Fahrzeugbau

Das übergeordnete Ziel des Teilprojekts »Energieflexibles Automobilwerk« ist die Ermittlung der Energieflexibilitätspotenziale für ausgewählte Kernprozesse eines Automobilwerks und die Abschätzung des kombinierten Potenzials, hochgerechnet auf die Branche im Wirtschaftszweig C des verarbeitenden Gewerbes »Herstellung von Personenkraftwagen und Personenkraftwagenmotoren«. Nach der Analyse von über 40 Energieflexibilisierungsmaßnahmen wurden 26 über eine Priorisierungsmethodik ausgewählt. Diese wurden den einzelnen Gewerken (Rohbau, Montage, Oberfläche und Werksebene) eines Automobilwerks zugeordnet. Mithilfe einer erarbeiteten Maßnahmenkombinatorik konnte das gepoolte Energieflexibilitätspotenzial für das energieflexible Automobilwerk ermittelt werden. Dieses Potenzial wurde mithilfe einer Hochrechnungsmethodik auf die gesamte Branche skaliert

The FOOT FragmentatiOn Of Target Experiment

International audienceIn proton-therapy clinical practice a constant RBE equal to 1.1 is adopted, regardless of the demonstrated RBE variations, which depends on physical and biological parameters. Among other mechanisms, nuclear interactions might influence the proton-RBE due to secondary heavier particles produced by target fragmentation that can significantly contribute to the total dose: an un-wanted and undetermined increase of normal tissues complications probability may occur. The FOOT experiment is designed to study these processes. Target ($^{16}$O,$^{12}$C) fragmentation induced by 150 − 250 M eV proton beam will be studied via inverse kinematic approach, where $^{16}$O and $^{12}$C therapeutic beams, with the same kinetic energy per nucleon of the proton, collide on graphite and hydrocarbons target to provide the cross section on Hydrogen (to explore also the projectile fragmentation). The detector design, the performances and expected resolution results obtained form Monte Carlo study, based on the FLUKA code will be presented

Development and characterization of a Δ E-TOF detector prototype for the FOOT experiment

This paper describes the development and characterization of a ΔE-TOF detector composed of a plastic scintillator bar coupled at both ends to silicon photomultipliers. This detector is a prototype of a larger version which will be used in the FOOT (FragmentatiOn Of Target) experiment to identify the fragments produced by ion beams accelerated onto a hydrogen-enriched target. The final ΔE-TOF detector will be composed of two layers of plastic scintillator bars with orthogonal orientation and will measure, for each crossing fragment, the energy deposited in the plastic scintillator (ΔE), the time of flight (TOF), and the coordinates of the interaction position in the scintillator. To meet the FOOT experimental requirements, the detector should have energy resolution of a few percents and time resolution of 70 ps, and it should allow to discriminate multiple fragments belonging to the same event. To evaluate the achievable performances, the detector prototype was irradiated with protons of kinetic energy in the 70–230 MeV range and interacting at several positions along the bar. The measured energy resolution σΔE∕ΔE was 6–14%, after subtracting the fluctuations of the deposited energy. A time resolution σ between 120 and 180 ps was obtained with respect to a trigger detector. A spatial resolution σ of 1.9 cm was obtained for protons interacting at the center of the bar

Overall survival in the OlympiA phase III trial of adjuvant olaparib in patients with germline pathogenic variants in BRCA1/2 and high-risk, early breast cancer

International audienc