To take the flow of leisure seriously: a theoretical extension of Csikszentmihalyi's flow

Csikszentmihalyi's (1975b) 'flow' theory has been extensively developed and utilised, providing the leading explanation for positive subjective experiences in the study of leisure. The prescriptive tenets along with the archetypal descriptive characteristics of the flow state have been well documented. What is less explicit, however, is what occurs within experience in the instances immediately prior to the onset of flow and those immediately following: in what the author has come to term as pre-flow and post-flow experience (Elkington, 2006 and 2007). This research approaches the dearth of knowledge concerning pre- and post-flow experience from the perspective of existential-phenomenological psychology with the aim of bringing clarity to the experiential, conceptual, and theoretical uncertainty surrounding what goes before and after a state of flow and with it a more complete and holistic understanding of flow experience. The research explores the intricacies of flow experiences of participants from one activity characteristic of each of Stebbins' (2007a) amateur, hobbyist, and career volunteer serious leisure categories, namely: amateur actors, hobbyist table tennis players, and volunteer sports coaches. Using narrative meaning as an interpretative tool to generate descriptions of the specific experiential situations and action sequences that comprise pre- and post-flow produced a single representative narrative of pre- and post-flow experience, and the first empirical insights into the phenomenology of such phases of experience. Examining flow in the context of serious leisure has revealed there to be significantly more to the act of experiencing flow than depicted in Csikszentmihalyi's (1975b) original framework, re-conceptualising flow as a focal state of mind in a broader experience-process model comprising distinct, intricate, and highly-personalised phases of pre-flow, flow-in-action, and post-flow experience. Combining flow and serious leisure has evoked the affinity of serious leisure activity for flow experience and the discovery that serious leisure and flow are not two disparate frameworks, but are structurally and experientially 'mutually reinforcing' of one another, revealing an explanatory framework of optimal leisure experience. The newly-emerged process view of flow was used to provide insights into the phenomenology of flow in serious leisure, adding to the explanatory capacity of Stebbins' serious leisure theoretical framework. Conflating flow and serious leisure in this way provides for significant and exciting opportunities for knowledge transfer between these two established leisure-related frameworks and signifies new vistas for future research in both fields

The development, of the mining, of lead in the Iberian, Peninsula and Britain under the Roman Empire until the end of the Second Century A.D

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Sustainability performance measurement : a preliminary classification framework of models and indicators

In this position paper we focus on the diversity of sustainability measurements. Based on existing research on performance measurement, we propose a preliminary classification framework summarizing sustainability models and indicators. By describing illustrative examples, we claim that several models and indicators can be distinguished with their own peculiarities. Having such a framework is interesting for both academia and business to structure the range of models and indicators and to ultimately select the appropriate sustainability measurement approach. The proposed framework should be validated by further research

Science Goals and Overview of the Radiation Belt Storm Probes (RBSP) Energetic Particle, Composition, and Thermal Plasma (ECT) Suite on NASA’s Van Allen Probes Mission

The Radiation Belt Storm Probes (RBSP)-Energetic Particle, Composition, and Thermal Plasma (ECT) suite contains an innovative complement of particle instruments to ensure the highest quality measurements ever made in the inner magnetosphere and radiation belts. The coordinated RBSP-ECT particle measurements, analyzed in combination with fields and waves observations and state-of-the-art theory and modeling, are necessary for understanding the acceleration, global distribution, and variability of radiation belt electrons and ions, key science objectives of NASA’s Living With a Star program and the Van Allen Probes mission. The RBSP-ECT suite consists of three highly-coordinated instruments: the Magnetic Electron Ion Spectrometer (MagEIS), the Helium Oxygen Proton Electron (HOPE) sensor, and the Relativistic Electron Proton Telescope (REPT). Collectively they cover, continuously, the full electron and ion spectra from one eV to 10’s of MeV with sufficient energy resolution, pitch angle coverage and resolution, and with composition measurements in the critical energy range up to 50 keV and also from a few to 50 MeV/nucleon. All three instruments are based on measurement techniques proven in the radiation belts. The instruments use those proven techniques along with innovative new designs, optimized for operation in the most extreme conditions in order to provide unambiguous separation of ions and electrons and clean energy responses even in the presence of extreme penetrating background environments. The design, fabrication and operation of ECT spaceflight instrumentation in the harsh radiation belt environment ensure that particle measurements have the fidelity needed for closure in answering key mission science questions. ECT instrument details are provided in companion papers in this same issue. In this paper, we describe the science objectives of the RBSP-ECT instrument suite on the Van Allen Probe spacecraft within the context of the overall mission objectives, indicate how the characteristics of the instruments satisfy the requirements to achieve these objectives, provide information about science data collection and dissemination, and conclude with a description of some early mission results

Mycobacterium tuberculosis subverts negative regulatory pathways in human macrophages to drive immunopathology.

Tuberculosis remains a global pandemic and drives lung matrix destruction to transmit. Whilst pathways driving inflammatory responses in macrophages have been relatively well described, negative regulatory pathways are less well defined. We hypothesised that Mycobacterium tuberculosis (Mtb) specifically targets negative regulatory pathways to augment immunopathology. Inhibition of signalling through the PI3K/AKT/mTORC1 pathway increased matrix metalloproteinase-1 (MMP-1) gene expression and secretion, a collagenase central to TB pathogenesis, and multiple pro-inflammatory cytokines. In patients with confirmed pulmonary TB, PI3Kδ expression was absent within granulomas. Furthermore, Mtb infection suppressed PI3Kδ gene expression in macrophages. Interestingly, inhibition of the MNK pathway, downstream of pro-inflammatory p38 and ERK MAPKs, also increased MMP-1 secretion, whilst suppressing secretion of TH1 cytokines. Cross-talk between the PI3K and MNK pathways was demonstrated at the level of eIF4E phosphorylation. Mtb globally suppressed the MMP-inhibitory pathways in macrophages, reducing levels of mRNAs encoding PI3Kδ, mTORC-1 and MNK-1 via upregulation of miRNAs. Therefore, Mtb disrupts negative regulatory pathways at multiple levels in macrophages to drive a tissue-destructive phenotype that facilitates transmission

Gender-dependent differences in plasma matrix metalloproteinase-8 elevated in pulmonary tuberculosis.

Tuberculosis (TB) remains a global health pandemic and greater understanding of underlying pathogenesis is required to develop novel therapeutic and diagnostic approaches. Matrix metalloproteinases (MMPs) are emerging as key effectors of tissue destruction in TB but have not been comprehensively studied in plasma, nor have gender differences been investigated. We measured the plasma concentrations of MMPs in a carefully characterised, prospectively recruited clinical cohort of 380 individuals. The collagenases, MMP-1 and MMP-8, were elevated in plasma of patients with pulmonary TB relative to healthy controls, and MMP-7 (matrilysin) and MMP-9 (gelatinase B) were also increased. MMP-8 was TB-specific (p<0.001), not being elevated in symptomatic controls (symptoms suspicious of TB but active disease excluded). Plasma MMP-8 concentrations inversely correlated with body mass index. Plasma MMP-8 concentration was 1.51-fold higher in males than females with TB (p<0.05) and this difference was not due to greater disease severity in men. Gender-specific analysis of MMPs demonstrated consistent increase in MMP-1 and -8 in TB, but MMP-8 was a better discriminator for TB in men. Plasma collagenases are elevated in pulmonary TB and differ between men and women. Gender must be considered in investigation of TB immunopathology and development of novel diagnostic markers

Hypoxia increases neutrophil-driven matrix destruction after exposure to Mycobacterium tuberculosis.

The importance of neutrophils in the pathology of tuberculosis (TB) has been recently established. We demonstrated that TB lesions in man are hypoxic, but how neutrophils in hypoxia influence lung tissue damage is unknown. We investigated the effect of hypoxia on neutrophil-derived enzymes and tissue destruction in TB. Human neutrophils were stimulated with M. tuberculosis (M.tb) or conditioned media from M.tb-infected monocytes (CoMTB). Neutrophil matrix metalloproteinase-8/-9 and elastase secretion were analysed by luminex array and gelatin zymography, gene expression by qPCR and cell viability by flow cytometry. Matrix destruction was investigated by confocal microscopy and functional assays and neutrophil extracellular traps (NETs) by fluorescence assay. In hypoxia, neutrophil MMP-8 secretion and gene expression were up-regulated by CoMTB. MMP-9 activity and neutrophil elastase (NE) secretion were also increased in hypoxia. Hypoxia inhibited NET formation and both neutrophil apoptosis and necrosis after direct stimulation by M.tb. Hypoxia increased TB-dependent neutrophil-mediated matrix destruction of Type I collagen, gelatin and elastin, the main structural proteins of the human lung. Dimethyloxalylglycin (DMOG), which stabilizes hypoxia-inducible factor-1α, increased neutrophil MMP-8 and -9 secretion. Hypoxia in our cellular model of TB up-regulated pathways that increase neutrophil secretion of MMPs that are implicated in matrix destruction

Event-specific chorus wave and electron seed population models in DREAM3D using the Van Allen Probes

Abstract The DREAM3D diffusion model is applied to Van Allen Probes observations of the fast dropout and strong enhancement of MeV electrons during the October 2012 double-dip storm. We show that in order to explain the very different behavior in the two dips, diffusion in all three dimensions (energy, pitch angle, and Lo) coupled with data-driven, event-specific inputs, and boundary conditions is required. Specifically, we find that outward radial diffusion to the solar wind-driven magnetopause, an event-specific chorus wave model, and a dynamic lower-energy seed population are critical for modeling the dynamics. In contrast, models that include only a subset of processes, use statistical wave amplitudes, or rely on inward radial diffusion of a seed population, perform poorly. The results illustrate the utility of the high resolution, comprehensive set of Van Allen Probes\u27 measurements in studying the balance between source and loss in the radiation belt, a principal goal of the mission. Key Points DREAM3D uses event-specific driving conditions measured by Van Allen Probes Electron dropout is due to outward radial diffusion to compressed magnetopause Event-specific chorus and seed electrons are necessary for the enhancement