a trav茅s de un aula virtual y que estos necesitan mentores que les sirvan de gu铆a, puesto que ahora muchos han asumido nuevas funciones, y se han realizado cambios en el banco, por lo que se necesita la participaci贸n de todos, por tanto se debe aplicar mentoring grupal bajo la modalidad Mixta, adem谩s dentro del dise帽o del programa, se deben tratar diferentes temas operativos referentes a sus funciones y utilizar recursos did谩cticos que faciliten la realizaci贸n del programa, as铆 como tambi茅n estrategias de evaluaci贸n que permitan evaluar tanto a los aprendices y al mentor, permitiendo ver el impacto que tuvo el programa

    Mejora del proceso acad茅mico aplicando BPM en la I.E.P. Ascensi贸n de Jes煤s, Huancayo, 2023

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    El presente proyecto de investigaci贸n presenta el desarrollo de un sistema BPM para la mejora del proceso acad茅mico en la I.E.P. Ascensi贸n de Jes煤s, a causa de que se observ贸 que la instituci贸n educativa requer铆a mejorar y agilizar los procesos de gesti贸n acad茅mica debido a dicha identificaci贸n del problema se investig贸 las siguientes dimensiones: Generaci贸n de boleta de notas, satisfacci贸n del servicio y seguimiento acad茅mico. Por lo cual, la presente tesis tiene por objetivo la mejora del proceso acad茅mico aplicando BPM en la I.E.P. Ascensi贸n de Jes煤s, Huancayo, 2023. Para ello se hace uso de Bizagui para el modelamiento de procesos adem谩s del software PowerBI para la tabulaci贸n de datos. El tipo de investigaci贸n que se identifico es aplicada, con un dise帽o es pre-experimental cuyo enfoque es cuantitativo. Se emple贸 una poblaci贸n de 52 personas con una muestra de 47 personas. El se desarroll贸 bajo una encuesta adem谩s de ficha de registro y ficha de observaci贸n

    Campa帽a de lanzamiento de producto para la bebida energizante Boom Power

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    El proyecto se centra en la elaboraci贸n de una campa帽a de lanzamiento de Boom Power, una nueva marca en la categor铆a de bebidas energizantes que est谩 ingresando al mercado con un nuevo producto que contiene maca, guaran谩, ginseng, te铆na, cafe铆na, taurina, y est谩 endulzado con extracto natural de yac贸n. El objetivo de marketing de la campa帽a de lanzamiento es lograr un 12 % de participaci贸n de mercado al t茅rmino del primer a帽o de operaciones. Tras investigar el contexto nacional, la categor铆a y el p煤blico objetivo, se logr贸 identificar los insights del p煤blico objetivo y c贸mo su estilo de vida influye en la decisi贸n de compra de bebidas energizantes independientemente de su nivel socioecon贸mico. El p煤blico objetivo posee un ritmo de vida acelerado, prioriza el trabajo sobre los dem谩s aspectos de su vida y, aunque sufra de estr茅s, considera ello una motivaci贸n para seguir adelante. Por ello se cre贸 Boom Power, una bebida energizante que te aviva y brinda la energ铆a extra que necesitas para el momento. El proyecto se divide en tres partes: la investigaci贸n realizada para la creaci贸n de la marca, la propuesta creativa de Boom Power y la sustentaci贸n del plan de medios para la campa帽a con sus respectivos materiales gr谩ficos.The project focuses on the development of the launching campaign of Boom Power, a new brand in the category of energy drinks that is entering the market with a new product that contains maca, guarana, ginseng, theine, caffeine, taurine, and is sweetened with natural yacon extract. The marketing goal of the launching campaign is to achieve 12% market share by the end of the first year of operations. After investigating the national context, the product鈥檚 category and the target audience, it was possible to identify the insights of the target audience and see how their lifestyle influences the decision to purchase energy drinks regardless of their socioeconomic level. The target audience has a fast pace of life, prioritizes work over other aspects of their life and, even if they鈥檙e stressed, considers such a motivation to work harder. That is why Boom Power was created, an energy drink that revives you and provides the extra energy you need for the moment. The project is divided into three parts: the research carried out for the creation of the brand, the creative proposal of Boom Power and the support of the media plan for the campaign with its respective graphic material

    Secretion of biologically active interferon-gamma inducible protein-10 (IP-10) by Lactococcus lactis

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    <p>Abstract</p> <p>Background</p> <p>Chemokines are a large group of chemotactic cytokines that regulate and direct migration of leukocytes, activate inflammatory responses, and are involved in many other functions including regulation of tumor development. Interferon-gamma inducible-protein-10 (IP-10) is a member of the C-X-C subfamily of the chemokine family of cytokines. IP-10 specifically chemoattracts activated T lymphocytes, monocytes, and NK cells. IP-10 has been described also as a modulator of other antitumor cytokines. These properties make IP-10 a novel therapeutic molecule for the treatment of chronic and infectious diseases. Currently there are no suitable live biological systems to produce and secrete IP-10. <it>Lactococcus lactis </it>has been well-characterized over the years as a safe microorganism to produce heterologous proteins and to be used as a safe, live vaccine to deliver antigens and cytokines of interest. Here we report a recombinant strain of <it>L. lactis </it>genetically modified to produce and secrete biologically active IP-10.</p> <p>Results</p> <p>The IP-10 coding region was isolated from human cDNA and cloned into an <it>L. lactis </it>expression plasmid under the regulation of the pNis promoter. By fusion to the usp45 secretion signal, IP-10 was addressed out of the cell. Western blot analysis demonstrated that recombinant strains of <it>L. lactis </it>secrete IP-10 into the culture medium. Neither degradation nor incomplete forms of IP-10 were detected in the cell or supernatant fractions of <it>L. lactis</it>. In addition, we demonstrated that the NICE (nisin-controlled gene expression) system was able to express IP-10 "de novo" even two hours after nisin removal. This human IP-10 protein secreted by <it>L. lactis </it>was biological active as demonstrated by Chemotaxis assay over human CD3+T lymphocytes.</p> <p>Conclusion</p> <p>Expression and secretion of mature IP-10 was efficiently achieved by <it>L. lactis </it>forming an effective system to produce IP-10. This recombinant IP-10 is biologically active as demonstrated by its ability to chemoattract human CD3+ T lymphocytes. This strain of recombinant <it>L. lactis </it>represents a potentially useful tool to be used as a live vaccine <it>in vivo</it>.</p

    Regulation of Intestinal Immune Response by Selective Removal of the Anterior, Posterior, or Entire Pituitary Gland in Trichinella spiralis Infected Golden Hamsters

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    The influence of anterior pituitary hormones on the gastrointestinal tract of humans and animals has been previously reported. Hypophysectomy (HYPOX) in the rat causes atrophy of the intestinal mucosa, and reduction of gastric secretion and intestinal absorption, as well as increased susceptibility to bacterial and viral infections. However, to our knowledge, no findings have been published concerning the immune response following HYPOX during worm infection, particularly that which is caused by the nematode Trichinella spiralis. The aim of this work was to analyze the effects of total or partial HYPOX on colonization of T. spiralis in the intestinal lumen, together with duodenal and splenic cytokine expression. Our results indicate that 5 days post infection, only neurointermediate pituitary lobectomy (NIL) reduces the number of intestinally recovered T. spiralis larvae. Using semiquantitative inmunofluorescent laser confocal microscopy, we observed that the mean intensity of all tested Th1 cytokines was markedly diminished, even in the duodenum of infected controls. In contrast, a high level of expression of these cytokines was noted in the NIL infected hamsters. Likewise, a significant decrease in the fluorescence intensity of Th2 cytokines (with the exception of IL-4) was apparent in the duodenum of control and sham infected hamsters, compared to animals with NIL surgeries, which showed an increase in the expression of IL-5 and IL-13. Histology of duodenal mucosa from NIL hamsters showed an exacerbated inflammatory infiltrate located along the lamina propria, which was related to the presence of the parasite. We conclude that hormones from each pituitary lobe affect the gastrointestinal immune responses to T. spiralis through various mechanisms

    Elaboramos esquemas sencillos para organizar informaci贸n

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    Comprende cr铆ticamente diversos tipos de textos escritos en variadas situaciones comunicativas prop贸sito de lectura, mediante procesos de interpretaci贸n y reflexi贸n.Trabajo de suficiencia profesiona

    Elaboramos esquemas sencillos para organizar informaci贸n

    Get PDF
    Comprende cr铆ticamente diversos tipos de textos escritos en variadas situaciones comunicativas prop贸sito de lectura, mediante procesos de interpretaci贸n y reflexi贸n.Trabajo de suficiencia profesiona

    Additive manufacturing in armor and military applications: research, materials, processing technologies, perspectives, and challenges

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    This review systematically examines the use of additive manufacturing (AM), also known as 3D printing (3DP), in the various aspects of military applications such as firearms, armor and ballistic resistant structures, including those bioinspired. The main goal is to provide a comprehensive exploration of AM in armor and military applications. The materials and structures created using AM technologies are analyzed and reported. Dynamic loading, and impact via Charpy and Izod tests were also explored in the search, although not considered in the armor results to be tests typically conducted at low strain rates, far from a real ballistic solicitation. Recently, an increase in military applications has been found, particularly gun prototypes fabricated in diverse materials with AM. Although the innovation, low costs, and manufacturing are clear advantages of these devices via 3D printing, there are limitations, such as the worrying panorama of unclear regulations that prevent these weapons from eventually reaching ordinary citizens. Current perspectives, opportunities, and challenges are discussed
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