33 research outputs found
Concepts on the contribution of chemistry to a sustainable development. Renewable raw materials
Hemostatic efficacy of pathogen-inactivated vs untreated platelets: a randomized controlled trial
Stemcel biology/Regenerative medicine (incl. bloodtransfusion
Methyltriphenylphosphonium Methylcarbonate, an All-In-One Wittig Vinylation Reagent
The methyltriphenylphosphonium methylcarbonate salt [Ph3 PCH3 ][CH3 OCO2 ], obtained directly by quaternarization of triphenylphosphine with dimethylcarbonate, is a latent ylide that promotes Wittig vinylation of aldehydes and ketones. Alkenes are obtained simply by mixing [Ph3 PCH3 ][CH3 OCO2 ] and the carbonyl and heating in a solvent (no base, no halides, and no inorganic byproducts). Deuterium exchange experiments and the particularly short anion-cation distance measured by XRD in [Ph3 PCH3 ][CH3 OCO2 ] allowed to explain the nature and reactivity of this species. Green chemistry metrics (atom economy, mass index, environmental factor) indicate that this vinylation procedure is more efficient than comparable ones. Deuterated [Ph3 PCD3 ][CH3 OCO2 ] promoted the synthesis of deuterated olefins
A Comparative Environmental Assessment for the Synthesis of 1,3-Oxazin-2-one by Metrics: Greenness Evaluation and Blind Spots
Alternative syntheses for the production of 3-benzyl-1,3-oxazinan-2-one are compared and evaluated employing
green metrics. An environmental assessment has been performed using the algorithm recently developed by Andraos that takes
into account the mass flows and the software EATOS that considers mass flows, environmental impacts of the substances
involved, and waste produced. Strengths and critical spots of the environmental tools employed are also discussed. Data collected
showed that the synthesis employing diethyl carbonate is the most promising one, having the lowest environmental impact
Measuring clinical bleeding using a standardized daily report form and a computer algorithm for adjudication of WHO bleeding grades
Clinical epidemiolog