90 research outputs found

    Macrophage Migration Is Impaired within Candida albicans Biofilms

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    Acknowledgments: We thank the Microscopy and Histology Core Facility at the University of Aberdeen. This work was funded by NHS Grampian Endowments (grant RG10191); the Wellcome Trust Strategic Award in Medical Mycology and Fungal Immunology (grant 097377); the Wellcome Trust Investigator award (grants 101873, 086827, 075470, & 200208) and the Medical Research Council Centre for Medical Mycology (grant MR/N006364/1).Peer reviewedPublisher PD

    Rab14 regulates the maturation of macrophage phagosomes containing the fungal pathogen Candida albicans and the outcome of the host-pathogen interaction

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    Date of Acceptance: 02/02/2015 Copyright © 2015, American Society for Microbiology. All Rights Reserved.Peer reviewedPublisher PD

    Immunoregulatory soluble CTLA-4 modifies effector T cell responses in systemic lupus erythematosus

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    Acknowledgments This work was supported by Arthritis Research UK (Grant no. 19282). We are grateful to Dr. Nick Fluck for his invaluable support in recruiting patients for the study, and Mrs. Vivien Vaughan for her invaluable expertise in recruiting study participants and maintaining ethical documentation.Peer reviewedPublisher PD

    SOCS3 is a modulator of human macrophage phagocytosis

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    ACKNOWLEDGMENTS This work was supported by Kidney Research UK (Grant Number RP1/2012). The authors thank the staff of the Aberdeen Microscopy and Histology Core Facility for advice and technical assistance. The authors acknowledge and are grateful to all volunteers for donating blood for macrophage and neutrophil isolation.Peer reviewedPublisher PD

    Characterizing infection in anti-neutrophil cytoplasmic antibody-associated vasculitis:results from a longitudinal, matched-cohort data linkage study

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    We wish to thank Information Division Services Scotland for assisting with data linkage and data access in the National Safe Haven. Information presented in this article was previously presented as a poster at the American College of Rheumatology Annual Conference 2018, Chicago, IL, USA. The study was conceived by S.H.S., A.M., C.B. and N.B. All authors contributed to the study design and data collection. Data analysis and interpretation and drafting of the manuscript were conducted by all authors. C.B. and N.B. were joint senior authors. All authors critically reviewed the manuscript and approved the final version. Funding: S.H.S. and the study were funded by the Aberdeen Development Trust and the Farr Institute of Health Informatics Research. The Farr Institute is supported by a 10-funder consortium: Arthritis Research UK, the British Heart Foundation, Cancer Research UK, the Economic and Social Research Council, the Engineering and Physical Sciences Research Council, the Medical Research Council, the National Institute of Health Research, the National Institute for Social Care and Health Research (Welsh Assembly Government), the Chief Scientist Office (Scottish Government Health Directorates) and the Wellcome Trust (Scotland MR/K007017/1). Disclosure statement: L.E. is a GlaxoSmithKline employee. The other authors have declared no conflicts of interest.Peer reviewedPublisher PD

    A novel 4-dimensional live-cell imaging system to study leukocyte-endothelial dynamics in ANCA-associated vasculitis

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    This work was supported by the Lauren Currie Twilight Foundation, NHS Grampian Renal Endowment Fund and Aberdeen University Development Fund.Peer reviewedPostprintPostprin

    Differential Kinetics of Aspergillus nidulans and Aspergillus fumigatus Phagocytosis

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    Acknowledgements: The authors would like to acknowledge Fraser P. Coxon and Ian Ganley for providing LC3-GFP-mCherry BMDMs. M.S.G. was supported by an FEMS research grant and F.L.v.d.V. was supported by ZonMW under the name EURO-CMC frame of E-Rare-2, the ERA-Net for Research on Rare Diseases.Peer reviewedPublisher PD

    Fungal spore swelling and germination are restricted by the macrophage phagolysosome

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    Acknowledgements We acknowledge Wellcome support of Senior Investigator (101873/Z/13/Z; 224323/Z/21/Z), Collaborative (200208/A/15/Z) and Strategic Awards (097377/Z11/Z) and the MRC for a programme grant (MR/M026663/2) and the MRC Centre for Medical Mycology (MR/N006364/2). We thank Kevin Mackenzie for help with microscopy. For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission.Peer reviewedPublisher PD
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