Risk and desistance factors for female acquisitive offending: a systematic review

Purpose This systematic review sought to examine the research body on acquisitive offending among female offenders, specifically exploring what factors may take females closer towards engaging in acquisitive offending and what factors may support desistance from this behaviour. Design/methodology/approach A systematic review was conducted, using the recommended guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. A total of 8,129 initial articles were identified from the search terms, 77 articles were deemed suitable to meet the inclusion criteria and are explored in the results section. Papers were screened for quality appraisal and risk of bias. Findings Ten factors were identified that took females closer towards offending. Five factors were identified that took females away from offending. Based on the findings, four typologies of female acquisitive offenders were identified: short-term orientation (adolescent); mental health orientation; life-course persistent (theft); and acquisitive diversity (including robbery and burglary). Research limitations/implications Future research would benefit from exploring a more rich understanding of the mechanisms that underpin why females engage in acquisitive offending and what factors contribute towards their desistance. A wider range of bio-psycho-social factors, which may increase the risk of acquisitive offending, should also be considered in future research alongside ways in which interventions may be gender-responsive. Originality/value This review provides insight into the differing functions and typologies of female acquisitive offending. Interventions for each of these typologies are considered within the review

18F-FDG Uptake on PET/CT in Symptomatic versus Asymptomatic Carotid Disease: a Meta-Analysis.

INTRODUCTION: The role of positron emission tomography (PET)/computed tomography (CT) in the determination of inflammation in arterial disease is not well defined. This can provide information about arterial wall inflammation in atherosclerotic disease, and may give insight into plaque stability. The aim of this review was to perform a meta-analysis of PET/CT with 18F-FDG (fluorodeoxyglucose) uptake in symptomatic and asymptomatic carotid artery disease. METHODS: This was a systematic review, following PRISMA guidelines, which interrogated the MEDLINE database from January 2001 to May 2017. The search combined the terms, "inflammation", "FDG", and "stroke". The search criteria included all types of studies, with a primary outcome of the degree of arterial vascular inflammation determined by 18F-FDG uptake. Analysis involved an inverse weighted variance estimate of pooled data, using a random effects model. RESULTS: A total of 14 articles (539 patients) were included in the meta-analysis. Comparing carotid artery 18F-FDG uptake in symptomatic versus asymptomatic disease yielded a standard mean difference of 0.94 (95% CI 0.58-1.130; p < .0001; I2 = 65%). CONCLUSIONS: PET/CT using 18F-FDG can demonstrate carotid plaque inflammation, and is a marker of symptomatic disease. Further studies are required to understand the clinical implication of PET/CT as a risk prediction tool

Mutations in the mitochondrial cysteinyl-tRNA synthase gene, CARS2, lead to a severe epileptic encephalopathy and complex movement disorder

Background: Mitochondrial disease is often suspected in cases of severe epileptic encephalopathy especially when a complex movement disorder, liver involvement and progressive developmental regression are present. Although mutations in either mitochondrial DNA or POLG are often present, other nuclear defects in mitochondrial DNA replication and protein translation have been associated with a severe epileptic encephalopathy. Methods: and results We identified a proband with an epileptic encephalopathy, complex movement disorder and a combined mitochondrial respiratory chain enzyme deficiency. The child presented with neurological regression, complex movement disorder and intractable seizures. A combined deficiency of mitochondrial complexes I, III and IV was noted in liver tissue, along with increased mitochondrial DNA content in skeletal muscle. Incomplete assembly of complex V, using blue native polyacrylamide gel electrophoretic analysis and complex I, using western blotting, suggested a disorder of mitochondrial transcription or translation. Exome sequencing identified compound heterozygous mutations in CARS2, a mitochondrial aminoacyl-tRNA synthetase. Both mutations affect highly conserved amino acids located within the functional ligase domain of the cysteinyl-tRNA synthase. A specific decrease in the amount of charged mt-tRNACys was detected in patient fibroblasts compared with controls. Retroviral transfection of the wild-type CARS2 into patient skin fibroblasts led to the correction of the incomplete assembly of complex V, providing functional evidence for the role of CARS2 mutations in disease aetiology. Conclusions: Our findings indicate that mutations in CARS2 result in a mitochondrial translational defect as seen in individuals with mitochondrial epileptic encephalopathy

Roundtable on teaching Work as an interdisciplinary first-year college seminar

This past year’s theme, “Work,” (2009-2010) asked students to interrogate the cultural construction of work from the early industrial revolution to our current economic moment, and to question how the new economy, as it develops, shapes the future conditions of work. Over the course of the year, we considered a number of overarching themes as we attempted to theorize “work” and its place in culture. For instance, we looked at terms we use to describe work (labor, career, job), personal and collective identities associated with work (unions; corporate culture; social and economic class positions; race, gender and ethnic identities), representations of work (photography, film, maps, music, literature), and theoretical interpretations of work (alienation from systems of production, gift economies)

X-ray eruptions every 22 days from the nucleus of a nearby galaxy

Galactic nuclei showing recurrent phases of activity and quiescence have recently been discovered, with recurrence times as short as a few hours to a day -- known as quasi-periodic X-ray eruption (QPE) sources -- to as long as hundreds to a thousand days for repeating nuclear transients (RNTs). Here we report the discovery of Swift J023017.0+283603 (hereafter Swift J0230+28), a source that exhibits X-ray quasi-periodic eruptions from the nucleus of a previously unremarkable galaxy at $\sim$ 165 Mpc, with a recurrence time of approximately 22 days, an intermediary timescale between known RNTs and QPE sources. We also report transient radio emission from the source, which is likely associated with the X-ray eruptions. Such recurrent soft X-ray eruptions from a low-mass black hole, with no accompanying UV/optical emission are strikingly similar to QPE sources. However, in addition to having a recurrence time that is $\sim 25$ times longer than the longest-known QPE source, Swift J0230+28's eruptions exhibit slightly distinct shapes and temperature evolution than the known QPE sources. The observed properties disfavor disk instability models, and instead favor scenarios involving extreme mass ratio inspirals. Our discovery reveals a new timescale for repeating extragalactic transients and highlights the need for a wide-field, time-domain X-ray mission, which would enable the exploration of the parameter space of recurring X-ray transients.Comment: Under review on Nature Astronomy. Main Section: 14 pages, 3 figures and 1 Table. Methods: 32 pages, 11 Figures, 4 Table

Plantar plate pathology is associated with erosive disease in the painful forefoot of patients with rheumatoid arthritis

Background: Disease-related foot pathology is recognised to have a significant impact on mobility and functional capacity in the majority of patients with rheumatoid arthritis (RA). The forefoot is widely affected and the metatarsophalangeal (MTP) joints are the most common site of symptoms. The plantar plates are the fibrocartilaginous distal attachments of the plantar fascia inserting into the five proximal phalanges. Together with the transverse metatarsal ligament they prevent splaying of the forefoot and subluxation of the MTP joints. Damage to the plantar plates is a plausible mechanism therefore, through which the forefoot presentation, commonly described as ‘walking on pebbles’, may develop in patients with RA. The aims of this study were to investigate the relationship between plantar plate pathology and clinical, biomechanical and plain radiography findings in the painful forefoot of patients with RA. Secondly, to compare plantar plate pathology at the symptomatic lesser (2nd-5th) MTP joints in patients with RA, with a group of healthy age and gender matched control subjects without foot pain. Methods: In 41 patients with RA and ten control subjects the forefoot was imaged using 3T MRI. Intermediate weighted fat-suppressed sagittal and short axis sequences were acquired through the lesser MTP joints. Images were read prospectively by two radiologists and consensus reached. Plantar plate pathology in patients with RA was compared with control subjects. Multivariable multilevel modelling was used to assess the association between plantar plate pathology and the clinical, biomechanical and plain radiography findings. Results: There were significant differences between control subjects and patients with RA in the presence of plantar plate pathology at the lesser MTP joints. No substantive or statistically significant associations were found between plantar plate pathology and clinical and biomechanical findings. The presence of plantar plate pathology was independently associated with an increase in the odds of erosion (OR = 52.50 [8.38–326.97], p < 0.001). Conclusion: The distribution of plantar plate pathology at the lesser MTP joints in healthy control subjects differs to that seen in patients with RA who have the consequence of inflammatory disease in the forefoot. Longitudinal follow-up is required to determine the mechanism and presentation of plantar plate pathology in the painful forefoot of patients with RA

Kepler Certified False Positive Table

This document describes the Kepler Certied False Positive table hosted at the Exoplanet Archive1, herein referred to as the CFP table. This table is the result of detailed examination by the Kepler False Positive Working Group (FPWG) of declared false positives in the Kepler Object of Interest (KOI) tables (see, for example, Batalha et al. (2012); Burke et al.(2014); Rowe et al. (2015); Mullally et al. (2015); Coughlin et al. (2015b)) at the Exoplanet Archive. A KOI is considered a false positive if it is not due to a planet orbiting the KOI's target star. The CFP table contains all KOIs in the Exoplanet Archive cumulative KOI table. The purpose of the CFP table is to provide a list of certified false positive KOIs. A KOI is certified as a false positive when, in the judgement of the FPWG, there is no plausible planetary interpretation of the observational evidence, which we summarize by saying that the evidence for a false positive is compelling. This certification process involves detailed examination using all available data for each KOI, establishing a high-reliability ground truth set. The CFP table can be used to estimate the reliability of, for example, the KOI tables which are created using only Kepler photometric data, so the disposition of individual KOIs may differ in the KOI and CFP tables. Follow-up observers may find the CFP table useful to avoid observing false positives

Community-associated Methicillin-resistant Staphylococcus aureus in Hospital Nursery and Maternity Units

Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has rarely been reported in the hospital setting. We report an outbreak of 7 cases of skin and soft tissue infections due to a strain of CA-MRSA. All patients were admitted to the labor and delivery, nursery, or maternity units during a 3-week period. Genetic fingerprinting showed that the outbreak strain was closely related to the USA 400 strain that includes the midwestern strain MW2. All isolates contained the staphylococcal chromosome cassette mec type IV. Genes for Panton-Valentine leukocidin and staphylococcal enterotoxin K were detected in all isolates, and most contained other enterotoxin genes. Testing of nearly 2,000 MRSA isolates collected during citywide surveillance studies from 1999 to 2003 showed that ≈1% were genetically related to MW2. CA-MRSA strain MW2 has been present in this region at least since 1999. This study documents the spread of this strain among healthy newborns at 1 hospital