Utilisation des noeuds DecaWiNo pour la localisation indoor précise d'objets communicants en UWB

Une des applications privilégiées de l'Ultra Wide Band (UWB) est la localisation indoor de noeuds communicants. Le mécanisme d'évaluation de la distance entre les noeuds (ranging) permet d'alimenter des algorithmes et des calculs géométriques afin de déterminer la position de noeuds communicants avec une précision d'une dizaine de centimètres. Les travaux de recherche présentés dans cet article s'inscrivent dans cette thématique et visent à utiliser les liens radio de type UWB, proposés par l'amendement [1] de l'année 2007 de la norme IEEE 802.15.4. Nous présentons les noeuds DecaWino, basés sur un tranceiver DecaWave [2] DW1000, et un processeur Cortex-M4 Freescale MK20DX256VLH7, présent sur le module Teensy 3.2 de l'écosystème Arduino. Associés aux noeuds DecaWino que nous avons conçus, notre plateforme logicielle Decaduino [3], offre un environnement logiciel [4] adapté et permet le prototypage rapide de solutions de localisation de noeuds UWB

Author Correction: Expanded encyclopaedias of DNA elements in the human and mouse genomes

Online Correction for: https://doi.org/10.1038/s41586-020-2493-4 | Erratum for https://bura.brunel.ac.uk/handle/2438/21299In the version of this article initially published, two members of the ENCODE Project Consortium were missing from the author list. Rizi Ai (Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA) and Shantao Li (Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA) are now included in the author list. These errors have been corrected in the online version of the article : 'Expanded encyclopaedias of DNA elements in the human and mouse genomes'.https://www.nature.com/articles/s41586-021-04226-3https://www.nature.com/articles/s41586-021-04226-

Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries

Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely

Perspectives on ENCODE

Supplementary information is available for this paper at https://doi.org/10.1038/s41586-020- 2449-8.© 2020, The Author(s). The Encylopedia of DNA Elements (ENCODE) Project launched in 2003 with the long-term goal of developing a comprehensive map of functional elements in the human genome. These included genes, biochemical regions associated with gene regulation (for example, transcription factor binding sites, open chromatin, and histone marks) and transcript isoforms. The marks serve as sites for candidate cis-regulatory elements (cCREs) that may serve functional roles in regulating gene expression1. The project has been extended to model organisms, particularly the mouse. In the third phase of ENCODE, nearly a million and more than 300,000 cCRE annotations have been generated for human and mouse, respectively, and these have provided a valuable resource for the scientific community.NIH grants: U01HG007019, U01HG007033, U01HG007036, U01HG007037, U41HG006992, U41HG006993, U41HG006994, U41HG006995, U41HG006996, U41HG006997, U41HG006998, U41HG006999, U41HG007000, U41HG007001, U41HG007002, U41HG007003, U41HG007234, U54HG006991, U54HG006997, U54HG006998, U54HG007004, U54HG007005, U54HG007010 and UM1HG009442

Sarco-IO : étude des facteurs de risque associés à la survenue d'une infection opportuniste chez les patients porteurs de sarcoïdose/thèse présentée pour le diplôme d'État de docteur en médecine, diplôme d'État, mention médecine interne

Médecine interneUn nombre important d'infections opportunistes (IO) chez les patients atteints de sarcoïdose a été décrit dans la littérature médicale jusqu'à présent, mais sans explication claire. Nous avons réalisé une revue de la littérature médicale sur la base de données Medline via PubMed incluant tous les cas d'IO à l'exclusion de l'aspergillose et de la tuberculose et une étude rétrospective par le biais d'un appel à observations d'IO chez des patients atteints de sarcoïdose à travers la France. Dans notre revue de la littérature, un total de 181 IO ont été identifiées. Les IO les plus fréquemment rapportées étaient des cryptococcoses (N=84 ; 42%). 49 patients ont été inclus dans l'étude et comparés à une population de 136 patients témoins atteints de sarcoïdose et sans IO. Les lymphadénopathies périphériques (OR=3.45 [1.59;7.54], p=0.002), la splénomégalie (OR=8.80 [2.12;46.3], p=0,003), l’atteinte pulmonaire parenchymateuse (OR=6.57 [2.98;16.2], p-0.001), l’atteinte du système nerveux central (OR=8.48 [2.28;42.4], p=0.001), l’utilisation de corticostéroïdes (OR=10.1 [4.43;26.5], p-0.001) ou de cyclophosphamide et d’anti TNFα (respectivement OR=9.00 [1.92 ;70.0] et OR=7.37 [1.46 ;59.0]) étaient statistiquement associés à un risque accru d'IO. Les IO dans la sarcoïdose surviennent ainsi chez des patients dont la maladie est plus sévère et plus souvent traités par immunosuppresseurs. La différence en termes de présentation clinique initiale pourrait s’expliquer par une susceptibilité intrinsèque accrue de certains patients au développement d’infections opportunistesA significant number of opportunistic infections (OIs) in patients with sarcoidosis have been described in the medical literature to date, but without clear explanation. We performed a review of the medical literature on the Medline database via PubMed including all cases of OIs excluding aspergillosis and tuberculosis and a retrospective study through a call for observations of OIs in sarcoidosis patients across France. In our literature review, a total of 181 OIs were identified. The most frequently reported OIs were cryptococcosis (N=84; 42%). 49 patients were included in the study and compared to a population of 136 control patients with sarcoidosis and no OI. Peripheral lymphadenopathy (OR=3.45 [1.59;7.54], p=0.002), splenomegaly (OR=8.80 [2.12;46.3], p=0.003), parenchymal lung involvement (OR=6.57 [2.98;16.2], p-0.001), central nervous system involvement (OR=8.48 [2. 28;42.4], p=0.001), corticosteroid use (OR=10.1 [4.43;26.5], p-0.001) and cyclophosphamide and anti TNFα (OR=9.00 [1.92;70.0] and OR=7.37 [1.46;59.0], respectively) were statistically associated with an increased risk of OI. OIs in sarcoidosis thus occur in patients with more severe disease and more often treated with immunosuppressants. The difference in initial clinical presentation could be explained by an increased intrinsic susceptibility of some patients to the development of opportunistic infection

Challenging Mimickers in the Diagnosis of Sarcoidosis: A Case Study

Sarcoidosis is a systemic granulomatous disease of unknown cause characterized by a wide variety of presentations. Its diagnosis is based on three major criteria: a clinical presentation compatible with sarcoidosis, the presence of non-necrotizing granulomatous inflammation in one or more tissue samples, and the exclusion of alternative causes of granulomatous disease. Many conditions may mimic a sarcoid-like granulomatous reaction. These conditions include infections, neoplasms, immunodeficiencies, and drug-induced diseases. Moreover, patients with sarcoidosis are at risk of developing opportunistic infections or lymphoma. Reliably confirming the diagnosis of sarcoidosis and better identifying new events are major clinical problems in daily practice. To address such issues, we present seven emblematic cases, seen in our department, over a ten-year period along with a literature review about case reports of conditions misdiagnosed as sarcoidosis

Estudio experimental del flujo y características químicas del agua en la zona no saturada

Tesis doctoral inédita leída en la Universidad Autónoma de Madrid. Facultad de Ciencias. Departamento de Geologia y Geoquímica. Fecha de lectura: 7-07-198

Tjänsteorienterad arkitektur (SOA) för integration mot upphandlingssystem

Validerat; 20101217 (root

Tjänsteorienterad arkitektur (SOA) för integration mot upphandlingssystem

Validerat; 20101217 (root