) and Other Risk Factors in Egyptian Subjects with Coronary Artery Disease

Abstract:Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide. Obesity has been suggested as a major risk factor for this disease. This study aims to assess the relation between obesity and CAD in a selected group of Egyptian population. Other risk factors, including blood pressure, blood glucose, and lipids have also been investigated. The study included 80 patients with CAD (mean age: 47.86 years, males / females: 43/37), and 40 healthy controls (mean age: 46.15 years, males / females: 13/27). CAD patients were divided according to their body mass index (BMI) into 2 main groups: normal weigh group (BMI: 18.5-24.9, n=40) and abnormal weight group (BMI≥25, n= 40), the latter group was further sub-divided into overweight group (BMI: 25.0-29.9, n= 20) and obese grou

دراسة التغيرات الهيستوباثولوجية المحدثة في أنسجة الكبد والطحال في حيوانات الفأر الصغير المعداة بالبلهارسيا وكذلك في حيوانات معداة ومعاملة بعقار البرازيكانتيل

Hepatic and splenic lesions were developed in mice of both sexes following their exposure to cercariae of Schistosoma mansoni (70 cercariae / animal). After 12 weeks of infection, the liver showed the formation of typical egg granuloma infiltered with abundant bilharzial pigments, meanwhile, paragranuloma hepatocytes displayed abnormal alterations. However, no egg lesions were observed in the spleen of infected mice and the only detectable change was distortion of splenic parenchyma with deposited bilharzial pigments. The present investigation was extended to include the effect of praziquantel administration on the liver and spleen of non infected and schistosome infected mice. The study revealed that, the drug induced areas of focal necrosis in the liver, whereas it was found to have no marked effect on the spleen of non infected mice. In addition, the drug administration to schistosome infected mice circumvented induced lesions in both liver and spleen.يستهدف البحث دراسة طبيعة التغيرات الهيستوباثولوجية المحدثة في أنسجة الكبد والطحال للفأر الصغير المصاب بحوالي 70 من سركاريا المستقيم وكذلك تهدف الدراسة إلى معرفة تأثير عقار البرازيكانتيل المضاد للبلهارسيا على كل من الكبد والطحال في حيوانات تجارب معداة وغيرمعداة بالبلهارسيا . وقد أجريت هذه الدراسة على إناث وذكور حيوانات التجارب . وكاث تقتل هذه الحيوانات بعد ثلاثة أشهر من بداية العدوى . وقد أوضحت هذه الدراسة ظهور تليفات نسيجية تحيط بويضات البلهارسيا المتجمعة في أكباد الفئران المعدات وكذلك ظهور تليفات تتخلل نسيج الطحال . وعتد دراسة تأثير البرازيكانثيل على حيوانات التجارب غير المعداة لوحظ وجود نكروز في الكبد وعدم وجود تغيرات هستوباثولوجية في الطحال . أما بالنسبة لتأثير العقار على الحيوانات المعداة فقد أثبتت هذه الدراسة فاعلية هذا العقار في علاج التغيرات النسيجية المحدثة في كل من الكبد والطحال نتيجة العدوى بالبلهارسيا

Bauhinia variegata L. leaf extract ameliorates oxidative stress, renal apoptotic damage and dietary-induced obesity in Wistar albino male rats

478-485Association between obesity and chronic kidney disease has received great attention in the recent years. This study aimed to characterize the efficiency of the Camel's foot tree, Bauhinia variegata L. ethanolic leaves extract (BEX) against kidney damage in high fat diet (HFD) fed male rats, as a model of obesity. Rats were randomly divided into five groups, the first three served as control, vehicle and BEX (40 mg/100 g body wt.), while the other two groups were fed HFD with and without BEX at the same mentioned dose, daily for 12 weeks. Results showed significantly increased weight gain, absolute and relative kidney weights, serum and kidney lipids, accompanied by elevated levels of urea and creatinine in serum of HFD-fed rats. Results also revealed marked reduction of kidney nitric oxide, alkaline phosphatase and gamma glutamyl transferase, with elevation in their activities in serum of the obese rats. An increase in the oxidative stress markers; malondialdehyde and hydrogen peroxide, paralleled by reduction of total antioxidant capacity, glutathione, glucose-6-phosphatase dehydrogenase and the antioxidant enzymes; superoxide dismutase, catalase and glutathione peroxidase were also detected. This goes with decline of the anti-apoptotic Bcl2 and elevation in the pro-apoptotic Bax and caspase-3, followed by increased apoptosis% and cell cycle arrest with decline in cells at S and G2/GM phases. Meanwhile, a significant reduction in RBCs count, Hb content and related indices was demonstrated. In contrast, administration of BEX to HFD-fed rats significantly ameliorated increased weight gain, oxidative stress, apoptosis, cell cycle arrest and hematological changes, thereby restored kidney functional parameters near the normal values, suggesting BEX as a promising natural therapy for managing obesity and associated kidney disease