Formation of concept of provision of economic security of organization : personnel aspect

Under the modern business conditions, characterized by constant changes and increase of the quantity of risk factors, organizations – for the purpose of conduct of successful activities – have to pay special attention to issues of provision of economic security. The article proves importance of personnel aspect of economic security of organization is proved and deter-mines main causes of personnel risks. Classification of factors, which influence personnel security of organization, is shown. For the purpose of minimization of personnel risks and prevention of threats, the authors offer regulation of personnel labor: special attention is paid to such component of personnel security as “selection of employees”, which, in authors’ opinion, is the most vulnerable aspect. As a result of thorough analysis of collected material, the authors offer a scheme of the process of management of personnel security with specific stages and sub-systems of management.peer-reviewe

Influence of excessive iodine intake on the thyroid function and spectrum of thyroid abnormalities in population of Turinsk, Sverdlovsk Region, of Russia

Background. Previous surveys showed chronic iodine excess - median urinary iodine concentration (UIC) over 500 mcg/l supposedly due to water contamination in population of Turinsk, a town in Sverdlovsk Region of Russia. Aim. Conduct an assessment of the effects of chronic iodine excess on thyroid function and spectrum of thyroid abnormalities in schoolchildren and adults. Materials and methods. Assessment was conducted in 100 schoolchildren and 100 adults residing in Turinsk and 97 schoolchildren and 100 adults in the control site (city of Pervouralsk) with optimal UIC. Assessment included thyroid ultrasonogrpahy, urinary iodine and dry spot TSH in schoolchildren and TSH and TPO-ab in adults. Iodine was also measured in random water samples from 10 households in Turinsk. Results. Median UIC in schoolchildren in Turinsk (719 mcg/l) was significantly higher (129 mcg/l) than in Pervouralsk resulting in higher prevalence of thyroid enlargement and TSH level. In adults TSH level as well as prevalence of sub-clinical hypothyroidism and autoimmune thyroiditis were higher in residents of Turinsk compared to control group from Pervouralsk. Conclusions. Iodine excess alters thyroid function in schoolchildren and adults increasing prevalence of thyroid enlargement in children and autoimmune thyroidis in adults

Adrenal vein sampling in differential diagnosis of primary aldosteronism on the example of a clinical case

Primary aldosteronism is the most common cause of endocrine hypertension, occurring in 5–10% of patients with hypertension. Convincing evidence has been obtained indicating that primary aldosteronism increases the risk of cardiovascular complications, respectively, early diagnosis and treatment of patients with the definition of further tactics is a key step to prevent the progression of cardiovascular complications. The choice of the most appropriate treatment method for patients with primary aldosteronism depends on the diagnosis of nosological subtypes – bilateral adrenal hyperplasia (also known as idiopathic aldosteronism), which recommends a conservative treatment or unilateral aldosteronism due to aldosterone-producing adenoma, in which surgical treatment (adrenalectomy) is the tactic of choice. In addition, the "obvious" adrenal adenomas may in fact turn out to be areas of focal hyperplasia – a diagnostic error in this case leads to the unreasonable implementation of adrenalectomy. In order to clarify the lateralization of aldosterone hyperproduction, adrenal venous sampling is used. However, this method requires constant radiography, qualified endovascular surgery and is carried out in centralized medical hospitals. In this clinical case, we want to demonstrate the importance of a diagnosis of primary aldosteronism step by step

Diagnosis and differential diagnosis of adrenal incidentalomas

This lecture focuses on the diagnosis and differential diagnosis of adrenal incidentalomas with special reference to diagnostic steps, major pharmacological tests, and instrumental studies. Strategies of management of patients with this pathology are described

Изменчивость морфометрических показателей красноокрашенных сортов амаранта с высоким содержанием биологически активных веществ в условиях открытого грунта Московской области

The study of variability of morphological features in red-colored varieties of amaranth and their correlations at different stages in the conditions of the Moscow region makes it possible to identify features that affect productivity, amount of amaranthine and other biologically active substances. After analyzing vegetative characteristics, the varietal features of amaranth plants were proved to have a smaller impact on ‘root length’, ‘plant height’ and ‘number of leaves’ characteristics than the cultivation conditions, especially at the initial stages (ISB (Influence share of the weather conditions) from 22 to 58 %). It follows from the phenotypic variability analysis that the genotypic component values varied significantly only at the last stages (Cvg > 35 %). The maximum values of phenotypic variability were marked in all varieties at the stage of active growth considering the ‘root length’ (Cve = 32...47 %) and the ‘number of leaves’ (Cve = 48...85 %). The generative characteristics seemed to be significantly influenced by the varietal factor (ISA (Influence share of varietal characteristics) = 40...88 %) starting from the third stage. The genotypic component of all varieties was high considering the inflorescence weight (Cvg = 75...86 %). In signs of general productivity, it was studied that the leaves (93...112 g/plant) contributed the most for amaranth forms, which mass in all varieties largely depended on weather conditions (ISB > 55 %). The interrelation of the leaves productivity was noted high with all the vegetative characteristics on phase III–V (r = 0.71...0.92) and with ‘inflorescence mass’ on phase V–VI.Изучение изменчивости морфологических признаков красноокрашенных сортов амаранта и их корреляционных взаимосвязей на разных стадиях онтогенеза в условиях Московской области позволило определить особенности, влияющие на формирование продуктивности, получение максимального количества амарантина и других биологически активных веществ. Анализ вегетативных признаков выявил, что сортовые особенности растений амаранта оказывают меньшее влияние на длину корня, высоту растений и число листьев, чем условия выращивания, особенно на начальных стадиях (ДВв от 22 до 58 %). Исследование фенотипической изменчивости показало, что значения генотипической составляющей изменчивости варьировали на последних стадиях созревания (Сvg > 35 %). На начальных стадиях высокой изменчивостью отличились вегетативные признаки: длина корня (Cvе = 32...47 %) и число листьев (Сvе = 48...85 %)—в зависимости от условий года. В репродуктивный период развития у всех генеративных признаков фактор сорта был наиболее существенным начиная со стадии цветения (ДВА = 40...88 %). Значения признака—массы соцветий—варьировали в зависимости от влияния генотипической составляющей изменчивости всех сортов (Cvg = 75...86 %).Из анализа признаков общей продуктивности растений следует, что основной вклад у сортов амаранта вносят листья (93...112 г/ растение), масса которых зависит от погодных условий (ДВВ > 55 %). Высокими корреляциями были отмечены взаимосвязи общей продуктивности листьев со всеми вегетативными признаками на III–V фазе (r = 0,71...0,92) и массой соцветия на V–VI фазах созревани

Heterologous <i>codA</i> Gene Expression Leads to Mitigation of Salt Stress Effects and Modulates Developmental Processes

Transgenic tobacco plants overexpressing the choline oxidase gene from A. globiformis showed an increase in resistance at the level of primary and secondary biosynthesis of metabolites, removing the damage characteristic of salinity and stabilizing the condition of plants. We used 200 mM NaCl, which inhibits the growth of tobacco plants at all stages of development. Leaves of transgenic and wild-type (WT) plants Nicotiána tabácum were used for biochemical, cytological and molecular biological analysis. However, for transgenic lines cultivated under normal conditions (without salinity), we noted juvenile characteristics, delay in flowering, and slowing down of development, including the photosynthetic apparatus. This caused changes in the amount of chlorophyll, a delay in the plastid grana development with the preservation of prolamellar bodies. It also caused changes in the amount of sugars and indirectly downstream processes. A significant change in the activity of antioxidant enzymes and a change in metabolism is probably compensated by the regulation of a number of genes, the expression level of which was also changed. Thus, the tolerance of transgenic tobacco plants to salinity, which manifested itself as a result of the constitutive expression of codA, demonstrates an advantage over WT plants, but in the absence of salinity, transgenic plants did not have such advantages due to juvenilization

Russian Association of Endocrinologists clinical practice guideline for adrenal incidentalomas differential diagnosis

This article discusses the management guidelines for serendipitously diagnosed adrenal masses cases, assessment of their hormonal activity and malignancy potential, pro- and contra indications for surgical treatment and follow-up algorithm for hormonally inactive tumors. Hypercathecholaminemya, endogenous hypercortisolism, primary hyperaldosteronism should be considered as variants of specific hormonal activity of tumor. The midnight suppression test with dexametasone 1 mg is recommended in all cases. Evaluation of basal ACTH in case of negative result of the test with dexametasone 1 mg (absence of morning cortisol level suppression) should be considered as confirmation test. For primary diagnosis of pheohromocytoma/paraganglioma (PPGL) a free plasma or fractionated urine methanephrines concentrations evaluation should be recommended. If test is positive, comprehensive examination to exclude or confirm PPGL is necessity. The aldosterone/rennin ratio exposure should be considered for patients with arterial hypertension to exclude primary hyperaldosteronism. To evaluate malignant pattern of a tumor in all unclear cases should be provide assessment of computed tomography quantitative indices. Adrenal incidentalomas treatment guidelines isnt considered in the field of this recommendations and reported in relevant guidelines

Diminishing benefits of urban living for children and adolescents’ growth and development

Optimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1–6. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5–19 years on the basis of rural and urban place of residence in 200 countries and territories from 1990 to 2020. In 1990, children and adolescents residing in cities were taller than their rural counterparts in all but a few high-income countries. By 2020, the urban height advantage became smaller in most countries, and in many high-income western countries it reversed into a small urban-based disadvantage. The exception was for boys in most countries in sub-Saharan Africa and in some countries in Oceania, south Asia and the region of central Asia, Middle East and north Africa. In these countries, successive cohorts of boys from rural places either did not gain height or possibly became shorter, and hence fell further behind their urban peers. The difference between the age-standardized mean BMI of children in urban and rural areas was <1.1 kg m–2 in the vast majority of countries. Within this small range, BMI increased slightly more in cities than in rural areas, except in south Asia, sub-Saharan Africa and some countries in central and eastern Europe. Our results show that in much of the world, the growth and developmental advantages of living in cities have diminished in the twenty-first century, whereas in much of sub-Saharan Africa they have amplified