45 research outputs found
Magyarországi intenzív osztályok szervdonációval kapcsolatos személyi és tárgyi feltételei = Personnel and material conditions of the Hungarian intensive care units dealing with organ donation
Absztrakt:
Bevezetés: A hazai transzplantációs várólistákon 2016 végén
kétszer annyi beteg volt, mint amennyi átültetés történt az év során. A
szervdonációs programok működésének intézményi szintű előfeltétele a megfelelő
dolgozói létszám és a tárgyi feltételek biztosítása az ellátási szükséglethez
képest. Célkitűzés: A jelen vizsgálat célja a hazai szakmai
környezet feltérképezése volt. Módszer: Az Országos Vérellátó
Szolgálat Szervkoordinációs Irodája kérdőíves felmérést készített a
magyarországi intenzív osztályok szervdonációval kapcsolatos személyi és tárgyi
feltételeiről. A felmérés eszköze online kérdőív volt, 43 kérdéssel. Az
ágyszámok és a dolgozói létszám mellett vizsgáltuk az agyhalál jogi és
orvosszakmai megállapításához szükséges eszközöknek, valamint a donorlekérdezőn
található vizsgálatoknak az elérhetőségét. Az adatgyűjtés 2016. december 12-től
2017. június 30-ig tartott. Eredmények: A kérdőívet 59 kórház
intenzív osztálya töltötte ki; a vizsgálat 640 betegágyat, 816 orvost, valamint
1252 ápolót érintett. Nappali műszakban egy betegágyra átlagosan 0,25 orvos,
0,41 ápoló jut, éjszakai műszakban 0,11 és 0,33. Az Országos Transzplantációs
Nyilvántartásból való lekérdezésre az orvosok 51,7%-a regisztrált,
agyhalál-megállapító bizottság a kórházak 83%-ában bármikor elérhető. A
képalkotó vizsgálatok között (koponya, has-mellkas) CT-vizsgálat 71–73%-ban,
hasi UH 75%-ban, transthoracalis echokardiográfia 37%-ban, transoesophagealis
echokardiográfia 4%-ban, bronchoszkópia 49%-ban, koronarográfia 19%-ban nonstop
elérhető, 75%-ban azonnali leletezéssel. Transcranialis Doppler-vizsgálat
30%-ban, négyér-angiográfia 45%-ban és SPECT 14%-ban áll rendelkezésre. A
donorlekérdezőn szereplő laborvizsgálatok több mint 90%-a a nap 24 órájában
elérhető. Következtetés: A 2008-ban történt felmérésünkhöz
képest az orvosok és az ápolók száma nem változott (2008: 0,18 orvos; 0,37
ápoló/intenzív osztályos ágy), miközben egy potenciális donor ellátása egyre
több erőforrást és időt igényel. A személyi és tárgyi feltételek rendelkezésre
állása a szervdonációs programok előfeltétele az életmentés szolgálatában. Orv
Hetil. 2018; 159(33): 1360–1367.
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Abstract:
Introduction: At the end of 2016, the number of patients on the
domestic transplant waiting list was twice as much as the number of the organ
transplantations accomplished that year. The institutional prerequisites for
functional organ donation programs are the sufficient number of personnel and
the adequate material conditions to be provided in relation to the needs.
Aim: The goal of the current study was to evaluate the
professional environment in Hungary. Method: The Organ
Coordination Office at the Hungarian National Blood Transfusion Service compiled
a questionnaire survey on the personnel and material conditions of the intensive
care units (ICUs) in Hungary in regards to organ donations. The survey applied
an online questionnaire including 43 questions. In addition to the number of
beds and employees, we investigated the tools needed for the legal and the
medical diagnosis of brain death as well as the accessibility of examinations on
the donor information form. The data collection spanned from 12 December 2016 to
30 June 2017. Results: 59 intensive care units completed the
questionnaire; the investigation involved 640 hospital beds, 816 physicians and
1252 nurses. In the daytime shift, 0.25 doctors and 0.41 nurses work on a
patient bed at an average, while in the night shift, the figures are 0.11 and
0.33, respectively. 51.7% of the doctors are registered to access the National
Non-Donor Registry, and brain death diagnosis committee is available in 83% of
the hospitals. Among the medical imaging methods (cranial, abdominal-thoracic),
CT scan in 71–73%, abdominal ultrasound in 75%, transthoracic echocardiograpy
(TTE) in 37%, transoesophageal echocardiography (TEE) in 4%, bronchoscopy in
49%, coronarography in 19% are non-stop available, with instant interpretation
in 75% of the cases. Transcranial Doppler (TCD) in 30%, four-vessel angiography
in 45% and SPECT in 14% of the cases are available. More than 90% of the
laboratory examinations on the donor information form are available 24 hours a
day. Conclusion: The number of doctors and nurses did not
change compared to our 2008 survey (0.18 doctors, 0.37 nurses/ICU beds in 2008),
but the care of potential donors needs more resources and time. The standby
availability of personnel and material conditions is a prerequisite for organ
donation programs in order to save lives. Orv Hetil. 2018; 159(33):
1360–1367
Quality indicators for patients with traumatic brain injury in European intensive care units
Background: The aim of this study is to validate a previously published consensus-based quality indicator set for the management of patients with traumatic brain injury (TBI) at intensive care units (ICUs) in Europe and to study its potential for quality measur
Changing care pathways and between-center practice variations in intensive care for traumatic brain injury across Europe
Purpose: To describe ICU stay, selected management aspects, and outcome of Intensive Care Unit (ICU) patients with traumatic brain injury (TBI) in Europe, and to quantify variation across centers. Methods: This is a prospective observational multicenter study conducted across 18 countries in Europe and Israel. Admission characteristics, clinical data, and outcome were described at patient- and center levels. Between-center variation in the total ICU population was quantified with the median odds ratio (MOR), with correction for case-mix and random variation between centers. Results: A total of 2138 patients were admitted to the ICU, with median age of 49 years; 36% of which were mild TBI (Glasgow Coma Scale; GCS 13–15). Within, 72 h 636 (30%) were discharged and 128 (6%) died. Early deaths and long-stay patients (> 72 h) had more severe injuries based on the GCS and neuroimaging characteristics, compared with short-stay patients. Long-stay patients received more monitoring and were treated at higher intensity, and experienced worse 6-month outcome compared to short-stay patients. Between-center variations were prominent in the proportion of short-stay patients (MOR = 2.3, p < 0.001), use of intracranial pressure (ICP) monitoring (MOR = 2.5, p < 0.001) and aggressive treatme
Machine learning algorithms performed no better than regression models for prognostication in traumatic brain injury
Objective: We aimed to explore the added value of common machine learning (ML) algorithms for prediction of outcome for moderate and severe traumatic brain injury. Study Design and Setting: We performed logistic regression (LR), lasso regression, and ridge regression with key baseline predictors in the IMPACT-II database (15 studies, n = 11,022). ML algorithms included support vector machines, random forests, gradient boosting machines, and artificial neural networks and were trained using the same predictors. To assess generalizability of predictions, we performed internal, internal-external, and external validation on the recent CENTER-TBI study (patients with Glasgow Coma Scale <13, n = 1,554). Both calibration (calibration slope/intercept) and discrimination (area under the curve) was quantified. Results: In the IMPACT-II database, 3,332/11,022 (30%) died and 5,233(48%) had unfavorable outcome (Glasgow Outcome Scale less than 4). In the CENTER-TBI study, 348/1,554(29%) died and 651(54%) had unfavorable outcome. Discrimination and calibration varied widely between the studies and less so between the studied algorithms. The mean area under the curve was 0.82 for mortality and 0.77 for unfavorable outcomes in the CENTER-TBI study. Conclusion: ML algorithms may not outperform traditional regression approaches in a low-dimensional setting for outcome prediction after moderate or severe traumatic brain injury. Similar to regression-based prediction models, ML algorithms should be rigorously validated to ensure applicability to new populations
Variation in Structure and Process of Care in Traumatic Brain Injury: Provider Profiles of European Neurotrauma Centers Participating in the CENTER-TBI Study.
INTRODUCTION: The strength of evidence underpinning care and treatment recommendations in traumatic brain injury (TBI) is low. Comparative effectiveness research (CER) has been proposed as a framework to provide evidence for optimal care for TBI patients. The first step in CER is to map the existing variation. The aim of current study is to quantify variation in general structural and process characteristics among centers participating in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study. METHODS: We designed a set of 11 provider profiling questionnaires with 321 questions about various aspects of TBI care, chosen based on literature and expert opinion. After pilot testing, questionnaires were disseminated to 71 centers from 20 countries participating in the CENTER-TBI study. Reliability of questionnaires was estimated by calculating a concordance rate among 5% duplicate questions. RESULTS: All 71 centers completed the questionnaires. Median concordance rate among duplicate questions was 0.85. The majority of centers were academic hospitals (n = 65, 92%), designated as a level I trauma center (n = 48, 68%) and situated in an urban location (n = 70, 99%). The availability of facilities for neuro-trauma care varied across centers; e.g. 40 (57%) had a dedicated neuro-intensive care unit (ICU), 36 (51%) had an in-hospital rehabilitation unit and the organization of the ICU was closed in 64% (n = 45) of the centers. In addition, we found wide variation in processes of care, such as the ICU admission policy and intracranial pressure monitoring policy among centers. CONCLUSION: Even among high-volume, specialized neurotrauma centers there is substantial variation in structures and processes of TBI care. This variation provides an opportunity to study effectiveness of specific aspects of TBI care and to identify best practices with CER approaches
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Use and impact of high intensity treatments in patients with traumatic brain injury across Europe: a CENTER-TBI analysis
Abstract: Purpose: To study variation in, and clinical impact of high Therapy Intensity Level (TIL) treatments for elevated intracranial pressure (ICP) in patients with traumatic brain injury (TBI) across European Intensive Care Units (ICUs). Methods: We studied high TIL treatments (metabolic suppression, hypothermia (< 35 °C), intensive hyperventilation (PaCO2 < 4 kPa), and secondary decompressive craniectomy) in patients receiving ICP monitoring in the ICU stratum of the CENTER-TBI study. A random effect logistic regression model was used to determine between-centre variation in their use. A propensity score-matched model was used to study the impact on outcome (6-months Glasgow Outcome Score-extended (GOSE)), whilst adjusting for case-mix severity, signs of brain herniation on imaging, and ICP. Results: 313 of 758 patients from 52 European centres (41%) received at least one high TIL treatment with significant variation between centres (median odds ratio = 2.26). Patients often transiently received high TIL therapies without escalation from lower tier treatments. 38% of patients with high TIL treatment had favourable outcomes (GOSE ≥ 5). The use of high TIL treatment was not significantly associated with worse outcome (285 matched pairs, OR 1.4, 95% CI [1.0–2.0]). However, a sensitivity analysis excluding high TIL treatments at day 1 or use of metabolic suppression at any day did reveal a statistically significant association with worse outcome. Conclusion: Substantial between-centre variation in use of high TIL treatments for TBI was found and treatment escalation to higher TIL treatments were often not preceded by more conventional lower TIL treatments. The significant association between high TIL treatments after day 1 and worse outcomes may reflect aggressive use or unmeasured confounders or inappropriate escalation strategies. Take home message: Substantial variation was found in the use of highly intensive ICP-lowering treatments across European ICUs and a stepwise escalation strategy from lower to higher intensity level therapy is often lacking. Further research is necessary to study the impact of high therapy intensity treatments. Trial registration: The core study was registered with ClinicalTrials.gov, number NCT02210221, registered 08/06/2014, https://clinicaltrials.gov/ct2/show/NCT02210221?id=NCT02210221&draw=1&rank=1 and with Resource Identification Portal (RRID: SCR_015582)
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Quality indicators for patients with traumatic brain injury in European intensive care units: a CENTER-TBI study
Abstract: Background: The aim of this study is to validate a previously published consensus-based quality indicator set for the management of patients with traumatic brain injury (TBI) at intensive care units (ICUs) in Europe and to study its potential for quality measurement and improvement. Methods: Our analysis was based on 2006 adult patients admitted to 54 ICUs between 2014 and 2018, enrolled in the CENTER-TBI study. Indicator scores were calculated as percentage adherence for structure and process indicators and as event rates or median scores for outcome indicators. Feasibility was quantified by the completeness of the variables. Discriminability was determined by the between-centre variation, estimated with a random effect regression model adjusted for case-mix severity and quantified by the median odds ratio (MOR). Statistical uncertainty of outcome indicators was determined by the median number of events per centre, using a cut-off of 10. Results: A total of 26/42 indicators could be calculated from the CENTER-TBI database. Most quality indicators proved feasible to obtain with more than 70% completeness. Sub-optimal adherence was found for most quality indicators, ranging from 26 to 93% and 20 to 99% for structure and process indicators. Significant (p < 0.001) between-centre variation was found in seven process and five outcome indicators with MORs ranging from 1.51 to 4.14. Statistical uncertainty of outcome indicators was generally high; five out of seven had less than 10 events per centre. Conclusions: Overall, nine structures, five processes, but none of the outcome indicators showed potential for quality improvement purposes for TBI patients in the ICU. Future research should focus on implementation efforts and continuous reevaluation of quality indicators. Trial registration: The core study was registered with ClinicalTrials.gov, number NCT02210221, registered on August 06, 2014, with Resource Identification Portal (RRID: SCR_015582)