Rancang Bangun Sistem Informasi Simpan Pinjam Karyawan Menggunakan Metode Object Oriented Programming (Studi Kasus: PT. Arta Buana Sakti Tangerang)

- Computes provide an appropriate solution to generate information for the needy at this time. Just as happens in any company, either company owned goverment adn private relatively large transaction that required a database to store and process data efficiently, fast and can be usedanytime when needed. PT. Arta Buana Sakti is a company engaged in the property has made a savings and loans to employees where the employee saving and loan was founded in 2014 with the number of members has reached 121 members in march 2016. There are constraints that have progressed saving which this employee to perform reporting pieces mandatory saving and loan installment payments need to see all the membership book and add up all the bills, it takes computerized system so that transactions go well and quickly implemented at this stage, the authors conducted a saving and loan information system design and design the look of the program employees use integrated development environment (IDE) netbeans with Java programming language and MySQL as the databas

Effect of Intercropping Leguminous Tree Species on Soil Nutrient Status, Growth and Yield of Arable Crops in Ukan Edemaya, Ikot Abasi Local Government Area, Akwa Ibom State, Nigeria

Intercropping improves the usage rate of a land while also maintaining soil fertility. This study is to examine the preliminary intercropping effect of leguminous trees species (Leucaena leucocephala (Lam), Gliricidia sepium (Jacq), and Senna siamae (Lam) on soil nutrient status, growth and yield of arable crops (Zea mays L) in two cropping seasons (2017 and 2018) using a field trial at Ukan Edemaya, Ikot Abasi Local Government Area of Akwa Ibom State, Nigeria. Treatments were randomized within the blocks and reproduced four (4) times on a 0.04 hectare plot of land that was cleared, demarcated into four blocks, and manually tilled. The study was a two-factor factorial using a Randomized Complete Block Design layout (RCBC). The data was analyzed using Analysis of Variance (ANOVA), and treatment means were separated using Least Significant Difference (LSD < 0.05). The findings revealed that all arable crop growth and production were not significant in weeks 1-6 (WAP), but significant from weeks 7 to 14 (WAP). Arable crops planted in leucaena alleys outperformed those planted in Gliricidia and senna alleys and outperformed those planted in plots without leguminous plants. Leguminous tree species were shown to boost the growth and yield of arable crops, as well as rehabilitate a damaged fertility soil quality, according to the study. Farmers are urged to intercrop their arable crops with leguminous tree species in order to increase yield and provide fuel wood

Isolasi dan Karakterisasi Senyawa Aktif terhadap Mortalitas Kutu Beras dari Ekstrak Etil Asetat Rimpang Jeringau (Acorus Calammus L.)

Telah dilakukan isolasi dan karakterisasi senyawa aktif terhadap mortalitas pada rimpang jeringau (Acorus calammus. L). Penelitian diawali dengan mengekstrak 450 gram serbuk rimpang jeringau (Acorus calammus. L) dengan pelarut metanol menggunakan teknik maserasi. Ekstrak kental metanol difraksinasi dengan pelarut n-Heksan dan etil asetat. Identifikasi senyawa yang terkandung pada rimpang jeringau dilakukan dengan uji fitokimia pada ekstrak kental dan masing-masing fraksi. Melalui kromatografi kolom, ekstrak kental fraksi etil asetat menghasilkan 308 fraksi kemudian diuji menggunakan KLT. Isolat murni yang positif pada uji terpenoid dianalisis keberadaan gugus fungsinya dengan spektrofotometer IR dan UV-Vis. Pada Spektrofotometer IR menunjukkan gugus fungsi adanya ulur C-H, ulur C=O, ulur C=C aromatik, tekuk O-H, tekuk C-H dan ulur C-O alkohol. Sedangkan untuk UV-Vis menunjukkan pita dengan serapan gelombang maksimum pada 248,60 nm. Maka senyawa yang diduga adalah senyawa terpenoid yang merupakan senyawa aktif mortalitas

Studi Komparasi Hasil Belajar Kimia Pada Materi Koloid Menggunakan Model Pembelajaran Berbasis Proyek Dan Model Pembelajaran Berbasis Masalah Siswa Kelas XI IPA Man 2 Mataram Tahun Ajaran 2013/2014

: The aims of this quasi experimental research is to compare the chemistry study result by using the project based learning model and problem based learning model at class XI science of MAN 2 Mataram in academic year 2013/2014. Sample of this research were class XI science U1 as experiment I class and class XI science U2 as experiment II class which taken by using purposive sampling technique.Data cognitive of the result study obtained through a written test (post-test) were analyzed using a different test (t test). The results showed that the experimental class I obtained an average value of 67 with classical completeness of 7.69% while the experimental class II obtained an average value of 70 with classical completeness 28.57%. T-test results of the unequal sample at the significant level of 5% was obtained tcalculation =-0,4709 andttable= 2,060, with the result that tcalculationin the range from to -2,060 and +2,060which means that the Ho in this research is approved. In conclusion, there is no significant difference in result study between students who are taught chemistry using project-based learning model and the problem based learning model students of class XI IPA 2 Mataram MAN in Academic Year 2013/2014

Vitamin D receptor gene polymorphisms have negligible effect on human height.

Human height is a highly heritable trait, with genetic factors explaining up to 90% of phenotypic variation. Vitamin D levels are known to influence several physiological processes, including skeletal growth. The vitamin D receptor (VDR) gene has been reported as contributing to variation in height. A meta-analysis of 13607 adult individuals found a small but significant association with the rs1544410 (Bsml) polymorphism. In contrast, the meta-analysis found no effect in a sample of 550 children. Two recent studies reported variants with large effect on height elsewhere in VDR (rs10735810 [Fokl] and rs7139166 [-1521] polymorphisms). We genotyped large Caucasian samples from Australia (N = 3906) and the Netherlands (N = 1689) for polymorphisms in VDR. The Australian samples were twin families with height measures from 3 time points throughout adolescence. The Dutch samples were adult twins. We use the available family data to perform both within and between family tests of association. We found no significant associations for any of the genotyped variants after multiple testing correction. The (non-significant) effect of rs1544410 in the Australian adolescent cohort was in the same direction and of similar magnitude (additive effect 0.3cm) to the effect observed in the published adult meta-analysis. An effect of this size explains similar to 0.1% of the phenotypic variance in height - this implies that many, probably hundreds, of such variants are responsible for the observed genetic variation. Our results did not support any role for two other regions (rs10735810, rs7139166) of VDR in explaining variation in height

Occupational exposure to gases/fumes and mineral dust affect DNA methylation levels of genes regulating expression

Many workers are daily exposed to occupational agents like gases/fumes, mineral dust or biological dust, which could induce adverse health effects. Epigenetic mechanisms, such as DNA methylation, have been suggested to play a role. We therefore aimed to identify differentially methylated regions (DMRs) upon occupational exposures in never-smokers and investigated if these DMRs associated with gene expression levels. To determine the effects of occupational exposures independent of smoking, 903 never-smokers of the LifeLines cohort study were included. We performed three genome-wide methylation analyses (Illumina 450 K), one per occupational exposure being gases/fumes, mineral dust and biological dust, using robust linear regression adjusted for appropriate confounders. DMRs were identified using comb-p in Python. Results were validated in the Rotterdam Study (233 never-smokers) and methylation-expression associations were assessed using Biobank-based Integrative Omics Study data (n = 2802). Of the total 21 significant DMRs, 14 DMRs were associated with gases/fumes and 7 with mineral dust. Three of these DMRs were associated with both exposures (RPLP1 and LINC02169 (2x)) and 11 DMRs were located within transcript start sites of gene expression regulating genes. We replicated two DMRs with gases/fumes (VTRNA2-1 and GNAS) and one with mineral dust (CCDC144NL). In addition, nine gases/fumes DMRs and six mineral dust DMRs significantly associated with gene expression levels. Our data suggest that occupational exposures may induce differential methylation of gene expression regulating genes and thereby may induce adverse health effects. Given the millions of workers that are exposed daily to occupational exposures, further studies on this epigenetic mechanism and health outcomes are warranted

Perceptions of Drinking Water Service of the ‘Off-Grid’ Community in Cimahi, Indonesia

From MDPI via Jisc Publications RouterHistory: accepted 2021-05-13, pub-electronic 2021-05-17Publication status: PublishedFunder: Newton Fund; Grant(s): pfact 71290Funder: Kementerian Riset dan Teknologi/Badan Riset dan Inovasi Nasional; Grant(s): 2/E1/KP.PTNBH/2020, 2/E1/KP.PTNBH/2021The establishment of decentralized drinking water systems in urban areas is technically and financially feasible, and these ‘off-grid’ systems can complement investment in traditional piped water systems. However, users often see ‘off-grid’ systems as the second-best option, compared to citywide piped water systems. Thus, although they are designed to improve access to water and reduce inequality, they can be perceived by users as infrastructural manifestations of extant inequality. In this paper, we present original research on the perceptions of users in Cimahi, Indonesia, surrounding their access to water and willingness to use and maintain ‘off-grid’ infrastructure. The majority of respondents used groundwater and packaged water as their primary water sources, and paid approximately twice the maximum tariff of piped water service. We interpreted the survey data with the theory of planned behavior framework and determined that respondents demonstrated a willingness to pay fees for ‘off-grid’ water systems, participate in water supply programs, and switch to new water sources. These intentions were affected by their attitude towards the behavior, subjective norm, and perceived behavioral control to various degrees. The findings are useful for those designing strategies to introduce novel water delivery systems aimed at improving water access for diverse and disadvantaged socioeconomic groups in urban areas in the Global South

Regulation of cell cycle transition and induction of apoptosis in HL-60 leukemia cells by lipoic acid: role in cancer prevention and therapy

<p>Abstract</p> <p>Background</p> <p>Lipoic acid (LA), a potent antioxidant, has been used as a dietary supplement to prevent and treat many diseases, including stroke, diabetes, neurodegenerative and hepatic disorders. Recently, potent anti-tumorigenic effects induced by LA were also reported and evident as assayed by suppression of cell proliferation and induction of apoptosis in malignant cells. However, the mechanism by which LA elicits its chemopreventive effects remains unclear.</p> <p>Methods and Results</p> <p>Herein, we investigated whether LA elicits its anti-tumor effects by inducing cell cycle arrest and cell death in human promyelocytic HL-60 cells. The results showed that LA inhibits both cell growth and viability in a time- and dose-dependent manner. Disruption of the G₁/S and G₂/M phases of cell cycle progression accompanied by the induction of apoptosis was also observed following LA treatment. Cell cycle arrest by LA was correlated with dose-dependent down regulation of Rb phosphorylation, likely via suppression of E2F-dependent cell cycle progression with an accompanying inhibition of cyclin E/cdk2 and cyclin B1/cdk1 levels. Evidence supporting the induction of apoptosis by LA was based on the appearance of sub-G₁peak in flow cytometry analysis and the cleavage of poly(ADP-ribose) polymerase (PARP) from its native 112-kDa form to the 89-kDa truncated product in immunoblot assays. Apoptosis elicited by LA was preceded by diminution in the expression of anti-apoptotic protein bcl-2 and increased expression of apoptogenic protein bax, and also the release and translocation of apoptosis inducing factor AIF and cytochrome c from the mitochondria to the nucleus, without altering the subcellular distribution of the caspases.</p> <p>Conclusion</p> <p>This study provides evidence that LA induces multiple cell cycle checkpoint arrest and caspase-independent cell death in HL-60 cells, in support of its efficacious potential as a chemopreventive agent.</p

Autobiographical memory and hierarchical search strategies in depressed and non-depressed participants

Background: There is a growing body of literature showing individuals with depression and other trauma-related disorders (e.g., posttraumatic stress disorder) recall more overgeneral and less specific autobiographical memories compared to normal participants. Although the mechanisms underlying overgeneral memory are quite clear, the search strategy operated within the autobiographical knowledge base, at time of recollection, requires further exploration. The current study aimed to examine the hierarchical search sequence used to recall autobiographical memories in depressed and non-depressed participants, with a view to determining whether depressed participants exhibited truncated search strategies. Methods: Thirteen depressed and an equal number of non-depressed participants retrieved 15 memories each, in response to 15 commonly used cue words. Participants reported the first memory that entered in their mind. All memory descriptions were recorded and later transcribed verbatim for content analysis.Results: Depressed participants retrieved autobiographical memories faster, produced shorter memory descriptions and were less likely to recall positive memories than non-depressed participants. Non-depressed participants were more likely to commence retrieval by accessing lifetime period knowledge followed by general event and event specific knowledge, whereas depressed participants showed a tendency to terminate retrieval at the general event level. Conclusions: It is concluded that depressed participants do adhere to the same hierarchical search strategy as non-depressed participants when retrieving specific autobiographical memories, but that they terminate their search early, resulting in overgeneral memories