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Perspectives on ENCODE
Authors
F Abascal
R Acosta
+100 more
NJ Addleman
J Adrian
V Afzal
B Aken
JA Akiyama
H Amrhein
SM Anderson
GR Andrews
I Antoshechkin
KG Ardlie
J Armstrong
M Astley
B Banerjee
AA Barkal
IHA Barnes
I Barozzi
D Barrell
G Barson
D Bates
UK Baymuradov
C Bazile
MA Beer
S Beik
MA Bender
R Bennett
BE Bernstein
A Berry
A Bhaskar
A Bignell
SM Blue
DM Bodine
C Boix
N Boley
T Borrman
B Borsari
LPB Bouvrette
AP Boyle
LA Brandsmeier
A Breschi
EH Bresnick
JA Brooks
M Buckley
CB Burge
R Byron
E Cahill
L Cai
L Cao
M Carty
RG Castanon
A Castillo
H Chaib
ET Chan
DR Chee
S Chee
H Chen
H Chen
JY Chen
S Chen
JM Cherry
SB Chhetri
JS Choudhary
J Chrast
D Chung
D Clarke
NAL Cody
CJ Coppola
J Coursen
S Dalton
C Danyko
C Davidson
J Davila-Velderrain
CA Davis
J Dekker
A Deran
G DeSalvo
G Despacio-Reyes
CN Dewey
DE Dickel
M Diegel
M Diekhans
V Dileep
B Ding
S Djebali
A Dobin
D Dominguez
S Donaldson
J Drenkow
TR Dreszer
Y Drier
MO Duff
D Dunn
AM D’Ippolito
C Eastman
JR Ecker
MD Edwards
N El-Ali
SI Elhajjajy
TR Gingeras
OA Jammal
MP Snyder
Publication date
30 July 2020
Publisher
'Springer Science and Business Media LLC'
Doi
Abstract
Supplementary information is available for this paper at https://doi.org/10.1038/s41586-020- 2449-8.© 2020, The Author(s). The Encylopedia of DNA Elements (ENCODE) Project launched in 2003 with the long-term goal of developing a comprehensive map of functional elements in the human genome. These included genes, biochemical regions associated with gene regulation (for example, transcription factor binding sites, open chromatin, and histone marks) and transcript isoforms. The marks serve as sites for candidate cis-regulatory elements (cCREs) that may serve functional roles in regulating gene expression1. The project has been extended to model organisms, particularly the mouse. In the third phase of ENCODE, nearly a million and more than 300,000 cCRE annotations have been generated for human and mouse, respectively, and these have provided a valuable resource for the scientific community.NIH grants: U01HG007019, U01HG007033, U01HG007036, U01HG007037, U41HG006992, U41HG006993, U41HG006994, U41HG006995, U41HG006996, U41HG006997, U41HG006998, U41HG006999, U41HG007000, U41HG007001, U41HG007002, U41HG007003, U41HG007234, U54HG006991, U54HG006997, U54HG006998, U54HG007004, U54HG007005, U54HG007010 and UM1HG009442
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Last time updated on 25/01/2021