APFIC/FAO Regional Consultative Workshop: Securing sustainable small-scale fisheries: Bringing together responsible fisheries and social development, Windsor Suites Hotel, Bangkok, Thailand 68 October 2010

In the Global Overview, we attempt to view reefs in terms of the poor who are dependent on reefs for their livelihoods, how the reefs benefit the poor, how changes in the reef have impacted the lives of the poor and how the poor have responded and coped with these changes. It also considers wider responses to reef issues and how these interventions have impacted on the lives of the poor

Key Factors Supporting Small-Scale Coastal Fisheries Management

This synthesis was designed to provide an evidence base on the success factors in small-scale coastal fisheries management in developing countries and, in turn, to assist the Rockefeller Foundation in developing its strategy for its Oceans and Fisheries Initiative. In doing so, it identifies and describes some 20 key factors believed to influence success in small-scale coastal fisheries management. The report was completed via a rapid review of key sources of knowledge from formal published literature, institutional literature, key informants and Internet searches. The focus was on key success factors in achieving a balance of social, economic and ecological benefits from the management of small-scale coastal fisheries. A summary of these success factors can also be explored via an interactive visualization that accompanies this report

Sites of Practice: Negotiating Sustainability and Livelihoods in Rural Cambodia

In literature and popular discourse sustainable development debates have a habit of polarizing around conflicting understandings. On the one hand sustainable development is interpreted as an extension of dominant neoliberal agendas, on the other it is constructed as an alternative to the mainstream. This thesis works through these positions, to argue for an understanding of sustainable development in the spaces between; where hegemony and counterhegemony slip and slide, collide, disrupt and confuse. It is a thesis about the entanglements of sustainable development policy; a study in which I contend that sustainable development is best understood through the multiple sites of practice where policy is enacted. Drawing upon notions of messiness and bringing together actor-orientated sociology and livelihoods approaches, I explore sustainable development as it is negotiated through networks of actors and livelihoods in rural Cambodia. Specifically, I present a study of two projects implementing community fisheries as an instrument of sustainable development policy in two remote provinces of Cambodia. It is a study about the different actors responsible for implementing each project, as well as the life worlds of rural villagers affected by them. Through an in-depth analysis grounded in the diverse realities of people in particular places, I uncover the struggles through which sustainable development is negotiated. I expose a policy interpreted through multiple, overlapping simplifications and assumptions and uncover how these are simultaneously produced, recirculated, contested and transformed in practice. Significantly, I highlight the destabalising consequences of a policy which attempts to legislate away diversity or difference. Thus, I reveal the possibility of alternative realities finding expression through spaces otherwise characterised by domination.CBNRM Learning Institute, CambodiaRGS-IBG Slawson AwardDepartmental Scholarship (fees only

Understanding the Factors that Support or Inhibit Livelihood Diversification in Coastal Cambodia

The DFID funded Aquatic Resource Dependency and Benefit Flows Project (ARDB) was a short research project (from January 2005 until August 2005) implemented by IMM of the UK, the Community Fisheries Development Office (CFDO) of the Department of Fisheries (DoF) and the Community Based Natural Resource Management Learning Institute (CBNRM LI), both based in Cambodia. It had two aims: 1) to build capacity amongst government and NGO staff in understanding the importance of livelihood diversification as a potential tool for natural resource management, and 2) to further our understanding of how factors that support or inhibit rural household diversification may apply in the Cambodian coastal context and beyond. The current report reviews the background to, and the findings of, that research

Validation of Plasmodium falciparum dUTPase as the target of 5'-tritylated deoxyuridine analogues with anti-malarial activity

BACKGROUND: Malaria remains as a major global problem, being one of the infectious diseases that engender highest mortality across the world. Due to the appearance of resistance and the lack of an effective vaccine, the search of novel anti-malarials is required. Deoxyuridine 5'-triphosphate nucleotido-hydrolase (dUTPase) is responsible for the hydrolysis of dUTP to dUMP within the parasite and has been proposed as an essential step in pyrimidine metabolism by providing dUMP for thymidylate biosynthesis. In this work, efforts to validate dUTPase as a drug target in Plasmodium falciparum are reported. METHODS: To investigate the role of PfdUTPase in cell survival different strategies to generate knockout mutants were used. For validation of PfdUTPase as the intracellular target of four inhibitors of the enzyme, mutants overexpressing PfdUTPase and HsdUTPase were created and the IC50 for each cell line with each compound was determined. The effect of these compounds on dUTP and dTTP levels from P. falciparum was measured using a DNA polymerase assay. Detailed localization studies by indirect immunofluorescence microscopy and live cell imaging were also performed using a cell line overexpressing a Pfdut-GFP fusion protein. RESULTS:Different attempts of disruption of the dut gene of P. falciparum were unsuccessful while a 3' replacement construct could recombine correctly in the locus suggesting that the enzyme is essential. The four 5'-tritylated deoxyuridine analogues described are potent inhibitors of the P. falciparum dUTPase and exhibit antiplasmodial activity. Overexpression of the Plasmodium and human enzymes conferred resistance against selective compounds, providing chemical validation of the target and confirming that indeed dUTPase inhibition is involved in anti-malarial activity. In addition, incubation with these inhibitors was associated with a depletion of the dTTP pool corroborating the central role of dUTPase in dTTP synthesis. PfdUTPase is mainly localized in the cytosol. CONCLUSION: These results strongly confirm the pivotal and essential role of dUTPase in pyrimidine biosynthesis of P. falciparum intraerythrocytic stages

Sites of practice : negotiating sustainability and livelihoods in rural Cambodia

In literature and popular discourse sustainable development debates have a habit of polarizing around conflicting understandings. On the one hand sustainable development is interpreted as an extension of dominant neoliberal agendas, on the other it is constructed as an alternative to the mainstream. This thesis works through these positions, to argue for an understanding of sustainable development in the spaces between; where hegemony and counterhegemony slip and slide, collide, disrupt and confuse. It is a thesis about the entanglements of sustainable development policy; a study in which I contend that sustainable development is best understood through the multiple sites of practice where policy is enacted. Drawing upon notions of messiness and bringing together actor-orientated sociology and livelihoods approaches, I explore sustainable development as it is negotiated through networks of actors and livelihoods in rural Cambodia. Specifically, I present a study of two projects implementing community fisheries as an instrument of sustainable development policy in two remote provinces of Cambodia. It is a study about the different actors responsible for implementing each project, as well as the life worlds of rural villagers affected by them. Through an in-depth analysis grounded in the diverse realities of people in particular places, I uncover the struggles through which sustainable development is negotiated. I expose a policy interpreted through multiple, overlapping simplifications and assumptions and uncover how these are simultaneously produced, recirculated, contested and transformed in practice. Significantly, I highlight the destabalising consequences of a policy which attempts to legislate away diversity or difference. Thus, I reveal the possibility of alternative realities finding expression through spaces otherwise characterised by domination.EThOS - Electronic Theses Online ServiceCBNRM Learning Institute, Cambodia : RGS-IBG Slawson Award : University of ExeterGBUnited Kingdo

Harnessing neuroplasticity to improve motor performance in infants with cerebral palsy: a study protocol for the GAME randomised controlled trial

Introduction Cerebral palsy (CP) is the most common physical disability of childhood worldwide. Historically the diagnosis was made between 12 and 24 months, meaning data about effective early interventions to improve motor outcomes are scant. In high-income countries, two in three children will walk. This evaluator-blinded randomised controlled trial will investigate the efficacy of an early and sustained Goals–Activity–Motor Enrichment approach to improve motor and cognitive skills in infants with suspected or confirmed CP.Methods and analysis Participants will be recruited from neonatal intensive care units and the community in Australia across four states. To be eligible for inclusion infants will be aged 3–6.5 months corrected for prematurity and have a diagnosis of CP or ‘high risk of CP’ according to the International Clinical Practice Guideline criteria. Eligible participants whose caregivers consent will be randomly allocated to receive usual care or weekly sessions at home from a GAME-trained study physiotherapist or occupational therapist, paired with a daily home programme, until age 2. The study requires 150 participants per group to detect a 0.5 SD difference in motor skills at 2 years of age, measured by the Peabody Developmental Motor Scales-2. Secondary outcomes include gross motor function, cognition, functional independence, social–emotional development and quality of life. A within-trial economic evaluation is also planned.Ethics and dissemination Ethical approval was obtained from the Sydney Children’s Hospital Network Human Ethics Committee in April 2017 (ref number HREC/17/SCHN/37). Outcomes will be disseminated through peer-reviewed journal publications, presentations at international conferences and consumer websites.Trial registration number ACTRN12617000006347