Coexistence in an African pastoral landscape: Evidence that livestock and wildlife temporally partition water resources

Funder: Department of Plant Sciences, University of OxfordFunder: Cincinnati Zoo and Botanical GardensFunder: Department of Zoology, University of OxfordFunder: Rob Walker GrantAbstract: African rangelands support substantial wildlife populations alongside pastoralists and livestock. Recent wildlife declines are often attributed to competition with livestock over water and grazing, in part because livestock are thought to spatially displace wildlife. However, more evidence is needed to understand this interaction and inform rangeland management. Here, we analysed the temporal overlap between wildlife and livestock at water points in a community‐governed area of Kenya's South Rift Valley, which is a dry season refuge where Maasai pastoralists, livestock and wildlife co‐occur. We used camera traps to capture images at water points in two time periods: first, when nearby settlements were unoccupied, and second, as people and their herds moved into the area. We measured wildlife activity (independent detections per hour) and the difference in temporal overlap between livestock and wildlife. We found no evidence that daily wildlife activity declined despite increased human and livestock settlement. However, temporal partitioning between livestock and wildlife at watering points increased with wildlife using water resources more at night. Maasai corral livestock overnight to protect them from predation, allowing wildlife to persist in a livestock‐dominated landscape. Our study demonstrates humans and wildlife co‐adapting to mitigate competition for shared water resources, thereby facilitating spatial coexistence

Dosage Parameters in Pediatric Outcome Studies Reported in 9 Peer-Reviewed Occupational Therapy Journals from 2008 to 2014: A Content Analysis

Occupational therapists determine the dosage when establishing the plan of care for their pediatric clients. A content analysis was conducted using 123 pediatric occupational therapy outcomes studies from 9 scholarly international occupational therapy journals. The parameters of dosage were calculated using descriptive statistics in order to obtain a representation of dosage available within the current collage of pediatric occupational therapy outcomes studies. The results revealed that most studies reported portions of dosage parameters within the published studies. The average findings for the subcomponents related to dosage were session length (minutes) M=58.7, duration of plan of care (weeks) M=12.1, session frequency (per week) M=3.4, and total hours of therapy (hours) M=18.1. This first attempt at describing and calculating dosage related to pediatric occupational therapy practice indicates that evidence is lacking within the published literature to adequately guide OT dosage decisions. Further research related to dosage in pediatric occupational therapy practice is needed

The Genetic Architecture of Depression in Individuals of East Asian Ancestry:A Genome-Wide Association Study

Importance: Most previous genome-wide association studies (GWAS) of depression have used data from individuals of European descent. This limits the understanding of the underlying biology of depression and raises questions about the transferability of findings between populations. Objective: To investigate the genetics of depression among individuals of East Asian and European descent living in different geographic locations, and with different outcome definitions for depression. Design, Setting, and Participants: Genome-wide association analyses followed by meta-analysis, which included data from 9 cohort and case-control data sets comprising individuals with depression and control individuals of East Asian descent. This study was conducted between January 2019 and May 2021. Exposures: Associations of genetic variants with depression risk were assessed using generalized linear mixed models and logistic regression. The results were combined across studies using fixed-effects meta-analyses. These were subsequently also meta-analyzed with the largest published GWAS for depression among individuals of European descent. Additional meta-analyses were carried out separately by outcome definition (clinical depression vs symptom-based depression) and region (East Asian countries vs Western countries) for East Asian ancestry cohorts. Main Outcomes and Measures: Depression status was defined based on health records and self-report questionnaires. Results: There were a total of 194548 study participants (approximate mean age, 51.3 years; 62.8% women). Participants included 15771 individuals with depression and 178777 control individuals of East Asian descent. Five novel associations were identified, including 1 in the meta-analysis for broad depression among those of East Asian descent: rs4656484 (β = -0.018, SE = 0.003, P = 4.43x10-8) at 1q24.1. Another locus at 7p21.2 was associated in a meta-analysis restricted to geographically East Asian studies (β = 0.028, SE = 0.005, P = 6.48x10-9 for rs10240457). The lead variants of these 2 novel loci were not associated with depression risk in European ancestry cohorts (β = -0.003, SE = 0.005, P =.53 for rs4656484 and β = -0.005, SE = 0.004, P =.28 for rs10240457). Only 11% of depression loci previously identified in individuals of European descent reached nominal significance levels in the individuals of East Asian descent. The transancestry genetic correlation between cohorts of East Asian and European descent for clinical depression was r = 0.413 (SE = 0.159). Clinical depression risk was negatively genetically correlated with body mass index in individuals of East Asian descent (r = -0.212, SE = 0.084), contrary to findings for individuals of European descent. Conclusions and Relevance: These results support caution against generalizing findings about depression risk factors across populations and highlight the need to increase the ancestral and geographic diversity of samples with consistent phenotyping.</p