Chemical Profiling and Extraction Processing of Basil (Ocimum L.)cultivars Grown in Oklahoma

Scope and Method of Study: The objectives for this study were to develop a chemical profile library for basil cultivars with potential production in Oklahoma while optimizing handling conditions for their dehydration processing as well as to evaluate and optimize ambient temperature extraction process (ATE) with propane for dehydrated basils. From 2005 to 2011, foliage harvests were intermittently conducted from sixteen cultivars prior to excessive flowering starting in early July and ending in late September at three to four week intervals, but in 2011 harvest frequency was varied on strict 2 week or 3 week intervals for five cultivars. Samples were typically dried at 40C after harvest. For ATE, dried samples were separated into flowers, leaves and stems. Extractions were then conducted using a custom built continuous flow propane extractor at ambient temperature (21-27C) and low pressure (1.1-1.9 MPa). Dried samples were ground before extracting with hexane while extracts were solubilized into hexaneHorticulture and Landscape Architecture Departmen

The Effects of Infliximab on Laminin, NF κ

The aim of this study was to investigate the possible protective effects of infliximab on expression of laminin, anti-TNF, and NFκB in the rat hepatic cells after ischemia/reperfusion (I/R). A total of 30 male Wistar albino rats were divided into three groups: Control (C), sham I/R (ISC), and I/R+ infliximab (ISC inf); each group comprised 10 animals. C group animals underwent laparotomy without I/R injury. In ISC groups after undergoing laparotomy, 1 hour of superior mesenteric artery ligation was done, which was followed by 1 hour of reperfusion. In the ISC inf group, 3 days before I/R, infliximab (3 mg/kg) was administered intravenously. All animals were killed at the end of reperfusion and hepatic tissue samples were obtained for histopathological and histochemical investigations in all groups. Laminin, anti-TNF, and NFκB immunoreactivity were performed for all groups. ISC caused severe histopathological injury including mucosal erosions, inflammatory cell infiltration, necrosis, hemorrhage, and villous congestion. Infliximab treatment significantly attenuated the severity of intestinal I/R injury and it is shown by laminin, anti-TNF, and NFκB immunoreactivity. Because of its anti-inflammatory and antioxidant effects, infliximab pretreatment may have protective effects on hepatic cells in the experimental intestinal I/R model of rats

Kamu Yöneticilerinin Siyasal Ve Yönetsel Ahlaki Davraniş Tipleri

Çalışmada siyasal-yönetsel ahlak ve siyasal-yönetsel yozlaşma kavramları incelenmiştir. Siyasi ve yönetsel yozlaşamaya sebep olan ahlaki tavırları açıklayabilmek için bireyin ahlak gelişimini anlatan teoriler üzerinde durulmuştur. Günümüz Türkiye’sindeki siyasi ve yönetsel yozlaşmalar sadece bugüne ait olmayıp geçmişten günümüze miras olarak gelmişlerdir. Bu durumun nedeni de ülkenin geçirmiş olduğu siyasi kültürel ve ekonomik değişimler olarak açıklanabilir

Characterization of greater middle eastern genetic variation for enhanced disease gene discovery

The Greater Middle East (GME) has been a central hub of human migration and population admixture. The tradition of consanguinity, variably practiced in the Persian Gulf region, North Africa, and Central Asia1-3, has resulted in an elevated burden of recessive disease4. Here we generated a whole-exome GME variome from 1,111 unrelated subjects. We detected substantial diversity and admixture in continental and subregional populations, corresponding to several ancient founder populations with little evidence of bottlenecks. Measured consanguinity rates were an order of magnitude above those in other sampled populations, and the GME population exhibited an increased burden of runs of homozygosity (ROHs) but showed no evidence for reduced burden of deleterious variation due to classically theorized ‘genetic purging’. Applying this database to unsolved recessive conditions in the GME population reduced the number of potential disease-causing variants by four- to sevenfold. These results show variegated genetic architecture in GME populations and support future human genetic discoveries in Mendelian and population genetics

Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries

Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely

Hafniya yüzeyinde tutunmuş rutenyum(0) nanoparçacıkları: oldukça aktif ve uzun ömürlü katalizörün amonyak boranın hidrolitik dehidrolizinde kullanılması.

Transition metal(0) nanoparticles are highly active and selective catalyst. When stabilized in organic or aqueous solutions, they can catalyze many reactions. The catalytic activity of metal(0) nanoparticles depends on the particle size and size distribution. However, transition metal(0) nanoparticles have tendency for aggregation to larger particles, ultimately to bulk metal. Metal(0) nanoparticles can be stabilized against aggregation by supporting on the oxide surface. In this project, nanopowder hafnia (HfO2) was used as support for the stabilization of ruthenium(0) nanoparticles which is found to be one of the most active catalysts in hydrogen release from ammonia borane. Ruthenium(III) cations were impregnated on the surface of HfO2 and then reduced by sodium borohydride in aqueous solution. Next, ruthenium(0) nanoparticles were used in the catalytic hydrolysis of ammonia borane. Ruthenium(0) nanoparticles supported on hafnia were isolated from the reaction solution by centrifugation and characterized by a combination of advanced analytical techniques including ICP-OES, BET, XRD, SEM, SEM-EDS, TEM, and XPS. Ruthenium(0) nanoparticles supported on hafnia were tested as catalyst in hydrogen generation from the hydrolysis of ammonia borane at ambient temperature. The kinetics of catalytic hydrolysis were studied depending on the catalyst concentration, metal loading of the support and temperature.M.S. - Master of Scienc

The Turkish Adaptation Of The Program Administration Scale

This study aims at conducting the Turkish translation and reliability study of the Program Administration Scale (PAS), developed by Talan and Bloom (2004) in order to measure early childhood leadership and management. The scale is used to determine quality in preschools in terms of administrative context. In this study the original version of PAS was translated into Turkish and back translated by bilingual individuals. After obtaining the Turkish form of the scale, the reliability study was done in 26 preschools. The results show that the scale is a highly reliable tool to support quality studies in early childhood education research. (C) 2010 Elsevier Ltd. All rights reserved.WoSScopu

Examining Preschools' Quality In Terms Of Physical Conditions

This study aims at investigating the quality of preschools in Turkey in terms of educational environment and comparing the qualities of public preschools, private preschools and preschools operating within an institution. The sample of the study consists of randomly selected 26 preschools located in Ankara. ECERS ( Harms et al, 1980) is used as data gathering instrument. The data are analyzed by Correlation Analysis and Kruskal-Wallis Test. As a result, the ECERS-R mean scores are found to be below the "good" level and no significant difference is found among three kinds of preschools in terms of educational environment. This shows that there appears to be a need to improve quality in early childhood education centers. (C) 2009 Elsevier Ltd. All rights reservedWoSScopu

Türkiye'de Adli Tıp Departmanında İncelenen İş kazaları: Beş yıllık retrospektif çalışma.

Abstract: Occupational accidents (OA) cause many deaths or injuries and have severe individual and socialconsequences, despite being preventable public health problems. Our study aims to obtain regional up-to-date data, riskyworking areas and the effects of COVID-19 pandemic, guide for preventive measures.The data was obtained retrospectively from the university hospital in Izmir, Turkey, from January 1, 2016, toDecember 31, 2020. Parameters include socio-demographic characteristics, injury type/localization, and sector. SPSS 24.0was used for statistical analysis.The total number of cases included in the study was 186. Results indicated that 92% of the cases were male, most caseswas working as a construction worker (29%), most of the accidents occurred in the building-construction sector (33.4%), andcommon mechanism of injuries was with cutting/penetrating/crushing tool (32.3%). Upper extremity injuries were the mostcommon body parts (n:100). The bone fracture occurred in 61.3% of all cases and had a high rate (83.8%) of injured by fallingfrom a height (p=0.002).This study revealed that the building-construction sector is one of the riskiest areas. Traffic accidents were morefrequent in our study than in the literature. The regional characteristics of OA need to be evaluated and the COVID-19pandemic may increase OA exposure in some occupational groups like motorcycle couriers. It is necessary to reveal theenvironmental and social factors that cause OA and to take precautions.Keywords: forensic traumatology, medicolegal evaluation, occupational accidents.</p