4 research outputs found
Gold(I) as an Artificial Cyclase: Short Stereodivergent Syntheses of (â)-Epiglobulol and (â)-4ÎČ,7α- and (â)-4α,7α-Aromadendranediols
Three natural aromadendrane sesquiterpenes, (â)âepiglobulol, (â)â4ÎČ,7αâaromadendranediol, and (â)â4α,7αâaromadendranediol, have been synthesized in only seven steps in 12, 15, and 17â% overall yields, respectively, from (E,E)âfarnesol by a stereodivergent gold(I)âcatalyzed cascade reaction which forms the tricyclic aromadendrane core in a single step. These are the shortest total syntheses of these natural compounds