„Szekspir katolikiem?”. Odpowiedź na książkę Hildegard Hammerschmidt-Hummel

The text “Catholic Shakespeare?” is a response to the book of Hildegard Hammerschmidt-Hummel titled William Shakespeare – Sein Zeit – Sein Leben – Sein Werk (2003). E.A.J. Honigmann joins the debate about a secret Catholic code in Shakespeare’s plays. The researcher disagrees with some theses, for example with mysterious inscriptions in the English College at Rheims. He also tries to convince that Shakespeare’s Catholicism isn’t that obvious as Hammerschmidt-Hummel says.The text “Catholic Shakespeare?” is a response to the book of Hildegard Hammerschmidt-Hummel titled William Shakespeare – Sein Zeit – Sein Leben – Sein Werk (2003). E.A.J. Honigmann joins the debate about a secret Catholic code in Shakespeare’s plays. The researcher disagrees with some theses, for example with mysterious inscriptions in the English College at Rheims. He also tries to convince that Shakespeare’s Catholicism isn’t that obvious as Hammerschmidt-Hummel says

”Catholic Shakespeare?”. A response to Hildegard Hammerschmidt- Hummel’s book

The text “Catholic Shakespeare?” is a response to the book of Hildegard Hammerschmidt-Hummel titled William Shakespeare – Sein Zeit – Sein Leben – Sein Werk (2003). E.A.J. Honigmann joins the debate about a secret Catholic code in Shakespeare’s plays. The researcher disagrees with some theses, for example with mysterious inscriptions in the English College at Rheims. He also tries to convince that Shakespeare’s Catholicism isn’t that obvious as Hammerschmidt-Hummel says

Coarsening of Surface Structures in Unstable Epitaxial Growth

We study unstable epitaxy on singular surfaces using continuum equations with a prescribed slope-dependent surface current. We derive scaling relations for the late stage of growth, where power law coarsening of the mound morphology is observed. For the lateral size of mounds we obtain $\xi \sim t^{1/z}$ with $z \geq 4$. An analytic treatment within a self-consistent mean-field approximation predicts multiscaling of the height-height correlation function, while the direct numerical solution of the continuum equation shows conventional scaling with z=4, independent of the shape of the surface current.Comment: 15 pages, Latex. Submitted to PR

Does CDX2 expression predict Barrett's metaplasia in oesophageal columnar epithelium without goblet cells?

Background: Intestinal metaplasia (Barrett's oesophagus), but not cardiac-type mucosa in columnar-lined oesophagus, is regarded as premalignant. As intestinal metaplasia and cardiac-type mucosa are endoscopically indiscernible, it is difficult to take targeted samples from columnar-lined oesophagus with consequently a risk of having undetected intestinal metaplasia. Aim: To investigate whether the intestinal markers CDX2, MUC2 and villin can predict the presence of undetected intestinal metaplasia in columnar-lined oesophagus. Methods: Presence of intestinal metaplasia or cardiac-type mucosa was identified in 122 biopsy sets of columnar-lined oesophagus from 61 patients, collected at two subsequent follow-up upper endoscopies. CDX2, MUC2 and villin expression were determined by immunohistochemistry. Results: All intestinal metaplasia samples (55) were positive for CDX2 and MUC2 and 32 of 55 for vil

The Localization Transition of the Two-Dimensional Lorentz Model

We investigate the dynamics of a single tracer particle performing Brownian motion in a two-dimensional course of randomly distributed hard obstacles. At a certain critical obstacle density, the motion of the tracer becomes anomalous over many decades in time, which is rationalized in terms of an underlying percolation transition of the void space. In the vicinity of this critical density the dynamics follows the anomalous one up to a crossover time scale where the motion becomes either diffusive or localized. We analyze the scaling behavior of the time-dependent diffusion coefficient D(t) including corrections to scaling. Away from the critical density, D(t) exhibits universal hydrodynamic long-time tails both in the diffusive as well as in the localized phase.Comment: 13 pages, 7 figures

Effect of gluon-exchange pair-currents on the ratio G(E(P))/G(M(P))

The effect of one-gluon-exchange (OGE) pair-currents on the ratio $\mu_p G_E^p/G_M^p$ for the proton is investigated within a nonrelativistic constituent quark model (CQM) starting from $SU(6) \times O(3)$ nucleon wave functions, but with relativistic corrections. We found that the OGE pair-currents are important to reproduce well the ratio $\mu_p G_E^p/G_M^p$. With the assumption that the OGE pair-currents are the driving mechanism for the violation of the scaling law we give a prediction for the ratio $\mu_n G_E^n/G_M^n$ of the neutron.Comment: 5 pages, 4 figure

Selective inhibition of anti-MAG IgM autoantibody binding to myelin by an antigen-specific glycopolymer.

Anti-myelin-associated glycoprotein (MAG) neuropathy is a disabling autoimmune peripheral neuropathy that is caused by circulating monoclonal IgM autoantibodies directed against the human natural killer-1 (HNK-1) epitope. This carbohydrate epitope is highly expressed on adhesion molecules such as MAG, a glycoprotein present in myelinated nerves. We previously showed the therapeutic potential of the glycopolymer poly(phenyl disodium 3-O-sulfo-β-d-glucopyranuronate)-(1→3)-β-d-galactopyranoside (PPSGG) in selectively neutralizing anti-MAG IgM antibodies in an immunological mouse model and ex vivo with sera from anti-MAG neuropathy patients. PPSGG is composed of a biodegradable backbone that multivalently presents a mimetic of the HNK-1 epitope. In this study, we further explored the pharmacodynamic properties of the glycopolymer and its ability to inhibit the binding of anti-MAG IgM to peripheral nerves. The polymer selectively bound anti-MAG IgM autoantibodies and prevented the binding of patients' anti-MAG IgM antibodies to myelin of non-human primate sciatic nerves. Upon PPSGG treatment, neither activation nor inhibition of human and murine peripheral blood mononuclear cells nor alteration of systemic inflammatory markers was observed in mice or ex vivo in human peripheral blood mononuclear cells. Intravenous injections of PPSGG to mice immunized against the HNK-1 epitope removed anti-MAG IgM antibodies within less than 1 hr, indicating a fast and efficient mechanism of action as compared to a B-cell depletion with anti-CD20. In conclusion, these observations corroborate the therapeutic potential of PPSGG for an antigen-specific treatment of anti-MAG neuropathy. Read the Editorial Highlight for this article on page 465

The use of non-invasive stool tests for verification of Helicobacter pylori eradication and clarithromycin resistance

Background: Clarithromycin resistance of Helicobacter pylori (H. pylori) represents a major challenge in eradication therapy. In this study, we assessed if non-invasive stool tests can be used to verify successful H. pylori eradication and determine clarithromycin resistance. Materials and methods:In this prospective study, patients undergoing urea breath testing (UBT) for confirmation of H. pylori eradication were asked to collect the stool as both a dry fecal sample and fecal immunochemical test (FIT). Stool H. pylori antigen testing (SAT) was performed on these samples and assessed for its accuracy in eradication verification. Type and duration of antibiotic treatment were retrospectively collected from patient records and compared with clarithromycin resistance determined by PCR of stool samples. Results: H. pylori eradication information was available for a total of 145 patients (42.7% male, median age: 51.2). Successful eradication was achieved in 68.1% of patients. SAT on FIT samples had similar accuracy for eradication assessment compared to dry fecal samples, 72.1% [95% CI 61.4–81.2] versus 72.2% [95% CI 60.9–81.7]. Clarithromycin resistance rate was 13.4%. Conclusion: H. pylori antigen testing on FIT stool samples to verify H. pylori eradication is feasible and has similar accuracy as H. pylori antigen testing on dry stool samples. Dry stool, but not FIT, was suitable for non-invasive identification of H. pylori clarithromycin resistance by rt-PCR personalizing antibiotic treatment strategies without the need for invasive diagnostics is desirable, as the cure rate of first-line empirical H. pylori treatment remains low.</p