N-Benzyl-N-methyl-3-phenyl-3-[4-(tri­fluoro­meth­yl)phen­oxy]propanamine (N-benzylflouoxetine)

In the title compound, C24H24F3NO, the N-benzyl derivative of fluoxetine {N-methyl-3-[4-(trifluoro­meth­yl)phen­oxy]­benzene­propanamine}, the three aromatic rings A, B and C are inclined to one another by 76.77 (12)° for A/B, 17.05 (14)° for A/C and 89.66 (14)° for B/C. In the crystal structure, mol­ecules are linked via C—H⋯π inter­actions to form one-dimensional chains propagating in the [010] direction

2-{1-[(2-Nitro­benzene­sulfonamido)­meth­yl]cyclo­hexyl}acetic acid

In the title compound, C15H20N2O6S, the C—SO2—NH—C torsion angle is 64.54 (14)°. In the mol­ecule, there is a bifurcated N—H⋯(O,O) hydrogen bond, forming S(7) rings. In the crystal, inversion dimers are formed via O—H⋯O hydrogen bonds involving the carboxyl group, so forming R 2 2(8) rings. These dimers are further linked via pairs of C—H⋯O hydrogen bonds, forming a C(6) chain propagating along the c-axis direction

Green and Facile Reaction of Gabapentin with Sulfonyl Chlorides to Synthesize Lactams and Sulfonamides Derivatives in Aqueous Medium

In the current research, a facile and green one pot synthesis of new gabapentin-lactams (G(2)-G(8)) has been achieved by reacting gabapentin (G(1)) with a variety of sulfonyl chlorides. The new lactamization protocol is furnished under the green solvent i.e., water and reaction was completed in a short period of time by just stirring at room temperature. Whereas in some cases, annulation could not happen and furnished un-cyclized sulfonamide products (G(9)-G(12)). The structures of the targeted compounds were established by elemental analysis, FT-IR, H-1-NMR and mass spectrometry. The crystals of some new lactams (G(2), G(3), G(4), and G(8)) were also evaluated by single crystal X-ray diffraction