Planteamiento de mejoras para disminuir el tiempo de entrega del producto terminado de una planta procesadora de cajas de cartón corrugado

El principal problema existente en la planta Corrupac, es el retraso existente en la entrega del producto terminado al cliente. La mayoría de los clientes de esta empresa son exportadores de banano, por esta razón es necesario que las cajas sean entregadas a tiempo para poder colocar el banano recién cortado, para luego exportarlo a los diferentes destinos. Las causales de este aumento en el de tiempo de entrega, se presentan en el área de producción, determinada por dos secciones, imprentas y corrugación. Luego de analizar estas áreas se comprobó que la imprenta Hooper 1, era la que incidía directamente en el retraso, debido a que ocupa un tiempo excesivo en la preparación de máquina y era la que tenía el mayor número de horas perdidas durante el año 2002. Una vez definida el área se procedió a analizar los procesos y tiempos de cada etapa, y se evaluaron los problemas que generan tiempo perdido en esta máquina. Se determinó que los paros de máquina y el bajo rendimiento de la misma, eran las principales causas incidentes en el retraso en la entrega. Con la ayuda del estudio de tiempos realizado en cada etapa de la imprenta se pudo determinar un tiempo estándar para cada actividad

Mediation Analysis Supports a Causal Relationship between Maternal Hyperglycemia and Placental DNA Methylation Variations at the Leptin Gene Locus and Cord Blood Leptin Levels.

Changes in fetal DNA methylation (DNAm) of the leptin (LEP) gene have been associated with exposure to maternal hyperglycemia, but their links with childhood obesity risk are still unclear. We investigated the association between maternal hyperglycemia, placental LEP DNAm (25 5-C-phosphate-G-3 (CpG) sites), neonatal leptinemia, and adiposity (i.e., BMI and skinfold thickness (ST) (subscapular (SS) + triceps (TR) skinfold measures, and the ratio of SS:TR) at 3-years-old, in 259 mother-child dyads, from Gen3G birth cohort. We conducted multivariate linear analyses adjusted for gestational age at birth, sex of the child, age at follow-up, and cellular heterogeneity. We assessed the causal role of DNAm in the association between maternal glycemia and childhood outcomes, using mediation analysis. We found three CpGs associated with neonatal leptinemia (p ≤ 0.002). Of these, cg05136031 and cg15758240 were also associated with BMI (β = -2.69, p = 0.05) and fat distribution (β = -0.581, p = 0.05) at 3-years-old, respectively. Maternal glycemia was associated with DNAm at cg15758240 (β = -0.01, p = 0.04) and neonatal leptinemia (β = 0.19, p = 0.004). DNAm levels at cg15758240 mediates 0.8% of the association between maternal glycemia and neonatal leptinemia (p < 0.001). Our results support that DNAm regulation of the leptin pathway in response to maternal glycemia might be involved in programming adiposity in childhood

Do Prices Coordinate Markets?

Walrasian equilibrium prices can be said to coordinate markets: They support a welfare optimal allocation in which each buyer is buying bundle of goods that is individually most preferred. However, this clean story has two caveats. First, the prices alone are not sufficient to coordinate the market, and buyers may need to select among their most preferred bundles in a coordinated way to find a feasible allocation. Second, we don't in practice expect to encounter exact equilibrium prices tailored to the market, but instead only approximate prices, somehow encoding "distributional" information about the market. How well do prices work to coordinate markets when tie-breaking is not coordinated, and they encode only distributional information? We answer this question. First, we provide a genericity condition such that for buyers with Matroid Based Valuations, overdemand with respect to equilibrium prices is at most 1, independent of the supply of goods, even when tie-breaking is done in an uncoordinated fashion. Second, we provide learning-theoretic results that show that such prices are robust to changing the buyers in the market, so long as all buyers are sampled from the same (unknown) distribution

Laying the foundation for a digital archaeology in Argentina: The role of e-research infrastructures

En el marco de las políticas públicas relacionadas con el desarrollo de la ciencia y técnica en la Argentina, es cada vez más evidente una orientación dirigida a la implementación de un modelo de ciencia abierta basado en la potencialidad ofrecida por los medios digitales. La arqueología no ha sido ajena a esto y, consciente o inconscientemente, se ha volcado hacia una práctica mediada por “lo digital”. Para este modelo de ciencia, la accesibilidad a los datos primarios y la construcción de infraestructuras digitales para la investigación son prioritarias. Siguiendo esta idea, se implementó el Repositorio Digital Institucional Suquía (IDACOR, Universidad Nacional de Córdoba-CONICET), centrado en datos arqueológicos. En esta infraestructura digital se incluyen diversos tipos de información, que comparten una característica común: su difícil acceso, tanto físico como virtual, en su formato original. Bases de datos, informes, imágenes de excavaciones, de objetos y colecciones arqueológicas, son algunas de las clases de archivos contenidos en el repositorio. Este nuevo tipo de infraestructura se propone como un elemento de cambio en cómo se piensa y realiza la práctica arqueológica, ya que permite el uso y reúso de datos generados por financiamiento público, tanto para la investigación arqueológica, la gestión del patrimonio y la divulgación científica, así como para interesados en la temática.In Argentina, public policies related to scientific and technological development foster an open science model that is based on the potential offered by digital media. Archaeological practice, mainly supported by public funding, has accordingly turned towards a digitally-mediated practice by. For this model of science, accessibility to primary data and to e-research infrastructures is a priority. To this end, the Suquía Institutional Digital Repository (IDACOR, Universidad Nacional de Córdoba-CONICET), focused on the archiving of archaeological data, was implemented. This e-research infrastructure includes various types of information that share a common characteristic: Low accessibility, both physical and virtual, in its original format. Databases, reports, images of excavations, archaeological objects and collections are just a few of the file types that can be found in the repository. This new infrastructure is proposed as a game-changer in how archaeological practice is thought of and carried out, since it allows the use and reuse of data generated by public funding for archaeological research, heritage management, and scientific knowledge dissemination.Fil: Izeta, Andres Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Antropología de Córdoba. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Instituto de Antropología de Córdoba; ArgentinaFil: Prado, Isabel Edith. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Antropología de Córdoba. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Instituto de Antropología de Córdoba; ArgentinaFil: Cattaneo, Gabriela Roxana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Antropología de Córdoba. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Instituto de Antropología de Córdoba; Argentin

Technology, impacting society through its different areas: Technological Surveillance, Data Analysis and treatment of plant species (guadua)

La apropiación social del conocimiento de los quince grupos de investigación de la Facultad de Tecnología había sido tradicionalmente divulgada en los eventos llevados a cabo por la vicerrectoría de investigación, innovación y extensión. En el 2022, se realizó la primera jornada y la que se institucionalizará para compartir e integrar las actividades de investigación y extensión de la facultad en la presentación de los avances científicos y tecnológicos que han efectuado los grupos de investigación en la formación de recurso humano a nivel de pregrado y posgrado para dar respuesta a las necesidades de los diversos sectores productivos de la región y del país. Esta jornada realizada el 12 de mayo, se inició con la conferencia plenaria: La Tecnología y la Industria 4.0 que ilustro sobre los nuevos paradigmas entre la tecnología y la industria para el siglo XXI. Así mismo se presentaron once trabajos académicos entre las Escuelas de Tecnología: Eléctrica, Industrial, Mecánica-Manufactura y Química. Esta publicación hace parte del esfuerzo de la facultad y de la Vicerrectoría de investigación innovación y extensión para dar a conocer a toda la comunidad de profesores, estudiantes, administrativos y al público en general los avances en investigación lo que conlleva a la transferencia y apropiación social del conocimiento, Agradecemos a todos los miembros de la facultad y a los que han contribuido con sus trabajos para este documento.PregradoCONTENIDO Presentación...................................................................................................................5 CAPÍTULO UNO Technology surveillance for selection of obtaining fibroin nanoparticles method from bombyx mori l hybrid pilamo 1 with active compounds encapsulation purposes/ Vigilancia tecnológica para la seleccion del método de obtención de nanopartículas de fibroina a partir bombyx mori l hibrido pilamo 1 con fines de encapsulación de compuestos activos.....................................................................................................9 Gloria Edith Guerrero Álvarez and Luz Marina Baena CAPÍTULO DOS Influence of a heat treatment on hygroscopicity and the mechanical strength of the Guadua angustifolia Kunth / Influencia de un tratamiento térmico en la higroscopicidad y en la resistencia mecánica de la Guadua angustifolia Kunth ..................................................................39 Acosta Acosta Ricardo, Montoya Arango Jorge Augusto and Londoño Echeverri Carlos André

Dynamics of Macronutrients in the San Jorge Gulf During Spring and Summer

Following designation of San Jorge Gulf (SJG) as a priority for marine conservation by the Argentine scientific community, it was included in the “Pampa Azul” government initiative. As a contribution to this initiative, we analyzed macronutrient distribution and its relationship to the stratification and primary producer biomass in the water column during austral summer 2014 and spring 2016. In addition, we determined dissolved oxygen, chlorophyll concentrations, and pH. During both seasons in the central and northern gulf, strong stratification separated nutrient-poor, oxygenated surface waters from nutrient-rich, less-oxygenated deep waters. Thermal stratification was correlated to nutrient concentrations. Oxygen decreased up to 60% in bottom waters, although hypoxic conditions were not found. Nitrate limited primary production in surface waters. A tidal front near the gulf’s mouth in the south and wind-forced upwelling in the southwestern coastal zone naturally fertilized the waters. Although there is no information on the precise amount of nutrients each source contributes to the SJG, a shortcut in the path toward resource conservation could be directed through the processes associated with water column stratification because it determines the availability of surface nutrients to primary producers.Fil: Torres, Américo Iadran. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Centro para el Estudio de Sistemas Marinos; ArgentinaFil: Paparazzo, Flavio Emiliano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Centro para el Estudio de Sistemas Marinos; ArgentinaFil: Williams, Gabriela Noemí. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Centro para el Estudio de Sistemas Marinos; ArgentinaFil: Rivas, Andres Lujan. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Centro para el Estudio de Sistemas Marinos; ArgentinaFil: Solis, Miriam Edith. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Centro para el Estudio de Sistemas Marinos; ArgentinaFil: Esteves, Jose Luis. Fundación Patagonia Natural, Chubut; Argentin

A systematic review of clinical applications and diagnostic efficacy of intravascular optical coherence tomography in cardiology

Intravascular Optical Coherence Tomography (OCT) has emerged advanced imaging modality in cardiology, offering high-resolution visualization of coronary artery structures. Since its inception in the late 1990s, OCT has undergone significant advancements, transitioning from time-domain to frequency-domain systems, thereby enhancing its clinical viability and diagnostic efficacy. We aimed to comprehensively assess the clinical applications and diagnostic efficacy of intravascular OCT in cardiology, particularly in guiding percutaneous coronary interventions (PCI) and evaluating coronary artery diseases. In methodology, A systematic search was conducted in PubMed and Google Scholar databases for studies published between 2013 and 2023, comparing OCT with intravascular ultrasound (IVUS) and conventional angiography (C.A.) in guiding PCI procedures. Studies were selected based on predefined inclusion and exclusion criteria, focusing on major adverse cardiovascular events (MACE), cardiac death, and revascularizations as outcomes. In results we included 28 studies from databased and 3 manuals, highlighting OCT's superior resolution in identifying thin-capped fibroatheromas (TCFAs), optimizing stent placement, and assessing plaque composition. Comparative analyses revealed no significant differences in clinical efficacy between OCT and IVUS, with both modalities showing superiority over C.A. in reducing cardiovascular events. The OCTIVUS trial further confirmed the non-inferiority of OCT-guided PCI compared to IVUS-guided PCI, with lower procedural complications reported in the OCT group. In conclusion, Intravascular OCT has revolutionized the diagnostic and interventional landscape in cardiology, offering unparalleled insights into coronary artery pathology. Its high-resolution imaging capabilities facilitate accurate plaque characterization, stent optimization, and real-time intervention guidance, thereby improving clinical outcomes in PCI procedures. Future research should focus on expanding OCT's applications and further validating its efficacy in diverse clinical settings

Sustainable reduction of antibiotic-induced antimicrobial resistance (ARena) in German ambulatory care: study protocol of a cluster randomised trial

Background: Despite many initiatives to enhance the rational use of antibiotics, there remains substantial room for improvement. The overall aim of this study is to optimise the appropriate use of antibiotics in German ambulatory care in patients with acute non-complicated infections (respiratory tract infections, such as bronchitis, sinusitis, tonsillitis and otitis media), community-acquired pneumonia and non-complicated cystitis, in order to counter the advancing antimicrobial resistance development. Methods: A three-armed cluster randomised trial will be conducted in 14 practice networks in two German federal states (Bavaria and North Rhine-Westphalia) and an added cohort that reflects standard care. The trial is accompanied by a process evaluation. Each arm will receive a different set of implementation strategies. Arm A receives a standard set, comprising of e-learning on communication with patients and quality circles with data-based feedback for physicians, information campaigns for the public, patient information material and performance-based additional reimbursement. Arm B receives this standard set plus e-learning on communication with patients and quality circles with data-based feedback tailored for non-physician health professionals of the practice team and information material for tablet computers (culture sensitive). Arm C receives the standard set as well as a computerised decision support system and quality circles in local multidisciplinary groups. The study aims to recruit 193 practices which will provide data on 23,934 patients each year (47,867 patients in total). The outcome evaluation is based on claims data and refers to established indicators of the European Surveillance of Antimicrobial Consumption Network (ESAC-Net). Primary and secondary outcomes relate to prescribing of antibiotics, which will be analysed in multivariate regression models. The process evaluation is based on interviews with surveys among physicians, non-physician health professionals of the practice team and stakeholders. A patient survey is conducted in one of the study arms. Interview data will be qualitatively analysed using thematic framework analysis. Survey data of physicians, non-physician health professionals of the practice team and patients will use descriptive and exploratory statistics for analysis. Discussion: The ARena trial will examine the effectiveness of large scale implementation strategies and explore their delivery in routine practice. Trial registration: ISRCTN, ISRCTN58150046 . Registered 24 August 2017

Plan De Responsabilidad Social Empresarial Administración Municipal De Garagoa.

Anexo realizo entrega de Video de la fase 3 Marketing corporativo vs Marketing SocialEl presente proyecto se realiza con el fin de establecer el plan de acción para ejecutar el plan de Responsabilidad Social Empresarial (RSE) a la Administración Municipal de Garagoa Boyacá, con el propósito de generar un impacto positivo a nivel Municipal en el Valle de Tenza, esto en las prácticas que se generan y en los diferentes ámbitos con los que la Administración se relaciona, en concreto con la Comunidad, Entes territoriales y todos los organismos que están directamente vinculados.This project is carried out to establish the action plan to be followed to execute the Corporate Social Responsibility (CSR) plan of the Municipal Administration of Garagoa Boyacá, in order to generate a positive impact at the municipal level in the Tenza Valley, Regional and national in multiple practices that are generated and in the different areas with which the Administration relates, specifically with the Community, territorial entities and all the bodies that are directly linked