Characteristics of food allergy in children: National multicenter study

Conference: Congress of the European-Academy-of-Allergy-and-Clinical-Immunology (EAACI) Location: Lisbon, PORTUGAL Date: JUN 01-05, 2019Background : Food allergies impose a significant burden on the life of the child and the family. In this study, to determine the demographic characteristics of food allergies, we investigated the characteristics of patients with food allergies in different regions of Pediatric Allergy- Immunology departments in Turkey. Method : Turkey ' s National Study of Allergy and Clinical Immunology Society has conducted a Study Group on Food Allergies. 25 centers participated in this multicenter, cross- sectional and descriptive study.European Academy of Allergy and Clinical Immunolog

Panik bozuklukta yaşam kalitesi : 3 aylık izlem çalışması

TEZ6069Tez (Uzmanlık) -- Çukurova Üniversitesi, Adana, 2006.Kaynakça (s.45-56) var.viii, 79 s. ; 29 cm.Panik Bozukluk, madde bagımlılıgı, özkıyım girişimleri ve fonksiyon kaybına neden olan, yaygın olarak görülen bir bozukluktur. Toplumda %1,4 ile %3,8 oranında ve kadınlarda 2-3 defa fazla görülür. Yapılan çalışmalarda Panik Bozuklukta yaşam kalitesi olumsuz olarak etkilendigi ve genel saglık( duygusal ve fiziksel saglık), sosyal yaşamı bozdugu, işsiz kalma olasılıgını arttırdıgı belirlenmiştir. Çalışmamızın amacı Panik Bozukluk ve Depresyonun yaşam kalitesi üzerindeki etkilerini araştırmak ve 3 aylık tedaviye verdikleri yanıtı degerlendirmektir. Çalışmaya, Panik Bozukluk tanısı alan yaşları 20-73(ortalama 40,3±12,9) olan 22 kadın ve 9 erkek(toplam 31); Agorafobili Panik Bozukluk tanısı alan yaşları 18- 57(ortalama 33,6±11,5) olan 27 kadın ve 15 erkek; Majör Depresyon tanısı alan yaşları 20-69(ortalama 38,5±11,7) olan 54 kadın ve 19 erkek(toplam 73) hasta dahil edildi. Yapılandırılmış bir görüşme formu ile (SCID-I) psikiyatrik görüşme yapıldı. Sosyodemografik veri formu, Hamilton Anksiyete Ölçegi(HAM-A), Hamilton Depresyon Ölçegi(HAM-D), Panik ve Agorafobi Ölçegi, Endicott Işte Üretkenlik Ölçegi 0., 1., 3. aylarda hastalara uygulandı. Sonuç olarak tüm gruplarda yaşam kalitesi olumsuz olarak etkilenmişti. Depresyonu olan grupta yaşam kalitesi ölçeginin agrı, genel saglık, enerji, sosyal fonksiyon, duygusal rol güçlügü ve ruhsal saglık alt gruplarındaki bozulma daha fazlaydı. Agorafobili Panik Bozuklugu olanların Agorafobisi olmayan Panik Bozuklugu olan hastalara göre yaşam kalitesini daha olumsuz etkiledigi belirlendi. Tedavinin sonunda yaşam kalitesi yönünden gruplar arasında istatistiksel olarak fark olmadıgı belirlendi.Panic Disorder is a common psychiatric condition which is higher risk for substance abuse, suicide attempts and functional disability. It is 2-3 times more common in women and estimated to range from 1,4% to 3,8% of the general population. Studies reported that quality of life in Panic Disorder is negatively affected and overall health (emotional and psyhical health), social activities, risk of unemployment increases. The aim of this study was investigate the affects of quality of life on panic disorder and depression and follow the treatment response after the 3 months. 22 women and 9 men (total 31) within in age range of 20-73(mean age 40,3±12,9) diagnosed as Panic Disorder; 27 women and 15 men (total 42) within in age range of 18- 57(mean age 33,6 ±11,5) diagnosed as Panic Disorder with Agoraphobia; 54 women and 19 men (total 73) within in age 20-69(mean age 38,5 ±11,7) diagnosed on Major Depression were included to study.Psychiatric interview were carried out using Structured Clinical Interview for Diagnose(SCID-I), Sociodemographic Data Form, Hamilton Anxiety Scale (HAM-A), Hamilton Depression Scale(HAM-D), Panic and Agoraphobia Scale and Endicott's Work Productivity Scale (EWPS) were applied in 0.,1.,3. months. As a result, quality of life had negatively affected in all of the groups. In this study we found significant impairment in pain, general health, energy, social function, emotional role disability and mental health subgroups of quality of life scale (SF-36) in Depression group than Panic Disorder group. Panic Disorder with Agoraphobia had affected the quality of life worse than comparison with Panic Disorder without Agoraphobia. At the and of the treatment, there were no differences in quality of life between all of the groups statistically.Bu çalışma Ç.Ü. Bilimsel Araştırma Projeleri Birimi Tarafından Desteklenmiştir. Proje No

Patients eligible for modulator drugs: Data from cystic fibrosis registry of Turkey

Background A better understanding of cystic fibrosis transmembrane conductance regulator biology has led to the development of modulator drugs such as ivacaftor, lumacaftor-ivacaftor, tezacaftor-ivacaftor, and elexacaftor-tezacaftor-ivacaftor. This cross-sectional study evaluated cystic fibrosis (CF) patients eligible for modulator drugs

Patients with cystic fibrosis who could not receive the CFTR modulator treatment: What did they lose in 1 year?

Background: Cystic fibrosis (CF) is an autosomal recessive disorder caused by CF transmembrane conductance regulator (CFTR) genetic variants. CFTR modulators improve pulmonary function and reduce respiratory infections in CF. This study investigated the clinical and laboratory follow-up parameters over 1 year in patients with CF who could not receive this treatment. Methods: This retrospective cohort study included 2018 and 2019 CF patient data from the CF registry of Turkey. Demographic and clinical characteristics of 294 patients were assessed, who had modulator treatment indications in 2018 but could not reach the treatment. Results: In 2019, patients younger than 18 years had significantly lower BMI z-scores than in 2018. During the 1-year follow-up, forced expiratory volumes (FEV1) and FEV1 z-scores a trend toward a decrease. In 2019, chronic Staphylococcus aureus colonization, inhaled antipseudomonal antibiotic use for more than 3 months, oral nutritional supplement requirements, and oxygen support need increased. Conclusions: Patients who had indications for modulator treatments but were unable to obtain them worsened even after a year of follow-up. This study emphasized the importance of using modulator treatments for patients with CF in our country, as well as in many countries worldwide

Clinical outcomes and independent risk factors for 90-day mortality in critically ill patients with respiratory failure infected with sars-cov-2: A multicenter study in turkish intensive care units

Background: There are limited data on the long-term outcomes of COVID-19 from different parts of the world. Aims: To determine risk factors of 90-day mortality in critically ill patients in Turkish intensive care units (ICUs), with respiratory failure. Study design: Retrospective, observational cohort. Methods: Patients with laboratory-confirmed COVID-19 and who had been followed up in the ICUs with respiratory failure for more than 24 hours were included in the study. Their demographics, clinical characteristics, laboratory variables, treatment protocols, and survival data were recorded. Results: A total of 421 patients were included. The median age was 67 (IQR: 57-76) years, and 251 patients (59.6%) were men. The 90-day mortality rate was 55.1%. The factors independently associated with 90-day mortality were invasive mechanical ventilation (IMV) (HR 4.09 [95% CI: [2.20-7.63], P 2 mmol/L (2.78 [1.93-4.01], P < .001), age ≥60 years (2.45 [1.48-4.06)], P < .001), cardiac arrhythmia during ICU stay (2.01 [1.27-3.20], P = .003), vasopressor treatment (1.94 [1.32-2.84], P = .001), positive fluid balance of ≥600 mL/day (1.68 [1.21-2.34], P = .002), PaO2 /FiO2 ratio of ≤150 mmHg (1.66 [1.18-2.32], P = .003), and ECOG score ≥1 (1.42 [1.00-2.02], P = .050). Conclusion: Long-term mortality was high in critically ill patients with COVID-19 hospitalized in intensive care units in Turkey. Invasive mechanical ventilation, lactate level, age, cardiac arrhythmia, vasopressor therapy, positive fluid balance, severe hypoxemia and ECOG score were the independent risk factors for 90-day mortality. Copyright@Author(s)