26 research outputs found

    Valorization of residues from refining of used vegetable oils

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    This study investigates the advantages of two-phase anaerobic digestion for treating a mixture (1/5 v/v) of used vegetable oils processing wastes and pig manure using two semi-continuous digesters operated at mesophilic temperature (37±1 ºC). The experiments were conducted at hydraulic retention times (HRT) of 0.5, 1, 2 and 4 days in the first stage (acidifier) and at HRT of 11.5, 15, 18 and 20 days in the second stage (methanizer). The results revealed that the HRT had a high influence on the soluble chemical oxygen demand (CODs) and total dissolved solids (TDS) removal. The maximum total CODs removal efficiency of 86.4% and TDS removal efficiency of 81.9% was achieved at 20 days of global HRT. The maximum biogas production of 0.65 m3 per kilogramme of volatile dissolved solids (VDS) removed (65% CH4) was also achieved at 20 days of HRT

    Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis

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    : Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) encodes several proteins that inhibit host interferon responses. Among these, ORF6 antagonizes interferon signaling by disrupting nucleocytoplasmic trafficking through interactions with the nuclear pore complex components Nup98-Rae1. However, the roles and contributions of ORF6 during physiological infection remain unexplored. We assessed the role of ORF6 during infection using recombinant viruses carrying a deletion or loss-of-function (LoF) mutation in ORF6. ORF6 plays key roles in interferon antagonism and viral pathogenesis by interfering with nuclear import and specifically the translocation of IRF and STAT transcription factors. Additionally, ORF6 inhibits cellular mRNA export, resulting in the remodeling of the host cell proteome, and regulates viral protein expression. Interestingly, the ORF6:D61L mutation that emerged in the Omicron BA.2 and BA.4 variants exhibits reduced interactions with Nup98-Rae1 and consequently impairs immune evasion. Our findings highlight the role of ORF6 in antagonizing innate immunity and emphasize the importance of studying the immune evasion strategies of SARS-CoV-2

    CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

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    Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research

    CIBERER: Spanish national network for research on rare diseases: A highly productive collaborative initiative

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    13 páginas,1 figura, 3 tablas, 1 apéndice. Se extraen los autores pertenecientes a The CIBERER network que trabajan en Centros del CSIC del Appendix ACIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research.This study has been funded by Instituto de Salud Carlos III (ISCIII) and Spanish Ministry of Science and InnovationPeer reviewe

    La renovación de la palabra en el bicentenario de la Argentina : los colores de la mirada lingüística

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    El libro reúne trabajos en los que se exponen resultados de investigaciones presentadas por investigadores de Argentina, Chile, Brasil, España, Italia y Alemania en el XII Congreso de la Sociedad Argentina de Lingüística (SAL), Bicentenario: la renovación de la palabra, realizado en Mendoza, Argentina, entre el 6 y el 9 de abril de 2010. Las temáticas abordadas en los 167 capítulos muestran las grandes líneas de investigación que se desarrollan fundamentalmente en nuestro país, pero también en los otros países mencionados arriba, y señalan además las áreas que recién se inician, con poca tradición en nuestro país y que deberían fomentarse. Los trabajos aquí publicados se enmarcan dentro de las siguientes disciplinas y/o campos de investigación: Fonología, Sintaxis, Semántica y Pragmática, Lingüística Cognitiva, Análisis del Discurso, Psicolingüística, Adquisición de la Lengua, Sociolingüística y Dialectología, Didáctica de la lengua, Lingüística Aplicada, Lingüística Computacional, Historia de la Lengua y la Lingüística, Lenguas Aborígenes, Filosofía del Lenguaje, Lexicología y Terminología

    Valorización de los residuos generados en el procesado de aceites

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    Se han investigado las ventajas de un sistema de digestión anaerobia en dos fases para el tratamiento de una mezcla de los residuos continuos operados a 37±1 ºC. Los experimentos fueron llevados a cabo a tiempos hidráulicos de residencia (THR) de 0.5, 1, 2 y 4 días en la primera etapa (reactor acidogénico) y de 11.5, 15, 18 y 20 días en la segunda etapa (reactor metanogénico). Los resultados revelaron que el THR tiene una gran influencia en la eliminación de demanda química de oxígeno soluble (DQOs) y sólidos disueltos totales (SDT). La máxima eficiencia de eliminación de DQOs, SDT y producción máxima de biogás fueron de 86.4% y 81.9% y 0.65 m3 biogás por kilogramo de sólido disuelto volátil (SDV) eliminado (65% CH4) respectivamente, conseguidas todas a un THR total de 20 días oleosos (RO) generados en el procesado de aceites vegetales usados y purín porcino (PP), 1/5 v/v, utilizando dos digestores sem

    Aportaciones a la integración del alumnado marroquí

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    Desde hace varios años la localidad de Talayuela ha sio un municipio receptor de inmigrantes, muchos de ellos de nacionalidad marroquí, que en su mayoría realizan labores agrícolas y que vienen acompañados de algún hijo en edad escolar. Atendiendo a las necesidades de estos alumnos, se desarrolla un plan que tiene como objetivo principal ayudar al alumnado inmigrante en la adquisición de los requisitos instrumentales básicos que les permita acceder al curriculum escolar normalizado en las mejores condiciones y en el menor tiempo posible para que a su vez le favorezca en su integración personal dentro de la comunidad escolar. El plan hace un especial énfasis en el aprendizaje de la lengua castellana y principalmente en lo relacionado con el lenguaje oral.ExtremaduraES
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