Preliminary data on movements and health condition of the first radio-collared huemul (Hippocamelus bisulcus) population study in Argentina

Aun cuando solo quedan menos de 500 ejemplares de huemul patagonico (Hippocamelus bisulcus) en Argentina, existe escasa información sobre su ecología y dinámicas poblacionales. Por primera vez en la historia de Argentina, se instalaron equipos de radio telemetría en un grupo de huemules para entender de mejor forma los factores que no han permito la recuperación de las poblaciones. Durante el invierno del 2017, se procedió a la captura de seis ejemplares en seis días (tres de cada género), al interior del parque protegido Shoonem, provincia de Chubut. Se presenta en este artículo una descripción de las condiciones particulares del clima y las características del paisaje que serán útiles considerar para mejorar el éxito de capturas de huemules, particularmente en Argentina. Aun cuando los animales capturados presentaban un aspecto sano a primera vista, durante la última evaluación (25 enero 2018), identificamos signos clínicos de enfermedad en 5 de 6 animales capturados durante el procedimiento; incluyendo renguera, pezuñas deterioradas, perdida de 2-7 incisivos y atrofia muscular. Los desplazamientos registrados desde el sitio de captura en régimen de invernada a zonas de uso estival fueron 187% mayores en las hembras comparativamente a los machos.Even though less than 500 Patagonian huemul (Hippocamelus bisulcus) remain in Argentina, information on their population ecology and dynamics is severely lacking. For the first time in Argentine history, radio-telemetry collars were placed on a group of huemul to better understand the factors behind the population?s failure to recover. Six adult huemul (3 of each gender) were captured in six days, the winter of 2017, inside Shoonem Protected Park, Chubut province. In this article, we present a description of the unique climatic conditions and characteristics of the environment that would be useful to consider in order improving the success of huemul captures, particularly in Argentina. Despite the outwardly healthy appearance of each radio-collared huemul on the last observation date (January 25, 2018), we identified clinical symptoms of disease in 5 of these 6 animals during their capture; these included lameness, affected hoof, exfoliation of 2-7 incisors, and muscular atrophy. Movement distances from the winter capture site to maximum summer distance recorded were 187% greater for females than males (n=6, p =0.05, Mann Whitney).Fil: Smith Flueck, Jo Anne. Universidad Nacional del Comahue; ArgentinaFil: Fluck, Werner Thomas. Universidad de Basilea; Suiza. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; ArgentinaFil: Escobar Ruiz, Miguel. Fundación Shoonem; Argentin

Role of the different eyes in the visual odometry in the Wolf spider Lycosa tarantula (Araneae, Lycosidae)

The wolf spider Lycosa tarantula returns home by means of path integration. Previous studies demonstrated: (i) that the angular component of the outbound run is measured using a polarized-light compass associated with the anterior median eyes; (ii) changes in direction of the substratum are detected by the anterior lateral eyes (ALEs); and (iii) in relation to the linear component of the outbound run, an increase of optic flow, in either the lateral or ventral fields of view, caused spiders to search for the burrow at a point nearer to the goal. However, the role of the secondary eyes [ALEs, posterior lateral eyes (PLEs) and posterior median eyes (PMEs)] in the perception of this optic flow and the importance of them for gauging the distance walked is still unknown. In this study, lateral or ventral gratings of wavelength λ=1 cm were used, with two groups of spiders in each setup: (1) PLEs+PMEs covered and (2) ALEs covered. The largest reduction in the distance walked to return to the burrow was observed with the ventral grating/ALEs covered. These results show the importance of the previously neglected ALEs for the visual behavior of these spiders. The possibility of gathering information for locomotion from the three pairs of secondary eyes in the mushroom bodies is discusse

Sistema de registro de control y monitoreo automatizado para la producción de leche de la finca “SAN LUIS”, ubicado en el barrio san isidro de la parroquia Mulaló perteneciente a la provincia de Cotopaxi.

Due to the high rate of milk waste in Latacunga, approximately 5.64% (MAG - Cotopaxi), and the zero registration, monitoring and control of the production and storage of raw milk in the "San Luis" farm in Mulaló parish, in Latacunga; there is a need to implement a system that allows the automation of the control and monitoring of the existing livestock heads in this farm and the effective production of each one of them; for making strategic decisions inherent to the productivity of the most demanded dairy in Ecuador; for this reason, it was proposed to design and implement an automated monitoring and control system for the production of milk, in which the electronic module "Arduino Uno" is used, which together taking advantage of the benefits of RFID technology, performs a control of each one of the cows and by means of a sensor, obtain the real liters of production of each cow. In the body of each animal, an identifier TAG is located to be recognized through the RFID reader, which in conjunction with the Arduino module becomes the unit of control and information process that each cow generates. The main conclusions include the response of the RFID from 4.65 to 5.4 seconds, to a distance of 8.5 to 12.6 cm of identification of the cow, with an accuracy of ± 1.53 liters of production of milk on the Excel sheet.Debido al elevado índice de desperdicio de leche en la ciudad de Latacunga, aproximadamente 5,64% (MAG - Cotopaxi), y al nulo registro, monitoreo y control de la producción y almacenamiento de leche cruda en la Finca “San Luis” de la parroquia de Mulaló, de la ciudad de Latacunga; surge la necesidad de implementar un sistema que permita automatizar el control y monitoreo de las cabezas de ganado existentes en esta finca y la producción efectiva de cada una de ellas; para la toma de decisiones estratégicas inherentes a la productividad del lácteo más demandado en el Ecuador; por esta razón se propuso diseñar e implementar un sistema de registro de control y monitoreo automatizado para la producción de leche, en el cual se emplea el módulo electrónico “Arduino Uno” que conjuntamente aprovechando los beneficios de la tecnología RFID realiza un control de registro de cada una de las vacas y por medio de un sensor, obtener los litros reales de producción de cada vaca. En el cuerpo de cada animal, se ubica un identificativo TAG para ser reconocido a través del lector RFID, que en conjunto con el módulo Arduino se convierten en la unidad de control y proceso de la información que genera cada vaca. Las principales conclusiones engloban la respuesta del RFID de 4,65 a 5,4 segundos, a una distancia de 8,5 a 12,6 cm de identificación de la vaca, con una precisión de registro de ±1,53 litros de la producción de leche en la hoja de Excel

Definition of a FPGA-based SoC architecture for PRBS transmission in optical spectroscopy

Optical spectroscopy is a well-known tool typically employed for characterizing the properties of materials by analyzing their iteration with light. One of the most spread techniques is the dual comb spectroscopy, since it accomplishes ultra-high resolution, and high sensitivity measurements with a relatively simple platform including a single, relatively narrowband photodetector. The employed optical dual comb can be implemented through electro-optical (EO) modulation driven by pseudo-ransom binary sequences (PRBS) at high data rates, commonly in the range of tens of Gbps. For that purpose, the runtime generation and transmission of adaptive PRBS is still an open challenge, often involving expensive and not flexible high-speed digital systems, with a few commercially available solutions that sometimes do not match the application requirements efficiently. In this context, this work describes the definition and implementation of a System-on-Chip (SoC) architecture, based on a FPGA device, capable of generating and transmitting two PRBS for a dual comb, at a data rate up to 5 Gbps. The architecture can be configured and its operation modified in run time, thanks to the general-purpose processor involved, in charge of managing an Ethernet link to receive new PRBS to be transmitted or set up certain parameters. The proposed design has been validated experimentally on a dual comb spectroscopy measurement, where the absorption of a hydrogen cyanide (HCN) gas cell has been successfully characterized.Agencia Estatal de InvestigaciónMinisterio de Ciencia e Innovació

Meteorologically forced subinertial flows and internal wave generation at the main sill of the Strait of Gibraltar

The generation of large-amplitude internal waves in the Strait of Gibraltar is a widely known phenomenon. Those waves are produced by the interaction of barotropic tidal flow with the main sill (Camarinal Sill) topography and the stratified water column. That interaction primarily causes internal tides that evolve, by non-linear processes, into large-amplitude (more than 100m) internal waves exhibiting much shorter oscillation periods than those related to the basic tidal variability. Recent observations have shown that on many occasions large-amplitude internal wave generation is dependent on the state of the subinertial flows, which are basically driven by the atmospheric pressure fluctuations over the Mediterranean. Therefore, depending on the meteorological situation over the Mediterranean, internal wave events may be inhibited or activated. (c) 2008 Elsevier Ltd. All rights reserved

Prevalence of bleeding secondary to anticoagulation and mortality in patients with atrial fibrillation admitted with SARS-CoV-2 infection

Supplementary data associated with this article can befound, in the online version, at https://doi.org/10.1016/j.medcli.2021.06.015Introduction and purpose: Atrial fibrillation (AF) is common in patients admitted with severe COVID- 19. However, there is limited data about the management of chronic anticoagulation therapy in these patients. We assessed the anticoagulation and incidence of major cardiovascular events in hospitalized patients with AF and COVID-19. Methods: We retrospectively investigated all consecutive patients with AF admitted with COVID-19 between March and May 2020 in 9 Spanish hospitals. We selected a control group of non-AF patients consecutively admitted with COVID-19. We compared baseline characteristics, incidence of major bleed- ing, thrombotic events and mortality. We used propensity score matching (PSM) to minimize potential confounding variables, as well as a multivariate analysis to predict major bleeding and death. Results: 305 patients admitted with AF and COVID-19 were included. After PSM, 151 AF patients were matched with 151 control group patients. During admission, low-molecular-weight heparin was the principal anticoagulant and the incidence of major bleeding and mortality were higher in the AF group [16 (10.6%) vs 3 (2%), p = 0.003; 52 (34.4%) vs 35 (23.2%), p = 0.03, respectively]. The multivariate analysis showed the presence of AF as independent predictor of in-hospital major bleeding and mortality in COVID-19 patients. In AF group, a secondary multivariate analysis identified high levels of D-dimer as independent predictor of in-hospital major bleeding. Conclusions: AF patients admitted with COVID-19 represent a population at high risk for bleeding and mortality during admission. It seems advisable to individualize anticoagulation therapy during admission, considering patient specific bleeding and thrombotic risk.Antecedentes y objetivos: La fibrilación auricular (FA) es frecuente en pacientes ingresados por COVID-19 grave. Sin embargo, los datos sobre el manejo de la anticoagulación crónica en estos pacientes son escasos. Analizamos la anticoagulación y la incidencia de episodios cardiovasculares mayores en pacientes con FA ingresados por la COVID-19. Métodos: Retrospectivamente, se identificaron todos los pacientes con FA ingresados por la COVID-19 entre marzo y mayo de 2020, en 9 hospitales espa ̃noles. Se seleccionó un grupo control de pacientes ingresados consecutivamente por la COVID-19 sin FA. Se compararon las características basales, inci- dencia de hemorragias mayores, episodios trombóticos y mortalidad. Para reducir potenciales factores de confusión se realizó un emparejamiento por puntuación de propensión, así como un análisis multivariante para predecir hemorragia mayor y mortalidad. Resultados: Se incluyeron 305 pacientes con FA ingresados por la COVID-19. Tras el emparejamiento por puntuación de propensión, 151 pacientes con FA fueron emparejados con 151 controles. Durante el ingreso, la heparina de bajo peso molecular fue el principal anticoagulante y la incidencia de hemorragia mayor y mortalidad fue mayor en el grupo de FA (16[10,6%] vs. 3[2%], p = 0,003; 52[34,4%] vs. 35[23,2%], p = 0,03, respectivamente). El análisis multivariante demostró la presencia de FA como predictor indepen- diente de sangrados y mortalidad intrahospitalaria en los pacientes con la COVID-19. En el grupo de FA, un segundo análisis multivariante identificó valores elevados de dímero-D como predictor independiente de hemorragia mayor intrahospitalaria. Conclusiones: Los pacientes con FA ingresados por la COVID-19 representan una población de alto riesgo de sangrado y mortalidad durante el ingreso. Parece recomendable individualizar la anticoagulación durante el ingreso, considerando el riesgo específico de sangrado y trombosis

Prevalence of bleeding secondary to anticoagulation and mortality in patients with atrial fibrillation admitted with SARS-CoV-2 infection.

Atrial fibrillation (AF) is common in patients admitted with severe COVID-19. However, there is limited data about the management of chronic anticoagulation therapy in these patients. We assessed the anticoagulation and incidence of major cardiovascular events in hospitalized patients with AF and COVID-19. We retrospectively investigated all consecutive patients with AF admitted with COVID-19 between March and May 2020 in 9 Spanish hospitals. We selected a control group of non-AF patients consecutively admitted with COVID-19. We compared baseline characteristics, incidence of major bleeding, thrombotic events and mortality. We used propensity score matching (PSM) to minimize potential confounding variables, as well as a multivariate analysis to predict major bleeding and death. 305 patients admitted with AF and COVID-19 were included. After PSM, 151 AF patients were matched with 151 control group patients. During admission, low-molecular-weight heparin was the principal anticoagulant and the incidence of major bleeding and mortality were higher in the AF group [16 (10.6%) vs 3 (2%), p=0.003; 52 (34.4%) vs 35 (23.2%), p=0.03, respectively]. The multivariate analysis showed the presence of AF as independent predictor of in-hospital major bleeding and mortality in COVID-19 patients. In AF group, a secondary multivariate analysis identified high levels of D-dimer as independent predictor of in-hospital major bleeding. AF patients admitted with COVID-19 represent a population at high risk for bleeding and mortality during admission. It seems advisable to individualize anticoagulation therapy during admission, considering patient specific bleeding and thrombotic risk.S

Finding immunological differences to help diagnosis and early treatment of Kawasaki Disease and MIS-C (Multisystem Inflammatory Syndrome in Children)

Resumen del trabajo presentado en el 43 Congreso De La Sociedad Española de Inmunología, celebrado en León (España) del 22 al 24 de septiembre de 2022.The recent COVID-19 pandemic was first thought to spare children from health deprivation caused by infection with SARS-CoV-2. However, soon a new syndrome resembling Kawasaki Disease (KD) was reported: Multisystem Inflammatory Syndrome in Children (MIS-C). The aim of this study is to provide new biomarkers for both diseases in order to facilitate diagnosis and reduce the time-lapse until treatment is provided – which will reduce the risk of developing severe cardiovascular complications. An extensive immune system characterization by flow cytometry and serum protein characterization by a multiplex technology (Olink) was performed from fresh blood samples of patients with acute MIS-C (n=19) and KD (n=10). For protein characterization we also analysed recovery samples for these groups (n=19 and n=8, respectively). Besides the already described lymphopenia in MIS-C, we found additional significant immune differences in both groups. Although lymphocyte numbers (cells/ml) were lower in MIS-C, percentages of activated T-CD4+ and T-CD8+ cells were higher compared to KD. Moreover, when comparing activated T cells in MIS-C and KD individually, regulatory T cells (Treg) showed the highest levels. These data suggest a stronger response of T cells in MIS-C, and higher Treg activity in both groups, which could reflect the response to the excessive inflammation. Ratios previously described in other inflammatory conditions were evaluated: MIS-C showed higher neutrophil/lymphocyte and Th17/Treg ratios than KD, suggesting higher inflammatory conditions in this group. In addition, monocyte and dendritic cells (DCs) numbers were decreased in MIS-C relative to KD. Parallel to these inflammatory cellular profiles, we identified increased levels of inflammatory cytokines in plasma of patients during the acute phase of the disease compared to recovery samples. Moreover, IL-6, which is one of the main cytokines involved in cytokine storm in adult COVID-19, was higher in MIS-C suggesting, again, stronger inflammatory conditions in this pathology compared to KD

Gold behavior in supergene profiles under changing redox conditions : the example of the Las Cruces Deposit, Iberian Pyrite Belt

The Las Cruces deposit is in the eastern end of the Iberian Pyrite Belt (SW Spain). It is currently being mined by Cobre Las Cruces S.A. The main operation is focused on the supergene Cu-enriched zone (initial reserves of 17.6 Mt @ 6.2% Cu). An Au-Ag-Pb–rich gossan resource (3.6 Mt @ 3.3% Pb, 2.5 g/t Au, and 56.3 g/t Ag) occurs in the upper part of the deposit. The Au grade ranges from 0.01 ppm to >100 ppm, and occurs as three different Au ore types: (1) Au mineralization in the upper part of the gossan linked to Fe-oxides lithofacies, (2) Au concentration in the lower part of the gossan associated with leached black shales, and (3) Au ore in the cementation zone related to subvertical fractures. A hydroseparation device has been used to obtain heavy mineral concentrates from selected samples of different ore types. Reflected-light microscopy, scanning electron microscopy-energy dispersive spectroscopy (SEM-EDS), and electron probe microanalysis (EPMA) were used to study the separated Au particles. Significant differences between the defined ore types include the Au-bearing lithologies, mineral associations, textural features, particle sizes, morphologies, and fineness. Au-rich minerals include native Au, Au-Ag electrum, and Au-Ag-Hg amalgams. Gold-bearing mineral associations include Pb-oxihalides, Fe-oxides, galena, pyrite, cinnabar, and Ag-sulfosalts. The Au enrichment mechanism in the supergene profile involves (1) dissolution of Au from the primary sulfides as chloride-rich ionic complexes during the weathering of the deposit under subaerial exposure; dissolved Au is transported downward through the supergene profile under acidic and oxidized conditions; (2) destabilization of the Au complexes by Fe-controlled redox reactions; as a consequence, coarse-grained, high-fineness Au particles precipitated in association with Fe-oxyhydroxides. This resulted in secondary concentration in the upper gossan; and (3) after deposition of cover sediments took place a progressive change in the system conditions resulting in a later Au remobilization as hydroxidehalide, hydroxide, thiosulfate, and bisulfide complexes in the lowermost gossan and cementation zone. The main pathways for migration of enriched fluids to the cementation zone are secondary permeability zones linked to Alpine reactivated faults. Deposition of Au seems to be related to fluid interaction with reductant lithologies, including black shales and the primary sulfides.This research is a contribution to projects P-S Anoxia (CGL2011-30011) and Metodica (CGL2010-21956-C02-02), which are supported by the Spanish government. The authors thank Cobre Las Cruces S.A. for the field assistance and the ongoing collaboration. We are also grateful to Joel Brugger, Steve Hill, and Tim Baker for their constructive suggestions to improve the manuscript

Staphylococcus aureus RESISTENTE A METICILINA EN HOSPITALES DE HERMOSILLO, SONORA

Se determinó la prevalencia de resistencia a meticilina y las características epidemiológicas de aislamientos de Staphylococcus aureus en el Centro Médico Dr. Ignacio Chávez (CMIC) y el Hospital Infantil del Estado de Sonora (HIES) de la ciudad de Hermosillo, Sonora, México. Se estudiaron 288 aislamientos de S. aureus recuperados de muestras clínicas, desde el 01 de septiembre de 2008 al 31 de agosto de 2009. La identifi cación y pruebas de susceptibilidad se realizaron utilizando el sistema Vitek2. La resistencia a meticilina se determinó por el método de difusión en disco utilizando cefoxitina. La prevalencia de S. aureus resistente a meticilina (SARM) en el CMIC fue de 9,5 y en el HIES 13,8%. SARM se aisló de muestras de piel y tejido blando (50,0%) y de muestras tomadas en los servicios de terapia intermedia (18,7%), cirugía (18,7%) e infectología (18,7%). Todos los aislamientos de SARM presentaron resistencia a eritromicina y fueron sensibles a vancomicina, nitrofurantoína y cloranfenicol. Este estudio reveló la ocurrencia de aislamientos de SARM en dos hospitales de la Ciudad de Hermosillo, durante un año de vigilancia epidemiológica. Aunque la prevalencia de SARM no presentó niveles alarmantes en ninguno de los hospitales estudiados, se recomienda reforzar las medidas para el control de infecciones