Lessons on Tumour Response: Imaging during Therapy with 177Lu-DOTA-octreotate. A Case Report on a Patient with a Large Volume of Poorly Differentiated Neuroendocrine Carcinoma

Favourable outcomes of peptide receptor radiotherapy (PRRT) of neuroendocrine tumours have been reported during the last years. Still, there are uncertainties on the radionuclides to be used, the treatment planning, and the indication in patients with a high proliferation rate

Evolution of phosphorus speciation with depth in an agricultural soil profile

With time, different soil-forming processes such as weathering, plant growth, accumulation of organic matter, and cultivation are likely to affect phosphorus (P) speciation. In this study, the depth distribution of P species was investigated for an agricultural clay soil, Lanna, Sweden. Small amounts of apatite-P was demonstrated in the topsoil whereas the speciation of Pat 70-100 cm depth consisted of approximately 86% apatite according to P K-edge XANES (X-ray absorption near-edge structure) spectroscopy. Because there were only minor differences in bulk mineralogy and texture, these variations in P speciation were interpreted as the result of apatite weathering of the topsoil. Speciation modeling on soil extracts supported this idea: hydroxyapatite was not thermodynamically stable in the top 50 cm of the soil. Apatite was enriched in the bulk soil relative to the clay fraction, as expected during apatite dissolution. Combined results from batch experiments, XANES spectroscopy and X-ray diffraction suggested chemical transformations of the topsoil as a result from accumulation of organic matter and airing from tillage followed by enhanced weathering of apatite, amphiboles, clay minerals, and iron oxides. This caused the formation of poorly crystalline secondary iron and aluminum (hydr)oxides in the topsoil, which retained part of the released P from apatite. Other P was incorporated into organic forms. Furthermore, the results also showed that short-term acidification below the current pH value (below 5.5 in the topsoil and 7.2 in the deeper subsoil) caused significant solubilization of P. This is attributed to two different mechanisms: the instability of Al-containing sorbents (e.g. Al hydroxides) at low pH (in the topsoil), and the acid-mediated dissolution of apatite (the subsoil). (C) 2016 Elsevier B.V. All rights reserved

Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids

This is an expert consensus from the European Neuroendocrine Tumor Society recommending best practice for the management of pulmonary neuroendocrine tumors including typical and atypical carcinoids. It emphasizes the latest discussion on nomenclature, advances and utility of new diagnostic techniques as well as the limited evidence and difficulties in determining the optimal therapeutic strateg

Factors promoting health-related quality of life in people with rheumatic diseases: a 12 month longitudinal study

<p>Abstract</p> <p>Background</p> <p>Rheumatic diseases have a significant adverse impact on the individual from physical, mental and social aspects, resulting in a low health-related quality of life (HRQL). There is a lack of longitudinal studies on HRQL in people with rheumatic diseases that focus on factors promoting HRQL instead of risk factors. The aim of this study was to investigate the associations between suggested health promoting factors at baseline and outcome in HRQL at a 12 month follow-up in people with rheumatic diseases.</p> <p>Methods</p> <p>A longitudinal cohort study was conducted in 185 individuals with rheumatic diseases with questionnaires one week and 12 months after rehabilitation in a Swedish rheumatology clinic. HRQL was assessed by SF-36 together with suggested health factors. The associations between SF-36 subscales and the health factors were analysed by multivariable logistic regressions.</p> <p>Results</p> <p>Factors predicting better outcome in HRQL in one or several SF-36 subscales were being younger or middle-aged, feeling painless, having good sleep structure, feeling rested after sleep, performing low effort of exercise more than twice per week, having strong sense of coherence (SOC), emotional support and practical assistance, higher educational level and work capacity. The most important factors were having strong SOC, feeling rested after sleep, having work capacity, being younger or middle-aged, and having good sleep structure.</p> <p>Conclusions</p> <p>This study identified several factors that promoted a good outcome in HRQL to people with rheumatic diseases. These health factors could be important to address in clinical work with rheumatic diseases in order to optimise treatment strategies.</p

Observationsfält med lerjord

Soil samples from five of the observations fields belonging to the programme "Observations Fields on Arable Land" were characterised for phosphorus (P) solubility and sorption. P concentration increased with the extraction agent (method) in the following order: calcium chloride (P-CaCl2) < water (Pw) < hydrogen carbonate (Olsen-P) < ammonium lactate (P-AL) < hydrochloric acid (P-HCl) < nitric acid (P-HNO3). Phosphorus sorption index (PSI) was found to be closely related to the concentrations of iron (Fe) and aluminum (Al) extracted with oxalate (ox) and acid ammonium lactate (AL) for most soils (r=0.87 and r= 0.71 respectively). It may be possible to include PSI value in a relationship between P concentration in soil and P concentration in drainage water

Kunskapsöverföring : från individ till organisation

Individers specifika, inneboende kunskap har kommit att bli ett allt viktigare redskap för att generera konkurrensfördelar i dagens föränderliga samhälle. Det ställer därmed krav på ledningen att kunna hantera organisationens komplexa tillgång och främja kunskapsöverföring mellan organisationsmedlemmarna genom tillämpliga processer. Lyckas detta, bevaras kunskapen inom organisationen. Syftet med studien är att skapa en ökad förståelse för ledningsdrivna processer och aktiviteter som avser att omvandla individbaserad kunskap till organisatorisk kunskap.  Studien belyser ett antal olika kunskapsöverföringsprocesser som nyttjas av organisationer i praktiken. Face-to-face metoder har visat sig föredras vid överföring av kunskap särskilt den tysta kunskapen, medan de tekniska/virtuella verktygen anses vara till fördel vid informationsspridning. En central slutsats för studien är att en verbal tvåvägskommunikation, såsom fysiska möten och telefonkommunikation, är mest tillämplig vid förmedling av den tysta kunskapen. Ytterligare ett centralt bidrag är att den individbaserade kunskapens betydelse för organisationen inte är branschspecifik utan värdesätts och uppmärksammas likvärdigt mellan de studerade företagsledarna. Tidigare studier har dock fokuserat på kunskapsintensiva organisationer