Adakite-like parental melt generation by partial fusion of juvenile lower crust, Sakarya Zone, NE Turkey: A far-field response to break-off of the southern Neotethyan oceanic lithosphere

Ersoy, Yalcin E/0000-0002-8563-9561; KANDEMIR, RAIF/0000-0002-0344-9159WOS: 000471738200004The timing of major tectonic events and the driving mechanisms for magma generation during Late Cenozoic convergence and collision between Arabia and Eurasia still remain unknown. the Sakarya Zone (SZ) in northern Turkey is a critical member of this collisional assemblage. in the easternmost part of the SZ, we have recognized a Late Miocene volcanic suite termed the Cagirankaya volcanics which displays characteristic post-collisional geochemical features. Here, we report a new data set of zircon U-Pb ages, whole-rock major and trace element, as well as Sr-Nd isotope analyses for dacite and and esite samples from the cagirankaya volcanics. Zircon U-Pb ages for a selected dacitic sample average 5.16 +/- 0.11 Ma (mean square of weighted deviates. MSWD = 0.45, n = 35), confirming a late Miocene age of this volcanic episode. the high-K calc-alkaline andesites and dacites exhibit an adakite-like geochemical signature, and are characterized by high Sr (424 to 552 ppm), Sr/Y ratios (31-43), and low Mg# (42 to 46) values, along with low Y (12-14 ppm) and heavy rare earth element (HREE) concentrations, that resemble those in adakites formed by partial melting of hot oceanic slab during subduction. Isotopic compositions are near bulk Earth (Sr-87/Sr-86(t) = 0.70482 to 0.70489, epsilon(Nd)(t) = +1.08 to +133), which rules out a solely asthenospheric origin. Elevated Nb/Ta (14 to 17) and K2O/Na2O (0.6-1.0) imply a juvenile mafic lower crustal source composed of similar to 20% garnet-bearing amphibolite. Geochemical modeling suggests that adakite-like parental melts were generated in the absence of subduction and without large-scale delamination of lower continental crust. Instead, our findings suggest that Late Miocene adakite-like volcanic rocks in the SZ formed in a post-collisional intra-continental setting, which experienced far-field extension after the subducted slab of the southern Neotethyan branch became detached in the collision zone. Asthenospheric upwelling and underplating of basaltic magma provided the heat for partial melting of lower crustal amphibolite, forming minor amounts of adakite-like melts in the SZ. (C) 2019 Elsevier B.V. All rights reserved.Recep Tayyip Erdogan UniversityRecep Tayyip Erdogan University [FBA-2018-869]This work was financially supported by the Recep Tayyip Erdogan University with a grant #FBA-2018-869. We appreciate Serhat Kasai at the Isotopic Laboratory in the Middle East Technical University, Ankara, for the Sr-Nd isotopic analyses. Yilmaz Demir is thanked for his scientific and logistical supports in the field. We gratefully acknowledge the English editing efforts of the manuscript by Jacqueline O'Neill Ozcelik. We express our gratitude to Chief Editor Xian-Hu Li, and reviewers Paterno Castillo and Senel Ozdamar for constructive comments and excellent suggestions improving our manuscript Rize-Turkey

Presentation of interleukin-12/-23 receptor beta 1 deficiency with various clinical symptoms of salmonella infections

Clinical disease caused by weakly pathogenic mycobacterial species, Mycobacterium bovis Bacille Calmette-Guerin (BCG) and non-tuberculous environmental mycobacteria (EM), which is known as Mendelian susceptibility to mycobacterial disease (MSMD), is a rare entity defined recently. Infections with the more virulent Mycobacterium species, M. tuberculosis, may have largely gone unnoticed in these patients due to early death. Mutations in five proteins (IFN gamma R1, IFN gamma R2, IL-12/IL-23R beta 1, IL-12/IL-23p40 and STAT1) have been found in MSMD. These patients are prone to surprisingly few other infectious diseases mainly to salmonellosis. Here we present three IL-12/IL-23R beta 1 deficient patients from three different families and with different genetic mutations, who presented exclusively with Salmonella infections. Bacteremia and lymph node involvement were common clinical expressions. Leukocytoclastic vasculitis developed in one of these patients. Two patients were not inoculated with BCG, the third patient did not develop BCG infection although BCG vaccine had been given twice at ages of 1 and 7 years. All three patients responded well to antibiotic treatment. In conclusion, patients with chronic, recurrent or complicated Salmonella infections should be screened for MSMD, particularly for IL-12/IL-23p40/IL-12R/-23R beta 1 deficiency. Conversely, in patients with genetic IL-12/-23R beta 1 deficiency a full evaluation for Salmonella infection is required. IL-12/IL-23p40/IL-12R/IL-23R beta 1 deficiency seem to be underdiagnosed in patients with salmonellosis, and since such patients need prolonged therapy, diagnosis is important

Tsunami Waves in Izmit Bay

Based on eyewitness reports and run-up and inundation measurements, the tsunami generated after the Kocaeli earthquake had a period shorter than a minute and arrived a few minutes after the earthquake on the northern coasts and about a minute after on the southern coasts. The sea receded first along northern and southern coastlines of Izmit Bay. This information provides valuable information on the generation mechanism of the tsunami waves, for it implies that there was a large subsidence near and/or at the shoreline, possibly caused by a stepover between two strands of the strike-slip fault system. The fairly consistent reports of approximately one-minute wave periods rule out bay oscillations as the source of the flooding and indicate that regions of subsidence may have been localized (Alpar 1999; Guneysu 1999). Tsunami waves may have also been generated by sediment slumping within the bay, in addition to tectonic subsidence. Local peaks in tsunami run-up along the northern and southern shorelines of the middle basin hint that these slumps may have generated waves near Degirmendere. The Kocaeli earthquake generated only small tsunami waves that caused no extensive damage to coastal structures. The tsunami hit close to highly populated areas, however. This is a cause of substantial concern, as there are hundreds of houses, hotels, and cafés within tens of meters of the coastline. Future earthquake hazard mitigation programs in Izmit Bay and the Sea of Marmara need to consider the hazards of tsunami waves, which may result from coseismic seafloor motion, underwater landslides, slumps, and subsidence

Spread of carbapenem-resistant international clones of Acinetobacter baumannii in Turkey and Azerbaijan: a collaborative study

WOS: 000385857700013PubMed ID: 27259712Epidemic clones of Acinetobacter baumannii, described as European clones I, II, and III, are associated with hospital epidemics throughout the world. We aimed to determine the molecular characteristics and genetic diversity between European clones I, II, and III from Turkey and Azerbaijan. In this study, a total of 112 bloodstream isolates of carbapenem-resistant Acinetobacter spp. were collected from 11 hospitals across Turkey and Azerbaijan. The identification of Acinetobacter spp. using conventional and sensitivity tests was performed by standard criteria. Multiplex polymerase chain reaction (PCR) was used to detect OXA carbapenemase-encoding genes (bla(OXA-23-like), bla(OXA-24-like), bla(OXA-51-like), and bla(OXA-58-like)). Pulsed-field gel electrophoresis (PFGE) typing was used to investigate genetic diversity. The bla(OXA-51-like) gene was present in all 112 isolates, 75 (67 %) carried bla(OXA-23-like), 7 (6.2 %) carried bla(OXA-58-like) genes, and 5 (4.5 %) carried bla(OXA-24-like) genes. With a 90 % similarity cut-off value, 15 clones and eight unique isolates were identified. The largest clone was cluster D, with six subtypes. Isolates from clusters D and I were widely spread in seven different geographical regions throughout Turkey. However, F cluster was found in the northern and eastern regions of Turkey. EU clone I was grouped within J cluster with three isolates found in Antalya, Istanbul, and Erzurum. EU clone II was grouped in the U cluster with 15 isolates and found in Kayseri and Diyarbakir. The bla(OXA-24-like) gene in carbapenemases was identified rarely in Turkey and has been reported for the first time from Azerbaijan. Furthermore, this is the first multicenter study in Turkey and Azerbaijan to identify several major clusters belonging to European clones I and II of A. baumannii.Erciyes University Scientific Research ProjectsErciyes University [BAP kodu 4059]This study was supported by Erciyes University Scientific Research Projects (BAP kodu 4059)

Spread of carbapenem-resistant international clones of Acinetobacter baumannii in Turkey and Azerbaijan: a collaborative study

Epidemic clones of Acinetobacter baumannii, described as European clones I, II, and III, are associated with hospital epidemics throughout the world. We aimed to determine the molecular characteristics and genetic diversity between European clones I, II, and III from Turkey and Azerbaijan. In this study, a total of 112 bloodstream isolates of carbapenem-resistant Acinetobacter spp. were collected from 11 hospitals across Turkey and Azerbaijan. The identification of Acinetobacter spp. using conventional and sensitivity tests was performed by standard criteria. Multiplex polymerase chain reaction (PCR) was used to detect OXA carbapenemase-encoding genes (bla(OXA-23-like), bla(OXA-24-like), bla(OXA-51-like), and bla(OXA-58-like)). Pulsed-field gel electrophoresis (PFGE) typing was used to investigate genetic diversity. The bla(OXA-51-like) gene was present in all 112 isolates, 75 (67 %) carried bla(OXA-23-like), 7 (6.2 %) carried bla(OXA-58-like) genes, and 5 (4.5 %) carried bla(OXA-24-like) genes. With a 90 % similarity cut-off value, 15 clones and eight unique isolates were identified. The largest clone was cluster D, with six subtypes. Isolates from clusters D and I were widely spread in seven different geographical regions throughout Turkey. However, F cluster was found in the northern and eastern regions of Turkey. EU clone I was grouped within J cluster with three isolates found in Antalya, Istanbul, and Erzurum. EU clone II was grouped in the U cluster with 15 isolates and found in Kayseri and Diyarbakir. The bla(OXA-24-like) gene in carbapenemases was identified rarely in Turkey and has been reported for the first time from Azerbaijan. Furthermore, this is the first multicenter study in Turkey and Azerbaijan to identify several major clusters belonging to European clones I and II of A. baumannii

Body mass index and complications following major gastrointestinal surgery: a prospective, international cohort study and meta-analysis.

AIM: Previous studies reported conflicting evidence on the effects of obesity on outcomes after gastrointestinal surgery. The aims of this study were to explore the relationship of obesity with major postoperative complications in an international cohort and to present a meta-analysis of all available prospective data. METHODS: This prospective, multicentre study included adults undergoing both elective and emergency gastrointestinal resection, reversal of stoma or formation of stoma. The primary end-point was 30-day major complications (Clavien-Dindo Grades III-V). A systematic search was undertaken for studies assessing the relationship between obesity and major complications after gastrointestinal surgery. Individual patient meta-analysis was used to analyse pooled results. RESULTS: This study included 2519 patients across 127 centres, of whom 560 (22.2%) were obese. Unadjusted major complication rates were lower in obese vs normal weight patients (13.0% vs 16.2%, respectively), but this did not reach statistical significance (P = 0.863) on multivariate analysis for patients having surgery for either malignant or benign conditions. Individual patient meta-analysis demonstrated that obese patients undergoing surgery for malignancy were at increased risk of major complications (OR 2.10, 95% CI 1.49-2.96, P < 0.001), whereas obese patients undergoing surgery for benign indications were at decreased risk (OR 0.59, 95% CI 0.46-0.75, P < 0.001) compared to normal weight patients. CONCLUSIONS: In our international data, obesity was not found to be associated with major complications following gastrointestinal surgery. Meta-analysis of available prospective data made a novel finding of obesity being associated with different outcomes depending on whether patients were undergoing surgery for benign or malignant disease