Characteristics of food allergy in children: National multicenter study

Conference: Congress of the European-Academy-of-Allergy-and-Clinical-Immunology (EAACI) Location: Lisbon, PORTUGAL Date: JUN 01-05, 2019Background : Food allergies impose a significant burden on the life of the child and the family. In this study, to determine the demographic characteristics of food allergies, we investigated the characteristics of patients with food allergies in different regions of Pediatric Allergy- Immunology departments in Turkey. Method : Turkey ' s National Study of Allergy and Clinical Immunology Society has conducted a Study Group on Food Allergies. 25 centers participated in this multicenter, cross- sectional and descriptive study.European Academy of Allergy and Clinical Immunolog

Congenital Fibrosis of the Extraocular Muscles

Congenital fibrosis of the extraocular muscles (CFEOM) is a rare disorder characterized by hereditary non-progressive restrictive strabismus and blepharoptosis. Although most of the cases are bilateral and isolated, some patients may have systemic findings. CFEOM is divided into three groups as CFEOM 1, 2, and 3 according to the phenotype. Primary responsible genes are KIF21A for CFEOM type 1 and 3 and PHOX2A/ARIX gene for CFEOM type 2. Studies suggest that abnormal innervation of the extraocular muscles is the cause of muscle fibrosis. Early treatment is important because of the risk of amblyopia. Surgery is the primary treatment option for strabismus and blepharoptosis. (Turk J Ophthalmol 2014; 44: 312-5

Retinal Ven Tıkanıklığına Bağlı Oluşan Maküler Ödem Tedavisinde İntravitreal Deksametazon İmplantın Erken Dönem Sonuçları

Amaç: Santral retinal ven tıkanıklığı (SRVT) ve retinal ven dal tıkanıklığına (RVDT) bağlı oluşan maküler ödem (MÖ) tedavisinde deksametazon implantın altı aylık etkisini ve yan etkilerini değerlendirmek. Gereç: Göz Hastalıkları Kliniğinde SRVT (n=19) ve RVDT(n=18) sonucu oluşan MÖ nedeniyle tek doz intravitreal dexametazon implant ile tedavi edilen 37 hasta (37 göz) çalışmaya dahil edildi. Hastaların kayıtları retrospektif olarak incelendi. En az 6 ay boyunca, aylık olarak takip edilen hastalar çalışmaya dahil edildi. Başlangıç ve tedavi sonrası her kontrolde yapılmış olan; biyomikroskopik muayene bulguları, en iyi düzeltilmiş görme keskinliği (EDGK) düzeyi ve spektral domain optik koherens tomografi (OKT) ile santral maküler kalınlık (SMK) ölçümleri ve yan etkiler kaydedilerek değerlendirildi. Bulgular: RVDT olguları grup 1 (n=18), SRVT olguları grup 2 (n=19) olmak üzere hastalar 2 gruba ayrıldı. Tüm hastalarda tedavi sonrası EDGK 4. aya kadar anlamlı olarak artarken SMK değerleri anlamlı olarak azaldı (p<0.05). Tedavinin 4. ayından sonra ise EDGK değeri tedavi öncesine göre istatistiksel olarak farklı değildi. Maximum görme keskinliğindeki artış grup 2’ye kıyasla grup 1’de anlamlı olarak fazla idi. İki grup arasında ortalama SMK azalması açısından istatistiksel olarak anlamlı bir fark bulunmadı (p>0.05). Tedavi edilen 8 hastada (%21,6) göz içi basınç artışı görüldü. Sonuç: SRVT ve RVDT’na ikincil maküler ödem olgularında intravitreal dexametazon implant, ilk 6 ayda anatomik ve fonksiyonel düzelme sağlamıştır. Göz içi basıncı artışı dışında yan etki görülmemiştir

Investigation into the effects of prenatal alcohol exposure on postnatal spine development and expression of synaptophysin and PSD95 in rat hippocampus

WOS: 000333002800014PubMed ID: 24365761Ethanol is known as a potent teratogen responsible for the fetal alcohol syndrome characterized by cognitive deficits especially pronounced in juveniles but ameliorating in adults. Since the mechanisms of these deficits and following partial recovery are not fully elucidated, the aim of the present study was to investigate the process of synaptogenesis in the hippocampus over the first two months of life in control and fetal-alcohol rats. Ethanol was delivered to the pregnant dams by intragastric intubation throughout 7-21 gestation days at the daily dose of 6 g/kg generating a mean blood alcohol level of 246.6 +/- 40.9 mg/dl on gestation day 20. The spine densities as well as the expression of pre- and postsynaptic proteins, synaptophysin (SYP) and PSD-95 protein, were evaluated for three distinct hippocampal regions: CA1, CA2+3, and DG and four postnatal days: PD1, PD10, PD30 and PD60, independently. Our results confirmed an intensive synaptogenesis within the brain spurt period (first 10 postnatal days), however, the temporal pattern of changes in the SYP and PSD-95 expression was different. The ethanol exposure during half of the 1st and the whole 2nd human trimester equivalent resulted in an overall trend toward lower values of synaptic indices at PD1 with a fast recovery from these deficits observed already at PD10. At PD30, around the age when the most pronounced behavioral deficits have been previously reported in juvenile fetal-alcohol subjects, no significant changes were found in either the hippocampal levels of synaptic proteins or in the spine density in principal hippocampal neurons. (C) 2013 ISDN. Published by Elsevier Ltd. All rights reserved.METU Scientific Research FoundTurkish Scientific and Technical Council (TUBITAK)The study was supported by the METU Scientific Research Found and by the grant from the Turkish Scientific and Technical Council (TUBITAK), SBAG-107S069 to EJD and by the TUBITAK PhD scholarship given to BEC. The authors would like to thank Signem Eyuboglu-Dinc for her kindly guidance and help with experimental protocols applied in this study

Posterior Capsular Opacification in Preschool- and School-Age Patients after Pediatric Cataract Surgery without Posterior Capsulotomy

Objectives: We aimed to evaluate the development of posterior capsular opacification (PCO) in preschool- and school-age children with cataract who underwent cataract surgery without posterior capsulotomy and anterior vitrectomy. Materials and Methods: The records of 30 eyes of 21 patients who underwent pediatric cataract surgery and intraocular lens (IOL) implantation were retrospectively reviewed. Patients’ age, PCO status and duration, need for neodymium-doped yttrium aluminium garnet (Nd:YAG) laser treatment based on coverage of visual axis, and follow-up period were recorded. Results: The mean age of the patients was 7.6±2.83 (4-12) years. Unilateral cataract surgery and IOL implantation were performed in 12 patients (57.14%) and bilateral cataract surgery and IOL implantation were performed in nine patients (42.86%). Average follow-up time was 17.7±22.67 (3-83) months. PCO developed in 21 eyes (70%) and covered the visual axis in 15 eyes (50%), which therefore required Nd:YAG laser posterior capsulotomy. The mean duration of postoperative PCO development was 8.91±18.7 months (1 week-71 months). Conclusion: We believe that with adequately experienced surgeons, performing both cataract surgery and posterior capsulotomy with anterior vitrectomy in the same session is appropriate for selected preschool- and school-age children with cataract

Evaluation of Central Corneal Thickness with Ultrasound Pachymetry After Micro-Coaxial Cataract Surgery

Pur po se: To evaluate the changes in central corneal thickness (CCT) in patients with different values before cataract surgery. Ma te ri al and Met hod: 90 eyes of 70 patients who had undergone uneventful cataract surgery because of senile cataract were included in this prospective study. The CCT was measured by ultrasound pachymetry. The patients were evaluated in 4 groups according to preoperative CCT values (group 1: 450-500 μm, group 2: 501-550μm, group 3: 551-600μm, and group 4: 601-650μm). The CCT was measured preoperatively and at 1st, 2nd, 4th, and 8th weeks postoperatively. The chi-square test and one-way analysis of variance test were used for statistical analysis. Re sults: The increase in CCT was highest in group 1 determined as 71.3 μm. The increase in group 2 was 43.4, 35.1 in group 3, and 16.6 μm in group 4. The increase in CCT was significant in all groups at week 1 ( p<0.05). The increase in group 1 was statistically significant than in groups 3 and 4 (group 1 and group 3, p=0.025; group 1 and group 4, p<0.01). The increase in group 2 was also statistically significant than in group 4 (p=0.032). The CCT was decreased after the 2nd week. The recovery of CCT to preoperative values was determined at 8th week in group 1, 4th week in groups 2 and 3, and 2nd week in group 4. Dis cus si on: In thin corneas, the increase in central corneal thickness is more prominent and stabilization occurs in a longer time after cataract surgery. (Turk J Ophthalmol 2013; 43: 145-8

Ubrzano izlaganje polipropilenskih kompozita ojačanih pregrijanim drvom vremenskim utjecajima i otpornost na propadanje

The aim of this study was to determine the accelerated weathering and decay resistance of the heattreated wood reinforced polypropylene composites (HT-WPC). Polypropylene (PP) was used as a matrix and the heat-treated wood treated at 180 °C and 220 °C as reinforcement fi ller. The effect of three fi ller type, such as 40, 60 and 100 mesh, on the outdoor performance of composites was also investigated. The composites were prepared with twin screw extruder, and the test samples were obtained with compression molding. Lightness index (L*), color changes (ΔE*) and physical changes on the surface of the composites after the accelerated weathering, and decay resistance of the composites were investigated. According to the results, the effects of heat-treated wood on color changes were found to be more than its fi ller size, and while the fi ller loadings were increased from 5 % to 20 %, it was determined to increase the color changes of the composites. In scanning electron microscopy (SEM) images, crack formation and deterioration on the surface of the composites were determined. In FTIR spectra, no difference was determined between the composites, and all peaks were similar to each one. The addition of heattreated wood improved the antifungal effi ciency of the composite, and the mass losses decreased with the increasing of heat treatment temperature. As a result, adding heat-treated wood to PP was found to improve the outdoor performance of the HT-WPCs