249 research outputs found
Bubbles and jackets: new scaling bounds in topological group field theories
We use a reformulation of topological group field theories in 3 and 4
dimensions in terms of variables associated to vertices, in 3d, and edges, in
4d, to obtain new scaling bounds for their Feynman amplitudes. In both 3 and 4
dimensions, we obtain a bubble bound proving the suppression of singular
topologies with respect to the first terms in the perturbative expansion (in
the cut-off). We also prove a new, stronger jacket bound than the one currently
available in the literature. We expect these results to be relevant for other
tensorial field theories of this type, as well as for group field theory models
for 4d quantum gravity.Comment: v2: Minor modifications to match published versio
Loop Quantum Gravity a la Aharonov-Bohm
The state space of Loop Quantum Gravity admits a decomposition into
orthogonal subspaces associated to diffeomorphism equivalence classes of
spin-network graphs. In this paper I investigate the possibility of obtaining
this state space from the quantization of a topological field theory with many
degrees of freedom. The starting point is a 3-manifold with a network of
defect-lines. A locally-flat connection on this manifold can have non-trivial
holonomy around non-contractible loops. This is in fact the mathematical origin
of the Aharonov-Bohm effect. I quantize this theory using standard field
theoretical methods. The functional integral defining the scalar product is
shown to reduce to a finite dimensional integral over moduli space. A
non-trivial measure given by the Faddeev-Popov determinant is derived. I argue
that the scalar product obtained coincides with the one used in Loop Quantum
Gravity. I provide an explicit derivation in the case of a single defect-line,
corresponding to a single loop in Loop Quantum Gravity. Moreover, I discuss the
relation with spin-networks as used in the context of spin foam models.Comment: 19 pages, 1 figure; v2: corrected typos, section 4 expanded
Health-related quality of life of Palestinian preschoolers in the Gaza Strip: a cross-sectional study
The Spin Foam Approach to Quantum Gravity
This article reviews the present status of the spin foam approach to the
quantization of gravity. Special attention is payed to the pedagogical
presentation of the recently introduced new models for four dimensional quantum
gravity. The models are motivated by a suitable implementation of the path
integral quantization of the Plebanski formulation of gravity on a simplicial
regularization. The article also includes a self-contained treatment of the 2+1
gravity. The simple nature of the latter provides the basis and a perspective
for the analysis of both conceptual and technical issues that remain open in
four dimensions.Comment: To appear in Living Reviews in Relativit
Quantization of Midisuperspace Models
We give a comprehensive review of the quantization of midisuperspace models.
Though the main focus of the paper is on quantum aspects, we also provide an
introduction to several classical points related to the definition of these
models. We cover some important issues, in particular, the use of the principle
of symmetric criticality as a very useful tool to obtain the required
Hamiltonian formulations. Two main types of reductions are discussed: those
involving metrics with two Killing vector fields and spherically symmetric
models. We also review the more general models obtained by coupling matter
fields to these systems. Throughout the paper we give separate discussions for
standard quantizations using geometrodynamical variables and those relying on
loop quantum gravity inspired methods.Comment: To appear in Living Review in Relativit
Stock price reaction to profit warnings: The role of time-varying betas
This study investigates the role of time-varying betas, event-induced variance and conditional heteroskedasticity in the estimation of abnormal returns around important news announcements. Our analysis is based on the stock price reaction to profit warnings issued by a sample of firms listed on the Hong Kong Stock Exchange. The standard event study methodology indicates the presence of price reversal patterns following both positive and negative warnings. However, incorporating time-varying betas, event-induced variance and conditional heteroskedasticity in the modelling process results in post-negative-warning price patterns that are consistent with the predictions of the efficient market hypothesis. These adjustments also cause the statistical significance of some post-positive-warning cumulative abnormal returns to disappear and their magnitude to drop to an extent that minor transaction costs would eliminate the profitability of the contrarian strategy
Positron Emission Tomography Imaging of CD105 Expression with a 64Cu-Labeled Monoclonal Antibody: NOTA Is Superior to DOTA
Optimizing the in vivo stability of positron emission tomography (PET) tracers is of critical importance to cancer diagnosis. In the case of 64Cu-labeled monoclonal antibodies (mAb), in vivo behavior and biodistribution is critically dependent on the performance of the bifunctional chelator used to conjugate the mAb to the radiolabel. This study compared the in vivo characteristics of 64Cu-labeled TRC105 (a chimeric mAb that binds to both human and murine CD105), through two commonly used chelators: 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA) and 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA). Flow cytometry analysis confirmed that chelator conjugation of TRC105 did not affect its CD105 binding affinity or specificity. PET imaging and biodistribution studies in 4T1 murine breast tumor-bearing mice revealed that 64Cu-NOTA-TRC105 exhibited better stability than 64Cu-DOTA-TRC105 in vivo, which resulted in significantly lower liver uptake without compromising the tumor targeting efficiency. In conclusion, this study confirmed that NOTA is a superior chelator to DOTA for PET imaging with 64Cu-labeled TRC105
Risk factors for alcohol and other drug use by healthcare professionals
<p>Abstract</p> <p>Background</p> <p>Given the increasingly stressful environment due to manpower shortages in the healthcare system in general, substance induced impairment among some healthcare professions is anticipated to grow. Though recent studies suggest that the prevalence of substance abuse is no higher in healthcare professionals (HPs) than the general population, given the responsibility to the public, any impairment could place the public at increased risk for errors. Few studies have ever reported predictors or risk factors for alcohol and other drug use (AOD) across a sample of HPs.</p> <p>Methods</p> <p>The study used a cross-sectional, descriptive self-report survey in a small northeastern state. A 7-page survey was mailed to a stratified random sample of 697 dentists, nurses, pharmacists and physicians registered in a northeastern state. The main outcome measures were demographic characteristics, lifetime, past year and past month prevalence of AOD use, the frequency of use, drug related dysfunctions, drug misuse and abuse potential. Six contacts during the summer of 2002 resulted in a 68.7% response rate (479/697).</p> <p>Results</p> <p>Risk factors contributing to any reported past year AOD use, as well as significant (defined as the amount of AOD use by the top 25% of respondents) past year AOD use by HPs were examined using logistic regression. Risk factors of any self-reported past year AOD use included moderate or more frequency of alcohol use, being in situations when offered AODs, feeling immune to the addictive effects of drugs (pharmaceutical invincibility) and socializing with substance abusers. Risk factors of significant past year AOD use were HPs with younger licensees, a moderate pattern of alcohol use and not socializing with substance abusers.</p> <p>Conclusion</p> <p>National and state organizations need to develop policies that focus on prevention, treatment, and rehabilitation of alcohol and other drug-using healthcare professionals. The results of this study may help to delineate the characteristics of HPs abusing drugs, leading to the development of more effective policies designed to protect the public, and move toward more tailored and effective intervention strategies for HPs.</p
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