Quasi-Exactly Solvable N-Body Spin Hamiltonians with Short-Range Interaction Potentials

We review some recent results on quasi-exactly solvable spin models presenting near-neighbors interactions. These systems can be understood as cyclic generalizations of the usual Calogero-Sutherland models. A nontrivial modification of the exchange operator formalism is used to obtain several infinite families of eigenfunctions of these models in closed form.Comment: This is a contribution to the Proc. of workshop on Geometric Aspects of Integrable Systems (July 17-19, 2006; Coimbra, Portugal), published in SIGMA (Symmetry, Integrability and Geometry: Methods and Applications) at http://www.emis.de/journals/SIGMA

A Haldane-Shastry spin chain of BC_N type in a constant magnetic field

We compute the spectrum of the trigonometric Sutherland spin model of BC_N type in the presence of a constant magnetic field. Using Polychronakos's freezing trick, we derive an exact formula for the partition function of its associated Haldane-Shastry spin chain.Comment: LaTeX, 13 page

Prognostic stratification improvement by integrating ID1/ID3/IGJ gene expression signature and immunophenotypic profile in adult patients with B-ALL

Characteristics of pronostic groups according to EuroFlow immunophenotype. (TIFF 1364 kb

Physics and Mathematics of Calogero particles

We give a review of the mathematical and physical properties of the celebrated family of Calogero-like models and related spin chains.Comment: Version to appear in Special Issue of Journal of Physics A: Mathematical and Genera

Superintegrable potentials on 3D Riemannian and Lorentzian spaces with non-constant curvature

A quantum sl(2,R) coalgebra is shown to underly the construction of a large class of superintegrable potentials on 3D curved spaces, that include the non-constant curvature analogues of the spherical, hyperbolic and (anti-)de Sitter spaces. The connection and curvature tensors for these "deformed" spaces are fully studied by working on two different phase spaces. The former directly comes from a 3D symplectic realization of the deformed coalgebra, while the latter is obtained through a map leading to a spherical-type phase space. In this framework, the non-deformed limit is identified with the flat contraction leading to the Euclidean and Minkowskian spaces/potentials. The resulting Hamiltonians always admit, at least, three functionally independent constants of motion coming from the coalgebra structure. Furthermore, the intrinsic oscillator and Kepler potentials on such Riemannian and Lorentzian spaces of non-constant curvature are identified, and several examples of them are explicitly presented.Comment: 14 pages. Based in the contribution presented at the Group 27 conference, Yerevan, Armenia, August 13-19, 200

Improved functionalization of oleic acid-coated iron oxide nanoparticles for biomedical applications

Superparamagnetic iron oxide nanoparticles can providemultiple benefits for biomedical applications in aqueous environments such asmagnetic separation or magnetic resonance imaging. To increase the colloidal stability and allow subsequent reactions, the introduction of hydrophilic functional groups onto the particles’ surface is essential. During this process, the original coating is exchanged by preferably covalently bonded ligands such as trialkoxysilanes. The duration of the silane exchange reaction, which commonly takes more than 24 h, is an important drawback for this approach. In this paper, we present a novel method, which introduces ultrasonication as an energy source to dramatically accelerate this process, resulting in high-quality waterdispersible nanoparticles around 10 nmin size. To prove the generic character, different functional groups were introduced on the surface including polyethylene glycol chains, carboxylic acid, amine, and thiol groups. Their colloidal stability in various aqueous buffer solutions as well as human plasma and serum was investigated to allow implementation in biomedical and sensing applications.status: publishe

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality