Néphrectomie bilatérale de sauvetage compliquant une sclérose tubéreuse de Bourneville

La sclérose tubéreuse de Bourneville (STB) est une phacomatose autosomique dominante en rapport avec la mutation de deux gènes suppresseurs de tumeurs TSC1 et TSC2. L'atteinte cutanée et neurologique est constante, celle des reins ou de la rétine est fréquente. Une patiente âgée de 28 ans, suivie depuis l'enfance pour STB retenue devant l'association d'atteinte neurologique (tubers corticaux compliqués d'épilepsie), cutanée (tubers faciaux, tâches achromiques), hépatique, splénique et rénale (angiomyolipomes). La patiente fut admise aux urgences pour choc hémorragique objectivant à la TDM abdominale de volumineux angiomyolipomes rénaux bilatéraux spontanément hyperdenses évoquant un saignement intralésionel (A). Par ailleurs, on notait des angiomyolipomes hépatiques, un épanchement intrapéritonéal et une thrombose de la veine cave inférieure. Une embolisation de l'artère rénale était tentée sans succès (B). L'évolution était marquée par l'apparition d'un syndrome de compartiment avec une détresse respiratoire et hémodynamique ayant motivé une néphro-surrénalectomie bilatérale d'hémostase en urgence. Un traitement de suppléance de la fonction rénale est initié par hémodialyse dans l'attente d'une transplantation rénale, ainsi qu'une corticothérapie substitutive de la fonction surrénalienne. L'atteinte rénale doit être dépistée précocement et comprend des angiomyolipomes et/ou des kystes rénaux. La présence de plages de nécrose ou d'hémorragie doit faire éliminer un carcinome rénal. Les principaux diagnostics différentiels sont la neurofibromatose type 1 et 2 et la maladie de Von Hippel Lindau. Le pronostic dépend de la sévérité des symptômes et de leur évolution imprévisible. La recherche médicale est toujours d'actualité pour retarder au maximum la survenue de tumeurs

Transgenerational Succession’ Effects on Financial Performance of Listed Family Firms in the Arab Countries

The purpose of this paper is to study the impact of succession events on the level and determinants of the financial performance of family businesses in the Arab world. This research is conducted through an empirical study on a sample of 166 family businesses in the Arab world. Firstly, the paper compares the financial performance of family businesses that continue to be managed by the founders with family businesses in which the management has been transferred to the successors. Secondly, this research identifies the determinants of the financial performance of the two categories through a multifactorial model based on the panel data method. The results revealed that succession negatively impacts the seizing of opportunities and growth in the market in the context of family businesses in the Arab region. Moreover, the paper clarifies the prudent policy that characterizes the transmitted family businesses, through the accumulation of resources and underinvestment. In this sense, this research provides evidence that family wealth and business affairs are interrelated in the tradition of clientelism, which is reflected in Arab countries by the transmission of family businesses to family successors. In other words, succession to inheritors is inevitable in the Arab context, and family businesses may show contradictory performances and stagnate, compared to first-generation family businesses

Applications des interactions quadripolaires dans des réactions de macrocyclisation par métathèse de fermeture de cycle

Thèse numérisée par la Division de la gestion de documents et des archives de l'Université de Montréal

In vitro activity of vancomycin, quinupristin/dalfopristin, and linezolid against intact and disrupted biofilms of staphylococci

Shed cells or disrupted parts of the biofilm may enter the circulation causing serious and very hard to treat biofilm-associated infections. The activity of antimicrobial agents against the shed cells/disrupted biofilms is largely unknown. METHODS: We studied the in vitro susceptibility of intact and disrupted biofilms of thirty clinical isolates of methicillin-resistant and methicillin–susceptible Staphylococcus aureus (MRSA and MSSA) and Staphylococcus epidermidis to vancomycin, quinupristin/dalfopristin, and linezolid and compared it to that of the suspended (planktonic) cells. RESULTS: Bacteria in the disrupted biofilms were as resistant as those in the intact biofilms at the minimum inhibitory concentrations of the antibiotics. At higher concentrations, bacteria in the disrupted biofilms were significantly (P < 0.001) less resistant than those in the intact biofilms but more resistant than the planktonic cells. Quinupristin/dalfopristin showed the best activity against cells of the disrupted biofilms at concentrations above MICs and vancomycin, at 500 and 1,000 μg/ml, was significantly more active against the biofilms of MRSA and S. epidermidis CONCLUSION: The difficulty of treating biofilm-associated infections may be attributed not only to the difficulty of eradicating the biofilm focus but also to the lack of susceptibility of cells disrupted from the biofilm to antimicrobial agents

Advance Price Agreement: An Option to Reduce Controversy Between Multinationals and Tax Administrations

This paper explores the disparities existing between multinational corporations (MNCs) and tax administrations in terms of transfer pricing strategies. Because transfer pricing is actually considered the main tax issue in the international taxation, tax authorities’ regulations have an important role when it comes to transfer pricing policies. In one hand, the manipulation of transfer prices (applied by MNCs) results in important losses in a country’s tax revenue, and thus, create inequalities between nations. In another hand, transfer pricing tax adjustments (applied by tax authorities), result in significant costs for MNCs. Accordingly, these two parties are forced to work together in order to find a fair consensus. The OECD has introduced the Advance Price Agreement (APA), which can be concluded between a MNC and one or many tax administrations. It provides certainty to the MNC regarding the transfer pricing method selected. However, this process can be hard to achieve for MNCs, which need to openly collaborate with many tax authorities, and therefore, expose themselves to important risks. In this respect, this exploratory qualitative study mobilises both the Agency Theory and the Stewardship Theory when analysing this dichotomous relationship between tax administrations and MNCs in respect of transfer pricing strategies. Keywords: Transfer Pricing, Multinational Corporation, Tax Administration, Advance Price Agreement DOI: 10.7176/RJFA/11-24-11 Publication date: December 31st 2020

Angio-embolization of a renal pseudoaneurysm complicating a percutaneous renal biopsy: a case report

We report the treatment of a bleeding renal pseudoaneurysm by angio-embolization. A 21 years old woman developed macroscopic haematuria following renal biopsy. Renal angio-scan showed a 1.4 cm renal  pseudoaneurysm in the left kidney. The presence of pseudoaneurysm was confirmed by selective renal  angiography. Successful embolization was performed using gelatine sponge particles.Key words: Angioembolization, renal pseudoaneurysm, kidne

EVALUATION DE LA QUALITÉ DE CERTAINES FACTEURS PÉDAGOGIQUES ET DIDACTIQUES DANS LA FACULTÉ DES SCIENCES DE KENITRA (MAROC), SELON LES ÉTUDIANTS DE LA FILIÈRE « LICENCE»

Since 1956, year of the independence of Morocco, the quality of education has suffered from many problems. The education system has known reform after reform without achieving the desired results. Thus, in the hope of participating in the development of a solution for this problem "chronic", this sector needs a profound diagnosis, which determines its weak points that block, and the constraints that oppose to the improving of Moroccan education. In the present work we contributed with a diagnosis whose purpose and to assess the degree of satisfaction of the students of the Faculty of Sciences of Kenitra (Morocco) of some activities or educational variables. The results show that among the 22 variables studied, the degree of student satisfaction exceeds 55% for 6 variables, between 45% and 55% for 4 variables, of 40% to 45% for 7 variables, and superior to 40% for 17 variables. The satisfaction rate is therefore less than 40% for only 5 variables. The dissatisfaction of students affects four areas of study ie study program, product availability and Lab equipment, student evaluation means and the conditions of the realization of end of Project study

AMÉLIORATION DE LA QUALITÉ DE L’ENSEIGNEMENT UNIVERSITAIRE AU MAROC ; CAS DE LA FACULTÉ DES SCIENCES KENITRA

The Moroccan Higher Education knows many problems, especially those concerning the quality of its services and its environment. Thus, this sector has known many reforms without reaching the expected results. Therefore, it is necessary to determine its weak points to have a better reform. The mainly objective of this study is a sensitization of policy makers to develop a national quality assurance system in universities. Based on the level of student satisfaction on many internal and external services of the Faculty of Sciences of Kenitra (Morocco), and comparing the results with those of a similar work previously done, we evaluated the evolution of quality of services and the environment of this establishment. The results showed that between the two surveys the degree of student satisfaction on many quality indicators significantly increased. Contrary to the results of the survey conducted during the academic year 2011/12, where there was a negative opinion of student satisfaction on 72% of all surveyed indicators, the 2015 survey did showed a negative opinion on 16% of all the indicators

Prediction, Diagnosis and Prevention of Fouling in Seawater Reverse Osmosis Membrane Systems.

The performance of pre-treatment and reverse osmosis (RO) membrane systems of a reverse osmosis (SWRO) desalination plant was evaluated using both in-situ fouling monitoring methods and theoretical standardisation and normalisation methods. The results showed that overall performance of the plant deteriorated after 6 months of operation due to fouling. In order to determine the identity and cause of th~ fouling two SWRO membranes were subjected to destructive membrane autopsy. The results showed formation of severe fouling on the surface of both membranes. Microscopic studies using atomic force microscopy (AFM) and scanning electron microscopy (SEM) with Energy Dispersion X-ray spectrometer (EDX), elucidated this layer. AFM, SEM and EDX results showed different types of fouling includes scaling, colloidal and biological fouling. The presence of these foulants on the membrane surfaces indicates malfunctions in the pre-treatment systems used 'in the plant, ultimately resulting in the formation of composite fouling. The effect of this composite fouling on the performance of the RO membrane systems was investigated using a laboratory-scale RO unit and raw seawater samples from the Mediterranean and the North Seas. A rapid flux decline was observed. In order to eliminate the formation of the composite fouling in the RO membrane systems, a novel fouling prevention method was examined. This was a depth ~ filter (DisruptorTM) made of nanoalumina fibres upstream 'to the RO membranes. The results show that this depth filter removes the majority of substances which cause the fouling on the RO membranes. Results are discussed in relation to the practicalities, of desalination plant operation