Signatures of Nucleon Disappearance in Large Underground Detectors

For neutrons bound inside nuclei, baryon instability can manifest itself as a decay into undetectable particles (e.g., $\it n \to \nu \nu \bar{\nu}$), i.e., as a disappearance of a neutron from its nuclear state. If electric charge is conserved, a similar disappearance is impossible for a proton. The existing experimental lifetime limit for neutron disappearance is 4-7 orders of magnitude lower than the lifetime limits with detectable nucleon decay products in the final state [PDG2000]. In this paper we calculated the spectrum of nuclear de-excitations that would result from the disappearance of a neutron or two neutrons from $^{12}$C. We found that some de-excitation modes have signatures that are advantageous for detection in the modern high-mass, low-background, and low-threshold underground detectors, where neutron disappearance would result in a characteristic sequence of time- and space-correlated events. Thus, in the KamLAND detector [Kamland], a time-correlated triple coincidence of a prompt signal, a captured neutron, and a $\beta^{+}$ decay of the residual nucleus, all originating from the same point in the detector, will be a unique signal of neutron disappearance allowing searches for baryon instability with sensitivity 3-4 orders of magnitude beyond the present experimental limits.Comment: 13 pages including 6 figures, revised version, to be published in Phys.Rev.

An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge

There is tremendous potential for genome sequencing to improve clinical diagnosis and care once it becomes routinely accessible, but this will require formalizing research methods into clinical best practices in the areas of sequence data generation, analysis, interpretation and reporting. The CLARITY Challenge was designed to spur convergence in methods for diagnosing genetic disease starting from clinical case history and genome sequencing data. DNA samples were obtained from three families with heritable genetic disorders and genomic sequence data were donated by sequencing platform vendors. The challenge was to analyze and interpret these data with the goals of identifying disease-causing variants and reporting the findings in a clinically useful format. Participating contestant groups were solicited broadly, and an independent panel of judges evaluated their performance. RESULTS: A total of 30 international groups were engaged. The entries reveal a general convergence of practices on most elements of the analysis and interpretation process. However, even given this commonality of approach, only two groups identified the consensus candidate variants in all disease cases, demonstrating a need for consistent fine-tuning of the generally accepted methods. There was greater diversity of the final clinical report content and in the patient consenting process, demonstrating that these areas require additional exploration and standardization. CONCLUSIONS: The CLARITY Challenge provides a comprehensive assessment of current practices for using genome sequencing to diagnose and report genetic diseases. There is remarkable convergence in bioinformatic techniques, but medical interpretation and reporting are areas that require further development by many groups

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

The original version of this article unfortunately contained a mistake

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Validation of standard neutron data libraries for LWR storage pools and transport casks criticality safety evaluations

This paper addresses the assessment of MCNPX-2.5.0 criticality calculations using continuous energy cross section libraries based on JEF-2.2, JENDL-3.3, ENDF/B-6.8, and the recently released JEFF-3.1 data files. For this purpose, validation calculations were performed for a suite of benchmarks from the International Handbook of Evaluated Criticality Safety Benchmark Experiments. The benchmarks were selected on the basis of their similarity to designs found in today's Light Water Reactor (LWR) compact storage pools and transport casks, including MOX fuel rod assemblies, and in total comprised as much as 149 cases. In order to define the ranges of applicability of the used calculational methods and to detect possible trends, the spectrum-related characteristics of the modeled critical experimental configurations were analysed. It is found that the recently released JEFF-3.1 library improves the older JEF-2.2 compilation and leads to a value for the weighted average of the normalized eigenvalues $\langle {\rm k}_{\rm eff}^{\rm calc}/{\rm k}_{\rm eff}^{\rm exp} \rangle$ very close to unity. All libraries have in common that any evidence of a statistically significant trend in the normalized eigenvalues versus both spectrum-related characteristics and experimental design parameters could not be found