How to be FAIR with your data

This handbook was written and edited by a group of about 40 collaborators in a series of six book sprints that took place between 1 and 10 June 2021. It aims to support higher education institutions with the practical implementation of content relating to the FAIR principles in their curricula, while also aiding teaching by providing practical material, such as competence profiles, learning outcomes, lesson plans, and supporting information. It incorporates community feedback received during the public consultation which ran from 27 July to 12 September 2021

How to be FAIR with your data

This handbook was written and edited by a group of about 40 collaborators in a series of six book sprints that took place between 1 and 10 June 2021. It aims to support higher education institutions with the practical implementation of content relating to the FAIR principles in their curricula, while also aiding teaching by providing practical material, such as competence profiles, learning outcomes, lesson plans, and supporting information. It incorporates community feedback received during the public consultation which ran from 27 July to 12 September 2021

Integration by differentiation. Draft and practice of the Swedish unity school

Schweden gilt als Land der vorbildlichen Integration von behinderten Menschen in die Gesellschaft. Eingliederung in die Gesellschaft wird hier durch ein hohes Maß an Differenzierung und homogene Lerngruppen in der Schule angestrebt. Schwedens Einheitsschule vereint hoch spezialisierte Sonderklassen und strukturell angebahntes außerunterrichtliches soziales Lernen. (DIPF/Orig.)Sweden counts as an exemplary state integrating handicapped people into society. Integration is attempted by a high measure of differentiation and homogeneous learning groups at school. Unity schools of Sweden combine highly specified classes for students with special needs and the initiation of extracurricular social learning. (DIPF/Orig.

Ergebnisse leitfadengestützter Interviews mit ehemaligen Schülern der ersten drei Einschulungsjahrgänge der Deutsch-Italienischen Gesamtschule Wolfsburg: Wissenschaftliche Begleitstudie zum Schulversuch "Deutsch-Italienische Gesamtschule Wolfsburg"

Die wissenschaftliche Begleitung des Schulversuchs „Deutsch-Italienische Gesamtschule Wolfsburg“ hat u. a. eine empirische Untersuchung zur Leistungs- und Persönlichkeitsentwicklung der Schüler an der Modellversuchsschule durchgeführt. In den Jahren 1996 bis 2006 erfolgten sowohl Quer- als auch Längsschnitterhebungen mit diversen Schulleistungstests sowie schriftliche Befragungen zu ausgewählten Persönlichkeitsmerkmalen der Schüler. An diese quantitativen Untersuchungen schlossen sich im Mai und Juni 2006 leitfadengestützte Gruppeninterviews mit Schülern der ersten drei Einschulungsjahrgänge an, die nach der 10. Klasse auf die gymnasiale Oberstufe eines Wolfsburger Gymnasiums gewechselt waren. Ziel dieser Interviews war es ein spezifisches Bild der „Deutsch-Italienischen Gesamtschule“ aus der Perspektive derer zu gewinnen, die einerseits zehn Jahre lang an dieser gelernt und gelebt haben, andererseits Erfahrungen an einer anderen Schule sammeln konnten. Als Ergebnisse lassen sich u.a. festhalten, dass der Entwicklung des Sozialverhaltens der Schüler an der Schule viel Aufmerksamkeit geschenkt wurde. Daher ist die Mehrheit der Befragten auch der Meinung, ein höheres Maß an sozialer Kompetenz zu besitzen, als andere Jugendliche. Obgleich die befragten Schüler ihre Kompetenzen in den Fächern Deutsch und Italienisch als gut bis sehr gut einschätzen offenbaren sich gleichzeitig Übereinstimmungen bezüglich der Defizite der Ausbildung in einigen Unterrichtsfächern. Dies betrifft in erster Linie die naturwissenschaftlichen Fächer einschließlich Mathematik sowie Englisch. Bilanzierend beschreiben die interviewten Schüler die „Deutsch-Italienische Gesamtschule“ als einen Ort, an dem sie sich immer sehr wohl gefühlt und den sie gern besucht haben. Ihre Beziehung zu den Lehrern bezeichnen die Schüler übereinstimmend als sehr eng und freundschaftlich, das Verhältnis unter den Schülern als geprägt von Vertrautheit und einem starken Gemeinschaftsgefühl

Data Management Plan Tools: Overview and Evaluation

Data Management Plans (DMPs) are crucial for a structured research data management and often a mandatory part of research proposals. DMP tools support the development of DMPs. Among the variety of tools available, it can be difficult for researchers, data stewards and institutions to choose the one that is most appropriate for their specific needs and context. We evaluated 18 DMP tools according to 31 requirement parameters covering aspects relating to basic functions, technical aspects and user-friendliness. The highest total evaluation scores were reached by Data Stewardship Wizard (703.5), DMPTool (615.5) and RDMO NFDI4Ing (549.5). The tools evaluated satisfied between 10 % and 87 % of the requirement parameters. 11 tools cover at least half of the parameters. Accounting for the recent developments in the area of DMP tools, this study provides an up-to-date evaluation that can support tool developers in identifying potential improvements, and hosting institutions to select a tool suited to their specific needs

D5.3 National Meetings Reports 2012

In 2012, DigCurV Partners organised or attended National Meetings for the express purpose of promoting the activities of DigCurV and the Curriculum Framework development. At each meeting, the rationale behind the lenses was discussed, and the uses of lenses themselves were explained. Many partners used the meetings as a means to promote DigCurV. UGOE suggest that their meeting ‘…served as a platform for the exchange of experiences...’ and highlighted how useful the meeting was for networking. Other partners found other useful feedback from the meetings, particularly with regards to promoting future events, discussing the Curriculum Framework in its current form, and using the CURATE! game as a means of raising topics for discussion. This report looks at each national meeting in turn by country of the reporting partner. Details of the reports are presented in sections looking at the audience profile of the event, the outcomes of the meetings, and the impact of the meeting. The report concludes with a summary of the feedback and information taken from each meetng, and present recommendatons for future meetngs and work of the network

A Parental-Report Questionnaire for Language Abilities and Pragmatics in Children and Adolescents with Autism Spectrum Disorders

The aim of this study was to test and validate a parental-report questionnaire, which assesses language abilities and pragmatics, in children with Autism Spectrum Disorders (ASD). We report two experiments: The first served as the initial test and the second sought to provide the first assessment of convergent validity. In total, we recruited 230 parents, where approximately two-thirds had a child with ASD. Results of factor analyses showed a consistent factor structure within each subscale, and the internal consistency was excellent for both sub-scales (Cronbach’s alpha >0.90). Convergent validity was assessed by correlating the results of the questionnaire with two sub-scales of the Autism Quotient questionnaire. The correlations were all greater than 0.60. The final version of the questionnaire (following exclusion of problematic items) contains 30 items (12 for language abilities and 18 for pragmatics). We conclude that the questionnaire is a concise and practical instrument for use in a variety of contexts for assessing language functioning and communication in children with ASD

a prospective clinical trial

Background Continuous glucose monitoring (CGM) has not yet been implemented in the intensive care unit (ICU) setting. The purpose of this study was to evaluate reliability, feasibility, nurse acceptance and accuracy of the Medtronic Sentrino® CGM system in critically ill patients. Methods Sensors were inserted into the subcutaneous tissue of the patient’s thigh, quantifying interstitial glucose concentration for up to 72 h per sensor. Reliability and feasibility analysis included frequency of data display, data gaps and reasons for sensor removal. We surveyed nurse acceptance in a questionnaire. For the accuracy analysis, we compared sensor values to glucose values obtained via blood gas analysis. Potential benefits of CGM were investigated in intra- individual analyses of factors, such as glycemic variability or time in target range achieved with CGM compared to that achieved with intermittent glucose monitoring. Results The device generated 68,655 real-time values from 31 sensors in 20 critically ill patients. 532 comparative blood glucose values were collected. Data were displayed during 32.5 h [16.0/62.4] per sensor, which is 45.1 % of the expected time of 72 h and 84.8 % of 37.9 h actual monitoring time. 21 out of 31 sensors were removed prematurely. 79.1 % of the nursing staff rated the device as not beneficial; the response rate was one- third. Mean absolute relative difference was 15.3 % (CI 13.5–17.0 %). Clarke error grid: 76.9 % zone A, 21.6 % zone B, 0.2 % zone C, 0.9 % zone D, 0.4 % zone E. Bland–Altman plot: mean bias +0.53 mg/dl, limits of agreement +64.6 and −63.5 mg/dl. Accuracy deteriorated during elevated glycemic variability and in the hyperglycemic range. There was no reduction in dysglycemic events during CGM compared to 72 h before and after CGM. If CGM was measuring accurately, it identified more hyperglycemic events when compared to intermittent measurements. This study was not designed to evaluate potential benefits of CGM on glucose control. Conclusions The subcutaneous CGM system did not perform with satisfactory accuracy, feasibility, or nursing acceptance when evaluated in 20 medical-surgical ICU patients. Low point accuracy and prolonged data gaps significantly limited the potential clinical usefulness of the CGM trend data. Accurate continuous data display, with a MARD < 14 %, showed potential benefits in a subgroup of our patients. Trial registration NCT02296372; Ethic vote Charité EA2/095/1

Junctional adhesion molecule-A deficient mice are protected from severe experimental autoimmune encephalomyelitis.

In multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE), early pathological features include immune cell infiltration into the central nervous system (CNS) and blood-brain barrier (BBB) disruption. We investigated the role of junctional adhesion molecule-A (JAM-A), a tight junction protein, in active EAE (aEAE) pathogenesis. Our study confirms JAM-A expression at the blood-brain barrier and its luminal redistribution during aEAE. JAM-A deficient (JAM-A-/-) C57BL/6J mice exhibited milder aEAE, unrelated to myelin oligodendrocyte glycoprotein-specific CD4+ T-cell priming. While JAM-A absence influenced macrophage behavior on primary mouse brain microvascular endothelial cells (pMBMECs) under flow in vitro, it did not impact T-cell extravasation across primary mouse brain microvascular endothelial cells. At aEAE onset, we observed reduced lymphocyte and CCR2+ macrophage infiltration into the spinal cord of JAM-A-/- mice compared to control littermates. This correlated with increased CD3+ T-cell accumulation in spinal cord perivascular spaces and brain leptomeninges, suggesting JAM-A absence leads to T-cell trapping in central nervous system border compartments. In summary, JAM-A plays a role in immune cell infiltration and clinical disease progression in aEAE

Association between potassium concentrations, variability and supplementation, and in‑hospital mortality in ICU patients: a retrospective analysis

BACKGROUND: Serum potassium concentrations are commonly between 3.5 and 5.0 mmol/l. Standardised protocols for potassium range and supplementation in the ICU are lacking. The purpose of this retrospective analysis of ICU patients was to investigate potassium concentrations, variability and supplementation, and their association with in-hospital mortality. METHODS: ICU patients ≥ 18 years, with ≥ 2 serum potassium values, treated at the Charité - Universitätsmedizin Berlin between 2006 and 2018 were eligible for inclusion. We categorised into groups of mean potassium concentrations:  3.5-4.0, > 4.0-4.5, > 4.5-5.0, > 5.0-5.5, > 5.5 mmol/l and potassium variability: 1st, 2nd and ≥ 3rd standard deviation (SD). We analysed the association between the particular groups and in-hospital mortality and performed binary logistic regression analysis. Survival curves were performed according to Kaplan-Meier and tested by Log-Rank. In a subanalysis, the association between potassium supplementation and in-hospital mortality was investigated. RESULTS: In 53,248 ICU patients with 1,337,742 potassium values, the lowest mortality (3.7%) was observed in patients with mean potassium concentrations between > 3.5 and 4.0 mmol/l and a low potassium variability within the 1st SD. Binary logistic regression confirmed these results. In a subanalysis of 22,406 ICU patients (ICU admission: 2013-2018), 12,892 (57.5%) received oral and/or intravenous potassium supplementation. Potassium supplementation was associated with an increase in in-hospital mortality in potassium categories from > 3.5 to 4.5 mmol/l and in the 1st, 2nd and ≥ 3rd SD (p < 0.001 each). CONCLUSIONS: ICU patients may benefit from a target range between 3.5 and 4.0 mmol/l and a minimal potassium variability. Clear potassium target ranges have to be determined. Criteria for widely applied potassium supplementation should be critically discussed. Trial registration German Clinical Trials Register, DRKS00016411. Retrospectively registered 11 January 2019, http://www.drks.de/DRKS00016411