The effect of potassium infusion on proximal sodium reabsorption and renin release in the dog

The effect of potassium infusion on proximal sodium reabsorption and renin release in the dog. The effect of infusions of potassium chloride (KC1) on sodium reabsorption by the proximal tubule and renal renin release was measured in 18 dogs. Following renal arterial infusions of 8 or 16 µEq/min/kg potassium chloride, fractional and absolute sodium reabsorption by the proximal tubule, measured by micropuncture techniques, was not significantly altered. As compared to five control dogs, urinary sodium excretion was significantly increased following both infusions of KC1. The release of renin was significantly decreased following both rates of potassium infusion. The inhibition of renin release was not associated with consistent changes in either glomerular filtration rate or renal plasma flow. The data indicate that the inhibition of renin release following the infusion of potassium is probably not the result of a marked increase in sodium delivery from the proximal tubule

Enhanced and reduced atom number fluctuations in a BEC splitter

We measure atom number statistics after splitting a gas of ultracold 87Rb atoms in a purely magnetic double-well potential created on an atom chip. Well below the critical temperature for Bose-Einstein condensation T_c, we observe reduced fluctuations down to -4.9dB below the atom shot noise level. Fluctuations rise to more than +3.8dB close to T_c, before reaching the shot noise level for higher temperatures. We use two-mode and classical field simulations to model these results. This allows us to confirm that the super-shot noise fluctuations directly originate from quantum statistics

Role of parathyroid hormone in the phosphaturia of extracellular fluid volume expansion

Role of parathyroid hormone in the phosphaturia of extracellular fluid volume expansion. Acute expansion of the extracellular fluid volume increases the urinary excretion of phosphate. The present study examined the importance of increased plasma parathyroid hormone concentration in the phosphaturia accompanying acute extracellular fluid volume expansion (ECVE). Infusion of a calcium-free Ringer's solution into dogs was associated with increased urinary phosphate excretion and serum immunoreactive parathyroid hormone concentration (iPTH), the latter being significantly correlated with a decrease in plasma ionized calcium concentration. Prevention of the fall in plasma ionized calcium concentration by infusion of a calcium containing Ringer's solution prevented the increase in serum iPTH but the magnitude of the phosphaturia was not affected. The phosphaturia associated with ECVE was also not affected in thyroparathyroidectomized (TPTX) dogs which received a maintenance infusion of bovine PTH. In contrast, in acutely TPTX dogs which did not receive a maintenance infusion of PTH, the phosphaturic response to ECVE was significantly depressed. These data indicate that 1) the increase in serum iPTH concentration following ECVE is the result of a fall in plasma ionized calcium concentration, 2) the increase in phosphate excretion accompanying ECVE is not dependent on an increase in serum iPTH concentration and 3) in the presence of a low or falling serum PTH concentration, the increase in phosphate excretion can be significantly blunted.Rôle de l'hormone parathyroïdienne dans la phosphaturie consécutive à l'expansion extracellulaire. L'expansion aiguë du volume extracellulaire augmente l'excrétion urinaire du phosphate. Ce travail examine le rôle de l'augmentation de la concentration d'hormone parathyroïdienne dans la phosphaturie qui accompagne l'expansion du volume extracellulaire (ECVE). L'administration à des chiens d'une solution de Ringer sans calcium est associée à une augmentation de l'excrétion urinaire de phosphate et à une augmentation de la concentration d'hormone parathyroïdienne immunoréactive du plasma (iPTH). Cette dernière est significativement corrélée à la diminution de la concentration plasmatique du calcium ionisé. L'empêchement de la diminution de la concentration plasmatique du calcium ionisé par l'administration d'une solution de Ringer contenant du calcium évite l'augmentation de iPTH dans le plasma mais n'affecte pas l'importance de la phosphaturie. La phosphaturie associée à ECVE n'est pas non plus modifiée chez des chiens thyroparathyroïdectomisés (TPTX) qui reçoivent une perfusion de PTH bovine. Au contraire chez des chiens TPTX aigus qui ne reçoivent pas de perfusion de PTX la réponse à ECVE est significativement diminuée. Ces résultats indiquent que 1) L'augmentation de iPTH du plasma après ECVE est la conséquence d'une diminution de la concentration plasmatique du calcium ionisé, 2) l'augmentation de l'excrétion du phosphate qui accompagne ECVE ne dépend pas de l'augmentation de iPTH du plasma et 3) quand la concentration plasmatique de PTH est faible ou en voie de diminution, l'augmentation de l'excrétion de phosphate peut être significativement masquée

Imaging of the gravitational lens system PG 1115+080 with the Hubble Space Telescope

This paper is the first of a series presenting observations of gravitational lenses and lens candidates, taken with the Wide Field/Planetary Camera (WFPC) of the Hubble Space Telescope (HST). We have resolved the gravitational lens system PG 1115 + 080 into four point sources and a red, extended object that is presumably the lens galaxy; we present accurate relative intensities, colors, and positions of the four images, and lower accuracy intensity and position of the lens galaxy, all at the epoch 1991.2. Comparison with earlier data shows no compelling evidence for relative intensity variations between the QSO components having so far been observed. The new data agree with earlier conclusions that the system is rather simple, and can be produced by the single observed galaxy. The absence of asymmetry in the HST images implies that the emitting region of the quasar itself has an angular radius smaller than about 10 milliarcsec (100 pc for H_0=50, q_0=0.5)

py4DSTEM: a software package for multimodal analysis of four-dimensional scanning transmission electron microscopy datasets

Scanning transmission electron microscopy (STEM) allows for imaging, diffraction, and spectroscopy of materials on length scales ranging from microns to atoms. By using a high-speed, direct electron detector, it is now possible to record a full 2D image of the diffracted electron beam at each probe position, typically a 2D grid of probe positions. These 4D-STEM datasets are rich in information, including signatures of the local structure, orientation, deformation, electromagnetic fields and other sample-dependent properties. However, extracting this information requires complex analysis pipelines, from data wrangling to calibration to analysis to visualization, all while maintaining robustness against imaging distortions and artifacts. In this paper, we present py4DSTEM, an analysis toolkit for measuring material properties from 4D-STEM datasets, written in the Python language and released with an open source license. We describe the algorithmic steps for dataset calibration and various 4D-STEM property measurements in detail, and present results from several experimental datasets. We have also implemented a simple and universal file format appropriate for electron microscopy data in py4DSTEM, which uses the open source HDF5 standard. We hope this tool will benefit the research community, helps to move the developing standards for data and computational methods in electron microscopy, and invite the community to contribute to this ongoing, fully open-source project

Four-shooter: a large format charge-coupled-device camera for the Hale telescope

We describe an astronomical camera for the 200-in. Hale telescope using four 800 X800 Texas Instruments CCDs in an optical arrangement that allows imaging of a contiguous 1600-pixel-square region of sky. The system employs reimaging optics to yield a scale of 0.33 arcsec per pixel, a good match to the best seeing conditions at Palomar Observatory. Modern high-efficiency coatings are used in the complex optical system to yield a throughput at peak efficiency of nearly 50% (including the losses in the telescope), corresponding to a quantum efficiency on the sky of about 30%. The system uses a fifth CCD in a spectroscopic channel, and it is possible to obtain simultaneous imaging and spectroscopic observations with the system. The camera may also be used in a scanning mode, in which the telescope tracking rate is offset, and the charge is clocked in the chips in such a manner as to keep the charge image aligned with the optical image. In this way, a survey for high-redshift quasars has been carried out over a large area of sky. The instrument has produced images for the most distant clusters of galaxies yet discovered as well as spectra of the most distant galaxies yet observed

The Time-Domain Spectroscopic Survey: Understanding the Optically Variable Sky with SEQUELS in SDSS-III

The Time-Domain Spectroscopic Survey (TDSS) is an SDSS-IV eBOSS subproject primarily aimed at obtaining identification spectra of ~220,000 optically-variable objects systematically selected from SDSS/Pan-STARRS1 multi-epoch imaging. We present a preview of the science enabled by TDSS, based on TDSS spectra taken over ~320 deg^2 of sky as part of the SEQUELS survey in SDSS-III, which is in part a pilot survey for eBOSS in SDSS-IV. Using the 15,746 TDSS-selected single-epoch spectra of photometrically variable objects in SEQUELS, we determine the demographics of our variability-selected sample, and investigate the unique spectral characteristics inherent in samples selected by variability. We show that variability-based selection of quasars complements color-based selection by selecting additional redder quasars, and mitigates redshift biases to produce a smooth quasar redshift distribution over a wide range of redshifts. The resulting quasar sample contains systematically higher fractions of blazars and broad absorption line quasars than from color-selected samples. Similarly, we show that M-dwarfs in the TDSS-selected stellar sample have systematically higher chromospheric active fractions than the underlying M-dwarf population, based on their H-alpha emission. TDSS also contains a large number of RR Lyrae and eclipsing binary stars with main-sequence colors, including a few composite-spectrum binaries. Finally, our visual inspection of TDSS spectra uncovers a significant number of peculiar spectra, and we highlight a few cases of these interesting objects. With a factor of ~15 more spectra, the main TDSS survey in SDSS-IV will leverage the lessons learned from these early results for a variety of time-domain science applications.Comment: 17 pages, 14 figures, submitted to Ap

Deep Yedoma permafrost: A synthesis of depositional characteristics and carbon vulnerability

Permafrost is a distinct feature of the terrestrial Arctic and is vulnerable to climate warming. Permafrost degrades in different ways, including deepening of a seasonally unfrozen surface and localized but rapid development of deep thaw features. Pleistocene ice-rich permafrost with syngenetic ice-wedges, termed Yedoma deposits, are widespread in Siberia, Alaska, and Yukon, Canada and may be especially prone to rapid-thaw processes. Freeze-locked organic matter in such deposits can be re-mobilized on short time-scales and contribute to a carbon cycle climate feedback. Here we synthesize the characteristics and vulnerability of Yedoma deposits by synthesizing studies on the Yedoma origin and the associated organic carbon pool. We suggest that Yedoma deposits accumulated under periglacial weathering, transport, and deposition dynamics in non-glaciated regions during the late Pleistocene until the beginning of late glacial warming. The deposits formed due to a combination of aeolian, colluvial, nival, and alluvial deposition and simultaneous ground ice accumulation. We found up to 130 gigatons organic carbon in Yedoma, parts of which are well-preserved and available for fast decomposition after thaw. Based on incubation experiments, up to 10% of the Yedoma carbon is considered especially decomposable and may be released upon thaw. The substantial amount of ground ice in Yedoma makes it highly vulnerable to disturbances such as thermokarst and thermo-erosion processes. Mobilization of permafrost carbon is expected to increase under future climate warming. Our synthesis results underline the need of accounting for Yedoma carbon stocks in next generation Earth-System-Models for a more complete representation of the permafrost-carbon feedback

The Postcollapse core of M15 imaged with the HST planetary camera

We have obtained U-band images of the M15 core with the Planetary Camera of the Hubble Space Telescope. We are able to resolve stars down to the main-sequence turnoff (m_v≈ 19.4) into the cluster center. We use crowded field photometry techniques to decompose M15 into bright resolved stars and a residual component consisting of stars at turnoff brightness or fainter. The residual component comprises 59% of the cluster light and follows a y = -0.71 power-law distribution for r > 1". The residual component flattens off interior to this radius and has a large core with r_c = 2".2 = 0.13 pc. The core size may reflect postcollapse core expansion. The resolved stars have a slightly shallower distribution (y = - 0.53) but have an abrupt overdensity for r < 1".5, which accounts for the unresolved surface brightness cusp at ground resolution. The bright stars do not become more highly concentrated at still smaller radii, however; neither the bright stars nor the residual component form a cusp at subarcsecond resolution. The total central density of light in all components is 8 x 10^5 L_☉ pc^(-3) (U-band). The Peterson, Seitzer, and Cudworth central velocity dispersion implies a high core M/L ≈ 8 (U-band). The existence of a core rather than a cusp at the 0.1 pc scale may imply that the centrally deduced dark matter is in a diffuse form rather than a massive black hole