14 research outputs found
A laboratory-scale annular continuous flow reactor for UV photochemistry using excimer lamps for discrete wavelength excitation and its use in a wavelength study of a photodecarboxlyative cyclisation
- Author
- Albini
- Albini
- Alder
- Amara
- Barberis
- Baumann
- Baxendale
- Baxendale
- Beke
- Bourne
- Cambié
- Carniti
- Carniti
- Carter
- Ciamician
- Clark
- Coyle
- Curzons
- Da Silva
- Darren S. Lee
- Davies
- Dionysiou
- Elliott
- Elliott
- Erica N. DeLaney
- Gandy
- Ghogare
- Griesbeck
- Griesbeck
- Griesbeck
- Griesbeck
- Griesbeck
- Griesbeck
- Griesbeck
- Han
- Henderson
- Hodgkinson
- Hook
- Horie
- Jing Jin
- Josland
- Jähnisch
- Kevin I. Booker-Milburn
- Knowles
- Kogelschatz
- Kärkäs
- Lee
- Levesque
- Luke D. Elliott
- Martyn Poliakoff
- Matafonova
- Michael W. George
- Noutsias
- Oelgemöller
- Oelgemöller
- Oelgemöller
- Oelgemöller
- Oelgemöller
- Okazaki
- Penders
- Poplata
- Pordanjani
- Protti
- Protti
- Ravelli
- Ravelli
- Romero
- Shvydkiv
- Shvydkiv
- Shvydkiv
- Skubi
- Sosnin
- Van Gerven
- Weng
- Yavorskyy
- Yoon
- Publication venue
- 'Royal Society of Chemistry (RSC)'
- Publication date
- 23/11/2016
- Field of study
This paper describes a new annular reactor for continuous UV photochemistry, which uses easily interchangeable excimer lamps of different wavelengths. The reactor has narrow clearance to form thin films of material for efficient irradiation of molecules. Its use is demonstrated by investigating the effect of discrete wavelength lamps (222, 282 and 308 nm) on the reaction of potassium N-phthalimidobutanoate 1. The ability of the reactor to be integrated into multistep processes is illustrated by combining it with an Amberlyst scavenger and a solid acid catalyst, NbOPO4, to access a second product 3 that is obtained in a single telescoped process. The tricyclic scaffold in 3 is a motif found in several biologically active compounds and has possibilities as a synthon for new pharmaceutical products
The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance
- Author
- Aanniz Tarek
- Abar Aden Elmi
- Abbad Anass
- Abdelfattah May
- Abdelhamid W.
- Abdella Saro
- Abdellah Faouzi
- Abdelmjid El Oualid
- Abdelmoula Fatma
- Abdelmoulah F.
- Abderrahmane Maaroufi
- Abderrazak Rfaki
- Abdillahi Idil Salah
- Abdissa Alemseged
- Abdo I.
- Abdoelraheem Mohamed Hassan
- Abe Haruka
- Abebe Markos
- Abechi Priscilla
- Abera Adugna
- Abi Rachid
- Abias Abe G.
- Abichu Getachew
- Abid N.
- Abid Nabil
- Abid Salma
- Abilio Nuro
- Abimbola Sharon
- Abo Shama Noura M
- Abosede O.
- Aboubaker Mohamed Houmed
- Abouelhoda Mohamed
- Abouelnaga S.
- Abualas Elamin
- Abubeker Ramalia Chabi
- Abuelenein Ehab Abdelkader
- Abuzaid Nadir
- Abworo Edward O.
- Ada Diosdado Odjama Nseng
- Addidle Michael
- Adegbola Richard
- Adegnika Akim A.
- Adegnika Ayola Akim
- Adel Abd Monaem
- Adeniji Johnson A.
- Adepetun Tomiwa
- Adesegun A.
- Adesuyi Omoare
- Adetifa Ifedayo M. O.
- Adewumi Olubusuyi M.
- Adewumi Oluwatimilehin
- Adewumi Praise
- Adeyemi Kayode T.
- Adhikari Bishwo N.
- Adil El Hamouchi
- Adjiratou Aissatou B. A.
- Adnew Bethlehem
- Adu Bright
- Adu Eric
- Adusei-Poku Mildred
- Agbenyo Seyram Bless
- Agbodzi B.
- Ageez A.M.
- Agoti Charles N.
- Aguenaou Hassan
- Agwa Sara Hassan
- Agweyu Ambrose
- Ahmed El Bara
- Ahmed Elhadi A.
- Ahmed Hatem
- Ahmed M.
- Ahmed O. S.
- Ahmed Rahma
- Ahmed Shymaa S.
- Ahmed Side Mohamed
- Ahmed Yahaya Ali
- Ahouidi Ambroise
- Ahuka-Mundeke Steve
- Ahumibe Anthony
- Ahyong Vida
- Aissam El Aliani
- Ajayi Nnennaya A.
- Ajibaye Solomon
- Ajili F.
- Ajogbasile F.V.
- Ajogbasile Fehintola V.
- Akanbi Olusola Anuoluwapo
- Akenji Blaise MBoringong
- Akhoud Youssef
- Akinola Monilade
- Akogbeto Petas
- Akoua-Koffi Chantal G.
- Akpede George O.
- Al Onifade Fattah
- Alain Etoundi Mballa
- Alaoui Afaf
- Alaoui-Amine Sanaa
- Alarif Ahlam
- Alaruusi A. M.
- Albert Mélanie
- AlEmam Adba Alfatih
- Alemayehu Dawit Hailu
- Alemu Fekadu
- Algheriani Raiva
- Ali Abraham
- Ali M.A.
- Ali Mohamed Ahmed
- Ali Mushal
- Ali Wael
- Alkarim Mona O.A.
- Allam Loubna
- Allam Mushal
- Allam Mushal
- Altamura Settimia
- Amar Narjis
- Amenga-Etego Lucas N.
- Amer K. E.
- Amer Khaled
- Amira Souissi
- Amoako Daniel G.
- Amoo Olufemi Samuel
- Amoth Patrick
- Amougou Marie
- Ampofo William K.
- Amuri Adrienne A.
- Amuzu Dominic S. Y.
- Amzazi Saaïd
- Anang Abraham Kwabena
- Anas Abbad
- Andeko Julia C.
- Andersen Kristian
- Andersson Hana Sofia
- Andika Brian
- Andres Moreira-Soto
- Andriam Soa Fy
- Andriamandimby Soa Fy
- Anga Latifa
- Ange Dossou
- Angelov Angel
- Anna-Lena Sander
- Annajr B.
- Anoh Etilé A.
- Anscombe Catherine
- Antwerpen Markus H.
- Anu Campbell
- Anyaneji Ugochukwu J.
- Anyika Chinyere
- Aouni M.
- Appiah Vincent
- Appiah-Kubi Joyce
- Arena Fabio
- Arjaquah Augustina
- Arjarquah A.
- Armand Edang-Minko
- Armanious Riad Mounir
- Armoo Samuel
- Arnaldo Paulo
- Arnold Catherine E.
- Arrouchi Housna
- Artesi Maria
- Aryeetey Sherihane
- Asamoah Jesse Addo
- Asante Ivy A.
- Asare K.M.
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- Assoumou Samira Zoa
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- Auld A.
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- JOEL Ireoluwa Yinka
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- Kalantar K.
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- Kandeil Ahmed
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- Kanyerezi Stephen
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- Kapata P.C.
- Kapaya F.
- Kapin'a M.
- Karidioula Safiatou
- Karim Wasim Abdul
- Karray Hakim H.
- Karray Hela
- Kartti Souad
- Kasambara W.
- Kasmy Zohour
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- Kassim Samar Kamal
- Katabazi Ashaba Fred
- Katagirya Eric
- Kateete David Patrick
- Katyshev A.D.
- Kavunga-Membo Hugo
- Kay Gemma L.
- Kayali Ghazi
- Kayed Ahmed E
- Kayeyi N.
- Kayiwa John T.
- Kayuki Charles
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- Khalifa Mohamed K.
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- Kone Amadou
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- Krasnov Ya.M.
- Kritsky A.A.
- Kujabi Mariama
- Kumordjie Selassie
- Kutkat Omnia
- Kutyrev V.V.
- Kwasah Lorreta
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- Yusuf Nyam Itse
- Yusuf Yacob Mohamed
- Zablon J. Matoke D.
- Zablon J.O.
- Zaher Tarek Refaat Elnagdy Raafat
- Zahra El Ansari Fatima
- Zahran Manal Hamdy
- Zekri Abdel-Rahman N.
- Zhang J.
- Zhou Pei
- Zinyowera Sekesai
- Zong Minko O.
- Zongo Arsène
- Zorgani A.
- Zouaki Amal
- Zulu P.
- Zumla Ali
- Zumla Alimuddin
- Zuze Boitumelo
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 07/10/2022
- Field of study
INTRODUCTION
Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoundly affected how public health officials in Africa have navigated the COVID-19 pandemic.
RATIONALE
We demonstrate how the first 100,000 SARS-CoV-2 sequences from Africa have helped monitor the epidemic on the continent, how genomic surveillance expanded over the course of the pandemic, and how we adapted our sequencing methods to deal with an evolving virus. Finally, we also examine how viral lineages have spread across the continent in a phylogeographic framework to gain insights into the underlying temporal and spatial transmission dynamics for several variants of concern (VOCs).
RESULTS
Our results indicate that the number of countries in Africa that can sequence the virus within their own borders is growing and that this is coupled with a shorter turnaround time from the time of sampling to sequence submission. Ongoing evolution necessitated the continual updating of primer sets, and, as a result, eight primer sets were designed in tandem with viral evolution and used to ensure effective sequencing of the virus. The pandemic unfolded through multiple waves of infection that were each driven by distinct genetic lineages, with B.1-like ancestral strains associated with the first pandemic wave of infections in 2020. Successive waves on the continent were fueled by different VOCs, with Alpha and Beta cocirculating in distinct spatial patterns during the second wave and Delta and Omicron affecting the whole continent during the third and fourth waves, respectively. Phylogeographic reconstruction points toward distinct differences in viral importation and exportation patterns associated with the Alpha, Beta, Delta, and Omicron variants and subvariants, when considering both Africa versus the rest of the world and viral dissemination within the continent. Our epidemiological and phylogenetic inferences therefore underscore the heterogeneous nature of the pandemic on the continent and highlight key insights and challenges, for instance, recognizing the limitations of low testing proportions. We also highlight the early warning capacity that genomic surveillance in Africa has had for the rest of the world with the detection of new lineages and variants, the most recent being the characterization of various Omicron subvariants.
CONCLUSION
Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve. This is important not only to help combat SARS-CoV-2 on the continent but also because it can be used as a platform to help address the many emerging and reemerging infectious disease threats in Africa. In particular, capacity building for local sequencing within countries or within the continent should be prioritized because this is generally associated with shorter turnaround times, providing the most benefit to local public health authorities tasked with pandemic response and mitigation and allowing for the fastest reaction to localized outbreaks. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
- Author
- ?ivko Iris
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Nick
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Adhikari Sheetal
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Enezi Farhan
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderman Meera
- Aldo Bonizzoni Matteo
- Alegria Ana
- Alessandro Carà Gianmarco
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Almeshhedani Hasham
- AlQahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Al Amri Ali
- Al Qasim Eman
- Amatya Sameena
- Ambrosino Richard
- Anderson Thomas
- Andreae Mark
- Aneman Anders
- Angus Derek C.
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Aquino Maia
- Arabi Yaseen M.
- Arachchige Malka
- Aravindan Latha
- Arbane Gill
- Archambault Patrick
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arias Sonia
- Arishi Hatim
- Arnold Donald
- Arnold John
- Arnott Andrew
- Arora Anand
- Aryal Diptesh
- Asghar Adeeba
- Asif Namra
- Aspinwall Angelique
- Attokaran Antony
- Attwood Ben
- Au Carly
- Audry Mathilde
- Austin Karen
- Austin Pauline
- Auvet Adrien
- Avard Bronwyn
- Awan Sidra
- Ayee Robert
- Azaiz Amine
- Azzaui Harun
- Babu Suresh
- Bacon Gina
- Badalamenti Salvatore
- Badie Julio
- Bagavathy Kavitha
- Bagot Catherine
- Bagshaw Sean
- Baig Nadia
- Baikady Ravishankar
- Bailey Lucy
- Baillie Kenneth
- Bain William
- Baker Alice
- Baker Evelyn
- Baker Stuart
- Bakthavatsalam Dhanalakshmi
- Balaie Morteza
- Balls-Burgess Sam
- Bamford Amy
- Bamford Peter
- Banach Dorota
- Bannard-Smith Jonathan
- Barbash Ian
- Barber Russell
- Barbier François
- Barge Deborah
- Bariola Ryan
- Barker Gareth
- Barker Stephanie
- Barnes Nicky
- Baron Rebecca M.
- Barreau Amelie
- Barreau Amélie
- Bart Robert
- Bartholomew Jazz
- Bartley Shauna
- Barton David
- Barton Frances
- Bashyal Archana
- Basile Kim
- Bass Frances
- Bassford Christopher
- Bastos Joana Margarida Pereira Sousa
- Bates Michelle
- Bates Samantha
- Batista Teresa Margarida Oliveira
- Bauchmuller Kris
- Bayne Madeleine
- Bean Sarah
- Beane Abi
- Beane Abigail
- Beard Gregory
- Beasley Richard
- Beaudoin Rosalie
- Beavis Sarah
- Beddows Seonaid
- Bedford Caroline
- Beer Deborah
- Beer Sally
- Begin Phillipe
- Begum Salma
- Bell Gillian
- Bellemare David
- Belletti Allesandro
- Bendjemar Lynda
- Benettaib Fatna
- Bensen Nicole
- Bentley Andrew
- Benyon Sarah
- Benzekri Dalila
- Beqai Besa
- Berdaguer Fernando
- Beresford Stephanie
- Bergin Colin
- Berry Lindsay R.
- Berry Scott
- Berryman Emily
- Bertel Melanie
- Best-Lane Janis
- Besten Henny
- Bevan Emily
- Bewley Jeremy
- Beyerl Ashley
- Bhagani Sanjay
- Bhandal Khushpreet
- Bharaj Kiranjit
- Bhattarai Bina
- Bhattarai Binita
- Bhonagiri Deepak
- Biddie Simon
- Bigas Judit
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- Bradley Paul
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- Brunkhorst Frank M.
- Brunskill Nigel
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- Castle James
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- Catorze Nuno José Teodoro Amaro dos Santos
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- Cecconi Maurizio
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- Charlton Sam
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- Chartier Delphine
- Chasse Michael
- Chassé Michaël
- Chen Jonathan
- Chen Lixian
- Chen Yan
- Cheng Allen C.
- Cherian Shiney
- Chhablani Manish
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- Ciccarelli Michele
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- Daugherty Jason
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- Da Rocha Joana
- De Bus Liesbet
- de Courcy-Golder Kim
- de Groot Klaas
- de Jong Menno
- de Jonge Evert
- De Keulenaer Bart
- de la Torre Cisneros Julian
- de Man Angelique
- De Neef Mark
- De Smeytere Anouska
- Deacon Bethan
- Dean Steven
- Dean Tessa
- Dearden Joy
- Dechert William
- Declercq Pierre-Louis
- Degracia Anna
- del Sorbo Lorenzo
- Dela Rosa Arnold
- Delaney Kirsha
- Dell Abbie
- del Prado Michael
- Demetriou Carrie
- Dempster Debra
- Denham Lynn
- Denmade Craig
- Dent Martin
- Depante Maria
- Depuydt Pieter
- Dequin Pierre-François
- Derde Lennie P. G.
- Deshpande Kush
- Detry Michelle A.
- Deye Nicolas
- de la Fuente Carmen
- De Waele Jan
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- van de Veerdonk Frank L.
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- Woodward Robert
- Woolett Melissa
- Worner Ruth
- Wren Jess
- Wren Lynn
- Wrey Brown Caroline
- Wright Chris
- Wright Kim
- Wunderley Renee
- Wyatt Rachel
- Wylie Katharine
- Xavier Kugan
- Yamagishi Yoshiaki
- Yamashita Chizuru
- Yang Yang
- Yarad Elizabeth
- Yates Bryan
- Yates David
- Yealy Donald
- Young Ian
- Young Meredith
- Young Paul
- Youngstein Taryn
- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zarychanski Ryan
- Zdanavidiene Ausra
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
Single exon-resolution targeted chromosomal microarray analysis of known and candidate intellectual disability genes
- Author
- A Behnecke
- AJ Sharp
- Allen Delaney
- AM Lehman
- B Wisniowiecka-Kowalnik
- C Lee
- DA Koolen
- David Chai
- DF Conrad
- DT Miller
- Emmanuelle Lemyre
- Erica Tsang
- EV Haverfield
- Fadi F Hamdan
- Farah R Zahir
- FF Hamdan
- FF Hamdan
- FF Hamdan
- FR Zahir
- HH Ropers
- J Chelly
- J Friedman
- JA Bailey
- Jacques L Michaud
- Jan M Friedman
- JK Inlow
- KJ Franek
- LE Vissers
- LG Shaffer
- LJ Wong
- M Griffith
- Malachi Griffith
- Marco Marra
- MK Tayeh
- MS Ching
- N de Leeuw
- N Le Meur
- P Dhami
- Patrice Eydoux
- PM Boone
- RM Nascimento
- RV Davuluri
- S Jaillard
- S Yu
- Sylvia Dobrzeniecka
- Sylvie Langlois
- T Tucker
- Tracy Tucker
- Y Saillour
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging
- Author
- Adrienne M. Wang
- Amrita Solanky
- Anna Shemorry
- Annie Chia-Zong Chou
- Anthony S. Castanza
- Ariana A. Rodriguez
- Arieanna Anies
- Benjamin L. Spector
- Bie Nga Tchao
- Bopharoth Ros
- Brady Olsen
- Brett Robison
- Brian Muller
- Brian K. Kennedy
- Brian M. Wasko
- Caballero
- Chen
- Chiocchetti
- Christopher F. Bennett
- Christopher J. Murakami
- Curran
- Dan Lockshon
- Daniel Carr
- Delaney
- Delaney
- Delaney
- Delaney
- Dennis Wang
- Di Hu
- Diana Kim
- Diana N. Pak
- Dillon Pruett
- Dilreet Rai
- Donna Prunkard
- Elijah Johnston
- Elroy An
- Emily O. Kerr
- Eric Liao
- Erica D. Smith
- Eric A. Westman
- Eunice Choi
- Fontana
- Garigan
- Gentzsch
- George L. Sutphin
- Ghavidel
- Guarente
- Haldane
- Hansen
- Harada
- Harrison
- Helen Vander Wende
- Herndon
- Hillary A. Miller
- Hutzler
- Imai
- Jennifer Schleit
- Jessica Hui
- Jin Kim
- Joe R. Delaney
- Johnson
- Jonathan Oakes
- Juniper K. Pennypacker
- K. Linnea Welton
- Kaeberlein
- Kaeberlein
- Kaeberlein
- Kaeberlein
- Katie Kirkland
- Katie Snead
- Kenyon
- Ki-Soo Jeong
- Kim M. Pham
- Kristan K. Steffen
- Kruegel
- Labunskyy
- Lapierre
- Lee
- Li
- Li
- Lin
- Lindsay Fox
- Longo
- MacKay
- Manpreet K. Singh
- Marc K. Ting
- Marissa Fletcher
- Mark A. McCormick
- Matt Kaeberlein
- Mayeux
- McCormick
- Medawar
- Michael Lim
- Michael Sage
- Michael S. Lin
- Mitchell
- Mitsuhiro Tsuchiya
- Molly A. Holmberg
- Monika Jelic
- Morley
- Nick Dang
- Olsen
- Ostlund
- Pierce
- Prarthana Pradeep
- Qiu
- Quan
- Rachel B. Brem
- Ramos
- Richard M. Moller
- Richard P. Beyer
- Samara
- Sarani Goswami
- Sarkar
- Schroeder
- Schroeder
- Scott Tsuchiyama
- Sean A. Higgins
- Searle
- Shaheen
- Shannon Klum
- Shiena Enerio
- Simms
- Simon C. Johnson
- Smith
- Smith
- Soumya Kotireddy
- Steffen
- Steffen
- Steffen
- Steinkraus
- Sylvia Sim
- Tanaka
- Teixeira
- Theodor K. Bammler
- Tom G. Pollard
- Umema Ahmed
- Warde-Farley
- Weinberger
- Wilcoxon
- Winston C. Lo
- Winzeler
- Xin-guang Liu
- Yang
- Yanos
- Yao
- Yousin Suh
- Zhao
- Zhao Jun Peng
- Zhongjun Zhou
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Electronic health record design and implementation for pharmacogenomics: a local perspective
- Author
- A Shabo Shvo
- AH Ramirez
- AR Shuldiner
- B Chaudhry
- D Blumenthal
- D Trenk
- DA Hesselink
- Dan M. Roden
- EH Shortliffe
- Erica Bowton
- J Starren
- JA Johnson
- JA Johnson
- JA Johnson
- JC Denny
- JE Higgs
- Jennifer Mitchell
- Jill M. Pulley
- Jim N. Jirjis
- JK Hicks
- JL Mega
- JM Pulley
- Jonathan Schildcrout
- Josh C. Denny
- Josh F. Peterson
- JS Hulot
- JS Schildcrout
- JT Delaney
- Julie R. Field
- Kevin Johnson
- M Samwald
- Marc Beller
- MV Relling
- MV Relling
- NF Noy
- NS Ferder
- PH O’Donnell
- Q Zeng
- Q Zhu
- R Marcucci
- RA Wilke
- RA Wilke
- RB Altman
- RR Gullapalli
- S Silow-Carroll
- SA Scott
- SD Wiviott
- SEARCH Collaborative Group
- SR Ghate
- The International Warfarin Pharmacogenetics Consortium
- William Gregg
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
The quality of the evidence base for clinical pathway effectiveness: Room for improvement in the design of evaluation trials
- Author
- AD Brook
- Andreas Machotta
- BJ Smith
- BW Warner
- CP Delaney
- CS Kelly
- D Henry
- D Sulch
- D Sulch
- D Summers
- DM Smith
- E Crunden
- EF Philbin
- Erica James
- Ewout W Steyerberg
- Excel
- G Brattebo
- GA Joiner
- GP Marelich
- H Campbell
- H Yamauchi
- HJ Joh
- J Kimberly
- JA Falconer
- JJ Deeks
- JP Bittinger
- JP Pestian
- K Turley
- K Usui
- KB Johnson
- L Bero
- L Kinsman
- Leigh Kinsman
- M Bookbinder
- M Borenstein
- MA Gomez
- MD Walsh
- MG Cole
- MH Kim
- MH Kollef
- MM Dowsey
- MS Bauer
- N Board
- P Kampan
- PF Choong
- PH Perlstein
- Review-Manager
- RR Roberts
- S Doherty
- S Greenland
- S Namiki
- SD Wilson
- SH Chen
- SJ Card
- T Abe
- T Aizawa
- T Kiyama
- T Ogawa
- T Rotter
- Thomas Rotter
- TJ Marrie
- VP Tilden
- Y Chadha
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Genome-Wide Association Study of Serum Creatinine Levels during Vancomycin Therapy
- Author
- A Kottgen
- A Köttgen
- A Marsot
- A Wong-Beringer
- Amy L. Potts
- Ben R. Saville
- BN Howie
- C Pattaro
- C. Buddy Creech
- CA McCarty
- Christian M. Shaffer
- CJ Willer
- D Deck
- Dan M. Roden
- Dana C. Crawford
- DC Crawford
- DF Gudbjartsson
- Digna R. Velez Edwards
- DM Roden
- E Bowton
- E Yaoita
- Erica A. Bowton
- Farook Thameem
- H Ishikawa
- Hayan Jouni
- Iftikhar J. Kullo
- J Marchini
- J Toubas
- J Yao
- JC Chambers
- JE Murphy
- Jessica T. Delaney
- JK Pritchard
- Josh C. Denny
- Kyle B. Brothers
- Lana M. Olson
- LK Hidayat
- M Rybak
- Murray Brilliant
- N Adly
- Neelam Patel
- PA Harris
- Prince J. Kannankeril
- Richard H. Ho
- S Elyasi
- S Purcell
- Sara L. Van Driest
- Sarah Wilson
- Scott J. Hebbring
- Susan I. Vear
- Terrie E. Kitchner
- Tracy L. McGregor
- X Gao
- X Gao
- Yuki Bradford
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging
- Author
- Ahmed Umema
- An Elroy
- Anies Arieanna
- Bammler Theodor K
- Bennett Christopher F
- Beyer Richard P
- Brem Rachel B
- Carr Daniel
- Castanza Anthony S
- Choi Eunice
- Chou Annie Chia-Zong
- Dang Nick
- Delaney Joe R
- Enerio Shiena
- Fletcher Marissa
- Fox Lindsay
- Goswami Sarani
- Higgins Sean A
- Holmberg Molly A
- Hu Di
- Hui Jessica
- Jelic Monika
- Jeong Ki-Soo
- Johnson Simon C
- Johnston Elijah
- Kaeberlein Matt
- Kennedy Brian K
- Kerr Emily O
- Kim Diana
- Kim Jin
- Kirkland Katie
- Klum Shannon
- Kotireddy Soumya
- Liao Eric
- Lim Michael
- Lin Michael S
- Liu Xin-guang
- Lo Winston C
- Lockshon Dan
- McCormick Mark A
- Miller Hillary A
- Moller Richard M
- Muller Brian
- Murakami Christopher J
- Oakes Jonathan
- Olsen Brady
- Pak Diana N
- Peng Zhao Jun
- Pennypacker Juniper K
- Pham Kim M
- Pollard Tom G
- Pradeep Prarthana
- Pruett Dillon
- Prunkard Donna
- Rai Dilreet
- Robison Brett
- Rodriguez Ariana A
- Ros Bopharoth
- Sage Michael
- Schleit Jennifer
- Shemorry Anna
- Sim Sylvia
- Singh Manpreet K
- Smith Erica D
- Snead Katie
- Solanky Amrita
- Spector Benjamin L
- Steffen Kristan K
- Suh Yousin
- Sutphin George L
- Tchao Bie Nga
- Ting Marc K
- Tsuchiya Mitsuhiro
- Tsuchiyama Scott
- Wang Adrienne M
- Wang Dennis
- Wasko Brian M
- Welton K Linnea
- Wende Helen Vander
- Westman Eric A
- Zhou Zhongjun
- Publication venue
- eScholarship, University of California
- Publication date
- 01/11/2015
- Field of study
Many genes that affect replicative lifespan (RLS) in the budding yeast Saccharomyces cerevisiae also affect aging in other organisms such as C. elegans and M. musculus. We performed a systematic analysis of yeast RLS in a set of 4,698 viable single-gene deletion strains. Multiple functional gene clusters were identified, and full genome-to-genome comparison demonstrated a significant conservation in longevity pathways between yeast and C. elegans. Among the mechanisms of aging identified, deletion of tRNA exporter LOS1 robustly extended lifespan. Dietary restriction (DR) and inhibition of mechanistic Target of Rapamycin (mTOR) exclude Los1 from the nucleus in a Rad53-dependent manner. Moreover, lifespan extension from deletion of LOS1 is nonadditive with DR or mTOR inhibition, and results in Gcn4 transcription factor activation. Thus, the DNA damage response and mTOR converge on Los1-mediated nuclear tRNA export to regulate Gcn4 activity and aging
Oxidative Stress and Inflammation, Key Targets of Atherosclerotic Plaque Progression and Vulnerability: Potential Impact of Physical Activity
- Author
- A Callegari
- A Millon
- A-L Yang
- AB Fraile-Bermúdez
- AC Montezano
- AC Toledo-Arruda
- AE Vendrov
- AF Rubio-Guerra
- AK Khanna
- Antoine Millon
- AP Burke
- AS Schmidt-Trucksäss
- AW Gardner
- AW Gardner
- B Brüne
- BJ Dunmore
- BK Pedersen
- BL Horta
- C Anderson
- C Cardillo
- C Forbes
- C Silvestre-Roig
- C Weber
- CAJ Farquharson
- CB Breneman
- CL Delaney
- CP Chan
- Cris A. Slentz
- D Skrypnik
- D Sorescu
- DA Chistiakov
- DK Bowles
- E Hopps
- E Stamatakis
- E Zorba
- EA Nikkilä
- Earl S. Ford
- Emmanuelle Canet-Soulas
- Erica N. Chirico
- ES Kim
- F Cesari
- F Cosentino
- F Giallauria
- F He
- F Mattusch
- F Sigala
- F Sofi
- G Brenes
- G Turc
- G Vogiatzi
- G Yakeu
- G Zoppini
- GM Rubanyi
- H Li
- H Miyazaki
- H Palmefors
- H Tanaka
- H Tanaka
- H-H Lu
- Herbert C. Stary
- HM Dansky
- I Tabas
- IH Zucker
- J Frostegård
- J George
- J Golledge
- J Khallou-Laschet
- J Pelisek
- J Rius
- J Szostak
- J Wesnigk
- J Xue
- J-J Chiu
- J-S Wang
- J.-B. Michel
- JA Berlin
- JA Forsythe
- JA Vita
- JC Sluimer
- JC Sluimer
- JD Favor La
- JG Dickhout
- JK Brunelle
- JK Smith
- JN Redgrave
- JWE Rush
- K E Powell
- K Iiyama
- K Saito
- KJ Moore
- KS Pälve
- L Badimon
- L Ghiadoni
- L Li
- L Saba
- LA Lesniewski
- LM Sanmarco
- Loreana Sanches Silveira
- LR Silva
- M Fleiner
- M Hamer
- M Kargarfard
- M Krause
- M Kwaśniewska
- M Marnane
- M Nishitani-Yokoyama
- M Pigłowska
- M Ried-Larsen
- M Sadowski
- M Sandrock
- M-A Ewart
- M-L Mono
- Mathilde Mura
- MC Bourdillon
- MD Gross
- ME Widlansky
- MH Laughlin
- MI Cybulsky
- Minkyung Kim
- MJ LaMonte
- MJ Mihm
- ML Bots
- ML Bots
- MM Mughal
- Mohammed S. Ellulu
- MR Dasu
- MY Desai
- N Ahn
- N Ferrara
- N Inoue
- N Kawanishi
- N Takaya
- N Takaya
- NP Greene
- NPE Kadoglou
- O Beloqui
- O Kilic-Erkek
- ON Okafor
- P Gao
- P Libby
- P Moustardas
- P Pacher
- P Schnohr
- Pauline Mury
- PD Thompson
- PJ Gough
- PJ Kuhlencordt
- PJ Mills
- PJ Murray
- PK Shah
- PK Shah
- PM Ridker
- PN Herbert
- R Elosua
- R Hambrecht
- R Hambrecht
- R Hambrecht
- R Hutter
- R Rauramaa
- R Rauramaa
- R Rowiński
- R Semple
- R Tian
- R Virmani
- RA Stein
- RAK Srivastava
- RD Rudic
- RD Stout
- RG Collins
- RH Kampmeier
- RJ Bloomer
- RJ Gryglewski
- RJ Valentine
- S Baldus
- S Chuaiphichai
- S Ebrahim
- S Gielen
- S Gordon
- S Lee
- S Mora
- S Spiekermann
- S Steven
- S Taleb
- S-M Shon
- SA Anderssen
- SF Crouse
- SM McCarthy
- SP Gieseg
- SY Chan
- SY Jae
- T Kizaki
- T Nishiguchi
- T Ookawara
- T Pischon
- TA Lakka
- TJ Guzik
- U Laufs
- V Adams
- V Nizet
- V Pialoux
- Vincent Pialoux
- VS Soumyarani
- W Martinet
- Walter Swardfager
- X Geeraerts
- Y Huo
- Y Li
- Y Nakashima
- Y-M Go
- Z Radak
- Z Yu
- ZM Dong
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study