Octavian and Egyptian Cults: Redrawing the Boundaries of Romanness

Octavian's decision in 28 B.C.E. to ban Egyptian cults from within the pomerium was not a sign of hostility to foreign cults, especially since the emperor himself arranged for the restoration of those shrines outside the city's religious boundary. Rather, his action served to reassert the Roman openness to foreign religions while at the same time underlining the distinctions between Roman and foreign religious practices. Using the pomerium to demarcate a clear boundary between Roman and non-Roman helped to reconstruct the sense of Roman identity that had been shattered by the civil wars of the previous fifty years

Augustan Religion and the Reshaping of Roman Memory

This paper argues that the Augustan period witnessed a dramatic reconception of Roman religion—a reconception that played a vital role in the emperor's efforts to create a unified sense of identity that included both Romans and Italians. Instead of a religion of place tied to specific historical developments, both Virgil in the Aeneid and Augustus in his rebuilding of the eighty-two temples emphasized religious practices ordained by a single authoritative figure and connected to pre-Roman Italy. The reconstruction program reshaped Roman memory as well as the physical city, because Roman temples served not only as religious sites, but also as monuments in which Roman memories and Roman history resided. This reordering of Roman topographical and chronological space thus linked Roman identity not to the history of expansionist Rome over the previous 500 years, but rather to Augustan Rome and its fuller inclusiveness of Italy

Investigation of the influence of calibration practices on cytogenetic laboratory performance for dose estimation

Purpose: In the frame of the QA program of RENEB, an inter-laboratory comparison (ILC) of calibration sources used in biological dosimetry was achieved to investigate the influence of calibration practices and protocols on the results of the dose estimation performance as a first step to harmonization and standardization of dosimetry and irradiation practices in the European biological dosimetry network. Materials and methods: Delivered doses by irradiation facilities used by RENEB partners were determined with EPR/alanine dosimetry system. Dosimeters were irradiated in the same conditions as blood samples. A short survey was also performed to collect the information needed for the data analysis and evaluate the diversity of practices. Results: For most of partners the deviation of delivered dose from the targeted dose remains below 10%. Deviations larger than 10% were observed for five facilities out of 21. Origins of the largest discrepancies were identified. Correction actions were evaluated as satisfactory. The re-evaluation of some ILC results for the fluorescence in situ hybridization (FISH) and premature chromosome condensation (PCC) assays has been performed leading to an improvement of the overall performances. Conclusions: This work has shown the importance of dosimetry in radiobiology studies and the needs of harmonization, standardization in irradiation and dosimetry practices and educational training for biologists using ionizing radiation

A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants.

This is the author accepted manuscript. The final version is available from Nature Publishing Group via http://dx.doi.org/10.1038/ng.3448Advanced age-related macular degeneration (AMD) is the leading cause of blindness in the elderly, with limited therapeutic options. Here we report on a study of >12 million variants, including 163,714 directly genotyped, mostly rare, protein-altering variants. Analyzing 16,144 patients and 17,832 controls, we identify 52 independently associated common and rare variants (P < 5 × 10(-8)) distributed across 34 loci. Although wet and dry AMD subtypes exhibit predominantly shared genetics, we identify the first genetic association signal specific to wet AMD, near MMP9 (difference P value = 4.1 × 10(-10)). Very rare coding variants (frequency <0.1%) in CFH, CFI and TIMP3 suggest causal roles for these genes, as does a splice variant in SLC16A8. Our results support the hypothesis that rare coding variants can pinpoint causal genes within known genetic loci and illustrate that applying the approach systematically to detect new loci requires extremely large sample sizes.We thank all participants of all the studies included for enabling this research by their participation in these studies. Computer resources for this project have been provided by the high-performance computing centers of the University of Michigan and the University of Regensburg. Group-specific acknowledgments can be found in the Supplementary Note. The Center for Inherited Diseases Research (CIDR) Program contract number is HHSN268201200008I. This and the main consortium work were predominantly funded by 1X01HG006934-01 to G.R.A. and R01 EY022310 to J.L.H