The Best Specimen of a Tyrant: The Ambitious Dr. Abraham Van Norstrand and the Wisconsin Insane Hospital

Review of: The Best Specimen of a Tyrant: The Ambitious Dr. Abraham Van Norstrand and the Wisconsin Insane Hospital, by Ellen Dwyer

Educational Effects of a Vocabulary Intervention on Preschoolers' Word Knowledge and Conceptual Development: A Cluster‐Randomized Trial

The purpose of this study was to examine the hypothesis that helping preschoolers learn words through categorization may enhance their ability to retain words and their conceptual properties, acting as a bootstrap for self‐learning. We examined this hypothesis by investigating the effects of the World of Words instructional program, a supplemental intervention for children in preschool designed to teach word knowledge and conceptual development through taxonomic categorization and embedded multimedia. Participants in the study included 3‐ and 4‐year‐old children from 28 Head Start classrooms in 12 schools, randomly assigned to treatment and control groups. Children were assessed on word knowledge, expressive language, conceptual knowledge, and categories and properties of concepts in a yearlong intervention. Results indicated that children receiving the WOW treatment consistently outperformed their control counterparts; further, treatment children were able to use categories to identify the meaning of novel words. Gains in word and categorical knowledge were sustained six months later for those children who remained in Head Start. These results suggest that a program targeted to learning words within taxonomic categories may act as a bootstrap for self‐learning and inference generation. كان الغرض من هذه الدراسة هو فحص فرضية أن مساعدة الأطفال في الروضة تعلم كلمات عن طريق التصنيف بإمكانه أن يعزز من قدراتهم على تذكر الكلمات وخصائصها المفاهيمية، بوصفها محفزا للتعلم. قمنا بفحص هذه الفرضية وذلك بالتحقيق في أثر البرنامج التعليمي "عالم المفردات" (WOW) الذي يعتبر تدخلا تكميليا لأطفال الروضة ومصمما من أجل تعليم معرفة الكلمات والتطور المفاهيمي، من خلال النظام التصنيفي ووسائل الإعلام. تضمنت الدراسة مشاركين تتراوح أعمارهم بين 3 و4 سنوات ينتمون إلى 28 روضة أطفال، التي تنتمي إلى 12 مدرسة, خضعت عشوائيا للبحث ومراقبة المجموعات. جرى تقييم الأطفال على معرفة الكلمات واللغة التعبيرية والمعرفة المفاهيمية وأصناف وخصائص المفاهيم في تدخل لمدة سنة كاملة. أظهرت النتائج أن الأطفال الذين خضعوا للبرنامج التعليمي "عالم المفردات" (WOW) قد تفوقوا بصورة مستمرة على نظرائهم الذين خضعوا للمراقبة. علاوة على ذلك, فإن أطفال البحث قد تمكنوا من استخدام الأصناف والتعرف على معنى الكلمات الجديدة. استمر اكتساب الكلمات والمعرفة التصنيفية بعد 6 أشهر بالنسبة للأطفال الذين بقوا في روضة الأطفال. توحي هذه النتائج إلى أنه يمكن لبرنامج يهدف إلى تعلم الكلمات أن يعمل كمحفز للتعلم الذاتي، وتوليد الاستنتاجات. 本研究旨在考查一个假设：帮助学龄前儿童通过分类来学习单词，可提高他们记忆单词及其概念属性的能力，从而发展他们的自主学习能力。作者通过调查「单词世界」(WOW)教学计划的影响来考查这个假设。该教学计划是一个学龄前儿童补充干预计划，旨在透过使用分类学的分类方法及嵌入式多媒体，教授单词知识和发展单词概念。研究参与者是来自12所学校中的28个「启蒙计划」学前儿童班里的3‐4岁儿童，他们被随机分配到干预组和对照组。在一年的干预中，儿童接受单词知识、表达语言、概念知识、类别和概念属性的评估。结果显示，「单词世界」(WOW)干预组的表现一致地优于对照组；此外，干预组儿童可以使用类别来确定新词的词义。仍然留在「启蒙计划」班里的儿童，其单词和类别知识的改进保持稳定至干预后6个月。这些研究结果显示，针对透过分类学的分类方法来学习单词的教学计划，可引导儿童凭自己的力量学习自学和产生推断。 Cette étude avait pour but d'examiner l'hypothíse qu'aider des enfants d'âge préscolaire à apprendre des mots en les catégorisant pourrait favoriser leur capacité à retenir les mots et leurs propriétés, agissant alors comme une amorce d'auto‐apprentissage. Nous avons examiné cette hypothíse en analysant les effets du matériel d'enseignement le Monde des Mots (MDM), un supplément pédagogique destiné aux enfants d'âge préscolaire conçu pour la connaissance des mots et le développement des concepts à l'aide d'une catégorisation taxinomique avec multimédia impliqué. Ont participé à l'étude des enfants de 3 et 4 ans provenant de 28 classes Head Start issus de 12 écoles assignées au hasard au groupe de traitement et au groupe contrôle. Les enfants ont été évalués sur leur connaissance des mots, l'expression orale, les connaissances conceptuelles, les catégories et les propriétés des concepts tout au long de l'année de l'intervention. Les résultats ont montré que les enfants du groupe de traitement MDM ont de maniíre systématique dépassé leur contrepartie du groupe contrôle; en outre, les enfants soumis au traitement ont été en mesure de se servir des catégories pour trouver le sens des mots nouveaux. Les bénéfices dans la connaissance des mots et les connaissances catégorielles sont demeurés six mois plus tard chez les enfants restés dans Head Start. Ces résultats suggírent qu'un programme visant l'apprentissage de mots au sein de catégories taxonomiques peut agir comme une amorce pour l'auto‐apprentissage et la production d'inférences. Проверялась гипотеза о том, что категоризация лексики при обучении дошкольников новым словам может существенно увеличить способность к запоминанию слов и их концептуальных свойств и стимулировать малышей к самообучению. Для расширения их словарного запаса и умения работать с концептами авторы исследовали учебный модуль “Мир слов” (WOW), разработанный в качестве дополнительного вмешательства для дошкольников, которые обучаются по программе Head Start. WOW знакомит детей с таксономической классификацией посредством мультимедийных средств. Трех‐ и четырехлетние дети из 28‐и дошкольных групп в 12‐и школах были случайным образом включены либо в экспериментальную, либо в контрольную группу. На протяжении годичного обучения оценивалось знание слов, выразительность речи, знание концептов, их свойств и категорий, к которым они могут быть причислены. Дети, обучавшиеся по программе WOW, стабильно показывали более высокие результаты, чем их ровесники из контрольных групп. Помимо прочего, эти дети способны использовать категоризацию для определения значений новых слов. Через полгода после окончания обучения эти дети продолжали опережать сверстников по знанию слов и умению категоризировать. Это свидетельствует о том, что программа, предлагающая изучение слов в рамках таксономических категорий, может помочь вырастить поколение, которое будет способно к самообучению и к самостоятельным выводам. La meta de este estudio fue el de investigar la hipótesis que ayudar a los preescolares a aprender palabras por medio de la categorización mejoraría su capacidad de retener palabras y sus propiedades conceptuales, sirviendo de arranque para el auto aprendizaje. Investigamos esta hipótesis estudiando los efectos del programa de enseñanza World of Words (Mundo de palabras; WOW por sus siglas en inglés), una intervención adicional para niños preescolares diseñada para el aprendizaje de palabras y el desarrollo conceptual por medio de la categorización taxonómica y el uso de diversos medios. En este estudio participaron niños de 3 y 4 años de 20 aulas de Head Start en 12 escuelas escogidas al azar en cuanto a grupos de tratamiento y de control. En un año completo de intervención, se evaluaron los estudiantes en cuanto a su conocimiento de palabras, su lenguaje expresivo, su conocimiento conceptual, y las categorías y propiedades de los conceptos. Los resultados mostraron que los niños del grupo de WOW sistemáticamente superaban a los niños del grupo de control; además, los niños del grupo de tratamiento podían usar categorías para encontrar el significado de palabras nuevas. Los adelantos en el conocimiento de palabras y categorías todavía existían 6 meses más tarde para los niños que seguían con Head Start. Estos resultados sugieren que un programa dedicado al aprendizaje de palabras dentro de categorías taxonómicas puede ayudar al autoaprendizaje y la producción de inferencias.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/88072/1/RRQ.46.3.3.pd

Associations between changes in ferritin levels and susceptibility-weighted imaging filtered phase in patients with relapsing–remitting multiple sclerosis over 24weeks of therapy with subcutaneous interferon beta-1a three times weekly

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Hypoperfusion of brain parenchyma is associated with the severity of chronic cerebrospinal venous insufficiency in patients with multiple sclerosis: a cross-sectional preliminary report

<p>Abstract</p> <p>Background</p> <p>Several studies have reported hypoperfusion of the brain parenchyma in multiple sclerosis (MS) patients. We hypothesized a possible relationship between abnormal perfusion in MS and hampered venous outflow at the extracranial level, a condition possibly associated with MS and known as chronic cerebrospinal venous insufficiency (CCSVI).</p> <p>Methods</p> <p>We investigated the relationship between CCSVI and cerebral perfusion in 16 CCSVI MS patients and 8 age- and sex-matched healthy controls. Subjects were scanned in a 3-T scanner using dynamic susceptibility, contrast-enhanced, perfusion-weighted imaging. Cerebral blood flow (CBF), cerebral blood volume (CBV) and mean transit time (MTT) were measured in the gray matter (GM), white matter (WM) and the subcortical GM (SGM). The severity of CCSVI was assessed according to the venous hemodynamic insufficiency severity score (VHISS) on the basis of the number of venous segments exhibiting flow abnormalities.</p> <p>Results</p> <p>There was a significant association between increased VHISS and decreased CBF in the majority of examined regions of the brain parenchyma in MS patients. The most robust correlations were observed for GM and WM (<it>r </it>= -0.70 to -0.71, <it>P </it>< 0.002 and <it>P </it>corrected = 0.022), and for the putamen, thalamus, pulvinar nucleus of thalamus, globus pallidus and hippocampus (<it>r </it>= -0.59 to -0.71, <it>P </it>< 0.01 and <it>P </it>corrected < 0.05). No results for correlation between VHISS and CBV or MTT survived multiple comparison correction.</p> <p>Conclusions</p> <p>This pilot study is the first to report a significant relationship between the severity of CCSVI and hypoperfusion in the brain parenchyma. These preliminary findings should be confirmed in a larger cohort of MS patients to ensure that they generalize to the MS population as a whole. Reduced perfusion could contribute to the known mechanisms of virtual hypoxia in degenerated axons.</p

Comparison of Standard 1.5 T vs. 3 T Optimized Protocols in Patients Treated with Glatiramer Acetate. A Serial MRI Pilot Study

This study explored the effect of glatiramer acetate (GA, 20 mg) on lesion activity using the 1.5 T standard MRI protocol (single dose gadolinium [Gd] and 5-min delay) or optimized 3 T protocol (triple dose of Gd, 20-min delay and application of an off-resonance saturated magnetization transfer pulse). A 15-month, phase IV, open-label, single-blinded, prospective, observational study included 12 patients with relapsing-remitting multiple sclerosis who underwent serial MRI scans (Days −45, −20, 0; the minus ign indicates the number of days before GA treatment; and on Days 30, 60, 90, 120, 150, 180, 270 and 360 during GA treatment) on 1.5 T and 3 T protocols. Cumulative number and volume of Gd enhancing (Gd-E) and T2 lesions were calculated. At Days −45 and 0, there were higher number (p < 0.01) and volume (p < 0.05) of Gd-E lesions on 3 T optimized compared to 1.5 T standard protocol. However, at 180 and 360 days of the study, no significant differences in total and cumulative number of new Gd-E and T 2 lesions were found between the two protocols. Compared to pre-treatment period, at Days 180 and 360 a significantly greater decrease in the cumulative number of Gd-E lesions (p = 0.03 and 0.021, respectively) was found using the 3 T vs. the 1.5 T protocol (p = NS for both time points). This MRI mechanistic study suggests that GA may exert a greater effect on decreasing lesion activity as measured on 3 T optimized compared to 1.5 T standard protocol

Sensitivity and specificity for screening of chronic cerebrospinal venous insufficiency using a multimodal non-invasive imaging approach in patients with multiple sclerosis

The aim of this study was to investigate whether a combination of Doppler sonography (DS) and magnetic resonance venography (MRV) on 3T MRI increases specificity for detection of chronic cerebrospinal venous insufficiency (CCSVI) in 171 (113 relapsing-remitting, 47 secondary-progressive, 11 primary progressive) patients with multiple sclerosis (MS) and 79 age- and sexmatched healthy controls (HCs). One hundred ten (64.3%) MS patients and 30 (38%) HCs presented ≥2 venous hemodynamic CCSVI criteria (p<.0001). Both DS and MRV showed relatively high specificity but lower sensitivity for determining a CCSVI diagnosis in patients with MS vs HCs and between MS subgroups. In MS patients this diagnostic specificity increased to over 90% by combining internal jugular vein and vertebral vein abnormal DS and MRV findings, reflux in deep cerebral veins and MRV findings of >1 collateral veins. This study suggests that a multimodal non-invasive approach (DS and MRV) increases the specificity for a diagnosis of CCSVI in patients with MS

A formative study exploring perceptions of physical activity and physical activity monitoring among children and young people with cystic fibrosis and health care professionals

Background: Physical activity (PA) is associated with reduced hospitalisations and maintenance of lung function in patients with Cystic Fibrosis (CF). PA is therefore recommended as part of standard care. Despite this, there is no consensus for monitoring of PA and little is known about perceptions of PA monitoring among children and young people with CF. Therefore, the research aimed to explore patients’ perceptions of PA and the acceptability of using PA monitoring devices with children and young people with CF. Methods: An action research approach was utilised, whereby findings from earlier research phases informed subsequent phases. Four phases were utilised, including patient interviews, PA monitoring, follow-up patient interviews and health care professional (HCP) interviews. Subsequently, an expert panel discussed the study to develop recommendations for practice and future research. Results: Findings suggest that experiences of PA in children and young people with CF are largely comparable to their non-CF peers, with individuals engaging in a variety of activities. CF was not perceived as a barrier per se, although participants acknowledged that they could be limited by their symptoms. Maintenance of health emerged as a key facilitator, in some cases PA offered patients the opportunity to ‘normalise’ their condition. Participants reported enjoying wearing the monitoring devices and had good compliance. Wrist-worn devices and devices providing feedback were preferred. HCPs recognised the potential benefits of the devices in clinical practice. Recommendations based on these findings are that interventions to promote PA in children and young people with CF should be individualised and involve families to promote PA as part of an active lifestyle. Patients should receive support alongside the PA data obtained from monitoring devices. Conclusions: PA monitoring devices appear to be an acceptable method for objective assessment of PA among children and young people with CF and their clinicians. Wrist-worn devices, which are unobtrusive and can display feedback, were perceived as most acceptable. By understanding the factors impacting PA, CF health professionals will be better placed to support patients and improve health outcomes