Characteristics of Esophageal Cancer Cases in Tanzania.

PurposeAge-standardized incidence rates for esophageal cancer (EC) in East Africa have been reported as disproportionately high compared with the worldwide incidence of nine per 100,000 population. This study aimed to characterize EC cases seen at Muhimbili National Hospital and Ocean Road Cancer Institute in Dar es Salaam, Tanzania.MethodsDemographic, clinical, and treatment variables were abstracted from charts of patients who received care for a diagnosis of EC at one or both institutions between 2011 and 2013. Categorical data were summarized as frequency counts and percentages. Continuous data were presented as medians and ranges. To compare men and women, Pearson's χ2 and two-sample t tests were applied.ResultsSeven hundred thirty-eight unique cases of EC were identified, of whom 68% were men and the median age was 60 years (range, 19 to 95 years). Notably, 93 cases (13%) were ≤ 40 years old at diagnosis. Squamous cell carcinoma was the dominant histology, comprising 90% of cases with documented histopathology. However, 34% of cases with a diagnosis of EC were not pathologically confirmed. The stage was documented as locoregional in 4% of cases, locally advanced in 20% of cases, metastatic in 14% of cases, and unknown in 63% of cases. Of 430 patients who received treatment at Ocean Road Cancer Institute, 76% were treated with radiation, 44% were treated with chemotherapy, 3% underwent a cancer-related surgical procedure, and 10% of cases received no cancer-directed therapy. The median overall survival for all patients was 6.9 months (95% CI, 5.0 to 12.8), regardless of stage at presentation.ConclusionBetween 2011 and 2013, cases of EC represented a large clinical burden at both institutions

Xi and AntiXi production in Pb+Pb collisions at 40 AGeV at CERN SPS

First results on the production of Xi and AntiXi hyperons in Pb+Pb interactions at 40 AGeV are presented. The AntiXi/Xi ratio at midrapidity is studied as a function of collision centrality. The ratio shows no significant centrality dependence within statistical errors; it ranges from 0.07 to 0.15. The AntiXi/Xi ratio for central Pb+Pb collisions increases strongly with the collision energy.Comment: 6 pages, 6 figures, proceedings of SQM03, to be published in Journal of Physics G; V2: changes in table 1 and figure

Role of the Tracy-Widom distribution in the finite-size fluctuations of the critical temperature of the Sherrington-Kirkpatrick spin glass

We investigate the finite-size fluctuations due to quenched disorder of the critical temperature of the Sherrington-Kirkpatrick spin glass. In order to accomplish this task, we perform a finite-size analysis of the spectrum of the susceptibility matrix obtained via the Plefka expansion. By exploiting results from random matrix theory, we obtain that the fluctuations of the critical temperature are described by the Tracy-Widom distribution with a non-trivial scaling exponent 2/3

Importance of reaction volume in hadronic collisions: Canonical enhancement

We study the canonical flavor enhancement arising from exact conservation of strangeness, and charm flavor. Both the theoretical motivation, and the practical consequences are explored. We argue using qualitative theoretical arguments and quantitative evaluation, that this proposal to reevaluate strangeness signature of quark--gluon plasma is not able to explain the majority of available experimental results.Comment: 14 pages including 6 figures, submitted to Journal of Physics G Presented at: Strange Quark Matter, September 2001, Frankfur

An overview and prospective on Al and Al-ion battery technologies

Aluminum batteries are considered compelling electrochemical energy storage systems because of the natural abundance of aluminum, the high charge storage capacity of aluminum of 2980 mA h g−1/8046 mA h cm−3, and the sufficiently low redox potential of Al3+/Al. Several electrochemical storage technologies based on aluminum have been proposed so far. This review classifies the types of reported Al-batteries into two main groups: aqueous (Al-ion, and Al-air) and non-aqueous (aluminum graphite dual-ion, Al-organic dual-ion, Al-ion, and Al-sulfur). Specific focus is given to Al electrolyte chemistry based on chloroaluminate melts, deep eutectic solvents, polymers, and “chlorine-free” formulations

Uncovering current pyroregions in Italy using wildfire metrics

Background: Pyrogeography is a major field of investigation in wildfire science because of its capacity to describe the spatial and temporal variations of fire disturbance. We propose a systematic pyrogeographic analytical approach to cluster regions on the basis of their pyrosimilarities. We employed the Affinity Propagation algorithm to cluster pyroregions using Italian landscape as a test bed and its current wildfire metrics in terms of density, seasonality and stand replacing fire ratio. A discussion follows on how pyrogeography varies according to differences in the human, biophysical, socioeconomic, and climatic spheres. Results: The algorithm identified seven different pyroregion clusters. Two main gradients were identified that partly explain the variability of wildfire metrics observed in the current pyroregions. First, a gradient characterized by increasing temperatures and exposure to droughts, which coincides with a decreasing latitude, and second, a human pressure gradient displaying increasing population density in areas at lower elevation. These drivers exerted a major influence on wildfire density, burnt area over available fuels and stand replacing, which were associated to warm-dry climate and high human pressure. The study statistically highlighted the importance of a North–South gradient, which represents one of the most important drivers of wildfire regimes resulting from the variations in climatic conditions but showing collinearity with socioeconomic aspects as well. Conclusion: Our fully replicable analytical approach can be applied at multiple scales and used for the entire European continent to uncover new and larger pyroregions. This could create a basis for the European Commission to promote innovative and collaborative funding programs between regions that demonstrate pyrosimilarities

<i>Herschel</i> observations of B1-bS and B1-bN: two first hydrostatic core candidates in the Perseus star-forming cloud

We report far-infrared Herschel observations obtained between 70 μm and 500 μm of two star-forming dusty condensations, [HKM99] B1-bS and [HKM99] B1-bN, in the B1 region of the Perseus star-forming cloud. In the western part of the Perseus cloud, B1-bS is the only source detected in all six PACS and SPIRE photometric bands, but it is not visible in the Spitzer map at 24 μm. B1-bN is clearly detected between 100 μm and 250 μm. We have fitted the spectral energy distributions of these sources to derive their physical properties, and find that a simple greybody model fails to reproduce the observed spectral energy distributions. At least a two-component model is required, consisting of a central source surrounded by a dusty envelope. The properties derived from the fit, however, suggest that the central source is not a Class 0 object. We then conclude that while B1-bS and B1-bN appear to be more evolved than a pre-stellar core, the best-fit models suggest that their central objects are younger than a Class 0 source. Hence, they may be good candidates to be examples of the first hydrostatic core phase. The projected distance between B1-bS and B1-bN is a few Jeans lengths. If their physical separation is close to this value, this pair would allow studying the mutual interactions between two forming stars at a very early stage of their evolution

The Herschel view of the on-going star formation in the Vela-C molecular cloud

As part of the Herschel guaranteed time key program 'HOBYS', we present the photometric survey of the star forming region Vela-C, one of the nearest sites of low-to-high-mass star formation in the Galactic plane. Vela-C has been observed with PACS and SPIRE in parallel mode between 70 um and 500 um over an area of about 3 square degrees. A photometric catalogue has been extracted from the detections in each band, using a threshold of 5 sigma over the local background. Out of this catalogue we have selected a robust sub-sample of 268 sources, of which 75% are cloud clumps and 25% are cores. Their Spectral Energy Distributions (SEDs) have been fitted with a modified black body function. We classify 48 sources as protostellar and 218 as starless. For two further sources, we do not provide a secure classification, but suggest they are Class 0 protostars. From SED fitting we have derived key physical parameters. Protostellar sources are in general warmer and more compact than starless sources. Both these evidences can be ascribed to the presence of an internal source(s) of moderate heating, which also causes a temperature gradient and hence a more peaked intensity distribution. Moreover, the reduced dimensions of protostellar sources may indicate that they will not fragment further. A virial analysis of the starless sources gives an upper limit of 90% for the sources gravitationally bound and therefore prestellar. We fit a power law N(logM) prop M^-1.1 to the linear portion of the mass distribution of prestellar sources. This is in between that typical of CO clumps and those of cores in nearby star-forming regions. We interpret this as a result of the inhomogeneity of our sample, which is composed of comparable fractions of clumps and cores.Comment: 9 pages, 7 figures, accepted by A&

Efficacy of lisdexamfetamine dimesylate throughout the day in children and adolescents with attention-deficit/hyperactivity disorder:results from a randomized, controlled trial

Lisdexamfetamine dimesylate (LDX) is a long-acting, prodrug stimulant therapy for patients with attention-deficit/hyperactivity disorder (ADHD). This randomized placebo-controlled trial of an optimized daily dose of LDX (30, 50 or 70 mg) was conducted in children and adolescents (aged 6–17 years) with ADHD. To evaluate the efficacy of LDX throughout the day, symptoms and behaviors of ADHD were evaluated using an abbreviated version of the Conners’ Parent Rating Scale-Revised (CPRS-R) at 1000, 1400 and 1800 hours following early morning dosing (0700 hours). Osmotic-release oral system methylphenidate (OROS-MPH) was included as a reference treatment, but the study was not designed to support a statistical comparison between LDX and OROS-MPH. The full analysis set comprised 317 patients (LDX, n = 104; placebo, n = 106; OROS-MPH, n = 107). At baseline, CPRS-R total scores were similar across treatment groups. At endpoint, differences (active treatment − placebo) in least squares (LS) mean change from baseline CPRS-R total scores were statistically significant (P < 0.001) throughout the day for LDX (effect sizes: 1000 hours, 1.42; 1400 hours, 1.41; 1800 hours, 1.30) and OROS-MPH (effect sizes: 1000 hours, 1.04; 1400 hours, 0.98; 1800 hours, 0.92). Differences in LS mean change from baseline to endpoint were statistically significant (P < 0.001) for both active treatments in all four subscales of the CPRS-R (ADHD index, oppositional, hyperactivity and cognitive). In conclusion, improvements relative to placebo in ADHD-related symptoms and behaviors in children and adolescents receiving a single morning dose of LDX or OROS-MPH were maintained throughout the day and were ongoing at the last measurement in the evening (1800 hours)

Strangeness Report

The paper provides a short report on strangeness production in ultrarelativistic nucleus-nucleus collision, with the main stress on strange particle abundances.Comment: Proceedings of Quark Matter 200